KEGG   Flavonifractor plautii: A4U99_10115
Entry
A4U99_10115       CDS       T04429                                 
Symbol
vanB
Name
(GenBank) D-alanine--(R)-lactate ligase
  KO
K18856  D-alanine---D-serine ligase [EC:6.3.2.35]
Organism
fpla  Flavonifractor plautii
Pathway
fpla01502  Vancomycin resistance
fpla02020  Two-component system
Module
fpla_M00652  Vancomycin resistance, D-Ala-D-Ser type
Brite
KEGG Orthology (KO) [BR:fpla00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   02020 Two-component system
    A4U99_10115 (vanB)
 09160 Human Diseases
  09175 Drug resistance: antimicrobial
   01502 Vancomycin resistance
    A4U99_10115 (vanB)
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   01504 Antimicrobial resistance genes [BR:fpla01504]
    A4U99_10115 (vanB)
Enzymes [BR:fpla01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.35  D-alanine---D-serine ligase
     A4U99_10115 (vanB)
Antimicrobial resistance genes [BR:fpla01504]
 Gene sets
  Vancomycin resistance modules
   Vancomycin resistance, D-Ala-D-Ser type [MD:M00652]
    A4U99_10115 (vanB)
SSDB
Motif
Pfam: Dala_Dala_lig_C Dala_Dala_lig_N ATP-grasp CPSase_L_D2 ATP-grasp_4 ATP-grasp_3
Other DBs
NCBI-ProteinID: ANU41409
UniProt: A0A1C7FNA2
LinkDB
Position
2081165..2082217
AA seq 350 aa
MKKITLAVLFGGSSTEYEISLQSAHAVLTHLDRDRYEPVPLGITRDGRWLLYQGPVDALL
DDTWHTDARHTVPAVISPDRGVHGLLLIAPAGPSTRYLDAAFPVLHGKNGEDGTVQGLLE
LAGIPVVGCGVLASALCMDKDVAHRLVQAAGVAVPPSILFRAGEGLDTLPERTASLTYPL
FVKPARAGSSFGITKVEEPGVLAEAVTAALAHDSKVVIEEAVPGFEVGCAVLGNEVLTVG
HVDEIELSGGFFNYTEKYGLITSSIHMPARISQEKETEIQVTAQLIYRALECSGFARVDL
FLTPDGRIVFNEVNTIPGFTAHSRYPNMMRSIGLEFGPLLDRLIGLAVDA
NT seq 1053 nt   +upstreamnt  +downstreamnt
atgaaaaaaatcacattggccgtcctgttcggcggctcttccaccgaatatgagatctcc
ctccagtccgcccacgcggtactcacccacctggaccgggacaggtacgagcccgtcccc
ctgggtatcacgcgggatgggcgctggctgctctaccaggggccggtggacgccctgctg
gacgacacttggcacaccgacgcccgccataccgtcccggcggtgatctcccccgaccgc
ggcgtccacggcctgctgctcatcgcccccgctgggccctccacccgctatctggacgcc
gcctttccggtactccatggcaaaaacggggaggacggcacggtgcagggcctgctggag
ctggcaggtatccccgtagtgggctgcggggtgctcgcctccgccctatgcatggacaag
gacgtggcccaccgcttggtccaggccgccggtgtagcggtgcccccttccatcctcttt
cgcgccggagaagggctggacaccctgccggagcgcactgccagcctgacctatcccctg
tttgtcaagcccgcacgggcgggttcctcttttggcatcaccaaggtggaggagcccggc
gtgttggccgaagccgtcaccgccgccctggcccacgatagcaaggtggtcattgaggag
gccgtgcccggctttgaggtgggctgcgccgtactgggcaatgaggttctgacggtggga
catgtggacgagatcgagctctccggcggctttttcaactacacggagaagtacggcctg
atcacctccagcatacacatgcccgcccgaatttcccaggagaaggaaacagaaattcag
gtgaccgcccagttgatctaccgggcgctggagtgttccggctttgcacgggtggatttg
tttctcacgccggacgggcgcattgtctttaacgaggtaaacaccatccccggtttcaca
gctcacagccgctaccccaacatgatgcggagcataggcctggagttcggccctctgctg
gaccgtctcatcggactggcggtggacgcatga

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