Entry
Name
adenine glycosylase;
mutY (gene name);
A/G-specific adenine glycosylase
Class
Hydrolases;
Glycosylases;
Hydrolysing N-glycosyl compounds
BRITE hierarchy
Sysname
adenine-DNA deoxyribohydrolase (adenine-releasing)
Reaction(IUBMB)
Hydrolyses free adenine bases from 7,8-dihydro-8-oxoguanine:adenine mismatched double-stranded DNA, leaving an apurinic site.
Comment
The enzyme serves as a mismatch repair enzyme that works to correct 7,8-dihydro-8-oxoguanine:adenine mispairs that arise in DNA when error-prone synthesis occurs past 7,8-dihydro-8-oxoguanine (GO) lesions in DNA. The enzyme excises the adenine of the mispair, producing an apurinic site sensitive to AP endonuclease activity. After removing the undamaged adenine the enzyme remains bound to the site to prevent EC
3.2.2.23 (MutM) from removing the GO lesion, which could lead to a double strand break. In vitro the enzyme is also active with adenine:guanine, adenine:cytosine, and adenine:7,8-dihydro-8-oxoadenine (AO) mispairs, removing the adenine in all cases.
History
EC 3.2.2.31 created 2018
Orthology
K03575 A/G-specific adenine glycosylase
Genes
MUO : 115459583 115472108(MUTYH)
CAUA : 113070945 113107109
PPRM : 120482293 120482301
MASI : 127414797 127424420
SLUC : 116058725 116063263(mutyh)
MSAM : 119900837 119918673
LCF : 108877332(mutyh) 108893055
SLAL : 111656165 111656387(mutyh)
LPIC : 129271013 129271979
PPOI : 119112321 119112990
RPHI : 132713004 132748700
CSAT : 104719186 104728097 104728098 104733726 104773440 109127979 109132411
PVY : 116136005 116140137 116140242
HSYR : 120114027 120121087
LJA : Lj3g3v2389760.1(Lj3g3v2389760.1) Lj3g3v2389760.2(Lj3g3v2389760.2) Lj3g3v2389760.3(Lj3g3v2389760.3)
QSA : O6P43_017050 O6P43_017064 O6P43_017069
PAVI : 110745919 110748333
HBR : 110650431 110652660 110665786
SSPL : 121791319 121797573
SMIL : 130996245 131006497
CSIN : 114296332 114306605
CQI : 110700240 110700769 110727493 110729027
DOSA : Os12t0211400-00(Os12g0211400) Os12t0212100-00(Os12g0212100)
TAES : 123148385 123161434 123169207
PVIR : 120666677 120696956
MPP : MICPUCDRAFT_40419(JGI:MicpuC2_40419)
NTE : NEUTE1DRAFT48787(NEUTE1DRAFT_48787)
SMP : SMAC_07713 SMAC_07714
CCAC : CcaHIS019_0300190(CcaverHIS019_0300190)
ABP : AGABI1DRAFT64172(AGABI1DRAFT_64172)
ABV : AGABI2DRAFT226007(AGABI2DRAFT_226007)
SCM : SCHCO_02637425(SCHCODRAFT_02637425)
EHI : EHI_010700(95.t00006)
SMIN : v1.2.014787.t1(symbB.v1.2.014787.t1)
FCY : FRACYDRAFT_187316(MutY_a)
EHX : EMIHUDRAFT_70516 EMIHUDRAFT_75031
ECOO : ECRM13514_3847(mutY)
ECOH : ECRM13516_3692(mutY)
ECW : EcE24377A_3307(mutY)
EDJ : ECDH1ME8569_2861(mutY)
ECOI : ECOPMV1_03234(mutY)
REE : electrica_00731(mutY)
RTG : NCTC13098_00989(mutY_1)
SEHC : A35E_00548 A35E_00549
CLAP : NCTC11466_00579(mutY)
KIE : NCTC12125_04676(mutY)
AHN : NCTC12129_00874(mutY)
PSHI : SAMEA2665130_2524(mutY)
YPG : YpAngola_A0151(mutY)
YPI : YpsIP31758_0819(mutY)
SMW : SMWW4_v1c41450(mutY)
SFJ : SAMEA4384070_4159(mutY)
SOF : NCTC11214_02570(mutY)
PAQU : DMB82_0015975(mutY)
DIC : Dpoa569_002841(mutY)
EHD : ERCIPSTX3056_111(mutY)
BAPF : BUMPF009_CDS00051(muty)
BAPG : BUMPG002_CDS00051(muty)
BAPU : BUMPUSDA_CDS00051(muty)
BAPW : BUMPW106_CDS00051(muty)
TPTY : NCTC11468_00717(mutY)
PHEI : NCTC12003_00855(mutY)
PRJ : NCTC6933_00938(mutY)
LRI : NCTC12151_00508(mutY)
HIC : NTHIC486_00222(mutY)
HPIT : NCTC13334_00275(mutY)
HHZ : NCTC10839_00664(mutY)
HAEG : NCTC8502_00297(mutY)
PDAG : 4362423_01576(mutY)
ADP : NCTC12871_00525(mutY)
ALIG : NCTC10568_02113(mutY)
ASEG : NCTC10977_00189(mutY)
AVT : NCTC3438_00283(mutY)
RPNE : NCTC8284_00877(mutY_2)
PAET : NCTC13378_01902(mutY)
XFU : XFF4834R_chr25770(mutY)
XPH : XppCFBP6546_19640(mutY)
XHD : LMG31886_17350(mutY)
PSUW : WQ53_10985 WQ53_13850
LLZ : LYB30171_00923(mutY)
VAU : VANGNB10_cI0326c(mutY)
VPL : SA104470976_02248(mutY)
PMAI : CF386_01925 CF386_01930
PAEB : NCGM1900_5906(mutY)
PVD : CFBP1590__5159(mutY)
PPRC : PFLCHA0_c03650(mutY)
PMUD : NCTC8068_00331(mutY)
PFW : PF1751_v1c02990(mutY)
PPUU : PputUW4_00263(mutY)
PTRT : HU722_0002530(mutY)
PTW : TUM18999_57110(mutY)
PTAE : NCTC10697_04280(mutY)
PSYC : DABAL43B_2598(mutY)
MCAT : MC25239_01466(mutY)
MCUN : NCTC10297_00101(mutY)
SCAA : TUM17387_28020(mutY)
SALH : HMF8227_00306(mutY)
CBS : COXBURSA331_A1003(mutY)
LLG : 44548918_00934(mutY)
LJR : NCTC11533_01105(mutY)
LCJ : NCTC11976_01635(mutY)
LWA : SAMEA4504053_1229(mutY)
LSS : NCTC12082_00158(mutY)
LADL : NCTC12735_01234(mutY)
MISZ : MishRS11D_22090(mutY)
TIB : THMIRHAM_20730(mutY)
TSE : THMIRHAS_23570(mutY)
TZO : THMIRHAT_01310(mutY)
RHEI : ATY27_11105 ATY27_18550
TFRI : Thiofri_00015(mutY)
TNI : TVNIR_3589(mutY_[H])
GAI : IMCC3135_02350(mutY)
THIC : TspCOW1_21760(mutY)
ALCA : ASALC70_01771(mutY)
AEL : NCTC12917_03685(mutY)
CHJ : NCTC10426_01333(mutY)
CDIZ : CEDIAZO_01155(mutY)
NMM : NMBM01240149_0759(mutY)
NMS : NMBM01240355_1330(mutY)
NMQ : NMBM04240196_0810(mutY)
NMZ : NMBNZ0533_1383(mutY)
NMX : NMA510612_1792(mutY)
NWE : SAMEA3174300_0222(mutY)
NZO : SAMEA4504057_0878(mutY)
NCI : NCTC10296_02419(mutY)
NCZ : NCTC10294_00846(mutY)
NANI : NCTC12227_00205(mutY)
ECOR : SAMEA4412678_1853(mutY)
BMV : BMASAVP1_A0082(mutY)
BML : BMA10229_A1508(mutY)
BPM : BURPS1710b_0759(mutY)
BPL : BURPS1106A_0591(mutY)
PLG : NCTC10937_00417(mutY)
LMIR : NCTC12852_00162(mutY)
BUO : BRPE64_ACDS02470(mutY)
VTR : MYVALT_G_01140(mutY)
BTRM : SAMEA390648700808(micA)
AXX : ERS451415_00521(mutY)
LIM : L103DPR2_00895(mutY)
LIH : L63ED372_02346(mutY)
UPL : DSM104440_00077(mutY)
FPHO : SHINM1_019880(mutY)
RBS : RHODOSMS8_00248(mutY)
SMEL : SM2011_c00452(mutY)
SFD : USDA257_c06540(mutY)
SAME : SAMCFNEI73_Ch0988(mutY)
AGR : AGROH133_04473(mutY)
ALF : CFBP5473_11665(mutY)
AVV : RvVAT039_24280(mutY)
AVF : RvVAR031_11550(mutY)
ASAL : CFBP5507_02160(mutY)
RPUS : CFBP5875_02515(mutY)
ALEG : CFBP4996_02315(mutY)
REC : RHECIAT_CH0001087(mutY)
REL : REMIM1_CH01019(mutY)
REP : IE4803_CH01002(mutY)
REI : IE4771_CH01044(mutY)
RGA : RGR602_CH01038(mutY)
RPHA : AMC79_CH01025(mutY)
RLW : RlegWSM1455_03365(mutY)
RBW : RLCC275e_03420(mutY)
NEN : NCHU2750_05450(mutY)
LAS : CLIBASIA_01820(mutY)
BIO : BR141012304_10071(mutY)
BSEP : HAP48_0006735(mutY)
BCAN : BcanWSM471_11585(mutY)
VGO : GJW-30_1_00850(yfhQ)
BHS : BM1374165_00433(mutY)
BBK : BARBAKC583_0414(mutY)
BTX : BM1374166_00627(mutY)
BEZ : NCTC12898_00307(mutY)
MAQU : Maq22A_1p30855(mutY)
MMES : MMSR116_19520(mutY)
BVY : NCTC9239_02436(mutY)
TSV : DSM104635_02629(yfhQ)
RLI : RLO149_c042880(mutY)
PHP : PhaeoP97_03264(mutY)
PPIC : PhaeoP14_03152(mutY)
SINL : DSM14862_00381(mutY)
SPSE : SULPSESMR1_02991(mutY)
RMM : ROSMUCSMR3_02986(mutY)
AHT : ANTHELSMS3_00165(mutY)
LALG : LentiSH36_02698(mutY)
LVS : LOKVESSMR4R_03749(mutY)
SRHI : H9L12_09660 H9L12_10105
SFLA : SPHFLASMR4Y_03284(mutY)
PMAS : NCF86_02610 NCF86_16400(mutY)
ABS : AZOBR_p1130120(muty)
HCL : NCTC13205_00202(mutY)
HSH : NHP194022_02720(mutY)
HPUL : NCTC13154_00587(mutY)
CJV : MTVDSCj20_1577(mutY)
CLR : UPTC16701_0138(mutY)
CLM : UPTC16712_0137(mutY)
CAMR : CAQ16704_0131(mutY)
CHV : CHELV3228_1770(mutY)
PPOR : JCM14722_04880(mutY)
PCAY : FRD00_04160(mutY) FRD00_15495
BBAE : FRD01_13280 FRD01_21155(mutY)
BAZ : BAMTA208_03970(yfhQ)
BSON : S101395_01082(mutY)
BFD : NCTC4823_02972(mutY)
PARG : PspKH34_32810(mutY)
FPN : ABE65_002570 ABE65_012295
BLEN : NCTC4824_03130(mutY)
SAX : USA300HOU_1863(mutY)
SUQ : HMPREF0772_11276(mutY)
SDP : NCTC12225_00952(mutY)
SPIC : SAMEA4384060_1081(mutY)
SSH : NCTC13712_01887(mutY)
SSIM : SAMEA4384339_1787(mutY)
SSTE : SAMEA4384403_0830(mutY)
LMOC : LMOSLCC5850_1752(mutY)
LMW : LMOSLCC2755_1701(mutY)
LMX : LMOSLCC2372_1755(mutY)
LMZ : LMOSLCC2482_1753(mutY)
LMON : LMOSLCC2376_1648(mutY)
LMOS : LMOSLCC7179_1663(mutY)
LMOO : LMOSLCC2378_1710(mutY)
LMOY : LMOSLCC2479_1753(mutY)
LMOT : LMOSLCC2540_1772(mutY)
LMOA : LMOATCC19117_1704(mutY)
LGZ : NCTC10812_01162(mutY)
BAYD : BSPP4475_16920(mutY)
PPQ : PPSQR21_007510(mutY)
PCHI : PC41400_27725(mutY)
PAMY : P9222_00545 P9222_01710(mutY)
PNK : AASFL403_16360(mutY)
COHN : KCTCHS21_51720(mutY)
SACA : FFV09_13950(mutY) FFV09_15910
SPYM : M1GAS476_1634(mutY)
SPH : MGAS10270_Spy1624(mutY)
SPI : MGAS10750_Spy1616(mutY)
SPJ : MGAS2096_Spy1582(mutY)
SPK : MGAS9429_Spy1562(mutY)
STG : MGAS15252_1400(mutY)
STZ : SPYALAB49_001547(mutY)
SNV : SPNINV200_10070(mutY)
SNC : HMPREF0837_11274(mutY)
SPNE : SPN034156_01860(mutY)
SPNU : SPN034183_10980(mutY)
SPNM : SPN994038_10870(mutY)
SPNO : SPN994039_10880(mutY)
SMC : SmuNN2025_0276(mutY)
SGG : SGGBAA2069_c18760(mutY)
SCP : HMPREF0833_10455(mutY)
SVB : NCTC12167_01694(mutY)
SMEN : SAMEA4412692_1471(mutY)
SFER : NCTC12278_01639(mutY)
SCAI : NCTC12191_00897(mutY)
SPSU : NCTC13786_01487(mutY)
SPOC : NCTC10925_01670(mutY)
SAUP : NCTC3168_01745(mutY)
SURN : NCTC13766_00209(mutY)
SVF : NCTC3166_01002(mutY)
SMIE : NCTC11169_01017(mutY)
EFU : HMPREF0351_10952(mutY)
ECEC : NCTC12421_01445(mutY)
AUR : HMPREF9243_0589(mutY)
AMIT : DBT49_0007375(mutY)
SMAN : C12CBH8_19150(mutY)
PFAA : MM59RIKEN_10840(mutY)
BPRO : PMF13cell1_03124(mutY)
BLUI : Blut17040_23160(mutY)
CSCI : HDCHBGLK_00471(mutY)
ACEL : acsn021_32990(mutY)
CBAR : PATL70BA_1633(mutY)
AMIC : Ami3637_16900(mutY)
ABUT : Ami103574_08470(mutY)
CKI : Calkr_2127 Calkr_2642
PIV : NCTC13079_01579(mutY)
VRM : 44547418_01755(mutY)
VDN : NCTC11831_01829(mutY)
DHO : Dia5BBH33_03470(mutY)
MANA : MAMMFC1_01126(yfhQ)
STED : SPTER_12740(mutY_1) SPTER_26990(mutY_2)
AHK : NCTC10172_00401(mutY)
MMAE : MMARE11_49040(mutY)
MBAI : MB901379_04479(mutY)
MHEK : JMUB5695_00448(mutY)
MKY : IWGMT90018_57850(mutY)
MPHL : MPHLCCUG_00461(mutY)
MTHN : 4412656_04121(mutY)
MAUU : NCTC10437_05106(mutY)
MFLV : NCTC10271_00433(mutY)
MSAL : DSM43276_00469(mutY)
MTER : 4434518_03756(mutY)
CDIP : ERS451417_01984(mutY)
CUC : CULC809_01839a(mutY)
CUN : Cul210932_1967(mutY)
CUQ : Cul210931_1912(mutY)
CUJ : CUL131002_1879(mutY)
CMIN : NCTC10288_00349(mutY)
CRL : NCTC7448_00440(MutY)
CCYS : SAMEA4530656_0192(mutY)
CATR : CATRI_10395(mutY1) CATRI_11465(mutY2)
NFR : ERS450000_03807(mutY)
NAD : NCTC11293_01197(mutY)
RCR : NCTC10994_02187(mutY)
SAMB : SAM23877_4204(mutY)
SLE : sle_31890(sle_31890)
SXT : KPP03845_103477(mutY)
AMAU : DSM26151_10790(mutY)
MALK : MalAC0309_1798(mutY)
PSEV : USB125703_01606(mutY)
AAGI : NCTC2676_1_00118(mutY)
DCO : SAMEA4475696_0670(mutY)
CGRN : 4412665_00206(mutY)
PAUS : NCTC13651_00519(mutY)
NAQU : ENKNEFLB_00593(mutY)
TBW : NCTC13354_01398(mutY)
AHW : NCTC11636_01211(mutY)
ASLA : NCTC11923_02663(mutY)
AVC : NCTC10951_02831(mutY)
BALA : DSM104299_03498(mutY)
SBAE : DSM104329_03869(mutY)
SYR : SynRCC307_0103(mutY)
SYX : SynWH7803_0163(mutY)
SYH : Syncc8109_0122(mutY)
SYNW : SynWH8103_00121(mutY)
LET : O77CONTIG1_04616(yfhQ)
SYP : SYNPCC7002_A2741(mutY)
SYNN : NIES970_25220(mutY)
CYC : PCC7424_4529 PCC7424_5680
OXY : HCG48_11780(mutY) HCG48_15830
CTHE : Chro_2665 Chro_4393
PLP : Ple7327_1660 Ple7327_4430
CHL : Chy400_1564 Chy400_3159
TBH : Tbon_01575 Tbon_05375
TFLA : O0235_07875 O0235_12010
DEIN : DAAJ005_15660(mutY)
OPR : Ocepr_0090 Ocepr_0308
CSUI : Chls_409(A_G-specific_adenine_glycosylase)
OBG : Verru16b_00044(yfhQ)
LCRE : Pla8534_31760(mutY)
AMUC : Pan181_47430(mutY_2)
PPIO : CE91St28_17660(mutY)
BTHO : Btheta7330_01716(yfhQ)
BCEL : BcellWH2_01057(yfhQ)
BFC : BacF7301_22530(mutY)
PCRE : NCTC12858_00904(mutY)
PCAG : NCTC12856_00169(mutY)
CFAS : Cfast33896_10750(mutY)
BUY : D8S85_08220(mutY) D8S85_10190
BVIR : I6J59_05655 I6J59_17255(mutY)
BFH : F1611_10890(mutY) F1611_19405
PMZ : HMPREF0659_A5412(mutY)
PDN : HMPREF9137_2091(mutY)
POC : NCTC13071_00269(mutY)
CBAE : COR50_04535 COR50_06230(mutY)
COY : HF329_24300(mutY) HF329_33325
FLA : SY85_14350 SY85_17615
THEO : IMW88_01825 IMW88_04545(mutY)
SMIZ : 4412673_03668(mutY)
SDJ : NCTC13534_05090(mutY)
STHA : NCTC11429_01136(mutY)
SCN : Solca_1821 Solca_3518
PSEZ : HME7025_00259(mutY)
GRS : C7S20_04085(mutY) C7S20_16735
FOK : KK2020170_03890(mutY)
PHG : KCTC32516_00961(mutY)
AALG : AREALGSMS7_00908(mutY)
KOS : KORDIASMS9_00696(mutY)
KAN : IMCC3317_33130(mutY)
SPON : HME9304_01184(mutY)
OHM : MSHRCOH1_01540(mutY)
CGLE : NCTC11432_04938(mutY)
CTAI : NCTC12078_01095(mutY)
CTAK : 4412677_02468(mutY)
CJG : NCTC13459_02882(mutY)
CANT : NCTC13489_01222(mutY)
KFA : Q73A0000_00230(mutY)
EBV : F0358_03710(mutY) F0358_13170
PTAN : CRYO30217_02376(mutY)
PROC : Ptc2401_01080(yfhQ)
CABY : Cabys_3518 Cabys_773
SBAG : UW38_C0001G0620(mutY)
MEHF : MmiHf6_06680(nth_2)
HNO : LT974_10025 LT974_14140
HALX : M0R89_00935 M0R89_08165
HAXZ : M0R88_00695 M0R88_15785
HTA : BVU17_07810 BVU17_13715
HALA : Hrd1104_00170 Hrd1104_04830
HALZ : E5139_05500 E5139_14140
HAZP : GBQ70_05495 GBQ70_14155
HALI : BV210_02565 BV210_06895 BV210_16555
HLT : I7X12_12445 I7X12_17120
HVO : HVO_2834(mutY2) HVO_2896(mutY1)
HALB : EKH57_01090 EKH57_15030
HSAI : HPS36_09905 HPS36_11610
HMP : K6T50_06310 K6T50_18290
HDF : AArcSl_0766(mutY) AArcSl_1631(mutY2)
HAKZ : J0X25_08655 J0X25_17185
HXA : Halxa_1103 Halxa_2155
HJT : DVR14_18480 DVR14_22615
HRU : Halru_1793 Halru_3020
MEAM : MU439_07015 MU439_07030
THEL : IG193_08555 IG193_09035
LOKI : Lokiarch_28910(mutY)
PSYT : DSAG12_03016 DSAG12_03051
» show all
Taxonomy
Reference
Authors
Au KG, Clark S, Miller JH, Modrich P
Title
Escherichia coli mutY gene encodes an adenine glycosylase active on G-A mispairs.
Journal
Reference
Authors
Michaels ML, Tchou J, Grollman AP, Miller JH
Title
A repair system for 8-oxo-7,8-dihydrodeoxyguanine.
Journal
Other DBs
ExplorEnz - The Enzyme Database: 3.2.2.31
ExPASy - ENZYME nomenclature database: 3.2.2.31
LinkDB
All DBs