Homo sapiens (human): 8660 Help Entry 8660              CDS       T01001                                  Symbol IRS2, IRS-2 Name (RefSeq) insulin receptor substrate 2   KO K07187   insulin receptor substrate 2 Organism hsa  Homo sapiens (human) Pathway hsa04022   cGMP-PKG signaling pathway hsa04068   FoxO signaling pathway hsa04140   Autophagy - animal hsa04152   AMPK signaling pathway hsa04211   Longevity regulating pathway hsa04213   Longevity regulating pathway - multiple species hsa04910   Insulin signaling pathway hsa04920   Adipocytokine signaling pathway hsa04923   Regulation of lipolysis in adipocytes hsa04930   Type II diabetes mellitus hsa04931   Insulin resistance hsa04932   Non-alcoholic fatty liver disease hsa04935   Growth hormone synthesis, secretion and action hsa05010   Alzheimer disease hsa05206   MicroRNAs in cancer Network nt06325  Hormone/cytokine signaling   Element N01708   INS-AKT signaling pathway Brite KEGG Orthology (KO) [BR:hsa00001]  09130 Environmental Information Processing   09132 Signal transduction    04068 FoxO signaling pathway     8660 (IRS2)    04022 cGMP-PKG signaling pathway     8660 (IRS2)    04152 AMPK signaling pathway     8660 (IRS2)  09140 Cellular Processes   09141 Transport and catabolism    04140 Autophagy - animal     8660 (IRS2)  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     8660 (IRS2)    04923 Regulation of lipolysis in adipocytes     8660 (IRS2)    04920 Adipocytokine signaling pathway     8660 (IRS2)    04935 Growth hormone synthesis, secretion and action     8660 (IRS2)   09149 Aging    04211 Longevity regulating pathway     8660 (IRS2)    04213 Longevity regulating pathway - multiple species     8660 (IRS2)  09160 Human Diseases   09161 Cancer: overview    05206 MicroRNAs in cancer     8660 (IRS2)   09164 Neurodegenerative disease    05010 Alzheimer disease     8660 (IRS2)   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     8660 (IRS2)    04932 Non-alcoholic fatty liver disease     8660 (IRS2)    04931 Insulin resistance     8660 (IRS2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  IRS PH PH_11 MEKK4_N Motif Other DBs NCBI-GeneID:  8660 NCBI-ProteinID:  NP_003740 OMIM:  600797 HGNC:  6126 Ensembl:  ENSG00000185950 UniProt:  Q9Y4H2 Q9P084 Structure PDB LinkDB All DBs Position 13:complement(109752695..109786583) Genome browser AA seq 1338 aa AA seqDB search MASPPRHGPPGPASGDGPNLNNNNNNNNHSVRKCGYLRKQKHGHKRFFVLRGPGAGGDEA TAGGGSAPQPPRLEYYESEKKWRSKAGAPKRVIALDCCLNINKRADAKHKYLIALYTKDE YFAVAAENEQEQEGWYRALTDLVSEGRAAAGDAPPAAAPAASCSASLPGALGGSAGAAGA EDSYGLVAPATAAYREVWQVNLKPKGLGQSKNLTGVYRLCLSARTIGFVKLNCEQPSVTL QLMNIRRCGHSDSFFFIEVGRSAVTGPGELWMQADDSVVAQNIHETILEAMKALKELFEF RPRSKSQSSGSSATHPISVPGARRHHHLVNLPPSQTGLVRRSRTDSLAATPPAAKCSSCR VRTASEGDGGAAAGAAAAGARPVSVAGSPLSPGPVRAPLSRSHTLSGGCGGRGSKVALLP AGGALQHSRSMSMPVAHSPPAATSPGSLSSSSGHGSGSYPPPPGPHPPLPHPLHHGPGQR PSSGSASASGSPSDPGFMSLDEYGSSPGDLRAFCSHRSNTPESIAETPPARDGGGGGEFY GYMTMDRPLSHCGRSYRRVSGDAAQDLDRGLRKRTYSLTTPARQRPVPQPSSASLDEYTL MRATFSGSAGRLCPSCPASSPKVAYHPYPEDYGDIEIGSHRSSSSNLGADDGYMPMTPGA ALAGSGSGSCRSDDYMPMSPASVSAPKQILQPRAAAAAAAAVPSAGPAGPAPTSAAGRTF PASGGGYKASSPAESSPEDSGYMRMWCGSKLSMEHADGKLLPNGDYLNVSPSDAVTTGTP PDFFSAALHPGGEPLRGVPGCCYSSLPRSYKAPYTCGGDSDQYVLMSSPVGRILEEERLE PQATPGPSQAASAFGAGPTQPPHPVVPSPVRPSGGRPEGFLGQRGRAVRPTRLSLEGLPS LPSMHEYPLPPEPKSPGEYINIDFGEPGARLSPPAPPLLASAASSSSLLSASSPASSLGS GTPGTSSDSRQRSPLSDYMNLDFSSPKSPKPGAPSGHPVGSLDGLLSPEASSPYPPLPPR PSASPSSSLQPPPPPPAPGELYRLPPASAVATAQGPGAASSLSSDTGDNGDYTEMAFGVA ATPPQPIAAPPKPEAARVASPTSGVKRLSLMEQVSGVEAFLQASQPPDPHRGAKVIRADP QGGRRRHSSETFSSTTTVTPVSPSFAHNPKRHNSASVENVSLRKSSEGGVGVGPGGGDEP PTSPRQLQPAPPLAPQGRPWTPGQPGGLVGCPGSGGSPMRRETSAGFQNGLNYIAIDVRE EPGLPPQPQPPPPPLPQPGDKSSWGRTRSLGGLISAVGVGSTGGGCGGPGPGALPPANTY ASIDFLSHHLKEATIVKE NT seq 4017 nt NT seq  +upstreamnt  +downstreamnt atggcgagcccgccgcggcacgggccgcccgggccggcgagcggagacggccccaacctc aacaacaacaacaacaacaacaaccacagcgtgcgcaagtgcggctacctgcgcaagcag aagcatggccacaagcgcttcttcgtgctgcgcggacccggcgcgggcggcgacgaggcg acggcgggcggggggtcggcgccgcaaccgccgcggctcgagtactacgagagcgagaaa aagtggcggagcaaggcaggcgcgccgaaacgggtgatcgctctcgactgctgcctgaac atcaacaagcgcgccgacgccaagcacaagtacctgatcgccctctacaccaaggacgag tacttcgccgtggccgccgagaacgagcaggagcaggagggctggtaccgcgcgctcacc gacctggtcagcgagggccgcgcggccgccggagacgcgccccccgccgccgcgcccgcc gcgtcctgcagcgcctccctgcccggcgccctgggcggctctgccggcgccgccggggcc gaggacagctacgggctggtggctcccgccacggccgcctaccgtgaggtgtggcaggtg aacctgaagcccaagggtctgggccagagcaagaacctgacgggggtgtaccgtctgtgc ctgtctgcgcgcaccatcggcttcgtgaagctcaactgcgagcagccgtcggtgacgctg cagctcatgaacatccgccgctgcggccactcggacagcttcttcttcatcgaggtgggc cgctcggccgtcacaggccccggcgagctgtggatgcaggcggacgactcggtggtggcg cagaacatccacgagaccatcctggaggccatgaaggcgctcaaggagctcttcgagttc cggccgcgcagtaagagccaatcgtcggggtcgtcggccacgcaccccatcagcgtcccc ggcgcgcgccgccaccaccacctggtcaacctgccccccagccagacgggcctggtgcgc cgctcgcgcaccgacagcctggccgccaccccgccggcggccaagtgcagctcgtgccgg gtgcgcaccgccagcgagggcgacggcggcgcggcggcgggagcggcggccgcgggcgcc aggccggtgtcggtggctgggagccccctgagccccgggccggtgcgcgcgcccctgagc cgctcgcacaccctgagcggcggctgcggcggccgcgggagcaaggtggcgctgctgccg gcagggggcgcgctgcaacacagccgctccatgtccatgcccgtggcgcactcgccgccc gccgccaccagccccggctccctgtcgtccagcagcggccacggctcgggctcctacccg ccgccgcccggcccgcacccgcctctgccgcatccgctgcaccacggccccggccagcgg ccctccagcggcagcgcctccgcctcgggctcccccagcgaccccggcttcatgtccctg gacgagtacggctccagcccaggcgacctgcgcgccttctgcagccaccgaagcaacacg cccgagtccatcgcggagacgcccccggcccgagacggcggcggcggcggtgagttctac gggtacatgaccatggacaggcccctgagccactgtggccgctcctaccgccgggtctcg ggggacgcggcccaggacctggaccgagggctgcgcaagaggacctactccctgaccacg ccagcccggcagcggccggtgccccagccctcctctgcctcgctggatgaatacaccctg atgcgggccaccttctcgggcagcgcgggccgcctctgcccgtcctgccccgcgtcctct cccaaggtggcctaccacccctacccagaggactacggagacatcgagatcggctcccac aggagctccagcagcaacctgggggcagacgacggctacatgcccatgacgcccggcgcg gccctcgcgggcagtgggagcggcagctgcaggagcgacgactacatgcccatgagcccc gccagcgtgtccgcccccaagcagatcttgcagcccagggccgccgccgccgccgccgcc gccgtgccttctgcggggcctgcggggccagcacccacctctgcggcgggcaggacattc ccggcgagcgggggcggctacaaggccagctcgcccgccgagagctcccccgaggacagt gggtacatgcgcatgtggtgcggttccaagctgtccatggagcatgcagatggcaagctg ctgcccaacggggactacctcaacgtgtcccccagcgacgcggtcaccacgggcaccccg cccgacttcttctccgcagccctgcaccccggcggggagccgctcaggggcgttcccggc tgctgctacagctccttgccccgctcctacaaggccccctacacctgtggcggggacagc gaccagtacgtgctcatgagctcccccgtggggcgcatcctggaggaggagcgtctggag cctcaggccacgccagggcccagccaggcggccagcgccttcggggccggccccacgcag ccccctcaccctgtagtgccttcgcccgtgcggcctagcggcggccgcccggagggcttc ttgggccagcgcggccgggcggtgaggcccacgcgcctgtccctggaggggctgcccagc ctgcccagcatgcacgagtacccactgccaccggagcccaagagccccggcgagtacatc aacatcgactttggcgagcccggggcccgcctgtcgccgcccgcgcctcccctgctggcg tcggcggcctcgtcctcctcgctcttgtccgccagcagcccggcctcgtcgctgggctca ggcaccccgggcaccagcagcgacagccggcagcggtctccgctctccgactacatgaac ctcgacttcagctcccccaagtctcctaagccgggcgccccgagcggccaccccgtgggc tccttggacggcctcctgtcccccgaggcctcctccccgtatccgccgttgcccccgcgt ccgtccgcgtccccgtcgtcgtctctgcagccgccgccaccgccgccggccccgggggag ctgtaccgcctgccccccgcctcggccgttgccaccgcccagggcccgggcgccgcctca tcgttgtcctcggacaccggggacaatggtgactacaccgagatggcttttggtgtggcc gccaccccgccgcaacctatcgcggcccccccgaagccagaagctgcccgcgtggccagc ccgacgtcgggcgtgaagaggctgagcctcatggagcaggtgtcgggagtcgaggccttc ctgcaggccagccagcccccggacccccaccgcggcgccaaggtcatccgcgcagacccg caggggggccgccgccgccacagttccgagaccttctcctccaccacgacggtcaccccc gtgtccccgtccttcgcccacaaccccaagcgccacaactcggcctccgtggaaaatgtc tctctcaggaaaagcagcgagggcggcgtgggtgtcggccctggagggggcgacgagccg cccacctccccacgacagttgcagccggcgccccctttggcaccgcagggccggccgtgg accccgggtcagcccgggggcttggtcggttgtcctgggagcggtggatcgcccatgcgc agagagacctctgccggcttccagaatggtctcaactacatcgccatcgacgtgagggag gagcccgggctgccaccccagccgcagccgccgccgccgccgcttcctcagccgggagac aagagctcctggggccggacccgaagcctcgggggtctcatcagcgctgtgggcgtcggc agcaccggcggcgggtgcggggggccgggtcccggtgccctgccccctgccaacacctac gccagcattgacttcttgtcccaccacttgaaggaggccaccatcgtgaaagagtga

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