Escherichia coli W: ECW_m4378
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Entry
ECW_m4378 CDS
T02002
Symbol
metH
Name
(GenBank) homocysteine-N5-methyltetrahydrofolate transmethylase, B12-dependent
KO
K00548
5-methyltetrahydrofolate--homocysteine methyltransferase [EC:
2.1.1.13
]
Organism
elw
Escherichia coli W
Pathway
elw00270
Cysteine and methionine metabolism
elw00450
Selenocompound metabolism
elw00670
One carbon pool by folate
elw01100
Metabolic pathways
elw01110
Biosynthesis of secondary metabolites
elw01230
Biosynthesis of amino acids
elw04980
Cobalamin transport and metabolism
Module
elw_M00017
Methionine biosynthesis, aspartate => homoserine => methionine
Brite
KEGG Orthology (KO) [BR:
elw00001
]
09100 Metabolism
09105 Amino acid metabolism
00270 Cysteine and methionine metabolism
ECW_m4378 (metH)
09106 Metabolism of other amino acids
00450 Selenocompound metabolism
ECW_m4378 (metH)
09108 Metabolism of cofactors and vitamins
00670 One carbon pool by folate
ECW_m4378 (metH)
09150 Organismal Systems
09154 Digestive system
04980 Cobalamin transport and metabolism
ECW_m4378 (metH)
Enzymes [BR:
elw01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.13 methionine synthase
ECW_m4378 (metH)
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Paralog
Gene cluster
GFIT
Motif
Pfam:
Met_synt_B12
S-methyl_trans
Pterin_bind
B12-binding_2
B12-binding
Motif
Other DBs
NCBI-ProteinID:
ADT77667
UniProt:
E0J0I0
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Position
4486514..4490197
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AA seq
1227 aa
AA seq
DB search
MSSKVEQLRAQLNERILVLDGGMGTMIQSYRLNEADFRGERFADWPCDLKGNNDLLVLSK
PEVIAAIHNAYFEAGADIIETNTFNSTTIAMADYQMESLSAEINFAAAKLARACADEWTA
RTPEKPRYVAGVLGPTNRTASISPDVNDPAFRNITFDGLVAAYRESTKALVEGGADLILI
ETVFDTLNAKAAVFAVKTEFEALGVELPIMISGTITDASGRTLSGQTTEAFYNSLRHAEA
LTFGLNCALGPDELRQYVQELSRIAECYVTAHPNAGLPNAFGEYDLDADTMAKQIREWAQ
AGFLNIVGGCCGTTPQHIAAMSRAVEGLAPRKLPEIPVACRLSGLEPLNIGEDSLFVNVG
ERTNVTGSAKFKRLIKEEKYSEALDVARQQVENGAQIIDINMDEGMLDAEAAMVRFLNLI
AGEPDIARVPIMIDSSKWDVIEKGLKCIQGKGIVNSISMKEGVDAFIHHAKLLRRYGAAV
VVMAFDEQGQADTRARKIEICRRAYKILTEEVGFPPEDIIFDPNIFAVATGIEEHNNYAQ
DFIGACEDIKRELPHALISGGVSNVSFSFRGNDPVREAIHAVFLYYAIRNGMDMGIVNAG
QLAIYDDLPAELRDAVEDVILNRRDDGTERLLELAEKYRGSKTDDTANAQQAEWRSWEVN
KRLEYSLVKGITEFIEQDTEEARQQATRPIEVIEGPLMDGMNVVGDLFGEGKMFLPQVVK
SARVMKQAVAYLEPFIEASKEQGKTNGKMVIATVKGDVHDIGKNIVGVVLQCNNYEIVDL
GVMVPAEKILRTAKEVNADLIGLSGLITPSLDEMVNVAKEMERQGFTIPLLIGGATTSKA
HTAVKIEQNYSGPTVYVQNASRTVGVVAALLSDTQRDDFVARTRKEYETVRIQHGRKKPR
TPPVTLEAARDNDFAFDWQAYTPPVAHRLGVQEVEASIETLRNYIDWTPFFMTWSLAGKY
PRILEDEVVGVEAQRLFKDANDMLDKLSAEKTLNPRGVVGLFPANRVGDDIEIYRDETRT
HVINVSHHLRQQTEKTGFANYCLADFVAPKLSGKADYIGAFAVTGGLEEDALADAFEAQH
DDYNKIMVKALADRLAEAFAEYLHERVRKVYWGYAPNENLSNEELIRENYQGIRPAPGYP
ACPEHTEKATIWELLEVEKHTGMKLTESFAMWPGASVSGWYFSHPDSKYYAVAQIQRDQV
EDYARRKGMSVSDVERWLAPNLGYDAD
NT seq
3684 nt
NT seq
+upstream
nt +downstream
nt
gtgagcagcaaagtggaacaactgcgtgcgcagttaaatgaacgtattctggtgctggac
ggcggtatgggcaccatgatccagagctatcgactgaacgaagccgattttcgtggtgaa
cgctttgccgactggccatgcgatctcaaaggcaacaacgacctgctggtgctcagcaaa
ccggaagtgatcgccgctatccacaacgcctactttgaagcgggcgcggatatcatcgaa
accaacacctttaactccacgaccattgcgatggcggattaccagatggaatccctgtcg
gcggaaatcaactttgcggcggcgaaactggcgcgagcttgtgctgatgagtggaccgcg
cgcacgccggagaaaccgcgctacgttgccggtgttctcggcccgaccaaccgcacggcg
tctatttctccggacgtaaatgatccggcatttcgtaatatcacttttgacgggctggtg
gcggcttatcgagagtccaccaaagcgctggtggaaggtggcgcggatctgatcctgatt
gaaaccgttttcgacacccttaacgccaaagcggcggtttttgcggtgaaaacggagttt
gaagcgctgggcgttgagctgccgattatgatctccggcaccatcaccgacgcctccggg
cgcacgctctccgggcagaccaccgaagcattttacaactcattgcgccacgccgaagct
ctgacctttggcctgaactgtgcgctggggcccgatgaactgcgccagtacgtgcaggag
ctgtcacggattgcggaatgctacgtcaccgcgcacccgaacgccgggctacccaacgcc
tttggtgagtacgatctcgacgccgacacgatggcaaaacagatacgtgaatgggcgcaa
gcgggttttctcaatatcgtcggcggctgctgtggcaccacgccacaacatattgcagcg
atgagtcgtgcagtagaaggattagcgccgcgcaaactgccggaaatccccgtagcctgc
cgtttgtccggcctggagccgctgaacattggcgaagatagcctgtttgtgaacgtgggt
gaacgcaccaacgtcaccggttccgctaagttcaagcgcctgatcaaagaagagaaatac
agcgaggcactggatgtggcccgccagcaggtggaaaacggtgcgcagattatcgatatc
aacatggatgaagggatgctcgacgccgaagcggcgatggtgcgttttctcaatctgatt
gccggtgaaccggatatcgctcgcgtgccgattatgatcgactcctcaaaatgggatgtc
attgaaaaaggtctgaagtgtatccagggcaaaggcattgttaactctatctcgatgaaa
gagggcgtcgacgcctttatccatcacgcgaagctcttgcgtcgttacggtgcggcagtg
gtggtaatggcctttgacgaacagggacaggccgatacccgcgcacggaaaatcgagatt
tgccgtcgggcgtacaaaatcctcaccgaagaggttggcttcccgccagaagatatcatc
ttcgacccgaacatcttcgcggttgccaccggcattgaagagcacaacaactacgcgcag
gactttatcggcgcgtgtgaagacatcaaacgcgaactgccgcacgcgctaatttccggc
ggcgtatctaacgtttctttctcgttccgtggcaacgatccggtgcgcgaagccattcac
gcagtgttcctctactacgctattcgcaatggcatggatatggggatcgtcaatgccggg
cagctggcgatttacgacgacctgcccgctgaactgcgcgacgcggtggaagatgtgatt
cttaatcgtcgcgatgatggcactgagcgtttactggagcttgccgagaaatatcgcggc
agcaaaaccgacgacaccgctaacgcccagcaggcggagtggcgctcgtgggaagtgaat
aaacgtctggaatactcgctggttaaaggcattaccgagtttatcgagcaggataccgaa
gaagcccgccagcaggctacgcgcccgattgaagtgattgaaggcccgctgatggacggt
atgaacgtggtcggcgatctgtttggcgaagggaaaatgttcctgccacaggtggtcaaa
tcggcgcgcgtcatgaaacaggcagtggcgtatctcgaaccgtttattgaagccagcaaa
gagcagggcaaaaccaacggcaagatggtgatcgccaccgtgaagggcgacgtccacgac
atcggtaaaaatatcgttggtgtggtgctgcaatgtaacaactacgaaattgtcgatctc
ggcgttatggtgcctgcggaaaaaattctccgtaccgctaaagaagtgaatgctgatctg
attggactttcggggcttatcacgccgtcgctggacgagatggttaacgtggcgaaagag
atggagcgtcagggcttcaccatcccgctattgattggcggcgcgacgacctcaaaagcg
cacacggcggtgaaaattgagcagaactacagcggcccgacggtgtatgtacagaacgca
tcgcgcaccgttggtgtggtggcggcgctgctttccgatactcagcgtgatgattttgtc
gctcgtacccgcaaggagtacgaaaccgtacgtattcagcacgggcgtaagaaaccgcgc
acaccaccggtcacgctggaagcggcgcgcgataacgatttcgcttttgactggcaggct
tacacgccgccggtggcgcaccgtctcggcgtgcaggaagttgaagccagcatcgaaact
ctgcgtaattacatcgactggacaccgttctttatgacctggtcgctggccgggaagtat
ccgcgcattctggaagatgaagtggtgggcgttgaggcgcagcggctgtttaaagacgcc
aacgacatgctggataaattaagcgccgagaaaacgctgaatccgcgtggcgtggtgggc
ctgttcccggcaaaccgtgtgggcgatgacattgaaatctaccgtgacgaaacgcgcacc
catgtgatcaacgtcagccaccatctgcgtcaacagaccgaaaaaacgggattcgctaac
tactgtctcgctgacttcgttgcgccgaagctttctggtaaagcagattacatcggcgca
tttgccgtgactggcgggctggaagaggacgcactggctgatgcctttgaagcgcagcac
gatgattacaacaaaatcatggtgaaagcgcttgccgaccgtttagccgaagcctttgcg
gagtatctccatgagcgtgtgcgtaaagtctactggggctatgcgccgaacgagaacctc
agcaacgaagaactgatccgcgaaaactaccagggcatccgtccggcaccgggctacccg
gcctgcccggaacatacggaaaaagccaccatctgggagctgctggaagtggaaaaacat
accggcatgaaactcacagaatctttcgccatgtggcccggtgcatcggtttcgggttgg
tatttcagccacccggacagcaagtactacgccgtggcgcaaattcagcgcgatcaggtt
gaagactatgcccgccgtaaaggtatgagcgtctcagatgttgagcgctggctggcaccg
aatctggggtatgacgcggactga
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