Corynebacterium diphtheriae HC01: CDHC01_0342
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Entry
CDHC01_0342 CDS
T01693
Symbol
hemD
Name
(GenBank) uroporphyrin-III C-methyltransferase / uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
cdt
Corynebacterium diphtheriae HC01
Pathway
cdt00860
Porphyrin metabolism
cdt01100
Metabolic pathways
cdt01110
Biosynthesis of secondary metabolites
cdt01120
Microbial metabolism in diverse environments
cdt01240
Biosynthesis of cofactors
Module
cdt_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
cdt00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
CDHC01_0342 (hemD)
Enzymes [BR:
cdt01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
CDHC01_0342 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
CDHC01_0342 (hemD)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
HEM4
TP_methylase
ECH_1
Motif
Other DBs
NCBI-ProteinID:
AEX73595
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Position
325392..327062
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AA seq
556 aa
AA seq
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MRLIMKPEHSTRGRVIFVGAGPGNPDLLTVRAREVLGSTANAVVDSTVGVGIRAVIAEHL
EVPQAKLDAAEAEYERMCAAAKRRKPPRPDAPTAAEITEVSADASVDEVMAVLLPLLDEG
DVIRLVQGNPLADSRALDEITAVTQVGADFQIVPGMSLPAAVPAFAGITLGDSYTKTTVS
EDTNWDQLATAPLPLILQASKDDLLIIATELKDRKLPASTPVTVTMNGTTRLQRSFDVTL
KTMKSLVKQELDGTLVVTVGVSDRSTFSWWESRALFGWRVLVPRAKDQAGPMSSRIAAYG
AIAQEVPTISVEPPRNPAQLERAIKGIVEGRYQWVVFTSANAVKAVREKIVSFGLDSRAF
AGVHIAAVGAKTAAAIREFGITPELIPPRKEHNAAGMVSVFPNYVEGLDPVGRVLLPRAD
IATDVLVDGLVNLGWEVDDVVAYRTVRAAPPSAEVRDMIKSGDFDAVCFTSASTVRNLVG
IAGKPHARTIIACIGPMTAAEAEKQGLRVDVIPEVANVPALVDALAEHVEKLRAAGELPP
PRKKRRARRKSKEGAV
NT seq
1671 nt
NT seq
+upstream
nt +downstream
nt
atgcgattaatcatgaagcccgagcactcaacgcgaggacgtgtcatcttcgtcggcgcc
ggtcccggcaacccagatcttttgacggttcgagcccgcgaggtgctgggctccacagcc
aatgcagtggtggattccactgttggcgtaggtattcgcgcagttattgctgaacatctt
gaggtgccgcaggccaagcttgatgcagctgaggctgagtatgagcgcatgtgtgcggct
gcgaagcgtcgtaagcctccgcgtcccgacgcccccaccgccgcggaaatcactgaggtg
tccgctgatgcgagcgtcgatgaagtgatggcggtgctgttgcctttgctagacgaaggc
gatgtgatccgcctagtgcagggtaacccgttggcggattcccgcgcgttagatgagatt
acggctgttacacaggtgggcgcggatttccagattgtgccaggtatgtcgttgccggct
gcggttcctgctttcgcgggtattacgttgggtgattcttataccaagaccacggtgagt
gaggatactaactgggatcagttggcaaccgccccgctgccgttgattttgcaggcgagt
aaagacgacttgctgattatcgctacggagttgaaggatcgcaaactgccggcgagcact
ccggtgacggtgacgatgaatggcacgacgcgtttgcagcggagctttgacgtgacgctt
aaaactatgaagtcgttggtcaaacaggagctcgatggcactcttgtggtcacagtgggt
gtatcggatcgcagcacgttttcgtggtgggaaagccgcgcgttgtttggctggcgggtg
ttggttcctcgtgcgaaggatcaagctggtccgatgagcagccgaatcgccgcctatggt
gctattgcccaagaggttcccactatttctgtggagccgccgcgtaatcctgcgcagttg
gagcgtgcgattaagggcattgtggagggacgctaccagtgggtggtgtttaccagcgcg
aatgctgttaaggcagtgcgtgagaagatcgtatcgtttggtttggattctcgcgcgttc
gcgggggtgcatatcgctgcggtgggggctaagactgcggcggcgattcgtgagtttggc
attactcctgagctaattccgccacgtaaggagcataatgctgcgggtatggtgtcggtt
ttccctaattatgtggagggcttggacccggtaggtcgggtgttgctgccgcgggctgat
attgccactgatgtgctggttgatggtttggtcaaccttggctgggaagttgatgatgtg
gtggcgtatcgtacggtgcgtgccgcgccgccgagtgcggaagtccgcgacatgattaag
tccggcgattttgatgcggtgtgttttacctctgcgtcgacggtgcgcaatttggtgggt
attgcgggtaagccgcatgcacgcacgatcattgcatgtattgggccgatgaccgctgcg
gaggcagagaagcaagggctgcgtgtcgacgtcatccccgaggtggctaacgttccggct
cttgtggatgcgctggcggagcatgtggagaaactgcgtgctgcgggtgagttgccgccg
ccgcgtaagaagcgtcgggcccgtcgcaaatctaaggaaggtgctgtatga
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