Bubalus bubalis (water buffalo): 102405285 Help Entry 102405285         CDS       T05912                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism bbub  Bubalus bubalis (water buffalo) Pathway bbub01521   EGFR tyrosine kinase inhibitor resistance bbub04151   PI3K-Akt signaling pathway bbub04217   Necroptosis bbub04380   Osteoclast differentiation bbub04550   Signaling pathways regulating pluripotency of stem cells bbub04620   Toll-like receptor signaling pathway bbub04621   NOD-like receptor signaling pathway bbub04630   JAK-STAT signaling pathway bbub04658   Th1 and Th2 cell differentiation bbub04659   Th17 cell differentiation bbub05140   Leishmaniasis bbub05145   Toxoplasmosis bbub05152   Tuberculosis bbub05160   Hepatitis C bbub05161   Hepatitis B bbub05162   Measles bbub05163   Human cytomegalovirus infection bbub05164   Influenza A bbub05165   Human papillomavirus infection bbub05166   Human T-cell leukemia virus 1 infection bbub05167   Kaposi sarcoma-associated herpesvirus infection bbub05168   Herpes simplex virus 1 infection bbub05169   Epstein-Barr virus infection bbub05171   Coronavirus disease - COVID-19 bbub05200   Pathways in cancer bbub05203   Viral carcinogenesis bbub05212   Pancreatic cancer bbub05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:bbub00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102405285 (JAK1)    04151 PI3K-Akt signaling pathway     102405285 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102405285 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102405285 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     102405285 (JAK1)    04621 NOD-like receptor signaling pathway     102405285 (JAK1)    04658 Th1 and Th2 cell differentiation     102405285 (JAK1)    04659 Th17 cell differentiation     102405285 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     102405285 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102405285 (JAK1)    05203 Viral carcinogenesis     102405285 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102405285 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     102405285 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102405285 (JAK1)    05161 Hepatitis B     102405285 (JAK1)    05160 Hepatitis C     102405285 (JAK1)    05171 Coronavirus disease - COVID-19     102405285 (JAK1)    05164 Influenza A     102405285 (JAK1)    05162 Measles     102405285 (JAK1)    05168 Herpes simplex virus 1 infection     102405285 (JAK1)    05163 Human cytomegalovirus infection     102405285 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     102405285 (JAK1)    05169 Epstein-Barr virus infection     102405285 (JAK1)    05165 Human papillomavirus infection     102405285 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     102405285 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102405285 (JAK1)    05140 Leishmaniasis     102405285 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102405285 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:bbub01001]     102405285 (JAK1) Enzymes [BR:bbub01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102405285 (JAK1) Protein kinases [BR:bbub01001]  Non-receptor tyrosine kinases   JAK family [OT]    102405285 (JAK1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  102405285 NCBI-ProteinID:  XP_025144324 EnsemblRapid:  ENSBBUG00015006053 LinkDB All DBs Position 6:80116993..80252650 Genome browser AA seq 1158 aa AA seqDB search MQYLNIKEDCSAMAFCAKMRSSKKAEMNLEAPEPGVEVLFYLSDREPLRLGGGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMIKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN RFHPNDSGNVVCYEVMVTGNLGIQWRQKPHIVPVEKEKNKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGIQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLR RCCQPKPREISNLLVATKKAQEWQPVYTMSQLSFDRILKKDITQGEHLGRGTRTHIYSGT LTDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLTVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPTTEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSE SSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQHMRKCWEFQPSNRTT FQNLIEGFEALLRSMSNI NT seq 3477 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcagtgccatggctttctgtgctaaaatgagg agctccaagaaggcggagatgaatctggaggcccctgagccgggggtggaggtgctcttc tacctgtcggatagggagcctctccggctgggcggtggagagtacacggcggaggagctg tgcatccgggcggcgcaggagtgctgtatctctcctctgtgtcacaacctctttgccctg tatgacgagaacaccaagctctggtatgctccgaatcgcaccatcaccgtcgacgacaaa acgtcgctccggctgcactaccggatgaggttctatttcaccaactggcatgggaccaat gacaacgaacaatcagtatggcgacattctccaaagaagcagaaaaacggctatgagaaa aaaaaagttccagatgcaacacctctccttgacgccagctcactggagtatctgtttgct cagggacagtatgatttggtcaaatgcctggctcccattcgagaccccaagacggagcag gatgggcacgacattgagaacgagtgtcttgggatggctgtgctggccatctcccactac gccatgataaagaagatgcaattgccagaactccccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaggattttctaaaggagtttaacaacaagaccatttgtgacagcagc gtgtccacgcacgatctgaaggtgaaatacctggctaccctggaaactttgacaaaacat tatggtgctgaaatatttgagacttccatgctactgatttcatcagaaaatgagatgaat cggttccatcccaatgatagtggaaatgttgtctgctatgaagtgatggtgactggaaat cttggaatccagtggagacagaaaccacatattgttcctgttgaaaaggaaaaaaacaaa ctgaaacggaaaaaactggaaaataaacacaagaaggatgaggaaaaaaacaaaatccga gaagagtggaacaatttttcttacttccctgagatcactcacattgtaatcaaggagtct gtggtcagcattaataagcaggacaacaaaaaaatggaactgaagctctcttcccacgag gaggccttgtccttcgtgtccctggtggatggctacttccggctcacagcagatgcccat cactacctctgcactgacgtggctcccccattgatagtccacaacatacagaatggctgt catggtccaatctgcacggagtatgccatcaataagctgcggcaggaggggagcgaggag gggatgtacgtgctgcggtggagctgcactgactttgacaacatcctcatgaccgtcacc tgcttcgaaaagtctgaggtgctgggtatccagaaacagttcaagaactttcagatcgag gtgcagaagggccgctacagcctgcatggctcagaccgcagcttcccgagccttggggac ctcatgagccacctaaagaagcagatcctgcgcacggacaacatcagcttcgtgctgagg cgctgctgccagcccaagccccgagaaatctccaatctgctggtggccaccaagaaagcc caggagtggcagcctgtctacaccatgagccagctgagtttcgatcgaatcctcaagaaa gatattacgcaaggcgagcaccttgggagaggcacgcggacacacatctactctgggacc ctcacggattacaaggatgacgaagggacttctgaagagaagaggataaaagtcatcctg aaggtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg atgaggcaggtctcccacaaacacatcgtgtacctctatggggtttgtgtccgagacgtg gagaatatcatggtggaagagtttgtggaggggggacccctggatctcttcatgcatcgg aaaagtgacgtcctcaccacaccctggaagtttaaagttgccaaacagctggccagcgcc ctgagttacttggaggataaagacctggtccatggaaatgtgtgcactaaaaacctcctt ctggcccgcgagggcatcgacagtgagtgcggccccttcatcaagctcagtgaccctggc atccccatcactgtgctctccaggcaagagtgcatagagcgaatcccctggatcgctccc gagtgtgttgaagactccaagaatctgactgtggctgctgacaagtggagctttggaacc acactctgggaaatctgctacaatggcgagatccccttgaaagacaagacactgattgag aaagagagattctatgaaagccggtgcaggccagtgaccccgtcttgtaaggagctagct gacctgatgacccgctgcatgaactacgaccccaaccagagacccttcttccgggccatc atgagagacatcaataagctggaggagcagaatccagacattgtatcagaaaaaaagcca acaactgaagtggatcccacacattttgaaaagcggttcttaaagaggatccgtgacttg ggagagggccactttgggaaggtagagctctgcaggtatgaccctgagggggacaataca ggggagcaagtggctgtcaaatccctgaagcccgagagtggagggaaccacatcgctgat ctgaagaaggagattgaaatcttaagaaatctttatcatgagaacattgtgaagtataaa ggcatctgcacagaagacggtggaaatggtattaagctcatcatggagtttctgccttca gggagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcaatta aaatatgccgttcagatttgtaaggggatggactatctgggttctcggcagtacgttcac cgggacttggcagcaaggaacgtcctcgtggagagtgagcaccaggtgaaaatcggggac ttcggcctcaccaaagccatcgaaaccgataaggagtactacacagtcaaggacgaccgg gacagccccgtgttttggtatgctccagaatgtttaattcagtgtaagttctatatcgcc tctgatgtctggtctttcggagtgactttgcacgagctgctcacttactgtgattcagag tccagtcccatggccttgttcctgaaaatgataggcccaactcatggtcagatgacggta acaagactcgtgaacacattaaaagaaggaaaacgcttgccgtgtccaccaaactgtcca gatgaggtttatcaacatatgcgaaagtgttgggaatttcaaccatctaatcggacaacc tttcagaaccttattgaaggatttgaagcacttctaagaagcatgagtaacatttaa

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