Desmodus rotundus (common vampire bat): 112299737 Help Entry 112299737         CDS       T05907                                  Symbol JAK2 Name (RefSeq) tyrosine-protein kinase JAK2   KO K04447   Janus kinase 2 [EC:2.7.10.2] Organism dro  Desmodus rotundus (common vampire bat) Pathway dro01521   EGFR tyrosine kinase inhibitor resistance dro04062   Chemokine signaling pathway dro04148   Efferocytosis dro04151   PI3K-Akt signaling pathway dro04217   Necroptosis dro04550   Signaling pathways regulating pluripotency of stem cells dro04630   JAK-STAT signaling pathway dro04658   Th1 and Th2 cell differentiation dro04659   Th17 cell differentiation dro04725   Cholinergic synapse dro04917   Prolactin signaling pathway dro04920   Adipocytokine signaling pathway dro04933   AGE-RAGE signaling pathway in diabetic complications dro04935   Growth hormone synthesis, secretion and action dro05140   Leishmaniasis dro05145   Toxoplasmosis dro05152   Tuberculosis dro05161   Hepatitis B dro05164   Influenza A dro05167   Kaposi sarcoma-associated herpesvirus infection dro05168   Herpes simplex virus 1 infection dro05200   Pathways in cancer dro05207   Chemical carcinogenesis - receptor activation dro05235   PD-L1 expression and PD-1 checkpoint pathway in cancer dro05417   Lipid and atherosclerosis Brite KEGG Orthology (KO) [BR:dro00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     112299737 (JAK2)    04151 PI3K-Akt signaling pathway     112299737 (JAK2)  09140 Cellular Processes   09141 Transport and catabolism    04148 Efferocytosis     112299737 (JAK2)   09143 Cell growth and death    04217 Necroptosis     112299737 (JAK2)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     112299737 (JAK2)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     112299737 (JAK2)    04659 Th17 cell differentiation     112299737 (JAK2)    04062 Chemokine signaling pathway     112299737 (JAK2)   09152 Endocrine system    04920 Adipocytokine signaling pathway     112299737 (JAK2)    04917 Prolactin signaling pathway     112299737 (JAK2)    04935 Growth hormone synthesis, secretion and action     112299737 (JAK2)   09156 Nervous system    04725 Cholinergic synapse     112299737 (JAK2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     112299737 (JAK2)    05207 Chemical carcinogenesis - receptor activation     112299737 (JAK2)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     112299737 (JAK2)   09172 Infectious disease: viral    05161 Hepatitis B     112299737 (JAK2)    05164 Influenza A     112299737 (JAK2)    05168 Herpes simplex virus 1 infection     112299737 (JAK2)    05167 Kaposi sarcoma-associated herpesvirus infection     112299737 (JAK2)   09171 Infectious disease: bacterial    05152 Tuberculosis     112299737 (JAK2)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     112299737 (JAK2)    05140 Leishmaniasis     112299737 (JAK2)   09166 Cardiovascular disease    05417 Lipid and atherosclerosis     112299737 (JAK2)   09167 Endocrine and metabolic disease    04933 AGE-RAGE signaling pathway in diabetic complications     112299737 (JAK2)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     112299737 (JAK2)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:dro01001]     112299737 (JAK2) Enzymes [BR:dro01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      112299737 (JAK2) Protein kinases [BR:dro01001]  Non-receptor tyrosine kinases   JAK family [OT]    112299737 (JAK2) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl SH2 ABC1 FERM_C_FAK1 RIO1 Kinase-like FERM_M Motif Other DBs NCBI-GeneID:  112299737 NCBI-ProteinID:  XP_024410726 LinkDB All DBs Position Unknown AA seq 1130 aa AA seqDB search MACLTMTEMEGTSTFPIHHNGDIPGIADSVKQVDPVLQVYLYHSLGKTEGDYLKFPTGEY VAEEICVAASKACGITPVYHSMFALMSETERIWYPPNHVFHIDESTRHSVLYRIRFYFPY WYCNGSNRTYRHGISRGAEAPLVDDFVMSYLFAQWRHDFLHGWIKVPVTHETQEECLGMA VLDMMRIAKEKDQTPLDIYSSISYKTFLPKCVRAKIQDYHILTRKRIRYRFRRFIEQFSH CKATARNLKLKYLINLETLQSAFYTEQFEVKEPGRGPSGEEIFATIIITGNGGIQWSRGK HKESETLTEQDLQLYCDFPDIIDVSIKQANQEVSNESRIVTIHKQDGKNLEIELSSLREA LSFVSLIDGYYRLTADAHHYLCKEVAPPMVLENIQSNCHGPISMDFAISKLKKAGNQTGL YVLRCSPKEFNKYFLTFAVERENVIEYKHCLITKNENGEYNLSGTKKNFNNLKDLLNCYQ METVRSDNIIFQFTKCCPPKPKDKSNLLVFRTNGVSDVPTSPTLQRHNNVNQMVFHKIRN EDLIFNESLGQGTFTKIFKGIRREIGDYGQLHETEVLLKVLDKAHRNYSESFFEAASMMS QLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKTSINILWKLEVAKQLAWAMH FLEEKTLIHGNVCAKNILLIREEDRKTGNPPFIKLSDPGISITVLPKDILQERIPWVPPE CIENPKNLNLATDKWSFGTTLWEICSGGDKPLNALDSQRKLQFYEDRHQLPAPKWTELAN LINNCMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPT QFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEIL KSLQHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQKHKERIDHKKLLQYTFQICK GMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYA PESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELL KNNGRLPRPDGCPDEIYVIMTECWNNNVNQRPSFRHLALRVDQIRDSMAG NT seq 3393 nt NT seq  +upstreamnt  +downstreamnt atggcttgccttacaatgacagaaatggaaggaacatccacatttcctatacatcacaat ggtgatattcctggaattgctgattctgtgaagcaagtagatccagtcctacaggtgtat ctttatcattcccttgggaagactgagggagattacctgaagtttccaactggggagtat gttgcagaagaaatttgtgttgctgcttctaaagcctgtggaatcacaccagtgtatcac agtatgtttgccttgatgagtgaaacagaaaggatctggtatccgcccaaccatgtcttc catattgacgaatcaacgaggcacagtgtactctacagaataagattttactttccttac tggtattgtaatggcagcaacagaacctatcggcatggaatatctcgaggtgctgaagct cctcttgttgacgactttgtcatgtcttacctgtttgctcagtggcgtcatgattttttg catggatggataaaagtacctgtgactcatgaaacacaggaagaatgtcttgggatggca gtgttagatatgatgagaatagccaaagaaaaggatcagaccccactggacatctatagc tctatcagctacaaaacattcttaccaaaatgtgttcgagcaaagatccaagactatcat attttgacaagaaagcgaataaggtacagatttcgcagatttattgagcaattcagccat tgcaaagccactgccagaaacttgaaacttaagtatcttataaatctggaaactcttcag tctgcattctacacagaacaatttgaagtaaaagaacctggaagaggtccttcaggtgag gagatttttgcaaccattataataactggaaacggtggaattcagtggtcaagagggaaa cataaagaaagtgagacactgacagaacaggatttacagttatattgtgattttcctgat attattgatgtcagtattaagcaggcaaaccaagaagtctcaaatgaaagcagaattgta actatccataagcaagatggtaaaaatctggaaattgaacttagctcattaagggaagct ttgtcctttgtgtcattaattgatggatattacagattaactgcagatgcgcatcattac ctctgtaaagaagtggcccctccaatggtgcttgaaaatatacaaagcaactgtcatggc ccaatttcgatggatttcgccataagtaaactgaagaaagcaggtaatcagactggactc tatgtacttcgatgcagtcctaaggagtttaataaatactttttgacttttgctgtcgag cgagaaaatgtcattgaatataagcactgtttgattacaaaaaatgagaatggagaatac aacctcagtgggaccaagaagaacttcaataatcttaaagatcttttgaattgctaccag atggaaactgttcgctcagacaatataattttccagtttacgaaatgctgtcccccaaag ccaaaagataaatcaaaccttctagtcttcagaaccaacggtgtttctgatgtaccaacc tcaccaacactacagagacataataatgtgaaccaaatggtatttcacaaaatcagaaat gaagatttgatatttaatgaaagccttggacaaggcacttttacaaaaatttttaaaggt ataagaagagaaataggagactatggacaactgcatgaaacagaagttcttttaaaagtt ttggataaagcacatagaaactattcagagtctttctttgaagcagcaagcatgatgagc cagctttctcacaagcatctggttttaaattatggagtatgtgtctgtggagaggagaat attctggttcaggagtttgtgaaatttggatcactagatacatacttgaaaaagaataaa acttctataaatatattatggaaacttgaagtggctaaacagttggcatgggccatgcat tttctagaagaaaaaacccttattcatgggaatgtgtgtgccaaaaatattctacttatc agagaagaagacaggaagacgggaaatcctcctttcatcaaacttagtgatcctggcatt agtatcacagttttgccaaaggacatccttcaggagagaataccatgggtaccacctgaa tgcattgaaaatcctaaaaatttaaacttggcaacagacaagtggagttttggtaccact ttgtgggaaatctgcagtggaggagataagcctctgaatgctttggattctcagagaaaa ctacagttttatgaagacagacaccagcttcctgcaccaaagtggacagagttagcaaat cttattaataattgtatggattacgaaccagattttagaccttctttcagagccatcata cgagatctaaacagtttgtttactcccgattacgaactattaacagagaatgacatgtta ccaaatatgaggataggtgctctagggttttctggtgcttttgaagaccgagaccctact cagtttgaagagagacacttgaaatttctgcagcaacttggcaagggtaattttgggagt gtggagatgtgccggtatgaccctctacaggacaacactggggaggtggtggctgtgaaa aagcttcagcacagtactgaagagcacctcagggactttgaaagggaaattgaaatcctt aaatccctgcaacatgacaacattgtaaagtacaagggagtgtgctacagtgctggccgg cgtaatctaagattaattatggaatatttaccatatggaagtttacgcgactatctccaa aagcataaagaacggatagatcataaaaaacttctgcagtacacatttcaaatatgcaag ggtatggagtatcttggtacaaaaaggtatatccacagggatctggcaacaaggaatata ttggtggagaatgaaaacagagttaaaattggagattttggattaaccaaagtcttgccg caagacaaagaatactacaaagtgaaagaacctggtgaaagtcccatcttctggtatgct ccagaatcactgacagagagcaagttttctgtggcctcagatgtttggagctttggagtg gttctgtatgaacttttcacatacattgagaagagtaaaagtccaccagcggaattcatg cgtatgattggcaatgacaaacaaggacagatgattgtgttccatttgatagagctcttg aagaataatggaagattacctagaccagatggatgcccggatgagatttatgtgatcatg acagaatgctggaacaataatgtaaatcaacgcccctctttcagacacctcgcccttcga gttgatcaaataagggacagtatggctggatga

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