Canis lupus familiaris (dog): 485073
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Entry
485073 CDS
T01007
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
cfa
Canis lupus familiaris (dog)
Pathway
cfa00310
Lysine degradation
cfa01100
Metabolic pathways
cfa05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
cfa00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
485073 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
485073 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
cfa03036
]
485073 (DOT1L)
Enzymes [BR:
cfa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
485073 (DOT1L)
Chromosome and associated proteins [BR:
cfa03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
485073 (DOT1L)
HMT complexes
Dot1-containing complex
485073 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
HALZ
Motif
Other DBs
NCBI-GeneID:
485073
NCBI-ProteinID:
XP_038311720
Ensembl:
ENSCAFG00000019420
VGNC:
54298
LinkDB
All DBs
Position
20:complement(56598283..56663359)
Genome browser
AA seq
1707 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVP
ENKAAVPADTPMDSGAEEEKAGATTIKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMSTA
NPERKPKKSQTALDLLHAQAASQTAAPSPQDAYKSPHSPFYQLPPSVQRHPPDQLLLAPT
PPALQKLLESFKIQYLQFLAYTKTAQYKASLQQLLDQEKEKNARLLGAAQQLFGHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQTEQLQKDNRELRSQSLQLL
KARCEELKLDWSTLSLENLLKEKQALRSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDEALSAHLRGKGALGRELEADPSRLHLDLDCSKFSLPHFSSASPELSMNGHAANY
ELCSALSRPSSKQNTPQYLASPLDQEVVPCTPSHSSRSRLEKMSGLALPDYTRLSPAKLV
LRRHLSQDHATSGKPAASELHPRAEHTKENGLPYQSPGIANGIKLSPQDPRPSSPVALQM
TGERGSEKGLKERAYASSGEAITSLPVSIPLSTVQPSKLPVSIPLASVVLPSRAEKVRST
PSPVPQTRESSSTLEKQMGTNTHSAGSKSLASTPAGFYTGSVAVSGALAGSPAPLAPGAE
PSAFDEVSGSGSLFASMGSCSSTPQHPPLLPQSRGSGAASPAHPLCASPRLSSVAQGPLP
DANKGDLPSEAGFSDPEGEAKRRIVFTISAGGSSAKQSPPSKPSPLPTGARGDSSQGHGS
DSRKRGRRKRASAGTPSLSSGVSPKRRALPSVAGLFTQSSGSPLNLNSMVSNINQPLEIT
AISSPESLKSSPVPYQDNDQPPILKKEKPLSQTNGAHYSPLTSDEEQGSEDEPGSARIER
KIATISLESKSPPKTLESGGGLAGRKPTPASEPTNSSKWKSTFSPISDLGLAKCADSPLQ
AGSALSQNSLFTFRPPLDDPGSADTKLAAHPRKSFPGALSGAGGLSPSSNPPNGFAFGGG
LAADLSLHSFSDGASLSHKVPEAASLGAPLSFPAPRGKEGGATEPGTFVNKRQLDGLGGP
KGREAGELGLPVCGPPDKASLTHSKPTKGRDREPDLKNGHNLFISAATVPPAGLLSGPGL
ATVASSAVSAAPSAQTHRPFLGTFAPGPQFALGPMSLQANLGSSVLQSLFSSVPAAAGLV
HVSSAATRLTNSHAMGSFSSGVAGGAVGGVFNHAVPSASAHPFGASFGSGAACRSATLSL
TPLQAVASAPASSFQAPPPPPPGQPALPAPPPPNAALPPAPALLPANSEPVLLQNLASLP
ANQAFLPASSAASLQPANASLSIKLASLPHKAPRPSFTVHHQPLPGLALAQAAPVIPQAS
STGPSAVWVSLGMPPPYAARLAGVKPR
NT seq
5124 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgaggctcaagtcgcccgtgggggccgagcccgccgtctac
ccgtggccgctgccggtctacgacaaacaccacgatgctgctcatgaaatcatcgagacc
atccgatgggtctgtgaagagatcccagacctcaagcttgctatggagaattacgtttta
atcgactacgacaccaaaagcttcgaaagcatgcagaggctctgtgacaaatacaaccgt
gccatcgacagcatccaccagctgtggaaggggaccactcagcccatgaaactgaacact
cggccgtccaacgggctcctgaggcacatcctgcagcaggtgtacaaccactcggtgacg
gaccccgagaagctcaacaactatgagcccttctccccggaggtgtacggggagacctcc
tttgacttggtcgcacagatgatcgacgagatcaagatgaccgaggatgacctgtttgtg
gacctgggcagtggagtgggccaggttgtgctgcaggtcgccgcggccaccaactgcaaa
catcactatggcgtggagaaagctgacatcccagccaagtacgcggagaccatggaccga
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacactggaaaga
ggcgacttcctctcagaagagtggagagagcggattgccaacacaagtgttatatttgtg
aataattttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcgaacatg
aaggaaggcggcagaattgtgtcctcgaagcccttcgcacctctcaacttccggataaac
agcagaaacttgagcgacatcggcaccatcatgcgcgttgtggagctctcgcccctgaaa
ggctcggtgtcctggacggggaagccggtctcctactacctgcacactatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggaacaagaggca
gctcggcgccggcagcagcgagagaacaagagcaacacgaccactcccaccaaggtgccc
gagaacaaggctgctgtgcctgccgacacccctatggattctggtgccgaggaagaaaag
gctggggcaaccaccatcaaaaagccgtctccctccaaagcccggaagaagaagctgaat
aagaaggggcggaagatggccggccggaagcgtgggcgtcccaagaagatgagcactgca
aaccccgagcgtaagcccaagaagagccaaactgcactggacctcctgcatgcccaggcc
gcgtctcagacggcagcgccctcgccgcaggatgcgtacaagtcacctcatagcccgttt
tatcagctacctcccagtgtgcagcggcacccccctgaccagctgctgctggcacccacc
ccacccgcactgcagaagctgctagaatccttcaagattcagtacttgcagttcttggcg
tacaccaagaccgcccagtacaaggccagcctgcagcagctgctggaccaggagaaggag
aagaacgcccggttgctaggtgctgcgcagcagctgtttggccactgccaggcccagaaa
gaggagatcaagaggctcttccagcagaaactggatgagctgggagtgaaggcgctgacc
tacaacgacctgattcaggcacagaaggagatctcggctcataatcagcagctgagggaa
cagacggagcagctgcagaaggacaacagggagctgaggagccagagcctacagctgctc
aaggctcggtgtgaggagctaaagctggactggtccacgctgtccctggagaacctgctg
aaggagaagcaggccctgaggagccagatctccgagaagcagaggcactgcctggagctg
cagatcagcatcgtggagctggagaagagccagcggcagcaggagctcctgcagctcaag
tcctgtgtgcctccagacgaggccctgtcagcgcacctgcgtgggaagggcgccctgggc
cgggagctggaggccgaccccagccgactgcacctcgacctggactgctccaagttctct
ctgccccacttcagcagcgcaagcccagagctctccatgaacggccacgcagccaactac
gagctctgcagtgcgctgagccggccctcatccaagcagaacacgcctcagtacctggcc
tccccgctggaccaggaagtcgtaccctgcacccccagccacagcagccggtcgaggctc
gagaagatgtctggcctggccttgcccgactacaccaggctctccccggccaagctggtg
ctgcggcgtcacctgagccaggaccacgcgaccagcggcaagccagccgccagtgagctg
cacccgcgagctgagcataccaaggagaacggccttccataccagagccctggcatcgca
aacggcatcaagctgagccctcaggaccctcgaccctcgtcccccgtggccttacagatg
acaggggagaggggcagcgagaagggcttgaaggagcgtgcctatgccagcagcggagag
gccatcaccagcctgcccgttagcatcccgctcagcaccgtgcagcccagtaagctgccc
gtcagcatccctctggccagtgtggtgctgcccagccgcgccgagaaagtgagaagcacc
ccgagccctgtgccgcagacccgagagtcctcgtccacacttgaaaagcagatgggcaca
aacacccacagcgctggaagcaaaagccttgcctcaactcctgcaggcttttacacgggc
tcggtggctgtcagtggggccctggcaggcagcccagcgcccctggctcctggagcagag
cccagcgccttcgacgaggtctctggctcaggaagcctgttcgccagcatggggtcctgc
agctccaccccgcagcacccgcccctgctgccacagtcccgtggctccggtgcagcctca
cccgcccatccgctctgtgccagtccgcggctcagcagtgtcgcccagggcccgctcccc
gatgccaacaaaggggaccttccgtccgaggcgggcttctcagaccccgagggcgaagcc
aagaggaggattgtctttaccatctcagctggtggcagcagtgccaaacagtcgcctccc
agcaaacccagccctctgcccacgggtgcccgcggggacagcagccagggccatgggtcg
gacagccgcaagcggggcaggagaaagcgggcctcggcggggaccccgagcctgagctca
ggcgtatcgcctaagcgtcgggccttgccgtccgttgccggcctcttcacgcagtcttca
gggtccccactgaacctcaactctatggtcagcaacattaaccagcctttggaaatcacg
gccatctcgtcccccgagagcctgaagagctcccctgtcccttaccaggacaacgaccag
ccgcccattctcaagaaggagaagcccctgagccagaccaatggggcccactactcccca
ctgacctcagatgaggagcagggctccgaggacgagccaggcagtgccagaatcgaaaga
aaaattgcaacaatttccttagaaagcaaatcccctccaaaaaccttggaaagcggtggt
ggcctggccgggaggaagccgacccctgccagcgagcccaccaacagcagcaagtggaag
tccaccttctcgcccatctccgacctcggcctggccaagtgcgccgacagcccgctgcag
gccggctccgccctgagccagaactccctattcactttccggcctcccctcgatgatccc
ggctcggccgacaccaagctggctgcccaccccaggaaaagctttcccggcgctctgtca
ggggccggtgggctgagcccaagcagcaaccctcccaatggcttcgccttcggcgggggc
ctggccgccgacctcagtttacacagcttcagcgatggtgcttctctctcccacaaggtc
cccgaggcagccagcctgggcgcacccctgagctttcctgccccacggggcaaggagggc
ggtgccacagagcccggcacctttgtgaacaagaggcagctggacggactgggcggcccg
aagggcagggaggcgggcgagctgggcctgccagtgtgcgggcccccggacaaggcctcg
ctgacacacagcaagcccaccaagggccgggaccgcgagcccgacctgaagaatggccac
aacctcttcatttctgctgccaccgtgcctcccgcgggcctcctcagcggccccggcctc
gccacggtggcatcctcggcagtcagcgcggccccatctgcccagactcaccgccccttc
ctgggcaccttcgcccccgggccgcagttcgccctgggtcccatgtccctgcaggccaac
ctgggctcatccgtgctgcagtccttgttcagctccgtgccggctgctgctggcctggtg
cacgtctcgtccgctgcaaccagactgaccaactcgcacgccatgggcagcttttcctcg
ggggtggcaggcggcgcagttggaggtgtctttaaccacgcggtgccttccgcctccgct
catccgtttggagccagtttcggcagcggggctgcgtgtcgcagcgccacgctgagctta
accccgctgcaggcggtggccagcgcccccgcgtcttcctttcaggccccgcccccgccc
cctccggggcagcccgccctccccgcaccccctccccctaacgccgccttgcctcctgcc
cccgcgctgctcccggctaactctgagcccgtgcttctgcagaaccttgcgtccctccca
gctaaccaggctttcttacccgcctcctctgccgcctctctgcagcctgctaacgcctct
ctgtccatcaagctcgcctccctcccgcacaaggccccccgcccctccttcacggtgcac
caccagcccctgcccgggctggccctggcccaggccgcgcccgtgatcccgcaggccagc
tccacggggccgtctgccgtgtgggtttcccttggcatgccgcctccgtatgccgcgcgc
cttgcgggggttaagccgagataa
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integrated database retrieval system
