KEGG ORTHOLOGY: K00037

ORTHOLOGY: K00037

Entry

K00037                      KO

Symbol

AKR1C4

Name

3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase [EC:1.1.1.50 1.1.1.357 1.1.1.225]

Pathway

map00120

Primary bile acid biosynthesis

map00140

Steroid hormone biosynthesis

map01100

Metabolic pathways

map05208

Chemical carcinogenesis - reactive oxygen species

Module

M00104

Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate

M00977

C19-Steroid hormone biosynthesis (androgen backdoor pathway), pregnenolone => androsterone => dihydrotestosterone

Reaction

R02476

androsterone:NAD+ oxidoreductase

R02477

androsterone:NADP+ oxidoreductase

R04309

3alpha-hydroxy-5beta-androstan-17-one:NAD+ oxidoreductase (B-specific)

R04310

3alpha-hydroxy-5beta-androstan-17-one:NADP+ oxidoreductase (B-specific)

R04818

3alpha,7alpha-dihydroxy-5beta-cholestane:NAD+ oxidoreductase (B-specific)

R04819

3alpha,7alpha-dihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific)

R04824

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane:NAD+ oxidoreductase (B-specific)

R04825

3alpha,7alpha,12alpha-trihydroxy-5beta-cholestane:NADP+ oxidoreductase (B-specific)

R04829

urocortisone:NAD+ oxidoreductase (B-specific)

R04830

urocortisone:NADP+ oxidoreductase (B-specific)

R04832

urocortisol:NAD+ oxidoreductase (B-specific)

R04833

urocortisol:NADP+ oxidoreductase (B-specific)

R04835

3alpha,11beta,21-trihydroxy-20-oxo-5beta-pregnan-18-al:NAD+ oxidoreductase (B-specific)

R04836

3alpha,11beta,21-trihydroxy-20-oxo-5beta-pregnan-18-al:NADP+ oxidoreductase (B-specific)

R04837

tetrahydrocorticosterone:NAD+ oxidoreductase (B-specific)

R04838

tetrahydrocorticosterone:NADP+ oxidoreductase (B-specific)

R04842

3alpha,21-dihydroxy-5beta-pregnane-11,20-dione:NAD+ oxidoreductase (B-specific)

R04843

3alpha,21-dihydroxy-5beta-pregnane-11,20-dione:NADP+ oxidoreductase (B-specific)

R04845

3alpha-hydroxy-5beta-pregnane-20-one:NAD+ oxidoreductase (B-specific)

R04846

3alpha-hydroxy-5beta-pregnane-20-one:NADP+ oxidoreductase (B-specific)

R08963

androstan-3alpha,17beta-diol:NADP+ oxidoreductase

R13216

5alpha-pregnane-3alpha,17alpha-diol-20-one:NAD+ oxidoreductase

R13217

5alpha-pregnane-3alpha,17alpha-diol-20-one:NADP+ 3-oxidoreductase

Disease

H00607

46,XY gonadal dysgenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00120 Primary bile acid biosynthesis
    K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
   00140 Steroid hormone biosynthesis
    K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
09160 Human Diseases
  09161 Cancer: overview
   05208 Chemical carcinogenesis - reactive oxygen species
    K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.50  3alpha-hydroxysteroid 3-dehydrogenase (Si-specific)
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
    1.1.1.225  chlordecone reductase
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase
    1.1.1.357  3alpha-hydroxysteroid 3-dehydrogenase
     K00037  AKR1C4; 3alpha-hydroxysteroid 3-dehydrogenase / chlordecone reductase

Other DBs

GO:	0047042 0047743

Genes

HSA:	1109(AKR1C4)

PTR:	450274(AKR1C4)

PPS:	100987989(AKR1C4)

GGO:

101148343

PON:	100434557(AKR1C4)

NLE:

100605385

HMH:	116461800(AKR1C4)

MCC:	722483 722490(AKR1C4)

MCF:	102116844 102117205(AKR1C4)

MTHB:

MNI:

CSAB:

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:	117082119 117082359

CANG:

105521699 105521705

CJC:	100405255 100405615(AKR1C4)

SBQ:

101041915

CIMI:

108292324(AKR1C4) 108292325

OGA:

MMMA:

GVR:

ECB:

EPZ:

EAI:

LAV:

DNM:

XLA:	108712557(akr1c4.S)

XTR:	496490(akr1c4)

NPR:

RTEM:

BBUF:

BGAR:

Reference

PMID:3479982

Authors

Penning TM, Sharp RB

Title

Prostaglandin dehydrogenase activity of purified rat liver 3 alpha-hydroxysteroid dehydrogenase.

Journal

Biochem Biophys Res Commun 148:646-52 (1987)
DOI:10.1016/0006-291X(87)90925-9

Reference

PMID:8172617

Authors

Deyashiki Y, Ogasawara A, Nakayama T, Nakanishi M, Miyabe Y, Sato K, Hara A

Title

Molecular cloning of two human liver 3 alpha-hydroxysteroid/dihydrodiol dehydrogenase isoenzymes that are identical with chlordecone reductase and bile-acid binder.

Journal

Biochem J 299 ( Pt 2):545-52 (1994)
DOI:10.1042/bj2990545

Sequence

[hsa:1109]

Reference

PMID:2187532

Authors

Winters CJ, Molowa DT, Guzelian PS

Title

Isolation and characterization of cloned cDNAs encoding human liver chlordecone reductase.

Journal

Biochemistry 29:1080-7 (1990)
DOI:10.1021/bi00456a034

Sequence

[hsa:1109]

LinkDB

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