Heterocephalus glaber (naked mole-rat): 101713887 Help Entry 101713887         CDS       T02812                                  Symbol Adcy3 Name (RefSeq) adenylate cyclase 3   KO K08043   adenylate cyclase 3 [EC:4.6.1.1] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl00230   Purine metabolism hgl01100   Metabolic pathways hgl01522   Endocrine resistance hgl04015   Rap1 signaling pathway hgl04020   Calcium signaling pathway hgl04022   cGMP-PKG signaling pathway hgl04024   cAMP signaling pathway hgl04062   Chemokine signaling pathway hgl04072   Phospholipase D signaling pathway hgl04114   Oocyte meiosis hgl04211   Longevity regulating pathway hgl04213   Longevity regulating pathway - multiple species hgl04261   Adrenergic signaling in cardiomyocytes hgl04270   Vascular smooth muscle contraction hgl04371   Apelin signaling pathway hgl04540   Gap junction hgl04611   Platelet activation hgl04713   Circadian entrainment hgl04714   Thermogenesis hgl04723   Retrograde endocannabinoid signaling hgl04724   Glutamatergic synapse hgl04725   Cholinergic synapse hgl04727   GABAergic synapse hgl04740   Olfactory transduction hgl04750   Inflammatory mediator regulation of TRP channels hgl04911   Insulin secretion hgl04912   GnRH signaling pathway hgl04913   Ovarian steroidogenesis hgl04914   Progesterone-mediated oocyte maturation hgl04915   Estrogen signaling pathway hgl04916   Melanogenesis hgl04918   Thyroid hormone synthesis hgl04921   Oxytocin signaling pathway hgl04923   Regulation of lipolysis in adipocytes hgl04925   Aldosterone synthesis and secretion hgl04926   Relaxin signaling pathway hgl04927   Cortisol synthesis and secretion hgl04928   Parathyroid hormone synthesis, secretion and action hgl04934   Cushing syndrome hgl04935   Growth hormone synthesis, secretion and action hgl04962   Vasopressin-regulated water reabsorption hgl04970   Salivary secretion hgl04971   Gastric acid secretion hgl04972   Pancreatic secretion hgl04976   Bile secretion hgl05032   Morphine addiction hgl05163   Human cytomegalovirus infection hgl05166   Human T-cell leukemia virus 1 infection hgl05200   Pathways in cancer hgl05207   Chemical carcinogenesis - receptor activation hgl05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:hgl00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     101713887 (Adcy3)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101713887 (Adcy3)    04371 Apelin signaling pathway     101713887 (Adcy3)    04020 Calcium signaling pathway     101713887 (Adcy3)    04072 Phospholipase D signaling pathway     101713887 (Adcy3)    04024 cAMP signaling pathway     101713887 (Adcy3)    04022 cGMP-PKG signaling pathway     101713887 (Adcy3)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     101713887 (Adcy3)   09144 Cellular community - eukaryotes    04540 Gap junction     101713887 (Adcy3)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101713887 (Adcy3)    04062 Chemokine signaling pathway     101713887 (Adcy3)   09152 Endocrine system    04911 Insulin secretion     101713887 (Adcy3)    04923 Regulation of lipolysis in adipocytes     101713887 (Adcy3)    04912 GnRH signaling pathway     101713887 (Adcy3)    04913 Ovarian steroidogenesis     101713887 (Adcy3)    04915 Estrogen signaling pathway     101713887 (Adcy3)    04914 Progesterone-mediated oocyte maturation     101713887 (Adcy3)    04921 Oxytocin signaling pathway     101713887 (Adcy3)    04926 Relaxin signaling pathway     101713887 (Adcy3)    04935 Growth hormone synthesis, secretion and action     101713887 (Adcy3)    04918 Thyroid hormone synthesis     101713887 (Adcy3)    04928 Parathyroid hormone synthesis, secretion and action     101713887 (Adcy3)    04916 Melanogenesis     101713887 (Adcy3)    04925 Aldosterone synthesis and secretion     101713887 (Adcy3)    04927 Cortisol synthesis and secretion     101713887 (Adcy3)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101713887 (Adcy3)    04270 Vascular smooth muscle contraction     101713887 (Adcy3)   09154 Digestive system    04970 Salivary secretion     101713887 (Adcy3)    04971 Gastric acid secretion     101713887 (Adcy3)    04972 Pancreatic secretion     101713887 (Adcy3)    04976 Bile secretion     101713887 (Adcy3)   09155 Excretory system    04962 Vasopressin-regulated water reabsorption     101713887 (Adcy3)   09156 Nervous system    04724 Glutamatergic synapse     101713887 (Adcy3)    04727 GABAergic synapse     101713887 (Adcy3)    04725 Cholinergic synapse     101713887 (Adcy3)    04723 Retrograde endocannabinoid signaling     101713887 (Adcy3)   09157 Sensory system    04740 Olfactory transduction     101713887 (Adcy3)    04750 Inflammatory mediator regulation of TRP channels     101713887 (Adcy3)   09149 Aging    04211 Longevity regulating pathway     101713887 (Adcy3)    04213 Longevity regulating pathway - multiple species     101713887 (Adcy3)   09159 Environmental adaptation    04713 Circadian entrainment     101713887 (Adcy3)    04714 Thermogenesis     101713887 (Adcy3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101713887 (Adcy3)    05207 Chemical carcinogenesis - receptor activation     101713887 (Adcy3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101713887 (Adcy3)    05163 Human cytomegalovirus infection     101713887 (Adcy3)   09165 Substance dependence    05032 Morphine addiction     101713887 (Adcy3)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     101713887 (Adcy3)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101713887 (Adcy3)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101713887 (Adcy3) Enzymes [BR:hgl01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      101713887 (Adcy3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc AC_N HNOBA Peptidase_S49_N NCE101 Motif Other DBs NCBI-GeneID:  101713887 NCBI-ProteinID:  XP_004839155 LinkDB All DBs Position Un AA seq 1189 aa AA seqDB search MPRNQGFSEPEYSAEYSAEYSVSLPSDPERGVGRTHEISVRNSGSCLCLPRFMRLTFVPE SLENLYQTYFKRQRHETLLVLVVFAALFDCYVVVMCAVVFSSDKLAPLVVAGIGLLLDVI LFVLCKKGLLPDRVSRKVVPYLLWLLITAQIFSYLGLNFARAHAASDTVGWQAFFVFSFF ITLPLSLSPIVLISVASCVVHTLVLGVTVAQQQQEELQGMQLLREILANVFLYLCAIIVG VMSYYMADRKHRKAFLEARQSLEVKMNLEEQSQQQENLMLSILPKHVADEMLKDMKKDES QKDQQQFNTMYMYRHENVSILFADIVGFTQLSSACSAQELVKLLNELFARFDKLAAVSAR ASAAWTPLLRSWSPLAFLCPLPLPCWGGTGSPGRALPFQKYHQLRIKILGDCYYCICGLP DYREDHAVCSILMGLAMVEAISYVREKTRTGVDMRVGVHTGTVLGGVLGQKRWQYDVWST DVTVANKMEAGGIPGRVHISQSTLDCLKGEFDVEPGDGGSRCDYLEEKGIETYLVIASKP EVKNTATQKGRHGLALPNGAPVSSKPSSPVLIETKEPNGSAHTSGSTSEEPEEQEAQADN PSFPNPRRRLRLQDLADRVVDASEDEHELNQLLNEALLERESAQVVKKRNTFLLSMRFMD PEMETRYSVEKEKQSGAAFSCSCVVLLCTALVEILIDPWLMTNYVTFVVGEILLLILTIC SLAAIFPRAFPKKLVAFSTWIDRTRWARNTWAMLAIFILVMANVVDMLSCLQYYAGPYNG TAELELEGSCLENPKYYSYIAVLSLIATIMLVQVSHMVKLTLMLLVTGAAATISLYTWCP VFDKYDHKRFQEHAFPMVASEKMQVLSTPGLNGTDSRLPLVPSKYSMTVMILIMMLSFYY FSRHVEKLARTLFLWKIEVHDQKERVYEMRRWNEALVTNMLPEHVARHFLGSKKRDEELY SQSYDEIGVMFASLPNFADFYTEESINNGGIECLRFLNEIISDFDSLLDNPKFRVITKIK TIGSTYMAASGVTPDVNTNGFTSSNKEEKSDKERWQHLADLADFALAMKDTLTNINNQSF NNFMLRIGMNKGGVLAGVIGARKPHYDIWGNTVNVASRMESTGVMGNIQVVEETQIILRE YGFRFVRRGPIFVKGKGELLTFFLKGRDRPPAFPNGSSVTLPHQVVDNS NT seq 3570 nt NT seq  +upstreamnt  +downstreamnt atgccgaggaaccagggcttctccgagcccgagtactccgccgagtactcagcggagtat tccgtcagcctgccctctgaccctgaacgcggggtgggtcggacccatgaaatctccgtc cggaactcggggtcttgcctgtgtctgcctcgcttcatgcgcctgaccttcgtgcctgag tccttggagaacctctaccagacctacttcaaaaggcagcgtcacgagaccctgctggtt ctggtggtcttcgcggccctgtttgactgctacgtggtggtcatgtgcgctgtggtcttc tccagcgacaagctggcccccctcgtggtggcggggatcggactgctgttggacgtcatc ctctttgtactctgcaaaaagggtctgctccctgaccgggtcagccggaaggtggttccc tacctgctgtggctgctgatcacagcccagatcttctcctatctgggcctgaacttcgcc cgggcccacgcggccagtgacactgtgggctggcaggccttctttgtcttctccttcttc atcacgctgcctctcagcctcagccccatcgtgctcatctctgtggcctcctgtgttgtg cacacactcgtcctgggggtcacggtggcccagcagcagcaggaggagctgcaggggatg cagctgctgagagagatcctggccaatgtcttcctctacctgtgcgccatcatcgtgggc gtcatgtcctactacatggccgaccggaagcaccgcaaggccttcctggaggcccgccag tctctggaggtgaagatgaacttggaggagcagagccagcagcaggagaacctcatgctc tccatcctgcccaagcacgtggctgacgagatgttgaaggacatgaagaaagacgagagc cagaaggaccagcagcagttcaacaccatgtacatgtaccggcacgagaacgtcagcatc ctctttgcggacatcgtgggcttcacccagctgtcatctgcctgcagcgctcaggagctg gtgaagctgctcaacgagctctttgcccgctttgacaagctggccgctgtaagtgcccgg gcgtcggccgcctggacgcccctgcttcgcagttggtccccacttgccttcctttgccct ttgccactcccatgctggggagggactgggagcccaggccgtgccctgccctttcagaaa taccaccagctccggatcaagatcctgggcgactgctactactgcatctgcggcctgccc gactaccgcgaggaccacgccgtttgctccatcctcatggggctcgccatggtggaggcc atctcgtacgttcgtgagaagaccaggaccggagtggacatgcgtgtgggcgtgcacacg ggcacggtgctgggtggcgtcctgggccagaagcgctggcagtatgacgtgtggtccact gacgtcactgtggccaacaagatggaggctggcggcatcccagggcgcgtgcacatctcc cagagcaccttggactgtctgaagggcgagttcgacgtggagccgggcgatgggggcagc cgctgcgattacctggaagagaagggcatcgagacctacctggtcatcgcctccaagccg gaggtgaagaacacagccacccagaagggccgccacggcttggccctcccgaatggagcc ccagtgtcctcgaagcccagctcccctgtcctcattgagaccaaggagcctaatggcagt gcccacaccagcggctccacatcggaggagcctgaggagcaggaggcccaggccgacaac ccctcgttccccaacccccgccgcaggctgcgcctccaggacctggctgaccgagtggtg gatgcctccgaggatgagcatgagctcaaccagctgctcaatgaggccctgctggagcga gagtctgcccaggtggtaaagaagagaaacacattcctcctctccatgcgcttcatggac ccggagatggagacccgctactcggtggaaaaggagaagcagagtggggccgccttcagc tgctcctgtgtggtcctgctctgcaccgccctggttgagatcctcatcgacccgtggctg atgacaaactatgtgaccttcgtggttggggagatcctgctgctgatcctgaccatctgc tcactggccgccatctttccccgggcctttcctaagaagcttgtggccttctcaacttgg attgaccggacccgctgggccaggaatacctgggccatgctggccatcttcattctggtt atggcaaacgtcgtggacatgcttagctgtctccagtactacgcaggaccctacaacggg acggcagagctagagctagagggcagctgcctggagaaccccaagtattacagctacatc gccgtgctgtccctcattgccaccatcatgctggtgcaggtcagccacatggtgaagctt acactcatgctgctggtcacgggcgcagcggccaccatcagcctctacacctggtgccct gtctttgataaatacgaccacaaacgcttccaggagcatgcctttcccatggtggcctca gagaagatgcaggtgctttccacccctgggctcaatggcacagacagcaggctgcccctg gtaccttcgaagtactcgatgacagtgatgatactcatcatgatgctgagcttttactac ttctcccgacacgtggaaaaactggcacgaacactgtttttgtggaagattgaggtccat gaccagaaggaacgtgtgtatgagatgcgacgctggaatgaggccctggtcaccaacatg ttgcctgagcatgtcgcgaggcatttccttgggtccaagaagagagatgaggagctgtat agccagtcctatgatgagattggagtcatgtttgcctctctgcccaactttgctgacttt tatactgaggagagcatcaataatggtggcatcgagtgtctgcggttcctcaatgagatc atctctgatttcgactctctcctggacaaccccaaattccgggtcatcaccaagatcaaa accattggcagcacctatatggcagcttcaggagtcaccccagatgtgaacaccaatggc ttcaccagctcaaacaaggaggagaagtcagacaaggagcgttggcaacacctggctgac ctggcggactttgcccttgctatgaaggatacgcttacaaacatcaacaaccagtccttc aacaactttatgctgcgcataggcatgaacaaaggaggggttctggctggggtcattgga gcccggaaaccacactacgacatctggggcaatacagtcaacgtggccagcaggatggag tccacaggggtgatgggcaacattcaggtggtggaggaaacacaaatcatcctccgagag tacggcttccgctttgtgaggcgaggtcccatctttgtgaaggggaagggagagctgctg actttcttcttgaagggacgagacaggccacctgccttccccaatggctcctccgttaca ctgccccaccaggtggtggacaactcctga

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