KEGG DRUG Database

KEGG DRUG is a comprehensive drug information resource for approved drugs in Japan, USA and Europe, unified based on the chemical structure and/or the chemical component of active ingredients. Each KEGG DRUG entry is identified by the D number and associated with KEGG original annotations including therapeutic targets, drug metabolism, and other molecular interaction network information.

Current statistics (2021/6/21)
KEGG DRUG entries (D numbers) 11,662
D numbers with targets 6,179
   D numbers with human gene targets 5,002
   Unique human genes (hsa IDs) 1,086
   Unique human gene variants (hsa_var IDs) 50
D numbers linked to Japanese drug labels 2,263
   with indicated diseases (H numbers) 1,511
   Unique H numbers 458
D numbers linked to FDA drug labels 2,034
   with indicated diseases (H numbers) 1,364
   Unique H numbers 450
Special drug types
Antibody therapy products 454
Antisense therapy products 51
Enzyme replacement therapy products 27
Gene therapy products 10
Cellular therapy products 12

Drug Classification

KEGG DRUG entries are systematically organized in various ways, utilizing both established and KEGG-original classification systems and focusing on specific features such as drug targets and gene variants.

Generic Names and Trade Names

The generic names of drugs can be different in different countries or organizations. The same structure may be called differently and the same name may mean different structures. To accommodate such differences the generic names are associated with the following codes in parentheses.
  • JAN - Japanese Approved Name
  • USAN - United States Adopted Name
  • NF - National Formulary drug name
  • INN - International Nonproprietary Name
  • BAN - British Approved Name
  • DCF - Dénomination commune française
Specifically, for the drugs in Japan and USA whether they are listed in the pharmacopoeia is denoted by: which also imply the JAN and USAN names, respectively. Furthermore, the drugs in Japan include:
  • Non-JPS - Japanese standards for non-Pharmacopoeial crude drugs
for additional crude drugs.

When drug products are available in Japan and/or USA, the following notations are often utilized:
<JP> <JP/US> <US>

Additional Databases

There are three additional databases associated with KEGG DRUG.

KEGG DGROUP contains structurally and functionally related groups of D number entries in KEGG DRUG. Among them chemical groups are used to accommodate minor variations of chemical structures, such as salts and hydration states, especially for identifying essentially the same active ingredients of drugs in different countries.

Drug Interaction Database contains known adverse drug-drug interactions associated with contraindications (CI) and precautions (P) extracted from all the drug labels of Japanese prescription drugs. KEGG Drug Structure Maps are part of the KEGG PATHWAY database, graphically illustrating our knowledge of drug development, as many marketed drugs have been developed from lead compounds or existing drugs by introducing chemical structure transformations retaining the core chemical structures.

Last updated: June 9, 2021