Homo sapiens (human): 84444
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Entry
84444 CDS
T01001
Symbol
DOT1L, DOT1, KMT4
Name
(RefSeq) DOT1 like histone lysine methyltransferase
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
hsa
Homo sapiens (human)
Pathway
hsa00310
Lysine degradation
hsa01100
Metabolic pathways
hsa05202
Transcriptional misregulation in cancer
Network
nt06240
Transcription (cancer)
Element
N00119
MLL-AF4 fusion to transcriptional activation
Brite
KEGG Orthology (KO) [BR:
hsa00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
84444 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
84444 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
hsa03036
]
84444 (DOT1L)
Enzymes [BR:
hsa01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
84444 (DOT1L)
Chromosome and associated proteins [BR:
hsa03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
84444 (DOT1L)
HMT complexes
Dot1-containing complex
84444 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
Motif
Other DBs
NCBI-GeneID:
84444
NCBI-ProteinID:
NP_115871
OMIM:
607375
HGNC:
24948
Ensembl:
ENSG00000104885
UniProt:
Q8TEK3
Structure
PDB
LinkDB
All DBs
Position
19:2163933..2232578
Genome browser
AA seq
1537 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSTGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTDDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRESKSNAATPTKGP
EGKVAGPADAPMDSGAEEEKAGAATVKKPSPSKARKKKLNKKGRKMAGRKRGRPKKMNTA
NPERKPKKNQTALDALHAQTVSQTAASSPQDAYRSPHSPFYQLPPSVQRHSPNPLLVAPT
PPALQKLLESFKIQYLQFLAYTKTPQYKASLQELLGQEKEKNAQLLGAAQQLLSHCQAQK
EEIRRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLREQSEQLEQDNRALRGQSLQLL
KARCEELQLDWATLSLEKLLKEKQALKSQISEKQRHCLELQISIVELEKSQRQQELLQLK
SCVPPDDALSLHLRGKGALGRELEPDASRLHLELDCTKFSLPHLSSMSPELSMNGQAAGY
ELCGVLSRPSSKQNTPQYLASPLDQEVVPCTPSHVGRPRLEKLSGLAAPDYTRLSPAKIV
LRRHLSQDHTVPGRPAASELHSRAEHTKENGLPYQSPSVPGSMKLSPQDPRPLSPGALQL
AGEKSSEKGLRERAYGSSGELITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAERARST
PSPVLQPRDPSSTLEKQIGANAHGAGSRSLALAPAGFSYAGSVAISGALAGSPASLTPGA
EPATLDESSSSGSLFATVGSRSSTPQHPLLLAQPRNSLPASPAHQLSSSPRLGGAAQGPL
PEASKGDLPSDSGFSDPESEAKRRIVFTITTGAGSAKQSPSSKHSPLTASARGDCVPSHG
QDSRRRGRRKRASAGTPSLSAGVSPKRRALPSVAGLFTQPSGSPLNLNSMVSNINQPLEI
TAISSPETSLKSSPVPYQDHDQPPVLKKERPLSQTNGAHYSPLTSDEEPGSEDEPSSARI
ERKIATISLESKSPPKTLENGGGLAGRKPAPAGEPVNSSKWKSTFSPISDIGLAKSADSP
LQASSALSQNSLFTFRPALEEPSADAKLAAHPRKGFPGSLSGADGLSPGTNPANGCTFGG
GLAADLSLHSFSDGASLPHKGPEAAGLSSPLSFPSQRGKEGSDANPFLSKRQLDGLAGLK
GEGSRGKEAGEGGLPLCGPTDKTPLLSGKAAKARDREVDLKNGHNLFISAAAVPPGSLLS
GPGLAPAASSAGGAASSAQTHRSFLGPFPPGPQFALGPMSLQANLGSVAGSSVLQSLFSS
VPAAAGLVHVSSAATRLTNSHAMGSFSGVAGGTVGGN
NT seq
4614 nt
NT seq
+upstream
nt +downstream
nt
atgggggagaagctggagctgagactgaagtcgcccgtgggggctgagcccgccgtctac
ccgtggccgctgccggtctacgataaacatcacgatgctgctcatgaaatcatcgagacc
atccgatgggtctgtgaagaaatcccggatctcaagctcgctatggagaattacgtttta
attgactatgacaccaaaagcttcgagagcatgcagaggctctgcgacaagtacaaccgt
gccatcgacagcatccaccagctgtggaagggcaccacgcagcccatgaagctgaacacg
cggccgtccactggactcctgcgccatatcctgcagcaggtctacaaccactcggtgacc
gaccccgagaagctcaacaactacgagcccttctcccccgaggtgtacggggagacctcc
ttcgacctggtggcccagatgattgatgagatcaagatgaccgacgacgacctgtttgtg
gacttggggagcggtgtgggccaggtcgtgctccaggttgctgctgccaccaactgcaaa
catcactatggcgtcgagaaagcagacatcccggccaagtatgcggagaccatggaccgc
gagttcaggaagtggatgaaatggtatggaaaaaagcatgcagaatacacattggagaga
ggcgatttcctctcagaagagtggagggagcgaatcgccaacacgagtgttatatttgtg
aataattttgcctttggtcctgaggtggatcaccagctgaaggagcggtttgcaaacatg
aaggaaggtggcagaatcgtgtcctcgaaaccctttgcacctctgaacttcagaataaac
agtagaaacttgagtgacatcggcaccatcatgcgcgtggtggagctctcgcccctgaag
ggctcggtgtcgtggacggggaagccagtctcctactacctgcacactatcgaccgcacc
atacttgaaaactatttttctagtctgaaaaacccaaaactcagggaggaacaggaggca
gcccggcgccgccagcagcgcgagagcaagagcaacgcggccacgcccactaagggccca
gagggcaaggtggccggccccgccgacgcccccatggactctggtgctgaggaagagaag
gcgggagcagccaccgtgaagaagccgtctccctccaaagcccgcaagaagaagctaaac
aagaaggggaggaagatggctggccgcaagcgcgggcgccccaagaagatgaacactgcg
aaccccgagcggaagcccaagaagaaccaaactgcactggatgccctgcacgctcagacc
gtgtctcagacggcggcctcctcaccccaggatgcctacagatcccctcacagcccgttc
taccagctacctccgagcgtgcagcggcactcccccaacccgctgctggtggcgcccacc
ccgcccgcgctgcagaagcttctagagtccttcaagatccagtacctgcagttcctggca
tacacaaagaccccccagtacaaggccagcctgcaggagctgctgggccaggagaaggag
aagaacgcccagctcctgggtgcggctcagcagctcctcagccactgccaggcccagaag
gaggagatcaggaggctgtttcagcaaaaattggatgagctgggtgtgaaggcgctgacc
tacaacgacctgattcaagcgcagaaggagatctccgcccataaccagcagctgcgggag
cagtcggagcagctggagcaggacaaccgcgcgctccgcggccagagcttgcagctgctc
aaggctcgctgcgaggagctgcagctggactgggccacgctgtcgctggagaagctgttg
aaggagaagcaggccctgaagagccagatctcggagaagcagaggcactgcctggagctg
cagatcagcattgtggagctagagaagagccagcggcagcaggagctcctgcagctcaag
tcctgtgtgccgcctgacgacgccctgtccctgcacctgcgtgggaagggcgccctgggc
cgcgagctggagcctgacgccagccggctgcacctggagctggactgcaccaagttctcg
ctgcctcacttgagcagcatgagcccggagctctccatgaacggccaggctgctggctat
gagctctgcggtgtgctgagccggccttcgtcgaagcagaacacgccccagtacctggcc
tcacccctggaccaggaggtggtgccctgtacccctagccacgtcggccggccgcgcctg
gagaagctgtctggcctagccgcacccgactacactaggctgtccccggccaagattgtg
ctgaggcggcacctgagccaggaccacacggtgcccggcaggccggctgccagtgagctg
cattcgagagctgagcacaccaaggagaacggccttccctaccagagccccagcgtgcct
ggcagcatgaagctgagccctcaggacccgcggcccctgtcccctggggccttgcagctt
gctggagagaagagcagtgagaagggcctgagagagcgcgcctacggcagcagcggggag
ctcatcaccagcctgcccatcagcatcccgctcagcaccgtgcagcccaacaagctcccg
gtcagcattcccctggccagcgtggtgctgcccagccgcgccgagagggcgaggagcacc
cccagtcccgtgctgcagccccgtgacccctcgtccacacttgaaaagcagattggtgct
aatgcccacggtgctgggagcagaagccttgccctggcccccgcaggcttctcctacgct
ggctcggtggccatcagcggggccttggcgggcagcccggcctctctcacacctggagcc
gagccggccaccttggatgagtcctccagctctgggagcctttttgccaccgtggggtcc
cgcagctccacgccacagcaccccctgctgctggcacagccccggaactcgcttcctgcc
tctcccgcccaccagctctcctccagtccccggcttggtggggccgcccagggcccgttg
cccgaggccagcaagggagacctgccctccgattccggcttctcagatcctgagagtgaa
gccaagaggaggattgtgttcaccatcaccactggtgcgggcagtgccaagcagtcgccc
tccagcaagcacagccccctgaccgccagcgcccgtggggactgtgtgccgagccacggg
caggacagtcgcaggcgcggccggcggaagcgagcatctgcggggacgcccagcttgagc
gcaggcgtgtcccccaagcgccgagccctgccgtccgtcgctggccttttcacacagcct
tcggggtctcccctcaacctcaactccatggtcagtaacatcaaccagcccctggagatt
acagccatctcgtccccggagacctccctgaagagctcccctgtgccctaccaggaccac
gaccagccccccgtgctcaagaaggagcggcctctgagccagaccaatggggcacactac
tccccactcacctcagacgaggagccaggctctgaggacgagcccagcagtgctcgaatt
gagagaaaaattgcaacaatctccttagaaagcaaatctcccccgaaaaccttggaaaat
ggtggtggcttggcgggaaggaagcccgcgcccgccggcgagccagtcaatagcagcaag
tggaagtccaccttctcgcccatctccgacatcggcctggccaagtcggcggacagcccg
ctgcaggccagctccgccctcagccagaactccctgttcacgttccggcccgccctggag
gagccctctgccgatgccaagctggccgctcaccccaggaaaggctttcccggctccctg
tcgggggctgacggactcagcccgggcaccaaccctgccaacggctgcaccttcggcggg
ggcctggccgcggacctgagtttacacagcttcagtgatggtgcttctcttccccacaag
ggccccgaggcggccggcctgagctccccgctgagcttcccctcgcagcgcggcaaggag
ggctcggacgccaaccctttcctgagcaagaggcagctggacggcctggctgggctgaag
ggcgagggcagccgcggcaaggaggcaggggagggcggcctaccgctgtgcgggcccacg
gacaagaccccactgctgagcggcaaggccgccaaggcccgggaccgcgaggtcgacctc
aagaatggccacaacctcttcatctctgcggcggccgtgcctcccggaagcctcctcagc
ggccccggcctggccccggcggcgtcctccgcaggcggcgcggcgtcctccgcccagacg
caccggtccttcctgggccccttcccgccgggaccgcagttcgcgctcggccccatgtcc
ctgcaggccaacctcggctccgtggccggctcctccgtgctgcagtcgctgttcagctct
gtgccggccgccgcaggcctggtgcacgtgtcgtccgctgccaccagactgaccaactcg
cacgccatgggcagcttttccggggtggcaggcggcacagttggaggtaactag
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