KEGG   DRUG: RepaglinideHelp
Entry
D00594                      Drug                                   

Name
Repaglinide (JAN/USP/INN);
Prandin (TN);
Surepost (TN)
Product
  Generic
Formula
C27H36N2O4
Exact mass
452.2675
Mol weight
452.5857
Structure
Mol fileKCF fileDB searchJmolKegDraw
Simcomp SIMCOMP
Class
Antidiabetic agent
 DG01508  Sulfonylurea receptor agonist
 DG01735  Glinide
 DG02044  Hypoglycemics
  DG01735  Glinide
Cyp substrate
 DG01633  CYP3A substrate
Remark
Same as: 
Therapeutic category: 
ATC code: 
Efficacy
Antidiabetic, Hypoglycemic, Sulfonylurea receptor agonist
  Disease
Type 2 diabetes mellitus [DS:H00409]
Comment
Glinide derivative
Target
ABCC8(SUR1)/KCNJ11(KIR6.2) [HSA:6833 3767] [KO:K05032 K05004]
  Pathway
ABC transporters
Insulin secretion
Type II diabetes mellitus
Metabolism
Enzyme: CYP2C8 [HSA:1558], CYP3A4 [HSA:1576]
Transporter: SLCO1B1 [HSA:10599]
Interaction
Drug interaction
Structure map
Antidiabetics
Brite
Anatomical Therapeutic Chemical (ATC) classification [BR:br08303]
 A ALIMENTARY TRACT AND METABOLISM
  A10 DRUGS USED IN DIABETES
   A10B BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS
    A10BX Other blood glucose lowering drugs, excl. insulins
     A10BX02 Repaglinide
      D00594  Repaglinide (JAN/USP/INN)
USP drug classification [BR:br08302]
 Blood Glucose Regulators
  Antidiabetic Agents
   Repaglinide
    D00594  Repaglinide (JAN/USP/INN)
Therapeutic category of drugs in Japan [BR:br08301]
 3  Agents affecting metabolism
  39  Other agents affecting metabolism
   396  Antidiabetic agents
    3969  Others
     D00594  Repaglinide (JAN/USP/INN)
Target-based classification of drugs [BR:br08310]
 Transporters
  ABC transporters
   ABCC (CFTR/MRP) subfamily
    ABCC8 (sulfonylurea receptor 1)
     Repaglinide
      D00594  Repaglinide (JAN/USP/INN)
Drug classes of therapeutic agents [br08360.html]
 Antidiabetics
  D00594
New drug approvals in Europe [br08329.html]
 European public assessment reports (EPAR) authorised medicine
  D00594
New drug approvals in Japan [br08318.html]
 Drugs with new active ingredients
  D00594
New drug approvals in the USA, Europe and Japan [br08328.html]
 Approval dates by FDA, EMA and PMDA
  D00594
BRITE hierarchy
Other DBs
CAS: 
135062-02-1
PubChem: 
ChEBI: 
ChEMBL: 
DrugBank: 
LigandBox: 
NIKKAJI: 
LinkDB All DBs
KCF data Show

ATOM        33
            1   C8y C    29.5484  -19.4440
            2   C8y C    29.5543  -20.8486
            3   N1y N    28.3361  -18.7446
            4   C8x C    30.7608  -18.7446
            5   C1c C    28.3478  -21.5481
            6   C8x C    30.7608  -21.5423
            7   C1x C    28.3361  -17.3457
            8   C1x C    27.1296  -19.4497
            9   C8x C    31.9790  -19.4440
            10  N1b N    27.1296  -20.8486
            11  C1b C    28.3478  -22.9469
            12  C8x C    31.9790  -20.8486
            13  C1x C    27.1238  -16.6520
            14  C1x C    25.9114  -18.7503
            15  C5a C    25.9173  -21.5481
            16  C1c C    29.5543  -23.6521
            17  C1x C    25.9114  -17.3514
            18  C1b C    24.7049  -20.8486
            19  O5a O    25.9173  -22.9469
            20  C1a C    29.5543  -25.0569
            21  C1a C    30.7666  -22.9469
            22  C8y C    23.4867  -21.5481
            23  C8x C    22.2744  -20.8486
            24  C8x C    23.4867  -22.9469
            25  C8y C    21.0679  -21.5538
            26  C8x C    22.2744  -23.6521
            27  C8y C    21.0562  -22.9469
            28  O2a O    19.8556  -20.8603
            29  C6a C    19.8497  -23.6521
            30  C1b C    18.6432  -21.5538
            31  O6a O    18.6375  -22.9410
            32  O6a O    19.9140  -25.0510
            33  C1a C    17.4309  -20.8603
BOND        35
            1     1   2 1
            2     1   3 1
            3     1   4 2
            4     2   5 1
            5     2   6 2
            6     3   7 1
            7     3   8 1
            8     4   9 1
            9     5  10 1
            10    5  11 1 #Down
            11    6  12 1
            12    7  13 1
            13    8  14 1
            14   10  15 1
            15   11  16 1
            16   13  17 1
            17   15  18 1
            18   15  19 2
            19   16  20 1
            20   16  21 1
            21   18  22 1
            22   22  23 2
            23   22  24 1
            24   23  25 1
            25   24  26 2
            26   25  27 2
            27   25  28 1
            28   27  29 1
            29   28  30 1
            30   29  31 1
            31   29  32 2
            32   30  33 1
            33    9  12 2
            34   14  17 1
            35   26  27 1

» Japanese version   » Back

DBGET integrated database retrieval system