Gorilla gorilla gorilla (western lowland gorilla): 101134931
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Entry
101134931 CDS
T02442
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
ggo
Gorilla gorilla gorilla (western lowland gorilla)
Pathway
ggo00310
Lysine degradation
ggo01100
Metabolic pathways
ggo05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
ggo00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
101134931 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
101134931 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
ggo03036
]
101134931 (DOT1L)
Enzymes [BR:
ggo01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
101134931 (DOT1L)
Chromosome and associated proteins [BR:
ggo03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
101134931 (DOT1L)
HMT complexes
Dot1-containing complex
101134931 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Other DBs
NCBI-GeneID:
101134931
NCBI-ProteinID:
XP_030863670
Ensembl:
ENSGGOG00000006592
LinkDB
All DBs
Position
Unknown
AA seq
1460 aa
AA seq
DB search
MASHVWALEGCGQRWGFLWLNLLSFQEEQEAARRRQQRESKSNAATPTKGPEGKVAGPTD
APMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTANPERKPKKN
QTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPTPPALQKLLE
SFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQKEEIRRLFQQ
KLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLLKARCEELQL
DWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLKSCVPPDDAL
SLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGYELCGALSRP
SSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIVLRRHLSQDH
TVPGRPAVSELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQLAGEKSSEKG
LRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARSTPSPVLQPRD
PSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGAEPATLDESS
SSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPPPEAGKGDLP
SDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHGQDSRKRGRR
KRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEITAISSPETS
LKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARIERKIATISL
ESKSPPKTLENGGGLAGRKPTPAGEPVNSSKWKSTFSPISDIGLAKSADSPLQASSTLSQ
NSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGGGLAADLSLH
SFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLKGEGSRGKEA
GEGGLPLCGPTDKTPLLTGKAAKARDRELDLKNGHNLFISAAAVPPGSLLSGPGLAPAAS
SAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSSVPAAAGLVH
VSSAATRLTNSHAMGSFSGVAGGTVGEGHRAQGHQSITFSRGGHLLSVAARALARLWELV
LGVFNHAVPSASAHPFGARVGRGAACGSATLGPSPLQAAASASASSFQAPASVETRPPPP
PPPLPLPAHLGRSPAGPPVLHAPPPPNAALPPPPTLLASNPEPALLQSLASLPPNQAFLP
PTSAASLPPANASLSIKLTSLPHKGARPSFTVHHQPLPRLALAQAAPGIPQASATGPSAV
WVSLGMPPPYAAHLSGVKPR
NT seq
4383 nt
NT seq
+upstream
nt +downstream
nt
atggcgtcccacgtgtgggccttggagggctgtgggcagcgctggggcttcctgtggctc
aacctgctctccttccaggaggaacaggaggcagcccggcgccgccagcagcgcgagagc
aagagcaacgcggccacgcccactaagggcccagagggcaaggtggccggccccaccgac
gcccccatggactctggtgctgaggaagagaaggcgggagcagccaccgtgaagaagccg
tctccctccaaagcccgcaagaagaagctaaacaagaaggggaggaagatggctggccgc
aagcgcgggcgccccaagaagatgaacactgcgaatcccgagcggaagcccaagaagaac
caaactgcactggatgccctgcacgctcagaccgtgtctcagacggcggcctcctcaccc
caggatgcctacagatcccctcacagcccgttctaccagctacctccgagcgtgcagcgg
cactcccccaacccgctgctggtggcgcccaccccgcccgcgctgcagaagctgctagag
tccttcaagatccagtacctgcagttcctggcatacacaaagaccccccagtacaaggcc
agcctgcaggagctgctgggccaggagaaggagaagaatgcccagctcctgggcgcggct
cagcagctcctcagccactgccaggcccagaaggaggagatcaggaggctgttccagcaa
aaattggatgagctgggcgtgaaggcgctgacctacaacgacctgattcaagcgcagaag
gagatctccgcccataaccagcagctgcgggagcagtcggagcagctggagcaggacaac
cgcgcgctccgcggccagagcttgcagctgctcaaggctcgctgcgaggagctgcagctg
gactgggccacgctgtcgctggagaagctcttgaaggagaagcaggccctgaagagccag
atctcggagaagcagaggcactgcctggagctgcagatcagcatcgtggagctagagaag
agccagcggcagcaggagctcctgcagctcaagtcctgtgtgccgcctgacgacgccctg
tccctgcacctgcgtgggaagggcgccctgggccgcgagctggagcctgacgccagccgg
ctgcacctggagctggactgcaccaagttctcgctgcctcacttgagcagcatgagcccg
gagctctccatgaacggccaggctgctggctatgagctctgcggtgcgctgagccggcct
tcgtcgaagcagaacacgccccagtacctggcctcacccctggaccaggaggtggtgccc
tgtacccctagccacgtcggccggccgcgcctggagaagctgtctggcctagccgcaccc
gactacactaggctgtccccggccaagattgtgctgaggcggcacctgagccaggaccac
acggtgcccggcaggccggccgtcagtgagctgcattcgagagctgagcacaccaaggag
aacggccttccctaccagagccccagcgtgcctggcagcatgaagctgagccctcaggac
ccgcggcccctgtcccctggggccttgcagcttgctggagagaagagcagtgagaagggc
ctgagagagcgcgcctacggcagcagcggggagctcatcaccagcctgcccatcagcatc
ccgctcagcaccgtgcagcccaacaagctcccggtcagcatccccctggccagcgtggtg
ctgcccagccgcgccgagagggcgaggagcacccccagtcccgtgctgcagccccgtgac
ccctcgtccacacttgaaaagcagattggtgctaatgcccacggtgctgggagcagaagc
cttgccctggcccccgcaggcttctcctacgctggctcggtggctatcagcggggccttg
gcgggcagcccggcctctctcacacctggagccgagccggccaccttggatgagtcctcc
agctctgggagcctttttgccaccgtggggtcccgcagctccacgccacagcaccccctg
ctgctggcacagccccggaactcgcttccggcctctcccgcccaccagctctcctccagt
ccccggcttggtggggccgcccagggcccaccgcccgaggccggcaagggggacctgccc
tccgattccggcttctcagaccctgagagtgaagccaagaggaggattgtgttcaccatc
accactggtgcgggcagtgccaagcagtcgccctccagcaagcacagccccctgaccgcc
agcgcccgtggggactgcgtgccgagccacgggcaggacagccgcaagcgtggccggcgg
aagcgagcatctgcggggacgcccagcttgagcgcaggcgtgtcccccaagcgccgagcc
ctgccgtccgtcgctggccttttcacacagccttcggggtctcccctcaacctcaactcc
atggtcagtaacatcaaccagcccctggagattacagccatctcgtccccggagacctcc
ctgaagagctcccctgtgccctaccaggaccacgaccagccccccgtgctcaagaaggag
cggcctctgagccagaccaatggggcacactactccccactcacctcagacgaggagcca
ggctctgaggacgagcccagcagtgctcgaattgagagaaaaattgcaacaatctcctta
gaaagcaaatctcccccgaaaaccttggaaaatggtggtggcttggcgggaaggaagccc
acgcccgccggcgagccagtcaatagcagcaagtggaagtccaccttctcgcccatctcc
gacatcggcctggccaagtccgcagacagcccgctgcaggccagctccaccctcagccag
aactccctgttcacgttccggcccgccctggaggagccctctgccgatgccaagctggcc
gctcaccccaggaaaggctttcccggctccctgtcgggggctgacggactcagcccgggc
accaaccctgccaacggctgcaccttcggcgggggcctggccgcggacctgagtttacac
agcttcagtgatggtgcttctcttccccacaagggccccgaggcggccggcctgagctcc
ccgctgagcttcccctcgcagcgcggcaaggagggctcggacgccaaccctttcctgagc
aagaggcagctggacggcctggctgggctgaagggcgagggcagccgcggcaaggaggca
ggggagggcggcctaccgctgtgcgggcccacggacaagaccccactgctgaccggcaag
gccgccaaggcccgggaccgcgagctcgacctcaagaatggccacaacctcttcatctct
gcggcggccgtgcctcccggaagcctcctcagcggccccggcctggccccggcggcgtcc
tctgcaggcggcgcggcgtcctccgcccagacgcaccggtccttcctgggccccttcccg
ccgggaccgcagttcgcgctcggccccatgtccctgcaggccaacctcggctctgtggcc
ggctcctccgtgctgcagtcgctgttcagctctgtgccggccgccgcaggcctggtgcac
gtgtcgtccgctgccaccagactgaccaactcacacgccatgggcagcttttccggggtg
gcaggcggcacagttggagaaggccaccgtgcgcagggccaccagagcattactttctcc
cgtggaggtcacctgctaagtgtggccgcccgggctctggcaaggctctgggagctggtg
ttgggtgtctttaaccacgcggtgccttccgcctctgctcatccgtttggagcccgtgtc
ggccgcggggctgcatgtggcagcgccacactgggcccgagcccgctgcaggcggcggcc
agcgcctcggcctcttcctttcaggccccggcctcggttgagacccggccgccccctccg
cctcccccgctgcccctgcctgcgcacctgggccggtcccccgcggggccgcccgtcctc
cacgccccccctccacctaacgccgccttgcctcctcccccaacgctgctggcctctaat
cctgagcccgcgcttctgcagagcctcgcgtccctcccgcctaaccaagctttcttgccc
cccacctctgctgcctctctgccgcctgctaacgcctctttgtctatcaagctcacctcc
ctcccgcacaagggcgcccgtccctccttcacggtgcaccaccagcccctgccccggctg
gccctggcccaggccgcgcccgggatcccacaggccagcgccacggggccgtccgcggtg
tgggtgtccctcggcatgccgcctccctatgccgcgcacctttcgggggttaagccgcga
taa
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