Felis catus (domestic cat): 101084377 Help Entry 101084377         CDS       T02385                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism fca  Felis catus (domestic cat) Pathway fca01521   EGFR tyrosine kinase inhibitor resistance fca04151   PI3K-Akt signaling pathway fca04217   Necroptosis fca04380   Osteoclast differentiation fca04550   Signaling pathways regulating pluripotency of stem cells fca04620   Toll-like receptor signaling pathway fca04621   NOD-like receptor signaling pathway fca04630   JAK-STAT signaling pathway fca04658   Th1 and Th2 cell differentiation fca04659   Th17 cell differentiation fca05140   Leishmaniasis fca05145   Toxoplasmosis fca05152   Tuberculosis fca05160   Hepatitis C fca05161   Hepatitis B fca05162   Measles fca05163   Human cytomegalovirus infection fca05164   Influenza A fca05165   Human papillomavirus infection fca05166   Human T-cell leukemia virus 1 infection fca05167   Kaposi sarcoma-associated herpesvirus infection fca05168   Herpes simplex virus 1 infection fca05169   Epstein-Barr virus infection fca05171   Coronavirus disease - COVID-19 fca05200   Pathways in cancer fca05203   Viral carcinogenesis fca05212   Pancreatic cancer fca05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:fca00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     101084377 (JAK1)    04151 PI3K-Akt signaling pathway     101084377 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     101084377 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     101084377 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     101084377 (JAK1)    04621 NOD-like receptor signaling pathway     101084377 (JAK1)    04658 Th1 and Th2 cell differentiation     101084377 (JAK1)    04659 Th17 cell differentiation     101084377 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     101084377 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101084377 (JAK1)    05203 Viral carcinogenesis     101084377 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     101084377 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     101084377 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101084377 (JAK1)    05161 Hepatitis B     101084377 (JAK1)    05160 Hepatitis C     101084377 (JAK1)    05171 Coronavirus disease - COVID-19     101084377 (JAK1)    05164 Influenza A     101084377 (JAK1)    05162 Measles     101084377 (JAK1)    05168 Herpes simplex virus 1 infection     101084377 (JAK1)    05163 Human cytomegalovirus infection     101084377 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     101084377 (JAK1)    05169 Epstein-Barr virus infection     101084377 (JAK1)    05165 Human papillomavirus infection     101084377 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     101084377 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     101084377 (JAK1)    05140 Leishmaniasis     101084377 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     101084377 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:fca01001]     101084377 (JAK1) Enzymes [BR:fca01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      101084377 (JAK1) Protein kinases [BR:fca01001]  Non-receptor tyrosine kinases   JAK family [OT]    101084377 (JAK1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  101084377 NCBI-ProteinID:  XP_006934863 EnsemblRapid:  ENSFCTG00005020011 UniProt:  A0A2I2U8B7 LinkDB All DBs Position C1:complement(53470469..53598270) Genome browser AA seq 1156 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLRLGSGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRMITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHPDDSGNILYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKWKKLENKHKKDEEKNKIRE EWNNFSYFPEITHIVIKECVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHH YLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTC FEKSEVVGSLKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMNHLKKQILRTDNISFVLKR CCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGTL LDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVE NIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLL AREGIDSEFGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTT LWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIM RDINKLEEQNPDIVSERKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSG SLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDF GLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDS SPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPANRTTF QNLIKGFEALLEALLK NT seq 3471 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagacggaggtgaatctggaggcccccgaaccaggggtggaagtgctcttc tatctgtccgatagggagccgctccggctgggcagcggggagtacacggcagaggagctg tgcatcagggcggcgcaggaatgctgtatctctcctctgtgtcacaacctttttgccctg tatgatgagaacaccaagctttggtatgctccgaatcgcatgatcacagttgacgacaag acatcactccggctccactaccggatgaggttctatttcaccaactggcatgggaccaat gataatgagcagtctgtatggcgacattctccgaagaagcagaaaaatggctacgagaaa aaaaaagttccagatgcaacccctctccttgacgccagctccctggagtatctgtttgct cagggacaatatgatttggtcaaatgcctggctcccattcgagaccccaagaccgagcag gatggacacgatattgagaacgagtgtctgggaatggctgtcctggccatctcccactac gccatgatgaagaagatgcaattgccagaactgcccaaggacatcagctacaagcgatat atcccagaaacattgaataagtccatcaggcagaggaatcttctcaccaggatgcggata aataacgttttcaaggatttcctaaaggaatttaacaacaagaccatctgtgacagcagt gtatctactcatgacctgaaggtgaaatacctggcgaccttggagactttgacaaaacat tatggtgctgaaatatttgagacttccatgttactgatttcgtcagaaaatgagatgaat tggtttcatccagatgacagtggaaacattctctatgaagtgatggtaactggaaatctt ggaatccagtggagacagaaaccaaatgttgttcctgttgaaaaggaaaaaaacaaactg aaatggaaaaagctggaaaataaacacaagaaggatgaggagaaaaacaaaatccgggaa gagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtgtgtg gtcagcatcaataagcaggacaataaaaaaatggaactgaagctttcgtcccacgaggag gccttgtcctttgtgtccctggtagacggctacttccggctcacagcagatgcccatcat tacctctgcactgatgtggctcccccactgattgtccacaacatacagaatggttgtcac ggtcccatctgcacggaatatgccatcaataagttgcggcaagaaggaagtgaggaggga atgtatgtgctgaggtggagctgtaccgactttgacaatatcctcatgactgtcacctgc tttgaaaaatctgaggtggtgggtagcctgaaacagttcaagaactttcagatcgaggtg cagaagggccgttacagcctgcatggctcggaccgcagcttccccagcctgggggacctc atgaaccacctcaagaaacagatcctgcggacggacaacatcagcttcgtgctgaaacgc tgctgccagcccaagccccgagagatctccaatttgctggtggctactaagaaagcccag gagtggcagcctgtctactctatgagccagctgagttttgaccggatcctcaagaaagat atcgtgcaaggagagcaccttgggagaggcacgcggacgcatatctactctggaaccctt ctggattacaaagatgacgaaggaacttccgaagaaaagagaataaaagtgatcctcaaa gtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatgatg aggcaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgagatgtggaa aatatcatggtggaggagtttgtggagggggggcccctggatctcttcatgcaccggaaa agcgatgtcctcaccacaccgtggaagtttaaagttgccaaacaactggctagtgccttg agttacttggaggataaagacctggtccacggaaatgtgtgcactaaaaacctcctcttg gcccgtgagggcatcgacagtgagttcggcccgttcatcaagctcagtgaccccggcatc cccatcaccgtgctgtccaggcaagagtgcatagaacgaatcccgtggattgctcccgag tgtgttgaagactccaagaacctgagtgtggccgctgacaaatggagctttggaaccaca ctctgggaaatctgctacaatggcgagatccctctgaaagacaagacactgattgagaaa gagcgattctatgaaagccggtgccggccagtgacaccatcttgtaaggagctggctgac ctcatgacccgctgcatgaactatgaccccaaccagagacccttcttccgagccatcatg agagacatcaataaactggaggagcagaatccagacattgtttcggaacgaaagccggca accgaagtggatcccacacattttgaaaagcggttcttgaagagaatccgtgacttggga gagggccactttgggaaggttgagctctgcagatacgaccctgagggtgacaataccggg gagcaggtggctgtcaaatccctgaagcctgagagtggaggtaaccacatagctgatctg aagaaggaaattgaaatcttaaggaacctctatcatgagaacattgtgaagtacaaaggc atctgtacagaagacggaggaaatggtattaagctcatcatggagtttctaccttcagga agccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacaacagttaaaa tatgctgttcagatttgtaaggggatggactacttggggtctcggcagtacgttcaccgg gacttagcagcaagaaatgtcctcgttgagagtgagcaccaagtgaaaattggagacttc ggtttaaccaaagccattgaaaccgacaaagagtactacacagtcaaggatgatcgggac agccctgtgttttggtatgctccagaatgtttaattcagtgtaaattttatatcgcctct gacgtctggtcgtttggagtgactctgcatgagctgctcacttactgtgactccgattct agccccatggcattgttcctgaaaatgataggcccaacgcatggccagatgacagtcaca agacttgtgaacacgttaaaagaaggaaaacgtttgccctgtccacctaactgcccagat gaggtttatcaactcatgagaaagtgctgggaattccaaccagctaataggacaactttt cagaacctaattaaaggatttgaagcacttttagaagcacttttaaaataa

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