Equus przewalskii (Przewalski's horse): 103567623 Help Entry 103567623         CDS       T04644                                  Symbol ADCY8 Name (RefSeq) adenylate cyclase 8   KO K08048   adenylate cyclase 8 [EC:4.6.1.1] Organism epz  Equus przewalskii (Przewalski's horse) Pathway epz00230   Purine metabolism epz01100   Metabolic pathways epz01522   Endocrine resistance epz04015   Rap1 signaling pathway epz04020   Calcium signaling pathway epz04022   cGMP-PKG signaling pathway epz04024   cAMP signaling pathway epz04062   Chemokine signaling pathway epz04072   Phospholipase D signaling pathway epz04114   Oocyte meiosis epz04211   Longevity regulating pathway epz04213   Longevity regulating pathway - multiple species epz04261   Adrenergic signaling in cardiomyocytes epz04270   Vascular smooth muscle contraction epz04371   Apelin signaling pathway epz04540   Gap junction epz04611   Platelet activation epz04713   Circadian entrainment epz04714   Thermogenesis epz04720   Long-term potentiation epz04723   Retrograde endocannabinoid signaling epz04724   Glutamatergic synapse epz04725   Cholinergic synapse epz04727   GABAergic synapse epz04742   Taste transduction epz04750   Inflammatory mediator regulation of TRP channels epz04911   Insulin secretion epz04912   GnRH signaling pathway epz04913   Ovarian steroidogenesis epz04914   Progesterone-mediated oocyte maturation epz04915   Estrogen signaling pathway epz04916   Melanogenesis epz04918   Thyroid hormone synthesis epz04921   Oxytocin signaling pathway epz04923   Regulation of lipolysis in adipocytes epz04925   Aldosterone synthesis and secretion epz04926   Relaxin signaling pathway epz04927   Cortisol synthesis and secretion epz04928   Parathyroid hormone synthesis, secretion and action epz04934   Cushing syndrome epz04935   Growth hormone synthesis, secretion and action epz04970   Salivary secretion epz04971   Gastric acid secretion epz04972   Pancreatic secretion epz04976   Bile secretion epz05032   Morphine addiction epz05163   Human cytomegalovirus infection epz05166   Human T-cell leukemia virus 1 infection epz05200   Pathways in cancer epz05207   Chemical carcinogenesis - receptor activation epz05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:epz00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     103567623 (ADCY8)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     103567623 (ADCY8)    04371 Apelin signaling pathway     103567623 (ADCY8)    04020 Calcium signaling pathway     103567623 (ADCY8)    04072 Phospholipase D signaling pathway     103567623 (ADCY8)    04024 cAMP signaling pathway     103567623 (ADCY8)    04022 cGMP-PKG signaling pathway     103567623 (ADCY8)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     103567623 (ADCY8)   09144 Cellular community - eukaryotes    04540 Gap junction     103567623 (ADCY8)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     103567623 (ADCY8)    04062 Chemokine signaling pathway     103567623 (ADCY8)   09152 Endocrine system    04911 Insulin secretion     103567623 (ADCY8)    04923 Regulation of lipolysis in adipocytes     103567623 (ADCY8)    04912 GnRH signaling pathway     103567623 (ADCY8)    04913 Ovarian steroidogenesis     103567623 (ADCY8)    04915 Estrogen signaling pathway     103567623 (ADCY8)    04914 Progesterone-mediated oocyte maturation     103567623 (ADCY8)    04921 Oxytocin signaling pathway     103567623 (ADCY8)    04926 Relaxin signaling pathway     103567623 (ADCY8)    04935 Growth hormone synthesis, secretion and action     103567623 (ADCY8)    04918 Thyroid hormone synthesis     103567623 (ADCY8)    04928 Parathyroid hormone synthesis, secretion and action     103567623 (ADCY8)    04916 Melanogenesis     103567623 (ADCY8)    04925 Aldosterone synthesis and secretion     103567623 (ADCY8)    04927 Cortisol synthesis and secretion     103567623 (ADCY8)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     103567623 (ADCY8)    04270 Vascular smooth muscle contraction     103567623 (ADCY8)   09154 Digestive system    04970 Salivary secretion     103567623 (ADCY8)    04971 Gastric acid secretion     103567623 (ADCY8)    04972 Pancreatic secretion     103567623 (ADCY8)    04976 Bile secretion     103567623 (ADCY8)   09156 Nervous system    04724 Glutamatergic synapse     103567623 (ADCY8)    04727 GABAergic synapse     103567623 (ADCY8)    04725 Cholinergic synapse     103567623 (ADCY8)    04720 Long-term potentiation     103567623 (ADCY8)    04723 Retrograde endocannabinoid signaling     103567623 (ADCY8)   09157 Sensory system    04742 Taste transduction     103567623 (ADCY8)    04750 Inflammatory mediator regulation of TRP channels     103567623 (ADCY8)   09149 Aging    04211 Longevity regulating pathway     103567623 (ADCY8)    04213 Longevity regulating pathway - multiple species     103567623 (ADCY8)   09159 Environmental adaptation    04713 Circadian entrainment     103567623 (ADCY8)    04714 Thermogenesis     103567623 (ADCY8)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103567623 (ADCY8)    05207 Chemical carcinogenesis - receptor activation     103567623 (ADCY8)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103567623 (ADCY8)    05163 Human cytomegalovirus infection     103567623 (ADCY8)   09165 Substance dependence    05032 Morphine addiction     103567623 (ADCY8)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     103567623 (ADCY8)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     103567623 (ADCY8)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     103567623 (ADCY8) Enzymes [BR:epz01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      103567623 (ADCY8) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom Motif Other DBs NCBI-GeneID:  103567623 NCBI-ProteinID:  XP_008542547 LinkDB All DBs Position Un AA seq 757 aa AA seqDB search YVRSRTKHDVDMRIGIHSGSVLCGVLGLRKWQFDVWSWDVDIANKLESGGIPGRIHISKA TLDCLNGDYNVEEGHGKERNEFLRKHNIETYLIKQPEESLLSLPEDIVKESVSSSDRRNS GATFTEGSWSPELPFDNIVGKQNTLAALTRNSINLLPNHLAQALHVQSGPEEINKRIEHT IDLRSGDKLRREHIKPFSLMFKDSSLEHKYSQMRDEVFKSNLVCAFIVLLFITAIQSLLP SSRVMPMTIQFSILIMLHSALVLITTAEDYKCLPLVLRKTCCWINETYLARNVIIFASIL INFLGAILNILWCDFDKSIPLKNLTFNSSAVFTDICSYPEYFVFTGVLAMVTCAVFLRLN SVLKLAVLLIMIAIYALLTETIYAGLFLRYDNLNHSGEDFLGTKEASLLLMAMFLLAVFY HGQQLEYTARLDFLWRVQAKEEINEMKELREHNENMLRNILPSHVARHFLEKDRDNEELY SQSYDAVGVMFASIPGFADFYSQTEMNNQGVECLRLLNEIIADFDELLGEDRFQDIEKIK TIGSTYMAVSGLSPEKQHCEDKWGHLCALADFSLALTESIQEINKHSFNNFELRIGISHG SVVAGVIGAKKPQYDIWGKTVNLASRMDSTGVSGRIQVPEETYLILKDQGFAFDYRGEIY VKGISEQEGKIKTYFLLGRVQPNPFILPPRRMPGQYSLAAVVLGLVQSLNRQRQKQLLNE NNNTGIIKGHYNRRTLLTPSGPEPGTQAEGTDKSDLP NT seq 2275 nt NT seq  +upstreamnt  +downstreamnt gtatgtacggtcaaggacaaagcatgatgttgacatgaggatcggaattcactcaggctc agtgctatgtggcgttttgggactacggaagtggcagtttgatgtctggtcttgggatgt ggacattgcaaacaaacttgaatctggaggaatcccggggaggattcacatttccaaagc cacgctggactgtctcaacggtgactataacgtggaagagggtcacgggaaagagaggaa cgaattcttgaggaagcataatatagagacctatttaattaagcagcctgaagagagtct gctgtccttgcccgaagacattgtcaaggagtccgtgagctcctcagacaggagaaacag tggggcgacgttcacggaaggatcttggagccccgaactgcccttcgataacatagtggg gaaacagaacactctggctgccctaacaagaaattcaataaatctacttccaaaccatct tgcacaagctttgcatgtccagtctgggcctgaggaaattaacaagagaatagaacatac catcgacttgcggagtggcgataaattgagaagagagcatatcaagccattctcactgat gtttaaagactccagcctggagcacaagtattctcaaatgagagatgaagtattcaagtc aaacttggtctgtgcgttcatcgttcttctatttatcacggcaatacaaagtttgcttcc ttcttcaagggtgatgccaatgaccatccagttttccatcctgattatgctgcactcagc tctggtcctcatcaccacagcagaggactataagtgtttgcccctcgtcctccggaaaac ttgctgttggattaacgagacttatttggcccggaatgtcatcatctttgcatccatctt gattaatttcctgggagccatcctaaatattctgtggtgtgattttgacaagtcgatacc cttgaagaacctgactttcaattcctcagctgtgtttacagatatctgctcctacccaga gtactttgtcttcactggggtgctggccatggtgacctgtgcggttttcctccgactgaa ctctgtcctgaagctggccgtgctgctgatcatgatcgccatctacgccctgctgaccga gaccatctatgcaggtctctttctgcgctacgacaacctgaaccacagtggagaagattt cctggggaccaaggaggcgtcgctgctgctgatggccatgttcctccttgctgtgttcta ccacggacagcagctggagtacacagcccgcctggacttcctttggcgagtacaggccaa agaggagatcaatgagatgaaggagctgagggaacacaatgagaacatgctccggaacat cttacccagtcacgtggcccgccatttcctggagaaagaccgagacaatgaggagctgta ttctcaatcctatgatgccgttggggtgatgttcgcctccatcccagggtttgcagactt ttactctcagaccgaaatgaataaccaaggagtggaatgcctgcgcctcctgaatgagat cattgctgactttgatgagctgctcggcgaagaccggtttcaagacattgaaaaaattaa gaccattggcagcacctacatggctgtgtcaggcttgtcacctgaaaaacagcactgtga agacaagtggggccatctgtgtgctctggctgacttctccctcgccctgaccgaaagcat acaggagatcaacaagcattccttcaacaactttgaactccggattggcatcagccacgg ctcagtggtagctggtgtaattggcgctaagaaacctcagtatgacatttggggcaaaac cgtgaacctggcaagtcgaatggacagcacgggggtcagcggcaggatccaagtcccaga ggagacctatctcatcctgaaggaccagggctttgcctttgactaccgaggggagatcta cgtgaaaggtatcagcgaacaggagggaaagatcaaaacgtactttctcctgggaagagt ccagcccaacccgttcatcttgcccccgagaagaatgcccgggcagtactccttggccgc ggtcgtcctgggcctcgtccagtccctcaacaggcaaaggcagaagcagctactcaacga gaacaacaacacgggcatcatcaagggccattacaaccggcggactttgttgacacccag tgggccagagcctggaacccaagccgaaggcaccgacaagtccgatttgccataa

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