Homo sapiens (human): 476
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Entry
476 CDS
T01001
Symbol
ATP1A1, CMT2DD, HOMGSMR2
Name
(RefSeq) ATPase Na+/K+ transporting subunit alpha 1
KO
K01539
sodium/potassium-transporting ATPase subunit alpha [EC:
7.2.2.13
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa04022
cGMP-PKG signaling pathway
hsa04024
cAMP signaling pathway
hsa04260
Cardiac muscle contraction
hsa04261
Adrenergic signaling in cardiomyocytes
hsa04820
Cytoskeleton in muscle cells
hsa04911
Insulin secretion
hsa04918
Thyroid hormone synthesis
hsa04919
Thyroid hormone signaling pathway
hsa04925
Aldosterone synthesis and secretion
hsa04960
Aldosterone-regulated sodium reabsorption
hsa04961
Endocrine and other factor-regulated calcium reabsorption
hsa04964
Proximal tubule bicarbonate reclamation
hsa04970
Salivary secretion
hsa04971
Gastric acid secretion
hsa04972
Pancreatic secretion
hsa04973
Carbohydrate digestion and absorption
hsa04974
Protein digestion and absorption
hsa04976
Bile secretion
hsa04978
Mineral absorption
Network
nt06316
Renin-angiotensin-aldosterone signaling
Element
N00304
Mutation-inactivated ATP1A1 to angiotensin-aldosterone signaling pathway
Disease
H00264
Charcot-Marie-Tooth disease
H01210
Hypomagnesemia
H01603
Primary aldosteronism
Drug target
Acetyldigitoxin:
D06881
Acetyldigoxin:
D07555
Bepridil (
DG00333
):
D00631
<JP>
D07520
Bretylium tosilate:
D00645
Deslanoside:
D01240
<JP>
Digitoxin:
D00297
Digoxin:
D00298
<JP/US>
G-strophanthin:
D00112
Gitoformate:
D07147
Lanatoside C:
D01972
Metildigoxin (
DG00191
):
D02587
<JP>
D09847
Proscillaridin:
D01379
beta-Acetyldigoxin:
D07556
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09130 Environmental Information Processing
09132 Signal transduction
04024 cAMP signaling pathway
476 (ATP1A1)
04022 cGMP-PKG signaling pathway
476 (ATP1A1)
09140 Cellular Processes
09142 Cell motility
04820 Cytoskeleton in muscle cells
476 (ATP1A1)
09150 Organismal Systems
09152 Endocrine system
04911 Insulin secretion
476 (ATP1A1)
04918 Thyroid hormone synthesis
476 (ATP1A1)
04919 Thyroid hormone signaling pathway
476 (ATP1A1)
04925 Aldosterone synthesis and secretion
476 (ATP1A1)
09153 Circulatory system
04260 Cardiac muscle contraction
476 (ATP1A1)
04261 Adrenergic signaling in cardiomyocytes
476 (ATP1A1)
09154 Digestive system
04970 Salivary secretion
476 (ATP1A1)
04971 Gastric acid secretion
476 (ATP1A1)
04972 Pancreatic secretion
476 (ATP1A1)
04976 Bile secretion
476 (ATP1A1)
04973 Carbohydrate digestion and absorption
476 (ATP1A1)
04974 Protein digestion and absorption
476 (ATP1A1)
04978 Mineral absorption
476 (ATP1A1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
476 (ATP1A1)
04961 Endocrine and other factor-regulated calcium reabsorption
476 (ATP1A1)
04964 Proximal tubule bicarbonate reclamation
476 (ATP1A1)
09180 Brite Hierarchies
09183 Protein families: signaling and cellular processes
04147 Exosome [BR:
hsa04147
]
476 (ATP1A1)
Enzymes [BR:
hsa01000
]
7. Translocases
7.2 Catalysing the translocation of inorganic cations
7.2.2 Linked to the hydrolysis of a nucleoside triphosphate
7.2.2.13 Na+/K+-exchanging ATPase
476 (ATP1A1)
Exosome [BR:
hsa04147
]
Exosomal proteins
Exosomal proteins of haemopoietic cells (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
476 (ATP1A1)
Exosomal proteins of other body fluids (saliva and urine)
476 (ATP1A1)
Exosomal proteins of colorectal cancer cells
476 (ATP1A1)
Exosomal proteins of bladder cancer cells
476 (ATP1A1)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
E1-E2_ATPase
Cation_ATPase_C
Cation_ATPase
Cation_ATPase_N
Hydrolase
Hydrolase_3
HAD
Motif
Other DBs
NCBI-GeneID:
476
NCBI-ProteinID:
NP_000692
OMIM:
182310
HGNC:
799
Ensembl:
ENSG00000163399
UniProt:
P05023
Structure
PDB
LinkDB
All DBs
Position
1:116373244..116404774
Genome browser
AA seq
1023 aa
AA seq
DB search
MGKGVGRDKYEPAAVSEQGDKKGKKGKKDRDMDELKKEVSMDDHKLSLDELHRKYGTDLS
RGLTSARAAEILARDGPNALTPPPTTPEWIKFCRQLFGGFSMLLWIGAILCFLAYSIQAA
TEEEPQNDNLYLGVVLSAVVIITGCFSYYQEAKSSKIMESFKNMVPQQALVIRNGEKMSI
NAEEVVVGDLVEVKGGDRIPADLRIISANGCKVDNSSLTGESEPQTRSPDFTNENPLETR
NIAFFSTNCVEGTARGIVVYTGDRTVMGRIATLASGLEGGQTPIAAEIEHFIHIITGVAV
FLGVSFFILSLILEYTWLEAVIFLIGIIVANVPEGLLATVTVCLTLTAKRMARKNCLVKN
LEAVETLGSTSTICSDKTGTLTQNRMTVAHMWFDNQIHEADTTENQSGVSFDKTSATWLA
LSRIAGLCNRAVFQANQENLPILKRAVAGDASESALLKCIELCCGSVKEMRERYAKIVEI
PFNSTNKYQLSIHKNPNTSEPQHLLVMKGAPERILDRCSSILLHGKEQPLDEELKDAFQN
AYLELGGLGERVLGFCHLFLPDEQFPEGFQFDTDDVNFPIDNLCFVGLISMIDPPRAAVP
DAVGKCRSAGIKVIMVTGDHPITAKAIAKGVGIISEGNETVEDIAARLNIPVSQVNPRDA
KACVVHGSDLKDMTSEQLDDILKYHTEIVFARTSPQQKLIIVEGCQRQGAIVAVTGDGVN
DSPALKKADIGVAMGIAGSDVSKQAADMILLDDNFASIVTGVEEGRLIFDNLKKSIAYTL
TSNIPEITPFLIFIIANIPLPLGTVTILCIDLGTDMVPAISLAYEQAESDIMKRQPRNPK
TDKLVNERLISMAYGQIGMIQALGGFFTYFVILAENGFLPIHLLGLRVDWDDRWINDVED
SYGQQWTYEQRKIVEFTCHTAFFVSIVVVQWADLVICKTRRNSVFQQGMKNKILIFGLFE
ETALAAFLSYCPGMGVALRMYPLKPTWWFCAFPYSLLIFVYDEVRKLIIRRRPGGWVEKE
TYY
NT seq
3072 nt
NT seq
+upstream
nt +downstream
nt
atggggaagggggttggacgtgataagtatgagcctgcagctgtttcagaacaaggtgat
aaaaagggcaaaaagggcaaaaaagacagggacatggatgaactgaagaaagaagtttct
atggatgatcataaacttagccttgatgaacttcatcgtaaatatggaacagacttgagc
cggggattaacatctgctcgtgcagctgagatcctggcgcgagatggtcccaacgccctc
actccccctcccactactcctgaatggatcaagttttgtcggcagctctttggggggttc
tcaatgttactgtggattggagcgattctttgtttcttggcttatagcatccaagctgct
acagaagaggaacctcaaaacgataatctgtacctgggtgtggtgctatcagccgttgta
atcataactggttgcttctcctactatcaagaagctaaaagttcaaagatcatggaatcc
ttcaaaaacatggtccctcagcaagcccttgtgattcgaaatggtgagaaaatgagcata
aatgcggaggaagttgtggttggggatctggtggaagtaaaaggaggagaccgaattcct
gctgacctcagaatcatatctgcaaatggctgcaaggtggataactcctcgctcactggt
gaatcagaaccccagactaggtctccagatttcacaaatgaaaaccccctggagacgagg
aacattgccttcttttcaaccaattgtgttgaaggcaccgcacgtggtattgttgtctac
actggggatcgcactgtgatgggaagaattgccacacttgcttctgggctggaaggaggc
cagacccccattgctgcagaaattgaacattttatccacatcatcacgggtgtggctgtg
ttcctgggtgtgtctttcttcatcctttctctcatccttgagtacacctggcttgaggct
gtcatcttcctcatcggtatcatcgtagccaatgtgccggaaggtttgctggccactgtc
acggtctgtctgacacttactgccaaacgcatggcaaggaaaaactgcttagtgaagaac
ttagaagctgtggagaccttggggtccacgtccaccatctgctctgataaaactggaact
ctgactcagaaccggatgacagtggcccacatgtggtttgacaatcaaatccatgaagct
gatacgacagagaatcagagtggtgtctcttttgacaagacttcagctacctggcttgct
ctgtccagaattgcaggtctttgtaacagggcagtgtttcaggctaaccaggaaaaccta
cctattcttaagcgggcagttgcaggagatgcctctgagtcagcactcttaaagtgcata
gagctgtgctgtggttccgtgaaggagatgagagaaagatacgccaaaatcgtcgagata
cccttcaactccaccaacaagtaccagttgtctattcataagaaccccaacacatcggag
ccccaacacctgttggtgatgaagggcgccccagaaaggatcctagaccgttgcagctct
atcctcctccacggcaaggagcagcccctggatgaggagctgaaagacgcctttcagaac
gcctatttggagctggggggcctcggagaacgagtcctaggtttctgccacctctttctg
ccagatgaacagtttcctgaagggttccagtttgacactgacgatgtgaatttccctatc
gataatctgtgctttgttgggctcatctccatgattgaccctccacgggcggccgttcct
gatgccgtgggcaaatgtcgaagtgctggaattaaggtcatcatggtcacaggagaccat
ccaatcacagctaaagctattgccaaaggtgtgggcatcatctcagaaggcaatgagacc
gtggaagacattgctgcccgcctcaacatcccagtcagccaggtgaaccccagggatgcc
aaggcctgcgtagtacacggcagtgatctaaaggacatgacctccgagcagctggatgac
attttgaagtaccacactgagatagtgtttgccaggacctcccctcagcagaagctcatc
attgtggaaggctgccaaagacagggtgctatcgtggctgtgactggtgacggtgtgaat
gactctccagctttgaagaaagcagacattggggttgctatggggattgctggctcagat
gtgtccaagcaagctgctgacatgattcttctggatgacaactttgcctcaattgtgact
ggagtagaggaaggtcgtctgatctttgataacttgaagaaatccattgcttatacctta
accagtaacattcccgagatcaccccgttcctgatatttattattgcaaacattccacta
ccactggggactgtcaccatcctctgcattgacttgggcactgacatggttcctgccatc
tccctggcttatgagcaggctgagagtgacatcatgaagagacagcccagaaatcccaaa
acagacaaacttgtgaatgagcggctgatcagcatggcctatgggcagattggaatgatc
caggccctgggaggcttctttacttactttgtgattctggctgagaacggcttcctccca
attcacctgttgggcctccgagtggactgggatgaccgctggatcaacgatgtggaagac
agctacgggcagcagtggacctatgagcagaggaaaatcgtggagttcacctgccacaca
gccttcttcgtcagtatcgtggtggtgcagtgggccgacttggtcatctgtaagaccagg
aggaattcggtcttccagcaggggatgaagaacaagatcttgatatttggcctctttgaa
gagacagccctggctgctttcctttcctactgccctggaatgggtgttgctcttaggatg
tatcccctcaaacctacctggtggttctgtgccttcccctactctcttctcatcttcgta
tatgacgaagtcagaaaactcatcatcaggcgacgccctggcggctgggtggagaaggaa
acctactattag
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integrated database retrieval system