Bos taurus (cow): 535603 Help Entry 535603            CDS       T01008                                  Symbol ADCY3 Name (RefSeq) adenylate cyclase type 3   KO K08043   adenylate cyclase 3 [EC:4.6.1.1] Organism bta  Bos taurus (cow) Pathway bta00230   Purine metabolism bta01100   Metabolic pathways bta01522   Endocrine resistance bta04015   Rap1 signaling pathway bta04020   Calcium signaling pathway bta04022   cGMP-PKG signaling pathway bta04024   cAMP signaling pathway bta04062   Chemokine signaling pathway bta04072   Phospholipase D signaling pathway bta04114   Oocyte meiosis bta04211   Longevity regulating pathway bta04213   Longevity regulating pathway - multiple species bta04261   Adrenergic signaling in cardiomyocytes bta04270   Vascular smooth muscle contraction bta04371   Apelin signaling pathway bta04540   Gap junction bta04611   Platelet activation bta04713   Circadian entrainment bta04714   Thermogenesis bta04723   Retrograde endocannabinoid signaling bta04724   Glutamatergic synapse bta04725   Cholinergic synapse bta04727   GABAergic synapse bta04740   Olfactory transduction bta04750   Inflammatory mediator regulation of TRP channels bta04911   Insulin secretion bta04912   GnRH signaling pathway bta04913   Ovarian steroidogenesis bta04914   Progesterone-mediated oocyte maturation bta04915   Estrogen signaling pathway bta04916   Melanogenesis bta04918   Thyroid hormone synthesis bta04921   Oxytocin signaling pathway bta04923   Regulation of lipolysis in adipocytes bta04925   Aldosterone synthesis and secretion bta04926   Relaxin signaling pathway bta04927   Cortisol synthesis and secretion bta04928   Parathyroid hormone synthesis, secretion and action bta04934   Cushing syndrome bta04935   Growth hormone synthesis, secretion and action bta04962   Vasopressin-regulated water reabsorption bta04970   Salivary secretion bta04971   Gastric acid secretion bta04972   Pancreatic secretion bta04976   Bile secretion bta05032   Morphine addiction bta05163   Human cytomegalovirus infection bta05166   Human T-cell leukemia virus 1 infection bta05200   Pathways in cancer bta05207   Chemical carcinogenesis - receptor activation bta05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:bta00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     535603 (ADCY3)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     535603 (ADCY3)    04371 Apelin signaling pathway     535603 (ADCY3)    04020 Calcium signaling pathway     535603 (ADCY3)    04072 Phospholipase D signaling pathway     535603 (ADCY3)    04024 cAMP signaling pathway     535603 (ADCY3)    04022 cGMP-PKG signaling pathway     535603 (ADCY3)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     535603 (ADCY3)   09144 Cellular community - eukaryotes    04540 Gap junction     535603 (ADCY3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     535603 (ADCY3)    04062 Chemokine signaling pathway     535603 (ADCY3)   09152 Endocrine system    04911 Insulin secretion     535603 (ADCY3)    04923 Regulation of lipolysis in adipocytes     535603 (ADCY3)    04912 GnRH signaling pathway     535603 (ADCY3)    04913 Ovarian steroidogenesis     535603 (ADCY3)    04915 Estrogen signaling pathway     535603 (ADCY3)    04914 Progesterone-mediated oocyte maturation     535603 (ADCY3)    04921 Oxytocin signaling pathway     535603 (ADCY3)    04926 Relaxin signaling pathway     535603 (ADCY3)    04935 Growth hormone synthesis, secretion and action     535603 (ADCY3)    04918 Thyroid hormone synthesis     535603 (ADCY3)    04928 Parathyroid hormone synthesis, secretion and action     535603 (ADCY3)    04916 Melanogenesis     535603 (ADCY3)    04925 Aldosterone synthesis and secretion     535603 (ADCY3)    04927 Cortisol synthesis and secretion     535603 (ADCY3)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     535603 (ADCY3)    04270 Vascular smooth muscle contraction     535603 (ADCY3)   09154 Digestive system    04970 Salivary secretion     535603 (ADCY3)    04971 Gastric acid secretion     535603 (ADCY3)    04972 Pancreatic secretion     535603 (ADCY3)    04976 Bile secretion     535603 (ADCY3)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     535603 (ADCY3)   09156 Nervous system    04724 Glutamatergic synapse     535603 (ADCY3)    04727 GABAergic synapse     535603 (ADCY3)    04725 Cholinergic synapse     535603 (ADCY3)    04723 Retrograde endocannabinoid signaling     535603 (ADCY3)   09157 Sensory system    04740 Olfactory transduction     535603 (ADCY3)    04750 Inflammatory mediator regulation of TRP channels     535603 (ADCY3)   09149 Aging    04211 Longevity regulating pathway     535603 (ADCY3)    04213 Longevity regulating pathway - multiple species     535603 (ADCY3)   09159 Environmental adaptation    04713 Circadian entrainment     535603 (ADCY3)    04714 Thermogenesis     535603 (ADCY3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     535603 (ADCY3)    05207 Chemical carcinogenesis - receptor activation     535603 (ADCY3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     535603 (ADCY3)    05163 Human cytomegalovirus infection     535603 (ADCY3)   09165 Substance dependence    05032 Morphine addiction     535603 (ADCY3)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     535603 (ADCY3)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     535603 (ADCY3)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     535603 (ADCY3) Enzymes [BR:bta01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      535603 (ADCY3) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc AC_N HNOBA Peptidase_S49_N Motif Other DBs NCBI-GeneID:  535603 NCBI-ProteinID:  NP_001193013 BGD-bta:  BT17942 Ensembl:  ENSBTAG00000018705 VGNC:  25644 UniProt:  F1MPC9 LinkDB All DBs Position 11:74334641..74418321 Genome browser AA seq 1145 aa AA seqDB search MPRTQGFSEPEYSAEYSAEYSVSLPSDPDRGVGRTHEISVRNSGSCLCLPRFMRLTFVPE SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSGDKLAPLAVAGVGLVLDII LFVLCKKGLLPNRVTRRVVPYLLWLLISAQVFSYLGLNFSRAHAASDTVGWQAFFVFSFF ITLPLSLSPIVIISVVSCVVHTLVLGVTVAQQQQDGLKGVQLLREILANVFLYLCAIVVG IMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAKYHQ LRIKILGDCYYCICGLPDYREDHAVCSILMGLAMVEAISYVREKTKTGVDMRVGVHTGTV LGGVLGQKRWQYDVWSTDVTVANKMEAGGIPGRVHISQSTMDCLKGEFDVEPGEGGSRCD YLEEKGIETYLIIASKPEVKKTAAQNGLNGSALLNGAPPSSKPSSPALIETKESNGSIHT SGSVSEEPEEQDAQADNPSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESA QVVKKRNTFLLSMRFMDPEMETRYSVEKEKQSGAAFSCSCVVLLCTAVVEILIDPWLMTN YVTFVVGEALLLILTICSLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMAN VVDMLSCLQYYTGPTNGTAEMQVEDGCVENPKYYNYVAVLSLIATIMLVQVSHMVKLTLM LLIAGAVAVINIYAWCPIFDDYDRKRFQQHDFPMVALEKMQVFSSSGLNGTDRLPLVPSK YSMTVMIFVMMLSFYYFSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEH VARHFLGSKKRDEELYSQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDF DSLLDNPKFRVITKIKTIGSTYMAASGVTPDVNTNGFTSSNKDEKSDKERWQHLADLADF ALAMKDTLTNINNQSFNNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGV MGNIQVVEETQVILREYGFRFVRRGPIFVKGKGELLTFFLKGRDKLATFPNGASITLPHQ VVDNS NT seq 3438 nt NT seq  +upstreamnt  +downstreamnt atgccgaggacccagggcttctccgagcccgagtactccgcggagtactcggccgagtac tctgtcagcctgccttcggacccggaccgcggggtgggccggacccatgaaatctctgtc cggaactcggggtcgtgcctctgcttgcctcgcttcatgcggctgaccttcgtaccagag tccttggagaacctgtaccagacctacttcaagaggcagcgccacgagaccctgctggtg ctggtggtcttcgcggccctcttcgactgctatgtggtggtcatgtgcgctgtggtcttc tctggcgacaagctggcccccctggccgtggctggggtcgggctggtgttggacatcatc cttttcgtgctctgcaaaaaggggctgctccccaaccgggtcactcggagagtggtgccc tacctgctgtggctgctgatatcagcccaggtcttctcctacctgggcctgaacttctcc cgtgcccacgcggccagcgacacggtgggctggcaggccttcttcgtcttctccttcttc atcacgctgccgctcagcctcagccccattgtcatcatctccgtggtctcctgcgtcgtg cacacactcgtcttgggggtcactgtggcccagcagcagcaggatgggctgaagggagtg cagttgctgagggagattctggccaacgtcttcctctacctgtgcgccatcgtcgtgggc atcatgtcctactacatggcagaccgcaagcaccgcaaggccttcctggaggcccgccag tctctggaggtgaagatgaacctggaggagcagagtcagcagcaggagaaccttatgctc tccatcctgcccaagcacgtggccgacgagatgctgaaggacatgaagaaggatgagagc cagaaggaccagcagcagttcaacaccatgtacatgtaccgccatgagaacgtcagcatc ctctttgctgatatcgtgggcttcacccagctgtcctcagcctgcagcgcccaggagctt gtgaagctgcttaatgagctctttgcccgcttcgacaagctggcggctaaataccaccag ctgcggattaagatcctgggcgactgttactactgcatctgtgggctgcctgactaccgg gaggaccacgccgtctgctccatcctcatggggctcgccatggtggaggccatctcgtat gtgcgggagaagaccaagaccggggtggacatgcgcgtgggggtgcacacgggcaccgtg ctggggggcgtccttggccagaaacgctggcagtacgacgtgtggtccaccgacgtcacc gtggccaacaagatggaggctggcggcatccctgggcgtgtgcacatctcccagagcacc atggactgcctgaaaggagagttcgacgtggagccgggcgaggggggcagtcgctgtgat tacctggaagagaagggcattgagacctacctcatcatcgcttccaagccagaggtgaag aagacagctgcccaaaatggcctcaacggctcggccctgctgaacggagcgccgccttcc tcaaagcccagctcccctgccctcattgagaccaaggagtccaacgggagcattcacacc agcggctctgtatctgaggagcccgaggagcaagatgcccaggccgacaacccctcgttc cccaaccctcgccggaggctgcgccttcaggacctggctgatcgcgtggtggacgcctcc gaggacgagcatgagctcaaccagctactcaacgaggcgctgctagagcgggagtctgcc caggtagtgaagaagagaaacaccttcctcctgtccatgcggttcatggaccccgagatg gaaacccgctactcggtggagaaggagaagcagagcggggctgccttcagctgctcctgc gttgtcctactctgcacggctgtggtggagatcctcattgacccctggctcatgacgaac tatgtgacctttgtggttggggaggctctgctcctgatcctgacaatctgctcgctggct gccatctttccgcgggcctttcctaagaagctcgtggccttctctacttggattgaccgg acgcgctgggccaggaacacctgggccatgctggccatcttcattcttgtcatggcaaac gtggtggacatgctcagctgtctccagtactacacaggacccaccaacggcaccgcagag atgcaggtggaggatggctgcgtggagaaccccaagtattacaactacgtggccgtgctg tccctcatcgccaccatcatgctggtgcaggtcagccacatggtcaagctcacactcatg ctgctcatcgcgggggccgtggctgtcatcaacatctacgcctggtgccccatctttgac gactacgaccgcaaacgcttccagcaacacgactttccgatggtggccttagagaagatg caggtgttttccagctcggggctcaatggcactgacaggctgcccctggtgccgtctaag tactcgatgacagtgatgatctttgtcatgatgctgagcttttactacttctcccgccac gtggaaaagctggcacggacactgttcttgtggaagattgaggtccacgaccagaaggaa cgtgtctatgagatgcgacgctggaatgaagccttggtcaccaacatgctgcctgaacac gtggcacgccatttcctggggtccaagaagagagatgaggagctgtacagccagtcttat gatgagattggagttatgtttgcctccctgcccaattttgctgacttctacacagaggag agcatcaataacggtggcattgagtgtctacgcttcctcaatgagatcatctcagatttt gactctcttctggacaatcccaagttccgggtcatcaccaagatcaagaccattggtagc acctacatggcagcttcaggagtcaccccagatgtcaacaccaatggctttaccagctcc aacaaggacgagaagtcagacaaggagcgctggcagcacctggcagatctggccgatttt gcgctggccatgaaggacacgctcaccaacatcaacaaccagtccttcaacaacttcatg ctgcgcattggaatgaacaaaggaggggtcctggctggggtcattggagcccggaaacca cactatgacatctggggcaacacagtcaacgtagccagcaggatggagtccacaggggtc atgggcaacatccaggtggtggaagaaacccaagtcatccttcgagaatacggcttccgc ttcgtgaggagagggcccatctttgtgaaagggaagggggaactgctaacctttttcttg aagggccgagacaagctggccacattccctaacggcgcctcaatcacactgcctcaccag gtggtagacaactcctga

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