Bos taurus (cow): 510708 Help Entry 510708            CDS       T01008                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism bta  Bos taurus (cow) Pathway bta00230   Purine metabolism bta01100   Metabolic pathways bta01522   Endocrine resistance bta04015   Rap1 signaling pathway bta04020   Calcium signaling pathway bta04022   cGMP-PKG signaling pathway bta04024   cAMP signaling pathway bta04062   Chemokine signaling pathway bta04072   Phospholipase D signaling pathway bta04114   Oocyte meiosis bta04211   Longevity regulating pathway bta04213   Longevity regulating pathway - multiple species bta04261   Adrenergic signaling in cardiomyocytes bta04270   Vascular smooth muscle contraction bta04371   Apelin signaling pathway bta04540   Gap junction bta04611   Platelet activation bta04713   Circadian entrainment bta04714   Thermogenesis bta04723   Retrograde endocannabinoid signaling bta04724   Glutamatergic synapse bta04725   Cholinergic synapse bta04727   GABAergic synapse bta04750   Inflammatory mediator regulation of TRP channels bta04911   Insulin secretion bta04912   GnRH signaling pathway bta04913   Ovarian steroidogenesis bta04914   Progesterone-mediated oocyte maturation bta04915   Estrogen signaling pathway bta04916   Melanogenesis bta04918   Thyroid hormone synthesis bta04921   Oxytocin signaling pathway bta04922   Glucagon signaling pathway bta04923   Regulation of lipolysis in adipocytes bta04925   Aldosterone synthesis and secretion bta04926   Relaxin signaling pathway bta04927   Cortisol synthesis and secretion bta04928   Parathyroid hormone synthesis, secretion and action bta04934   Cushing syndrome bta04935   Growth hormone synthesis, secretion and action bta04970   Salivary secretion bta04971   Gastric acid secretion bta04972   Pancreatic secretion bta04976   Bile secretion bta05032   Morphine addiction bta05163   Human cytomegalovirus infection bta05166   Human T-cell leukemia virus 1 infection bta05200   Pathways in cancer bta05207   Chemical carcinogenesis - receptor activation bta05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:bta00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     510708 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     510708 (ADCY2)    04371 Apelin signaling pathway     510708 (ADCY2)    04020 Calcium signaling pathway     510708 (ADCY2)    04072 Phospholipase D signaling pathway     510708 (ADCY2)    04024 cAMP signaling pathway     510708 (ADCY2)    04022 cGMP-PKG signaling pathway     510708 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     510708 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     510708 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     510708 (ADCY2)    04062 Chemokine signaling pathway     510708 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     510708 (ADCY2)    04922 Glucagon signaling pathway     510708 (ADCY2)    04923 Regulation of lipolysis in adipocytes     510708 (ADCY2)    04912 GnRH signaling pathway     510708 (ADCY2)    04913 Ovarian steroidogenesis     510708 (ADCY2)    04915 Estrogen signaling pathway     510708 (ADCY2)    04914 Progesterone-mediated oocyte maturation     510708 (ADCY2)    04921 Oxytocin signaling pathway     510708 (ADCY2)    04926 Relaxin signaling pathway     510708 (ADCY2)    04935 Growth hormone synthesis, secretion and action     510708 (ADCY2)    04918 Thyroid hormone synthesis     510708 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     510708 (ADCY2)    04916 Melanogenesis     510708 (ADCY2)    04925 Aldosterone synthesis and secretion     510708 (ADCY2)    04927 Cortisol synthesis and secretion     510708 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     510708 (ADCY2)    04270 Vascular smooth muscle contraction     510708 (ADCY2)   09154 Digestive system    04970 Salivary secretion     510708 (ADCY2)    04971 Gastric acid secretion     510708 (ADCY2)    04972 Pancreatic secretion     510708 (ADCY2)    04976 Bile secretion     510708 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     510708 (ADCY2)    04727 GABAergic synapse     510708 (ADCY2)    04725 Cholinergic synapse     510708 (ADCY2)    04723 Retrograde endocannabinoid signaling     510708 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     510708 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     510708 (ADCY2)    04213 Longevity regulating pathway - multiple species     510708 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     510708 (ADCY2)    04714 Thermogenesis     510708 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     510708 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     510708 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     510708 (ADCY2)    05163 Human cytomegalovirus infection     510708 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     510708 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     510708 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     510708 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     510708 (ADCY2) Enzymes [BR:bta01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      510708 (ADCY2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  510708 NCBI-ProteinID:  XP_024837306 BGD-bta:  BT24683 Ensembl:  ENSBTAG00000019210 VGNC:  25643 LinkDB All DBs Position 20:complement(65388703..65843081) Genome browser AA seq 1091 aa AA seqDB search MWQEAMRRRRYLRDRAEAAAGGGDGLQRSRDWLYESYYRMSQQHPLIVFLLLIVMGACLA LLAVFFALRLEVEDHVAFLITVPTALAIFFAIFILVCVESVFKKLLRLFSLVIWICLVAM GYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT PGAKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQ ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFT RLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG VPGRVHISSVTLQHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPR HTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL RTKSQKKRFEEELNERMIQAIDGINAQKQWLKSEDIQRISLLFYNKIIEKEYRATALPAF KYYVTCACLIFFCIFIVQVLVLPKTSILGISFGAAFLSLAFILFVCFAGQLLQCSKKASA SLLWLLKSSGIIANRPWPRISLTVITTAIILTMAVFNMFFLSDSEETILPTANASNTSLS GASNQAAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMAALVGYNTIFLHT HAPLLDDYSQVLFERPGIWKDLKTMGSVSLFIFFITLLVLGRQNEYYCRLDFLWKNKFKK EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEELYHQSYDCVCVMFASIPDFKEFY TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHA QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI WGNTVNVASRMDSTGVLDKIQVTEETSIILQTLGYTCTCRGIINVKGKGDLKTYFVNTEM SRSLSQSNLTS NT seq 3276 nt NT seq  +upstreamnt  +downstreamnt atgtggcaggaggcgatgcggcggcgccgctacctgcgggaccgcgccgaggcggcggcg ggcggcggagacgggctgcagcggtcccgggactggctctacgagtcctactaccgcatg agccagcagcacccgctcatcgtcttcctgctgctcatcgtcatgggcgcctgcctcgcc ctgctcgccgtcttcttcgcgctccgcctggaagttgaagaccacgtggcatttttaatc acagttccgactgccctggcgatcttctttgcgatcttcatcctggtgtgcgtggagtcg gtgtttaagaagctgctgcgcctcttctctttggtgatatggatctgcctcgtggccatg ggctacttgttcatgtgtttcgggggcaccgtctctccctgggaccaggtgtcgttcttc ctcttcatcatcttcgtggtgtacaccatgctgcccttcaacatgcgagatgccatcatc gccagcgtcctcacctcctcttctcacaccatcgtgctgagcgtctgcctgtctgcaaca ccaggggccaaggagcacctggtctggcagatcctggccaacgtgatcatcttcatctgc gggaacctggcgggggcataccataagcacctcatggagctcgctctgcagcagacgtat caggacacgtgcaactgcatcaagtcccggatcaagttggaatttgaaaaacgtcagcag gagcggctgctgctgtccctgctgccggcacacatagccatggagatgaaagcggagatc atccagaggctgcagggccccaaagccggccagatggagaacaccaacaacttccacaac ctctacgtcaagcggcacaccaacgtcagtatcctctatgcggacattgttgggttcacc cgtctggccagtgactgctcccctggagagctcgtccatatgctgaatgaactctttgga aagttcgatcaaattgcaaaggagaatgaatgcatgagaataaaaattttaggagactgc tactactgtgtgtccggactgcctatatctctccctaaccatgccaagaattgtgtgaaa atgggactggatatgtgtgaagccataaagaaagtgagggatgccaccggagtggacatc aacatgcgcgtgggagtgcattctgggaacgtgctgtgcggcgtgatcgggctgcagaag tggcagtacgacgtgtggtcacatgacgtcaccctggccaaccacatggaagctggaggg gtccctggacgtgttcacatttcttctgttaccctgcaacacttgaatggagcttacaaa gtggaagaaggcgatggtgacatcagagacccgtatttaaagcaacatttggtgaaaact tactttgtaatcaaccccaagggagagcggcggagccctcagcacctctttaggcctcga cacacccttgacggagcgaagatgagggcttctgtccgcatgacccggtacctggagtcc tggggggcggccaagccctttgcacacctgcatcacagagacagcatgactacggagaac ggcaagatcagcaccacggatgtaccaatgggtcagcataattttcaaaatcgcacctta agaaccaagtcacaaaagaaaagatttgaagaggaattaaatgaaaggatgattcaagca atcgatggaatcaatgcacaaaagcaatggctcaagtctgaagacattcagagaatctca ttgcttttctacaataaaataatagaaaaagaataccgagccaccgcactgccggccttc aagtattacgtgacttgcgcttgcctgatcttcttctgcatctttatcgtgcaggttctg gtcttacccaaaacgtccattctcgggatttcctttggagcggcgtttctctcacttgcc tttatccttttcgtctgctttgctggacagcttttgcaatgcagcaagaaagcatctgct tctctcctgtggcttttaaagtcatcgggcatcatcgccaaccggccctggcctcggatc tccctgacggtcatcaccacggccatcatattgaccatggccgtgttcaatatgtttttc ctgagtgactcagaggaaacaattcttccgactgccaacgcgtccaacacaagtctttct ggcgcaagtaaccaggcagcaattctgcgtgcgcaaaatttgtttttcctgccgtacttt atatacagctgcatccttgggctgatctcctgttccgtcttcctgcgtgtgaattacgag ctgaagatgctgatcatgatggcagccttggtgggctacaacaccatcttcctccacact cacgctcccctcctggacgactacagccaggtcctgttcgagagaccaggcatttggaaa gacctaaagaccatgggctcagtatctctctttatatttttcatcacactgcttgttctg ggcagacagaatgaatattactgtaggttagacttcttatggaagaacaagttcaaaaaa gagcgggaggagatagaaaccatggagaacttgaaccgagtgctgctggagaacgtgctt cctgcgcacgtggctgagcacttcctggcacggagcctgaagaacgaggagttataccac cagtcctacgactgcgtctgcgtcatgtttgcctccattcctgatttcaaagaattctat acagaatcagacgtgaacaaggagggtttggaatgccttcggctcctgaacgagatcatt gccgactttgatgatctgctctccaagccgaagttcagtggtgttgaaaagatcaagacc atcggcagcacgtacatggcagcgacaggtctgagcgcggtgcccagccaggagcacgcc caggagccggagaggcagtacatgcacattggcaccatggtggagtttgcatttgccctg gtggggaagctggatgccatcaacaagcactccttcaatgacttcaagttacgagtaggt attaaccatggccctgtcatagccggtgtgattggagctcagaagccgcagtatgacatc tggggcaacaccgtcaatgtggccagcaggatggacagcaccggagtcctggacaaaatc caggtgacagaggagacgagcatcatcctacagaccctaggctacacgtgcacgtgtcgg ggaatcatcaatgtgaaaggaaagggggacctgaagacctacttcgtcaacacggagatg tcacggtccctttctcagagcaacctgacctcctga

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