Heterocephalus glaber (naked mole-rat): 101712483 Help Entry 101712483         CDS       T02812                                  Symbol Adcy7 Name (RefSeq) adenylate cyclase 7   KO K08047   adenylate cyclase 7 [EC:4.6.1.1] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl00230   Purine metabolism hgl01100   Metabolic pathways hgl01522   Endocrine resistance hgl04015   Rap1 signaling pathway hgl04020   Calcium signaling pathway hgl04022   cGMP-PKG signaling pathway hgl04024   cAMP signaling pathway hgl04062   Chemokine signaling pathway hgl04072   Phospholipase D signaling pathway hgl04114   Oocyte meiosis hgl04211   Longevity regulating pathway hgl04213   Longevity regulating pathway - multiple species hgl04261   Adrenergic signaling in cardiomyocytes hgl04270   Vascular smooth muscle contraction hgl04371   Apelin signaling pathway hgl04540   Gap junction hgl04611   Platelet activation hgl04713   Circadian entrainment hgl04714   Thermogenesis hgl04723   Retrograde endocannabinoid signaling hgl04724   Glutamatergic synapse hgl04725   Cholinergic synapse hgl04727   GABAergic synapse hgl04750   Inflammatory mediator regulation of TRP channels hgl04911   Insulin secretion hgl04912   GnRH signaling pathway hgl04913   Ovarian steroidogenesis hgl04914   Progesterone-mediated oocyte maturation hgl04915   Estrogen signaling pathway hgl04916   Melanogenesis hgl04918   Thyroid hormone synthesis hgl04921   Oxytocin signaling pathway hgl04923   Regulation of lipolysis in adipocytes hgl04925   Aldosterone synthesis and secretion hgl04926   Relaxin signaling pathway hgl04927   Cortisol synthesis and secretion hgl04928   Parathyroid hormone synthesis, secretion and action hgl04934   Cushing syndrome hgl04935   Growth hormone synthesis, secretion and action hgl04970   Salivary secretion hgl04971   Gastric acid secretion hgl04972   Pancreatic secretion hgl04976   Bile secretion hgl05032   Morphine addiction hgl05163   Human cytomegalovirus infection hgl05166   Human T-cell leukemia virus 1 infection hgl05200   Pathways in cancer hgl05207   Chemical carcinogenesis - receptor activation hgl05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:hgl00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     101712483 (Adcy7)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101712483 (Adcy7)    04371 Apelin signaling pathway     101712483 (Adcy7)    04020 Calcium signaling pathway     101712483 (Adcy7)    04072 Phospholipase D signaling pathway     101712483 (Adcy7)    04024 cAMP signaling pathway     101712483 (Adcy7)    04022 cGMP-PKG signaling pathway     101712483 (Adcy7)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     101712483 (Adcy7)   09144 Cellular community - eukaryotes    04540 Gap junction     101712483 (Adcy7)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101712483 (Adcy7)    04062 Chemokine signaling pathway     101712483 (Adcy7)   09152 Endocrine system    04911 Insulin secretion     101712483 (Adcy7)    04923 Regulation of lipolysis in adipocytes     101712483 (Adcy7)    04912 GnRH signaling pathway     101712483 (Adcy7)    04913 Ovarian steroidogenesis     101712483 (Adcy7)    04915 Estrogen signaling pathway     101712483 (Adcy7)    04914 Progesterone-mediated oocyte maturation     101712483 (Adcy7)    04921 Oxytocin signaling pathway     101712483 (Adcy7)    04926 Relaxin signaling pathway     101712483 (Adcy7)    04935 Growth hormone synthesis, secretion and action     101712483 (Adcy7)    04918 Thyroid hormone synthesis     101712483 (Adcy7)    04928 Parathyroid hormone synthesis, secretion and action     101712483 (Adcy7)    04916 Melanogenesis     101712483 (Adcy7)    04925 Aldosterone synthesis and secretion     101712483 (Adcy7)    04927 Cortisol synthesis and secretion     101712483 (Adcy7)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101712483 (Adcy7)    04270 Vascular smooth muscle contraction     101712483 (Adcy7)   09154 Digestive system    04970 Salivary secretion     101712483 (Adcy7)    04971 Gastric acid secretion     101712483 (Adcy7)    04972 Pancreatic secretion     101712483 (Adcy7)    04976 Bile secretion     101712483 (Adcy7)   09156 Nervous system    04724 Glutamatergic synapse     101712483 (Adcy7)    04727 GABAergic synapse     101712483 (Adcy7)    04725 Cholinergic synapse     101712483 (Adcy7)    04723 Retrograde endocannabinoid signaling     101712483 (Adcy7)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     101712483 (Adcy7)   09149 Aging    04211 Longevity regulating pathway     101712483 (Adcy7)    04213 Longevity regulating pathway - multiple species     101712483 (Adcy7)   09159 Environmental adaptation    04713 Circadian entrainment     101712483 (Adcy7)    04714 Thermogenesis     101712483 (Adcy7)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101712483 (Adcy7)    05207 Chemical carcinogenesis - receptor activation     101712483 (Adcy7)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101712483 (Adcy7)    05163 Human cytomegalovirus infection     101712483 (Adcy7)   09165 Substance dependence    05032 Morphine addiction     101712483 (Adcy7)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     101712483 (Adcy7)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101712483 (Adcy7)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101712483 (Adcy7) Enzymes [BR:hgl01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      101712483 (Adcy7) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N Motif Other DBs NCBI-GeneID:  101712483 NCBI-ProteinID:  XP_012928821 UniProt:  G5C247 LinkDB All DBs Position Un AA seq 1074 aa AA seqDB search MPAKGRYFLNEGEEGPDQAALYEKYRLTSQHGPLLLLLLVVAIAACVALIAIAFSHGDPS ENQAVLGTVFVTLAVFVGLYVLVYVECLVRRWLRASALLTWACLVTLGYVLAWSAWRRAA CAWAQVPFFLFVVFVVYTLLPFSMQVAIAVGVVSTVSHLVVFGTLMGGFAVPSVGVGLQL LANATILLCGNLTGAFHKHQMQDASRDLFTYTVKCIQIRKKLRIEKRQQENLLLSVLPAH ISMGMKLAIIERLKEGGDRRYMPDNNFHSLYVKRHQNVSILYADIVGFTQLASDCSPKEL VVVLNELFGKFDQIAKANECMRIKILGDCYYCVSGLPVSLPTHARNCVKMGLDICEAIKQ VREATGVDISMRVGIHSGNVLCGVIGLRKWQYDVWSHDVSLANRMEAAGVPGRVHITEAT LSHLDKAYEVEDGQGQQRDPYLKEMNIRTYLVIDPRSQQPPPPSQHLPKPKGDAALKMRA SVRMTRYLESWGAARPFAHLNHRESVSSSETPVPNGRRPKAIPLRRHRTPDRSTSPKGRS EDDSYDDEMLSAIEGLSSTRPCCSKSDDFYTFGPIFLEKGFEHEYRLAAIPRARYDFACA SLVFLCILFVHILLMPRMVPLGVSFGLVAGLLGLVLGLCFASEFMRCCPTQGMLKAISER VETRPLLRLSLAVLTIGSLLTVAIINLPLMPDQALGVPGGNETSRSSELLPYYSCTCILG FIACSVFLRMSLELKVLLLTVALVAYLVLFNLSACCSRSLGNLTDTDCPGNLTKTNRTPS GHCCSARDLKTMINFYLVLFYITLVMLSRQIDYYCRLDCLWKKKFKKEHEEFETMENVNR LLLENVLPAHVAAHFIGDKLNEEWYHQSYDCVCVMFASVPDFKVFYTECDVNKEGLECLR LLNEIIADFDELLLKPKFSGVEKIKTIGSTYMAAAGLSVPSGHENQDLERQHAHIGVLVE FSIALMSKLDGINRHSFNSFRLRVGINHGPVIAGVIGARKPQYDIWGNTVNVASRMESTG ELGKIQVTEETCTILQGLGYYCECRGLINVKGKGELRTYFVCTDTVKFQGLGLN NT seq 3225 nt NT seq  +upstreamnt  +downstreamnt atgccggccaaggggcgctacttcctcaatgagggcgaggagggcccggaccaggccgcg ctctatgagaagtaccgcctcaccagccagcacgggccgctgctgctcctgctccttgtg gtggccattgccgcctgtgtggcactcattgccatcgccttcagccacggggacccctcg gagaaccaggctgtcctgggcacggtgtttgtgacactggctgtgttcgtgggtctctat gtgctggtgtacgttgagtgcctggtccggcggtggctccgggcctcagcgctgctcacc tgggcctgcctggtgacactaggctacgtgctggcctggagcgcctggaggagggcggcc tgtgcgtgggcacaggtacccttcttcctgtttgtggtcttcgtggtgtacacgctactg cccttcagcatgcaggtggccatcgctgtgggtgtggtctccactgtctcccaccttgtg gtgtttggcaccctcatgggtggcttcgctgtgcccagcgttggggtagggctgcagctg ctggccaatgctaccatcctcctgtgtgggaacttgacaggtgcttttcacaagcaccag atgcaggatgcctcccgggacctcttcacctacacggtcaagtgcatccagatccgtaag aagctgcgtattgagaagcgccagcaggagaacctgctgctgtcagtgctgccagcccac atctccatgggcatgaagctggccatcattgagcgactcaaggagggcggggaccgccgc tacatgcctgacaacaacttccacagcctctatgtcaagcggcaccagaatgtcagcatc ctctacgcagacatcgtgggcttcacgcagctggccagcgactgctcccccaaggagctg gtggtagtgctgaatgagctcttcggcaagtttgaccagatcgccaaggccaacgagtgc atgcggatcaagatcctgggcgactgctactactgtgtgtcgggcttgcccgtgtccctg cccacccacgcccggaactgtgtgaaaatggggctggacatatgcgaggccattaagcag gtgcgggaggccacaggcgtggacatcagcatgcgcgttggcatccactcggggaacgtt ctgtgtggggtcatcgggctgcgcaagtggcagtacgacgtgtggtcccacgatgtgtcc ctggccaacaggatggaggcagctggagtccctggccgggtacacatcacagaggcgaca ctgagccacctggacaaggcctacgaggtggaagacgggcagggccagcagcgggacccc tacctgaaagaaatgaacatccggacctacctggtcatcgacccccggagccagcagccg ccaccacccagccagcacctccccaagcccaaaggggatgcagccctgaagatgcgggct tcagtgcgcatgacccgctaccttgagtcctggggtgccgcacggccctttgcgcacctc aaccaccgcgagagtgtgagcagtagtgagacccctgttcccaacgggcggagacccaag gccattcctctgcggcgccacaggacccccgacaggagcacgtcccccaaagggcgttca gaggatgactcctacgatgatgagatgctgtcagccattgagggtctcagctccacacgg ccctgctgctccaagtcggacgacttctacacctttgggcccatcttcctggagaagggc tttgagcatgagtaccgcctggcagccatcccccgggcccgctatgactttgcctgtgcc agccttgtcttcctctgcatcctgtttgtccacatcctgctgatgcctaggatggtgcct ctgggcgtgtcctttgggctggtggctggcctgctgggactggtgctaggcctatgcttt gcttcggagttcatgaggtgctgcccgacccaggggatgctcaaggccatctctgagagg gtggagactcggcccctgctgaggctgtccctggctgtgctgactatcggcagcctgctc actgtcgccatcatcaacctgcccctgatgcctgaccaagccctgggggtgcccggaggc aatgagacttcgaggagcagtgagcttctcccgtattatagctgtacttgcatcctgggc ttcattgcctgctctgtcttcctgcggatgagcctggagctgaaggtcctgctgctgaca gtggcgctggtggcctacctggtgctcttcaatctctctgcatgctgcagccgcagcctg ggcaacctcactgacaccgactgcccaggcaacctcaccaagaccaacagaacccccagt ggccactgctgttcagcgagggatctgaagaccatgatcaacttctacctggtcctgttc tacatcacccttgtcatgctgtccagacagattgactattactgccgcttggactgtttg tggaagaagaagttcaagaaggaacacgaggagtttgaaaccatggagaatgtgaaccgc ctcctccttgagaatgtgctgccagcccacgtggctgcccacttcattggcgacaagcta aacgaggagtggtaccatcagtcctatgactgtgtctgtgtcatgtttgcgtccgtgccg gatttcaaagtgttctacacagagtgtgatgtcaacaaagaagggctggagtgtctgcgc ctgctaaacgagattatcgctgactttgatgagttgttgctaaagcccaagttcagtggt gtagagaagatcaagaccatcgggagcacctacatggcagcggcagggctcagtgtcccc tcagggcatgagaaccaggacctggagcggcagcatgcccacatcggggtcctggtggag ttcagcatcgccctgatgagcaagctggatggcatcaacaggcattccttcaactccttc cgcctccgagttggcataaaccatgggcctgtgattgctggagtgattggggcacgaaag cctcagtatgacatctgggggaacacagtaaatgttgccagccgcatggagagcactgga gaacttgggaaaatccaggttactgaagagacatgcaccatcctccagggcctgggttac tactgtgagtgccggggactgatcaacgtcaaaggcaaaggcgagcttcggacgtacttt gtgtgcacagacactgtcaagtttcaggggctggggctgaactga

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