Bos indicus (zebu cattle): 109561797
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Entry
109561797 CDS
T04792
Symbol
DOT1L
Name
(RefSeq) LOW QUALITY PROTEIN: histone-lysine N-methyltransferase, H3 lysine-79 specific
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
biu
Bos indicus (zebu cattle)
Pathway
biu00310
Lysine degradation
biu01100
Metabolic pathways
biu05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
biu00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
109561797 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
109561797 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
biu03036
]
109561797 (DOT1L)
Enzymes [BR:
biu01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
109561797 (DOT1L)
Chromosome and associated proteins [BR:
biu03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
109561797 (DOT1L)
HMT complexes
Dot1-containing complex
109561797 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
109561797
NCBI-ProteinID:
XP_019820094
UniProt:
A0A6P5C3B2
LinkDB
All DBs
Position
7:20096113..20148848
Genome browser
AA seq
1713 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVVFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ESKAAVPADTPVDSGAEEEKAGTATVKKPSPSKARKKKLNKKGRKMVGRKRGRPKKMSAT
NPERKPKKTQSSLDLLHAQTXSRAASPLPQDAHRPPHSPFYQLPPSVQRPTPEQLLLAPT
PPALHRLLESFRIQYLQFLAYTKTPQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLEKGNWELRSQSLRLL
KARCEELKLDWSTLSLENLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDEALALQLRGKPEAEPSRLHLELDCARFSLPPFSSLSPELSMNGHAAGYELCSAL
GRPSPKQNTPQYLASPLDQEVVPCTPSHSGRPRLEKLSSLALPDYTRLSPAKLVLRRHLS
QDHAASGKAAASELHPRAEHAKENGLPYQSPGITNGIKLSPQDPRPSSPTALQMGEKGPE
KGVKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKARSTPSPGPPA
RESSSTLEKQVAANTHGAGGNAAGSKSLALAPTGFAYAGSVAISGALAGSPAPLAXGAEP
PALDESSSSGSLFATVGSRSSTPQHPPLLTQPRTCGSASPAPQLCSSPRLGALGPLPDSG
KGDLPCEASFSDPESEAKRRIVFTISAGASSTKQSPSSKHSPLPSGARGDGGQGHGPDGR
KRGRRKRASAGTPSLSSSVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEITAIS
SPESSLKSSPVPYQDNDQPPVLKKEKPLSQTNGAHYSPLTSDEEPGSEDEPGSARIERKI
ATISLESKSPPKTLENGGSLAGRKAPLASEPVNSSKWKSTFSPISDLGLAKAADSPLQAA
SALSHNSLFAFRPGLEEPSAADAKLATHSRKSFPGTLPGAGGLSPSSLPASGFALGGGLA
ADLSLHSFSDGASLSHKAPEAAGLGAPLSFPGPRGKEGGAAESGPFVNKRQLDGLGPKGE
GGLPTCGPPDKASTAHSKAGKGREREPDVKNGHNLFMAAATAPPAGLLSGPGLAPAASSA
GGAAPSVQTHRPFLGAFAPGPQFALGPMSLQANLGPSVLQSLFSSVPAAGLVHVSTAATR
LTNSHAMGSFSSGVAGGAVGGVFNHAVPPASAHPFGASFGSGAACRSATLSLTPLQAVAS
TPASSFQAPSSAEPRPPPPPPHLXXPPPGQPALHAPPHPNATLPPPPALLPANSEPVLLQ
NLVSLPANQAFLPASSAASLPPANASLSIKLASLPHKVSRPSLTVHHQPLPGLALAQAAP
VNPQASSTGPPAVWVSLGMPPPYAARLAGVKPR
NT seq
5142 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atcagatgggtctgtgaagaaatcccggatctcaagcttgctatggagaattacgtttta
attgactacgataccaaaagctttgagagtatgcagaggctctgtgacaagtacaaccgg
gccatcgacagcatccaccagctgtggaagggcaccacacagcccatgaagctgaacaca
cggccatccacggggctcctgcggcacatcctgcagcaggtctacaaccactcagtgacc
gaccctgagaagctcaacaactacgagcccttctccccagaggtgtatggggagacctcc
ttcgacctggtcgcccagatgatcgatgagatcaagatgaccgaagatgacctgttcgtg
gacctgggcagtggagtgggccaggttgtgctgcaggttgccgcggccaccaactgcaaa
catcactacggtgtagagaaagctgacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggagagg
ggggacttcctctcggaggagtggagagaacggattgctaacacaagtgttgtatttgtg
aataactttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcaaacatg
aaggaaggtggcagaatcgtgtcctcgaagccctttgcgcctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtcgtggagctgtcgccgctaaaa
ggctcggtgtcatggacggggaagccagtctcctactacctgcacaccatcgaccgcacc
atacttgaaaactatttttctagtctaaaaaatccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgggagaacaagagcaacacaaccacgcccaccaaggtgccc
gagagcaaggcagctgtgccggcggacacccccgtggactctggtgctgaggaggagaaa
gccgggacggccactgtcaagaagccatctccctccaaggcccggaagaagaagctgaac
aagaagggccggaagatggtgggtcggaagcgtgggcgccccaagaagatgagtgccacc
aaccccgagcgcaagcccaagaagacccagagctcactggacctgctgcacgcccagacc
rcgtcacgagcggcctcccccttgccgcaggacgcgcacaggccacctcacagcccattc
taccagctacctcccagcgtgcagcggcctacccccgagcagctgctgctggcacccacc
ccgcccgcactgcacaggctgctagagtccttcaggattcagtacctacagttcctggca
tacacgaagacccctcagtacaaggccagcctgcagcagctcctggaccaggagaaggag
aagaatgcccggttgctaggcgcagcgcagcagctatttggccactgccaagctcagaag
gaggagatcaagaggctcttccagcagaaactggacgagctgggagtgaaggcgctgacc
tacaacgacctgatccaagcgcagaaggagatctcggctcacaaccagcagttgagggag
cagacggagcagctggagaagggcaactgggagctgaggagccagagcctgaggctgctc
aaggcacgatgcgaggagctgaagctggactggtccacgctgtcgctggagaatctgctg
aaggagaagcaggccctgaagagccagatctcagagaagcagaggcactgcctggagctg
cagatcagcatcgtggagctggagaagagccagcggcagcaggagttgctgcagctcaag
tcctgcgtgccgcctgatgaggcactggctctgcagcttcgtgggaagccagaggctgag
cctagccggctgcacttggagctggactgcgcccgcttctccctgccacccttcagcagc
ttgagccccgagctctctatgaatggccacgcagccggctatgagctctgcagcgcactg
ggtcggccctcgcccaagcagaacaccccccagtacctggcctccccgctagaccaggag
gtcgtgccctgcacccctagccacagcggccggccacggctagagaagctgtccagcctg
gccctgcctgactacaccaggctatcccctgccaagctggtgctgcggcgccacctgagc
caggaccacgcggccagtggcaaggcagctgccagtgagctgcacccacgagccgagcat
gccaaggagaatgggctcccttaccagagccctggcatcactaatggcatcaagctgagc
ccacaagacccccgaccttcatcccccacggctttacagatgggagagaagggccccgag
aagggtgtgaaggagcgtgcctacgccagcagtggggaggccatcaccagcctgcccgtc
agcatcccgctgagcaccgtgcagcccagcaagctgcccgtcagcatccccctggccagc
gtggtgctgcccagccgcgccgagaaggcgagaagcacacccagccctgggccaccggcc
cgagagtcctcatccacgctggagaagcaggtggctgctaacactcatggtgccgggggc
aacgctgctgggagcaagagcctcgccctggctcccacaggctttgcatacgccggctcg
gtggccatcagtggggccctggccggcagcccggcacccctcgccyctggagccgagccc
ccagccctggacgagtcctccagctctggaagcctctttgccaccgtggggtcccgcagc
tccaccccgcagcacccacccctgctgacgcagccacgcacctgtggctcggcctcgcca
gccccccagctctgctccagcccccggcttggcgctctgggcccactccccgactctggc
aaaggggacctgccctgcgaggccagcttctcagaccctgagagcgaagccaaaaggaga
atcgtcttcaccatctcggcgggcgccagcagcaccaagcagtcaccttccagcaaacac
agccctctgccgtcgggtgcccgcggggacggtggccagggccatgggccagacggccgc
aagcggggccggaggaagcgggcatcggcggggacccccagcctgagctcgagtgtgtcc
cccaagcgccgggccttgccatctgtcgctgggcttttcacgcagtcttcagggtccccc
ctgaacctcaactccatggtcagcaacatcaaccagcccctggagatcacagcaatctcg
tcccctgagagctccytaaagagctcacccgtcccctaccaggacaacgaccaaccaccc
gtgctcaagaaggagaagcccctgagccagaccaatggtgcccactactccccactgact
tcggacgaggagccaggctctgaggatgagcccggcagtgccagaattgagagaaaaatt
gcaacgatctccttagaaagcaagtctccgccaaaaaccttggaaaatggtggcagccta
gcaggaaggaaggcgccgctggccagcgagccggtcaacagcagcaagtggaagtccacc
ttctcacccatctccgacctgggcctggccaaggcggccgacagcccgctgcaggctgcc
tctgctctgagccacaactctctgttcgctttccggcctggcctggaggagcccagtgcg
gccgatgccaagctggccacccactccaggaagagcttcccgggcaccctgccaggggcg
ggcgggctgagccccagtagccttcctgccagcggcttcgccctgggcgggggcctagca
gctgacctcagtttacacagcttcagtgatggtgcttctctctcccacaaggcccccgag
gcagctggcctgggtgcccccctgagcttccccggcccacggggcaaagagggtggcgct
gcagagtctggccccttcgtgaacaagcggcagctggacggactgggcccaaaaggcgag
gggggccttcccacatgcggacccccggacaaggcctccacagcgcatagcaaggcaggc
aagggccgcgagcgcgagcctgacgtcaagaacggccacaacctgttcatggccgctgcc
actgcgccccctgcaggcctcctcagcggcccaggtcttgccccagcggcatcctcggca
ggtggcgcagccccgtccgtgcagacccaccgccccttcctgggcgccttcgcccccggg
ccacagttcgcactgggccccatgtcgctacaggccaacctgggcccatctgtgctgcag
tccctgttcagttccgtgcccgccgccggcctggttcacgtctcgaccgccgccaccaga
ttgaccaactcgcacgccatgggcagcttctcctctggggtggccggcggcgcagttgga
ggtgtctttaaccacgcggtgcctcccgcctccgcccatccgttyggagccagtttcggc
agtggggctgcatgtcgcagcgccacgctgagcttaaccccgctgcaggcggtggccagc
accccggcctcttcctttcaggccccgtcctctgcggagccgaggccacccccaccccct
ccgcacctggnnnnaccccctccggggcagcccgccctccacgcaccccctcatcctaac
gccaccttgcctcctccccctgcgctgctcccagctaactctgagcccgtgcttctgcag
aacctcgtatccctccctgctaaccaagctttcttacccgcctcctctgccgcctctctg
ccgcctgctaacgcctctctgtccatcaagctcgcctccctcccgcacaaggtgtcccgg
ccctccttgacggtgcaccaccagcccctgcctgggctggccctggcccaggccgcgccc
gtgaacccacaggccagctccacggggccgcccgccgtgtgggtttcccttggcatgccg
cctccgtatgccgcgcgccttgcgggggttaagccgcgataa
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