KEGG   Addendum: AAF86396
Entry
AAF86396          CDS       T10000                                 
Symbol
fkbA
Name
(KEGG) polyketide synthase FkbA
  KO
K16377  polyketide synthase FkbA
Taxonomy
TAX:1912
  Lineage
Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales; Streptomycetaceae; Streptomyces; Streptomyces violaceusniger group
Organism
Streptomyces hygroscopicus
SSDB
Motif
Pfam: ketoacyl-synt Acyl_transf_1 Ketoacyl-synt_C KR KAsynt_C_assoc PKS_DH_N PP-binding PS-DH ADH_zinc_N_2 Thiolase_N ADH_zinc_N ADH_N adh_short ACP_syn_III Docking
Other DBs
NCBI-ProteinID: AAF86396
GB: AF235504
UniProt: Q9KID7
LinkDB
AA seq 6396 aa
MPEQDKTVEYLRWATAELQKTRAELAAHSEPLAIVGMACRLPGGVASPEDLWQLLESGGD
GITAFPTDRGWETTADGRGGFLTGAAGFDAAFFGISPREALAMDPQQRLALETSWEAFEH
AGIDPQTLRGSDTGVFLGAFFQGYGIGADFDGYGTTSIHTSVLSGRLAYFYGLEGPAVTV
DTACSSSLVALHQAGQSLRSGECSLALVGGVTVMASPAGFADFSEQGGLAPDARCKAFAE
AADGTGFAEGSGVLIVEKLSDAERNGHRVLAVVRGSAVNQDGASNGLSAPNGPSQERVIR
QALANAGLTPADVDAVEAHGTGTRLGDPIEAQAVLATYGQGRDTPVLLGSLKSNIGHTQA
AAGVAGVIKMVLAMRHGTLPRTLHVDTPSSHVDWTAGAVELLTDARPWPETDRPRRAGVS
SFGVSGTNAHIILESHPRPAPEPAPAPDTGPLPLLLSARTPQALDAQVHRLRAFLDDNPG
ADRVAVAQTLARRTQFEHRAVLLGDTLITVSPNAGRGPVVFVYSGQSTLHPHTGRQLAST
YPVFAEAWREALDHLDPTQGPATHFAHQTALTALLRSWGITPHAVIGHSLGEITAAHAAG
VLSLRDAGALLTTRTRLMDQLPSGGAMVTVLTSEEKARQVLRPGVEIAAVNGPHSLVLSG
DEEAVLEAARQLGIHHRLPTRHAGHSERMQPLVAPLLDVARTLTYHQPHTAIPGDPTTAE
YWAHQVRDQVRFQAHTEQYPGATFLEIGPNQDLSPLVDGVAAQTGTPDEVRALHTALAQL
HVRGVAIDWTLVLGGDRAPVTLPTYPFQHKDYWLRPTSRADVTGAGQEQVAHPLLGAAVA
LPGTGGVVLTGRLSLASHPWLGEHAVDGTVLLPGAAFLELAARAGDEVGCDLLHELVIET
PLVLPATGGVAVSVEIAEPDDTGRRAVTVHARADGSGLWTRHAGGFLGTAPAPATATDPA
PWPPAEAGPVDVADVYDRFEDIGYSYGPGFRGLRAAWRAGDTVYAEVALPDEQSADAARF
TLHPALLDAAFQAGALAALDAPGGAARLPFSFQDVRIHAAGATRLRVTVGRDGERSTVRM
TGPDGQLVAVVGAVLSRPYAEGSGDGLLRPVWTELPMPVPSADDPRVEVLGADPGDGDVP
AATRELTARVLGALQRHLSAAEDTTLVVRTGTGPAAAAAAGLVRSAQAENPGRVVLVEAS
PDTSVELLAACAALDEPQLAVRDGVLFAPRLVRMSDPAHGPLSLPDGDWLLTRSASGTLH
DVALIADDTPRRALEAGEVRIDVRAAGLNFRDVLIALGTYTGATAMGGEAAGVVVETGPG
VDDLSPGDRVFGLTRGGIGPTAVTDRRWLARIPDGWSFTTAASVPIVFATAWYGLVDLGT
LRAGEKVLVHAATGGVGMAAAQIARHLGAELYATASTGKQHVLRAAGLPDTHIADSRTTA
FRTAFPRMDVVLNALTGEFIDASLDLLDADGRFVEMGRTELRDPAAIVPAYLPFDLLDAG
ADRIGEILGELLRLFDAGALEPLPVRAWDVRQARDALGWMSRARHIGKNVLTLPRPLDPE
GAVVLTGGSGTLAGILARHLRERHVYLLSRTAPPEGTPGVHLPCDVGDRDQLAAALERVD
RPITAVVHLAGALDDGTVASLTPERFDTVLRPKADGAWYLHELTKEQDLAAFVLYSSAAG
VLGNAGQGNYVAANAFLDALAELRHGSGLPALSIAWGLWEDVSGLTAALGEADRDRMRRS
GFRAITAQQGMHLYEAAGRTGSPVVVAAALDDAPDVPLLRGLRRTTVRRAAVRECSSADR
LAALTGDELAEALLTLVRESTAAVLGHVGGEDIPATAAFKDLGIDSLTAVQLRNALTEAT
GVRLNATAVFDFPTPHVLAGKLGDELTGTRAPVVPRTAATAGAHDEPLAIVGMACRLPGG
VASPEELWHLVASGTDAITEFPTDRGWDVDAIYDPDPDAIGKTFVRHGGFLTGATGFDAA
FFGISPREALAMDPQQRVLLETSWEAFESAGITPDSTRGSDTGVFVGAFSYGYGTGADTD
GFGATGSQTSVLSGRLSYFYGLEGPAVTVDTACSSSLVALHQAGQSLRSGECSLALVGGV
TVMASPGGFVEFSRQRGLAPDGRAKAFGAGADGTSFAEGAGVLIVERLSDAERNGHTVLA
VVRGSAVNQDGASNGLSAPNGPSQERVIRQALANAGLTPADVDAVEAHGTGTRLGDPIEA
QAVLATYGQERATPLLLGSLKSNIGHAQAASGVAGIIKMVQALRHGELPPTLHADEPSPH
VDWTAGAVELLTSARPWPETDRPRRAAVSSFGVSGTNAHVILEAGPVTETPAASPSGDLP
LLVSARSPEALDEQIRRLRAYLDTTPDVDRVAVAQTLARRTHFAHRAVLLGDTVITTPPA
DRPDELVFVYSGQGTQHPAMGEQLAAAHPVFADAWHEALRRLDNPDPHDPTHSQHVLFAH
QAAFTALLRSWGITPHAVIGHSLGEITAAHAAGILSLDDACTLITTRARLMHTLPPPGAM
VTVLTSEEKARQALRPGVEIAAVNGPHSIVLSGDEDAVLTVAGQLGIHHRLPAPHAGHSA
HMEPVAAELLATTRGLRYHPPHTSIPNDPTTAEYWAEQVRKPVLFHAHAQQYPDAVFVEI
GPAQDLSPLVDGIPLQNGTADEVHALHTALAHLYARGATLDWPRILGAGSRHDADVPAYA
FQRRHYWIESARPAASDAGHPVLGSGIALAGSPGRVFTGSVPTGADRAVFVAELALAAAD
AVDCATVERLDIASVPGRPGHGRTTVQTWVDEPADDGRRRFTVHTRTGDAPWTLHAEGVL
RPHGTALPDAADAEWPPPGAVPADGLPGVWRRGDQVFAEAEVDGPDGFVVHPDLLDAVFS
AVGDGSRQPAGWRDLTVHASDATVLRACLTRRTDGAMGFAAFDGAGLPVLTAEAVTLREV
ASPSGSEESDGLHRLEWLAVAEAVYDGDLPEGHVLITAAHPDDPEDIPTRAHTRATRVLT
ALQHHLTTTDHTLIVHTTTDPAGATVTGLTRTAQNEHPHRIRLIETDHPHTPLPLAQLAT
LDHPHLRLTHHTLHHPHLTPLHTTTPPTTTPLNPEHAIIITGGSGTLAGILARHLNHPHT
YLLSRTPPPDATPGTHLPCDVGDPHQLATTLTHIPQPLTAIFHTAATLDDGILHALTPDR
LTTVLHPKANAAWHLHHLTQNQPLTHFVLYSSAAAVLGSPGQGNYAAANAFLDALATHRH
TLGQPATSIAWGMWHTTSTLTGQLDDADRDRIRRGGFLPITDDEGMRLYEAAVGSGEDFV
MAAAMDPAQPMTGSVPPILSGLRRSARRVARAGQTFAQRLAELPDADRGAALTTLVSDAT
AAVLGHADASEIAPTTTFKDLGIDSLTAIELRNRLAEATGLRLSATLVFDHPTPRVLAAK
LRTDLFGTAVPTPARTARTHHDEPLAIVGMACRLPGGVASPEDLWQLVASGTDAITEFPT
DRGWDIDRLFDPDPDAPGKTYVRHGGFLAEAAGFDAAFFGISPREARAMDPQQRVILETS
WEAFENAGIVPDTLRGSDTGVFMGAFSHGYGAGVDLGGFGATATQNSVLSGRLSYFFGME
GPAVTVDTACSSSLVALHQAAQALRTGECSLALAGGVTVMPTPLGYVEFCRQRGLAPDGR
CQAFAEGADGTSFSEGAGVLVLERLSDAERNGHTVLAVVRSSAVNQDGASNGISAPNGPS
QQRVIRQALDKAGLAPADVDVVEAHGTGTPLGDPIEAQAIIATYGQDRDTPLYLGSVKSN
IGHTQTTAGVAGVIKMVMAMRHGIAPKTLHVDEPSSHVDWTEGAVELLTEARPWPDAGRP
RRAGVSSLGISGTNAHVILEGVPGPSRVEPSVDGLVPLPVSARSEASLRGQVERLEGYLR
GSVDVAAVAQGLVRERAVFGHRAVLLGDARVMGVAVDQPRTVFVFPGQGAQWVGMGVELM
DRSAVFAARMEECARALLPHTGWDVREMLARPDVAERVEVVQPASWAVAVSLAALWQAHG
VVPDAVIGHSQGEIAAACVAGALSLEDAARVVALRSQVIAARLAGRGAMASVALPAGEVG
LVEGVWIAARNGPASTVVAGEPSAVEDVVTRYETEGVRVRRIAVDYASHTPHVEAIEDEL
AEVLKGVAGKAASVAWWSTVDSAWVTEPVDESYWYRNLRRPVALDAAVAELDGSVFVECS
AHPVLLPAMEQAHTVASLRTGDGGWERWLTALAQAWTLGAAVDWDTVVEPVPGRLLDLPT
YAFERRRYWLEAAGATDLSAAGLTGAAHPMLAAITALPADDGGVVLTGRISLRTHPWLAD
HAVRGTVLLPGTAFVELVIRAGDETGCGIVDELVIESPLVVPATAAVDLSVTVEGADEAG
RRRVTVHARTEGTGSWTRHASGTLTPDTPDTPNASGVVGAEPFSQWPPATAAAVDTSEFY
LRLDALGYRFGPMFRGMRAAWRDGDTVYAEVALPEDRAADADGFGMHPALLDAALQSGSL
LMLESDGEQSVQLPFSWHGVRFHATGATMLRVAVVPGPDGLRLHAADSGNRPVATIDALV
TRSPEADLAPADPMLRVGWAPVPVPAGAGPSDADVLTLRGDDADPLGETRDLTTRVLDAL
LRADRPVIFQVTGGLAAKAAAGLVRTAQNEQPGRFFLVETDPGEVLDGAKRDAIAALGEP
HVRLRDGLFEAARLMRATPSLTLPDTGSWQLRPSATGSLDDLAVVPTDAPDRPLAAGEVR
IAVRAAGLNFRDVTVALGVVADARPLGSEAAGVVLETGPGVHDLAPGDRVLGMLAGAFGP
VAITDRRLLGRMPDGWTFPQAASVMTAFATAWYGLVDLAGLRPGEKVLIHAAATGVGAAA
VQIARHLGAEVYATTSAAKRHLVDLDGAHLADSRSTAFADAFPPVDVVLNSLTGEFLDAS
VGLLAAGGRFIEMGKTDIRHAVQQPFDLMDAGPDRMQRIIVELLGLFARDVLHPLPVHAW
DVRQAREAFGWMSSGRHTGKLVLTVPRPLDPEGAVVITGGSGTLAGILARHLGHPHTYLL
SRTPPPDTTPGTHLPCDVGDPHQLATTLARIPQPLTAVFHTAGTLDDALLDNLTPDRVDT
VLKPKADAAWHLHRLTRDTDLAAFVVYSAVAGLMGSPGQGNYVAANAFLDALAEHRRAQG
LPAQSLAWGMWADVSALTAKLTDADRQRIRRSGFPPLSAADGMRLFDAATRTPEPVVVAT
TVDLTQLDGAVAPLLRGLAAHRAGPARTVARNAGEEPLAVRLAGRTAAEQRRIMQEVVLR
HAAAVLAYGLGDRVAADRPFRELGFDSLTAVDLRNRLAAETGLRLPTTLVFSHPTAEALT
AHLLDLIDAPTARIAGESLPAVTAAPVAAARDQDEPIAIVAMACRLPGGVTSPEDLWRLV
ESGTDAITTPPDDRGWDVDALYDADPDAAGKAYNLRGGYLAGAAEFDAAFFDISPREALG
MDPQQRLLLETAWEAIERGRISPASLRGREVGVYVGAAAQGYGLGAEDTEGHAITGGSTS
LLSGRLAYVLGLEGPAVTVDTACSSSLVALHLACQGLRLGECELALAGGVSVLSSPAAFV
EFSRQRGLAADGRCKSFGAGADGTTWSEGVGVLVLERLSDAERLGHTVLAVVRGSAVTSD
GASNGLTAPNGLSQQRVIRKALAAAGLTGADVDVVEGHGTGTRLGDPVEADALLATYGQD
RPAPVWLGSLKSNIGHATAAAGVAGVIKMVQAIGAGTMPRTLHVEEPSPAVDWSTGQVSL
LGSNRPWPDDERPRRAAVSAFGLSGTNAHVILEQHRPAPVASQPPRPPREESQPLPWVLS
ARTPAALRAQAARLRDHLAAAPDADPLDIGYALATSRAQFAHRAAVVATTPDGFRAALDG
LADGAEAPGVVTGTAQERRVAFLFDGQGAQRAGMGRELHRRFPVFAAAWDEVSDAFGKHL
KHSPTDVYHGEHGALAHDTLYAQAGLFTLEVALLRLLEHWGVRPDVLVGHSVGEVTAAYA
AGVLTLADATELIVARGRALRALPPGAMLAVDGSPAEVGARTDLDIAAVNGPSAVVLAGS
PDDVAAFEREWSAAGRRTKRLDVGHAFHSRHVDGALDGFRTVLESLAFGAARLPVVSTTT
GRDAADDLITPAHWLRHARRPVLFSDAVRELADRGVTTFVAVGPSGSLASAAAESAGEDA
GTYHAVLRARTGEETAALTALAELHAHGVPVDLAAVLAGGRPVDLPVYAFQHRSYWLAPA
VAGAPATVADTGGPAESEPEDLTVAEIVRRRTAALLGVTDPADVDAEATFFALGFDSLAV
QRLRNQLASATGLDLPAAVLFDHDTPAALTAFLQDRIEAGQDRIEAGEDDDAPTVLSLLE
EMESLDAADIAATPAPERAAIADLLDKLAHTWKDYR
Reference
PMID:10863099
  Authors
Wu K, Chung L, Revill WP, Katz L, Reeves CD
  Title
The FK520 gene cluster of Streptomyces hygroscopicus var. ascomyceticus (ATCC 14891) contains genes for biosynthesis of unusual polyketide extender units.
  Journal
Gene 251:81-90 (2000)
DOI:10.1016/S0378-1119(00)00171-2

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