Corynebacterium diphtheriae HC03: CDHC03_0332
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Entry
CDHC03_0332 CDS
T01695
Symbol
hemD
Name
(GenBank) uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
cdr
Corynebacterium diphtheriae HC03
Pathway
cdr00860
Porphyrin metabolism
cdr01100
Metabolic pathways
cdr01110
Biosynthesis of secondary metabolites
cdr01120
Microbial metabolism in diverse environments
cdr01240
Biosynthesis of cofactors
Module
cdr_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
cdr00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
CDHC03_0332 (hemD)
Enzymes [BR:
cdr01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
CDHC03_0332 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
CDHC03_0332 (hemD)
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Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
ECH_1
Motif
Other DBs
NCBI-ProteinID:
AEX78063
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Position
333779..335449
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AA seq
556 aa
AA seq
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MRLIMKPEHSTRGRVIFVGAGPGNPDLLTVRAREVLGSTANAVVDSTVGVGIRAVIAEHL
EVPQAKLDAAEAEYERMCAAAKRRKPPRPDAPTAAEITEVSADASVDEVMAVLLPLLDEG
DVIRLVQGNPLADSRALDEITAVTQVGADFQIVPGMSLPAAVPAFAGITLGDSYTKTTVS
EDTNWDQLATAPLPLILQASKDDLLTIATELKDRKLPASTPVTVTMNGTTRLQRSFDVTL
KTMKSLVKQELDGTLVVTVGVSDRSTFSWWESRALFGWRVLVPRAKDQAGPMSSRIAAYG
AIAQEVPTISVEPPRNPAQLERAIKGIVEGRYQWVVFTSVNAVKAVREKIVSFGLDSRAF
AGVHIAAVGAKTAAAIREFGITPELIPPRKEHNAAGMVSVFPNYVEGLDPVGRVLLPRAD
IATDVLVDGLVNLGWEVDDVVAYRTVRAAPPSAEVRDMIKSGDFDAVCFTSASTVRNLVG
IAGKPHARTIIACIGPMTAAEAEKQGLRVDVIPEVANVPALVDALAEHVEKLRAAGELPP
PRKKRRARRKSKEGAV
NT seq
1671 nt
NT seq
+upstream
nt +downstream
nt
atgcgattaatcatgaagcccgagcactcaacgcgaggacgtgtcatcttcgtcggcgcc
ggtcccggcaacccagatcttttgacggttcgagcccgcgaggtgctgggctccacagcc
aatgcagtggtggattccactgttggcgtaggtattcgcgcagttattgctgaacatctt
gaggtgccgcaggccaagcttgatgcagctgaggctgagtatgagcgcatgtgtgcggct
gcgaagcgtcgtaagcctccgcgtcccgacgcccccaccgccgcggaaatcactgaggtg
tccgctgatgcgagcgtcgatgaagtgatggcggtgctgttgcctttgctagacgaaggc
gatgtgatccgcctagtgcagggtaacccgttggcggattcccgcgcgttagatgagatt
acggctgttacacaggtgggcgcggatttccagattgtgccaggtatgtcgttgccggct
gcggttcctgctttcgcgggtattacgttgggtgattcttataccaagaccacggtgagt
gaggatactaactgggatcagttggcaaccgccccgctgccgttgattttgcaggcgagt
aaagacgacttgctgactatcgctacggagttgaaggatcgcaaactgccggcgagcact
ccggtgacggtgacgatgaatggcacgacgcgtttgcagcgtagctttgacgtgacgctt
aaaactatgaagtcgctggtcaaacaggagctcgatggcactcttgtggtcacagtgggt
gtatcggatcgcagtacattttcgtggtgggaaagccgcgcgttgtttggctggcgggtg
ttggttccccgtgcgaaggatcaagctggtccgatgagcagccgaatcgccgcttatggt
gctattgcccaagaggttcccactatttctgtggagccgccgcgtaatccggcgcagttg
gagcgtgcgattaagggcattgtggagggacgctaccagtgggtggtgtttaccagcgtg
aatgctgttaaagcggtgcgtgagaagatcgtgtcgtttggtttggattctcgcgcgttc
gcgggggtgcatatcgctgcggtgggggctaagactgcggcggcgattcgtgagtttggc
attactcctgagctaattccgccacgtaaggagcataatgctgcgggtatggtgtcggtt
ttccctaattatgtggagggcttggaccccgtaggtcgagtgttgctgccgcgggctgat
attgccactgacgtgctggttgatggtttggtcaaccttggctgggaagttgatgatgtg
gtggcgtatcgtacggtgcgtgccgcgccgccgagtgcggaagtccgcgacatgattaag
tctggcgattttgatgcggtgtgttttacctctgcgtcgacggtgcgcaatttggtgggt
attgcgggtaagccgcatgcgcgcacgatcattgcatgtattgggccgatgaccgccgcg
gaggcagagaagcaagggctgcgtgtcgacgtcatccccgaggtggctaacgttccggct
cttgtggatgcgctcgcggagcatgtggagaaactgcgtgctgcgggtgagttgccgccg
ccgcgtaagaagcgtcgggcccgtcgcaaatctaaggaaggtgctgtatga
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