Actinobacillus pleuropneumoniae AP76 (serotype 7): APP7_0417
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Entry
APP7_0417 CDS
T00717
Symbol
leuA
Name
(GenBank) 2-isopropylmalate synthase
KO
K01649
2-isopropylmalate synthase [EC:
2.3.3.13
]
Organism
apa
Actinobacillus pleuropneumoniae AP76 (serotype 7)
Pathway
apa00290
Valine, leucine and isoleucine biosynthesis
apa00620
Pyruvate metabolism
apa01100
Metabolic pathways
apa01110
Biosynthesis of secondary metabolites
apa01210
2-Oxocarboxylic acid metabolism
apa01230
Biosynthesis of amino acids
Module
apa_M00432
Leucine biosynthesis, 2-oxoisovalerate => 2-oxoisocaproate
Brite
KEGG Orthology (KO) [BR:
apa00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00620 Pyruvate metabolism
APP7_0417 (leuA)
09105 Amino acid metabolism
00290 Valine, leucine and isoleucine biosynthesis
APP7_0417 (leuA)
Enzymes [BR:
apa01000
]
2. Transferases
2.3 Acyltransferases
2.3.3 Acyl groups converted into alkyl groups on transfer
2.3.3.13 2-isopropylmalate synthase
APP7_0417 (leuA)
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Gene cluster
GFIT
Motif
Pfam:
HMGL-like
LeuA_dimer
NAD_binding_10
Motif
Other DBs
NCBI-ProteinID:
ACE61069
UniProt:
B3H0Q7
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All DBs
Position
476056..477597
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AA seq
513 aa
AA seq
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MSNIIIFDTTLRDGEQSLKASLTVKEKLQIALALERLGVDVMEVGFPVSSAGDFESVKTI
AQHIKNSRVCALSRAVDKDIDVAAEALKVAEAFRIHTFIASSAIHVESKLKRSFDDVVEM
AVHAVKRARNYTDDVEFSCEDAGRTGIDNICRIVEAAINAGATTVNIPDTVGYCLPYQYG
EIIANVMNRVPNIDKAVVSVHCHNDLGMATANSLTAVLNGARQIECTINGIGERAGNTAL
EEVVMAIKTRQDMFNGRDTRINTQEIHRVSQMVSQLCNMPIQPNKAIVGSNAFAHSSGIH
QDGMVKNKNTYEIMSPETIGLKKEKLNLTARSGRAAVKNHMSEMGYQENDYDLDKLYDAF
LKLADKKGQVFDYDLEALAFIDMQAGDEGRLHLDVITSQMISHLPASAFVQVELDGEKLS
QVSSGGNGPVDAVFNAILAITGMDIKMLHYNLTAKGEGAEALGQVDIVVEHEGRRFHGVG
LATDIVESSARALIHAINAIYRAHKVADLKAKK
NT seq
1542 nt
NT seq
+upstream
nt +downstream
nt
atgagtaacattattatttttgatacgacattacgtgacggtgaacaatcgcttaaagca
agtttaaccgtaaaagaaaaactacaaattgcgttagcattagagcgtttaggcgttgat
gttatggaagtcggttttccggtttcatcggcaggggatttcgagtcggtaaaaaccatt
gctcaacacattaaaaacagccgtgtttgcgcattatcccgcgcagtggataaagatatt
gatgtggcggcggaagcattgaaagtcgcagaagcatttcgtattcatacatttatcgcc
agttccgctattcatgttgagtctaaattaaaacgttcgtttgatgatgtcgttgaaatg
gcggtgcatgcggttaaacgtgccagaaactataccgatgatgtggagttttcctgtgaa
gatgcgggacgtaccggtattgataacatttgtcgtattgtcgaagcggcaatcaatgcc
ggtgcgactacggtaaatattccggatacggtcggttactgtttaccgtatcagtacggc
gagattatcgccaatgtgatgaaccgtgtgccgaatattgataaagcggttgtttcggtg
cattgtcataacgatttaggtatggcgacggcaaactcgctcacggcagtgttaaatggt
gcgagacaaatcgaatgtacgattaacggtatcggcgagcgtgcggggaataccgcatta
gaagaagtggtcatggcaatcaaaactcgccaagatatgttcaatggtagagatacgcgc
attaacacgcaagaaattcatcgtgtcagccaaatggtcagccaattatgtaatatgccg
attcaaccgaataaagcgattgtcggttcgaatgcctttgcccattcatccggtatccac
caagacggtatggtaaaaaataaaaatacctatgaaattatgtcgcctgaaaccatcggt
ttgaagaaagaaaaattaaatttaaccgcccgttcaggacgtgccgccgtgaaaaatcat
atgagcgaaatgggttatcaagaaaacgactatgatttggataaactttatgacgcattc
ctaaaattggcggataagaaaggtcaagtgtttgattacgatttagaagcgcttgctttt
attgatatgcaggcaggtgatgaaggcagattacatttagacgtgattacttcgcaaatg
attagccatttaccagcttcggcatttgttcaagtcgaattagacggtgaaaaattaagc
caagtttccagtggcggtaacgggccagtcgatgcggtctttaatgcgattctagccatt
acggggatggatattaaaatgttacattataaccttaccgcaaaaggcgaaggtgcggaa
gcattaggtcaagtggatattgtggttgaacacgaaggtcgccgcttccacggtgtcggt
ttggcaaccgatattgtcgagtcttcggcgcgtgcgttaatccatgcgatcaatgcgatt
tatcgagcgcataaagtggcggatttaaaagctaaaaaataa
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