Heterocephalus glaber (naked mole-rat): 101719464 Help Entry 101719464         CDS       T02812                                  Symbol Adcy4 Name (RefSeq) adenylate cyclase 4   KO K08044   adenylate cyclase 4 [EC:4.6.1.1] Organism hgl  Heterocephalus glaber (naked mole-rat) Pathway hgl00230   Purine metabolism hgl01100   Metabolic pathways hgl01522   Endocrine resistance hgl04015   Rap1 signaling pathway hgl04020   Calcium signaling pathway hgl04022   cGMP-PKG signaling pathway hgl04024   cAMP signaling pathway hgl04062   Chemokine signaling pathway hgl04072   Phospholipase D signaling pathway hgl04114   Oocyte meiosis hgl04211   Longevity regulating pathway hgl04213   Longevity regulating pathway - multiple species hgl04261   Adrenergic signaling in cardiomyocytes hgl04270   Vascular smooth muscle contraction hgl04371   Apelin signaling pathway hgl04540   Gap junction hgl04611   Platelet activation hgl04713   Circadian entrainment hgl04714   Thermogenesis hgl04723   Retrograde endocannabinoid signaling hgl04724   Glutamatergic synapse hgl04725   Cholinergic synapse hgl04727   GABAergic synapse hgl04742   Taste transduction hgl04750   Inflammatory mediator regulation of TRP channels hgl04911   Insulin secretion hgl04912   GnRH signaling pathway hgl04913   Ovarian steroidogenesis hgl04914   Progesterone-mediated oocyte maturation hgl04915   Estrogen signaling pathway hgl04916   Melanogenesis hgl04918   Thyroid hormone synthesis hgl04921   Oxytocin signaling pathway hgl04923   Regulation of lipolysis in adipocytes hgl04925   Aldosterone synthesis and secretion hgl04926   Relaxin signaling pathway hgl04927   Cortisol synthesis and secretion hgl04928   Parathyroid hormone synthesis, secretion and action hgl04934   Cushing syndrome hgl04935   Growth hormone synthesis, secretion and action hgl04970   Salivary secretion hgl04971   Gastric acid secretion hgl04972   Pancreatic secretion hgl04976   Bile secretion hgl05032   Morphine addiction hgl05163   Human cytomegalovirus infection hgl05166   Human T-cell leukemia virus 1 infection hgl05200   Pathways in cancer hgl05207   Chemical carcinogenesis - receptor activation hgl05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:hgl00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     101719464 (Adcy4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101719464 (Adcy4)    04371 Apelin signaling pathway     101719464 (Adcy4)    04020 Calcium signaling pathway     101719464 (Adcy4)    04072 Phospholipase D signaling pathway     101719464 (Adcy4)    04024 cAMP signaling pathway     101719464 (Adcy4)    04022 cGMP-PKG signaling pathway     101719464 (Adcy4)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     101719464 (Adcy4)   09144 Cellular community - eukaryotes    04540 Gap junction     101719464 (Adcy4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101719464 (Adcy4)    04062 Chemokine signaling pathway     101719464 (Adcy4)   09152 Endocrine system    04911 Insulin secretion     101719464 (Adcy4)    04923 Regulation of lipolysis in adipocytes     101719464 (Adcy4)    04912 GnRH signaling pathway     101719464 (Adcy4)    04913 Ovarian steroidogenesis     101719464 (Adcy4)    04915 Estrogen signaling pathway     101719464 (Adcy4)    04914 Progesterone-mediated oocyte maturation     101719464 (Adcy4)    04921 Oxytocin signaling pathway     101719464 (Adcy4)    04926 Relaxin signaling pathway     101719464 (Adcy4)    04935 Growth hormone synthesis, secretion and action     101719464 (Adcy4)    04918 Thyroid hormone synthesis     101719464 (Adcy4)    04928 Parathyroid hormone synthesis, secretion and action     101719464 (Adcy4)    04916 Melanogenesis     101719464 (Adcy4)    04925 Aldosterone synthesis and secretion     101719464 (Adcy4)    04927 Cortisol synthesis and secretion     101719464 (Adcy4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101719464 (Adcy4)    04270 Vascular smooth muscle contraction     101719464 (Adcy4)   09154 Digestive system    04970 Salivary secretion     101719464 (Adcy4)    04971 Gastric acid secretion     101719464 (Adcy4)    04972 Pancreatic secretion     101719464 (Adcy4)    04976 Bile secretion     101719464 (Adcy4)   09156 Nervous system    04724 Glutamatergic synapse     101719464 (Adcy4)    04727 GABAergic synapse     101719464 (Adcy4)    04725 Cholinergic synapse     101719464 (Adcy4)    04723 Retrograde endocannabinoid signaling     101719464 (Adcy4)   09157 Sensory system    04742 Taste transduction     101719464 (Adcy4)    04750 Inflammatory mediator regulation of TRP channels     101719464 (Adcy4)   09149 Aging    04211 Longevity regulating pathway     101719464 (Adcy4)    04213 Longevity regulating pathway - multiple species     101719464 (Adcy4)   09159 Environmental adaptation    04713 Circadian entrainment     101719464 (Adcy4)    04714 Thermogenesis     101719464 (Adcy4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101719464 (Adcy4)    05207 Chemical carcinogenesis - receptor activation     101719464 (Adcy4)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101719464 (Adcy4)    05163 Human cytomegalovirus infection     101719464 (Adcy4)   09165 Substance dependence    05032 Morphine addiction     101719464 (Adcy4)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     101719464 (Adcy4)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101719464 (Adcy4)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101719464 (Adcy4) Enzymes [BR:hgl01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      101719464 (Adcy4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N DUF3180 CD52 Motif Other DBs NCBI-GeneID:  101719464 NCBI-ProteinID:  XP_004864137 LinkDB All DBs Position Un AA seq 1120 aa AA seqDB search MARLFSPRPPPSEDLFYETYYSLSQQYPLLLLLLVIVLCALLALLAVAWASGRELTSDPG FLPTVLSALGGFLLLLGLASREQRLQRWTRPLSGLVWAALLALGQAFLFTGGVVSAWDQV RWMAGKEWGNQHPGRLLCGPSASCALLQVSFFLFIIFTVYAMLPLGMWEAAAAGLTSSLS HLLVLGLYLGPQPDSQPALLPQLAANAVLFLCGNVVGAYHKALMERALRATFREALSSLH SRRRLDTEKKHQEHLLLSILPAYLAREMKAEIMARLQAGQGSQPENTNNFHSLYVKRHQG VSVLYADIVGFTRLASECSPKELVLMLNELFGKFDQIAKVPLHTRTHTPRSTNACGSKSW GTVTTASLGFPSHCQTMPSTACAWGWTCAAPSGQLWKLRAATGVDINMRVGVHSGSVLCG VIGLQKWQYDVWSHDVTLANHMEASGVPGRVHITGATLALLAGAYAVEDAAMEHRDPYLR ELGEPTYLVIDPRAEEEDEKGTEGGLLFSLEGHKMRPSLLMTRYLESWGAAKPFAHLSHI DSPVSTSTPLPEKALASFSPQWSLDRSRTPRGLDDELDTGDAKFFQVIEQLNSQKQWKQS KDFNLLTLYFREKEMEKQYRFSALPAFKYYTACTFLVFLSNFIIQMLVTNRPPALAFTYS ITFLLFLLLLFVCFSEHLTWCVQKGPKMLHRLPALSGLVATWPGLRVALGTATILLVFTM AIASLFFLPALADCPFQAPGVSSMDFNLSWELPGSLPLISVPYSMHCCVLGFLSCSLFLH MSFELKLVLLLLWLVASCSVFLHSHAWLSDCLIAHLYPGSLDSSPGVLKEPKLMGAISFF IFFFTLLVLARQNEYYCRLDFLWKKKLRQEREETETMENLTRLLLENVLPAHVAPQFIGQ NRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGLECLRLLNEIIADFDELLSKPK FSGVEKIKTIGSTYMAATGLNATSGQDPQQDAERSCSHLGTMVEFAMALGSKLDVINKHS FNNFRLRVGLNHGPVVAGVIGAQKPQYDIWGNTVNVASRMESTGVLGKIQVTEETAQALQ SLGYTCYSRGVIKVKGKGQLCTYFLNTDLTRTGPPSATLG NT seq 3363 nt NT seq  +upstreamnt  +downstreamnt atggcccgcctcttcagcccccggccgccccccagcgaggacctcttctatgagacctac tacagcctgagccagcaatacccgctgctgctcctgctgctcgtcatcgtgctctgcgcg ctcctggcgctcctcgccgtggcctgggcgagcggcagggagctgacctcggacccaggc ttccttcccacagtgttaagtgctttgggtggcttcttgctgctgctgggcctagcttcc cgtgagcagcgactgcagcgctggacacgaccactgtctggccttgtgtgggctgcattg ctggccctaggccaggccttcctgtttacagggggcgtcgtgagcgcctgggaccaggta agatggatggcaggaaaggaatgggggaaccagcacccaggccgtttgctgtgtgggcct tcagcttcctgcgccctgctccaggtgtcctttttcctcttcatcatcttcacggtgtat gccatgctgcccctgggcatgtgggaggctgccgccgcaggtcttacctcctcactctcg cacttgctggtcctcgggctgtaccttgggccacagccagactcccaacctgcactgctg ccacagttggcagcaaatgcagtgctcttcctgtgcgggaatgtggtgggggcataccac aaggcgctgatggagcgtgcgctgcgggccaccttccgggaggcactcagctccctgcac tctcggcggagactggacacagagaaaaagcaccaggaacaccttctcttgtccatcctt cctgcctacctggcccgagagatgaaagcagagatcatggcacggctgcaggccggacag gggtcacagccagaaaacaccaataatttccacagcctctatgtgaagaggcaccaagga gtcagtgtgttgtatgctgacatcgtgggcttcacgcggctggccagcgagtgctcccct aaggagctggtgctcatgctcaatgagctcttcggcaagtttgaccagatcgccaaggtt cctctacacacccgcacacacactcccaggagcacgaatgcatgcggatcaaaatcctgg gggactgttactactgcgtctctgggcttcccctctcactgccagaccatgccatcaact gcgtgcgcatggggctggacatgtgccgcgccatcaggtcagctctggaaacttcgggca gccactggtgtggacataaacatgcgtgtgggagtgcactctggcagtgtactttgcgga gtcatcgggctgcagaagtggcagtatgatgtctggtcccacgacgtcacactggccaac cacatggaggcgagcggtgtgccaggtcgggtgcacatcacaggggctaccctggccctg ctggcaggggcctatgctgtggaggatgcagccatggaacaccgagacccataccttcgg gagctcggggagcctacatacctggtcattgatcctcgggctgaggaagaagatgagaag ggcaccgaaggagggttactgttctctctggagggccacaagatgcgcccgtcactgctg atgacacgctacctggagtcctggggtgcagccaagccttttgcccacctgagccacata gacagccctgtgtccacctccactcctctcccggagaaggccctggcctccttcagcccc cagtggagcctggaccggagcaggaccccccggggactagatgatgaactggacaccggg gatgccaagttcttccaggtcatcgaacagctcaactctcagaaacagtggaagcagtcg aaggacttcaacttactgacactgtacttcagagagaaggagatggagaaacagtatcgg ttctctgctctccctgccttcaaatactatacagcctgcaccttcttggtttttctgtcc aatttcatcatccaaatgctggtgacaaacaggcccccagctctggcctttacttacagc atcaccttccttctcttccttctccttctcttcgtctgcttctcagagcacctgacgtgg tgtgtccagaaaggccccaagatgctgcaccggctgcctgcactgtctggcctagtggcc acatggcctggactgcgagtagccctgggcactgctaccatcctcctcgtcttcaccatg gccattgccagcctgttcttcttaccagcattagcagactgccctttccaggcccctggt gtgtcctccatggatttcaacctgtcctgggagctgcctgggtcactgcctctcatcagt gtcccgtactccatgcactgctgtgtgctgggtttcctctcctgttccctctttctgcac atgagctttgaattgaagctggtgctgctcctgctgtggctagtggcctcctgctccgtc ttcctgcactcccacgcctggctgtcagactgcctcattgcccacctttatccgggctcc ttggactccagcccaggagtgctgaaggaacccaagttgatgggagctatctccttcttc atcttcttcttcaccctccttgtcctggctcggcagaatgaatattactgccgcctggac ttcctgtggaagaagaaactgaggcaggagcgggaggagacagagacaatggagaacctg acccggctgctcttggagaatgtgctgcctgcacatgtggccccgcagttcattggccag aaccggcgcaatgaggacctctaccaccagtcctatgagtgtgtttgcgtgctctttgcc tcagtcccagactttaaggagttttattctgaatccaacatcaaccatgaggggctagag tgtctgcggctgctcaatgagataattgctgattttgatgagctgctctccaagcccaag ttcagtggagtagagaagatcaaaactattggcagtacctacatggcagccacaggctta aatgccacctctggacaagatccacaacaggatgctgaacggagctgcagccaccttggc accatggtggaatttgcaatggccctggggtctaagctggatgtcatcaacaagcactca tttaacaacttccgcctgcgtgtggggttgaatcatggaccagtagtggctggagtgatc ggggcccagaagccacaatatgatatctggggcaacacagtgaatgtggccagtcgcatg gagagcacaggagtccttggcaagatccaagtaactgaggagacagcccaggccctgcag tccctgggctatacatgctacagtcggggtgtcatcaaggtcaaaggcaaaggacagctc tgcacctacttcctgaacacagacttgacacgaactggacctccttccgccactctaggc tga

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