KEGG   ORTHOLOGY: K07433
Entry
K07433                      KO                                     
Symbol
CYP11B2
Name
steroid 11beta-monooxygenase / corticosterone 18-monooxygenase [EC:1.14.15.4 1.14.15.5]
Pathway
map00140  Steroid hormone biosynthesis
map01100  Metabolic pathways
map04925  Aldosterone synthesis and secretion
Module
M00108  C21-Steroid hormone biosynthesis, progesterone => corticosterone/aldosterone
Reaction
R02218  progesterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)
R02725  androstenedione,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)
R02843  steroid,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)
R03262  corticosterone,reduced-adrenal-ferredoxin:oxygen oxidoreductase (18-hydroxylating)
R03263  
R03329  steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11-hydroxylating)
R03851  11-deoxycorticosterone,reduced ferredoxin:oxygen oxidoreductase (11-hydroxylating)
R04850  17alpha,21-dihydroxypregnenolone:oxygen oxidoreductase (11-hydroxylating)
Disease
H00258  Aldosterone synthase deficiency
H00602  Glucocorticoid-remediable aldosteronism (GRA)
H01633  High blood pressure
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
 09150 Organismal Systems
  09152 Endocrine system
   04925 Aldosterone synthesis and secretion
    K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.4  steroid 11beta-monooxygenase
     K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
    1.14.15.5  corticosterone 18-monooxygenase
     K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP11 family
   K07433  CYP11B2; steroid 11beta-monooxygenase / corticosterone 18-monooxygenase
Other DBs
GO: 0004507 0047783
Genes
HSA: 1585(CYP11B2)
PTR: 745937(CYP11B2)
PPS: 100971238(CYP11B2)
GGO: 101142418
PON: 100461139
NLE: 115830633
MCC: 695914(CYP11B2)
MCF: 102137301(CYP11B2)
MTHB: 126961020 126961026
MNI: 105483796 105488428
CSAB: 103237547(CYP11B2)
CATY: 105581294
PANU: 101002842
MLEU: 105536288
RRO: 104679775
RBB: 108536550
TFN: 117078861
CANG: 105509012
CJC: 100415304(CYP11B2)
CIMI: 108291253(CYP11B1) 108291254(CYP11B2)
CSYR: 103276450
MMUR: 105867373 105867374
LCAT: 123644516 123644520
PCOQ: 105813307 105813360
OGA: 100948396 100958146
HGL: 101700701
CPOC: 100379213(Cyp11b2) 100727186
GVR: 103599088 103604864 103604866
 » show all
Reference
PMID:2592361
  Authors
Mornet E, Dupont J, Vitek A, White PC
  Title
Characterization of two genes encoding human steroid 11 beta-hydroxylase (P-450(11) beta).
  Journal
J Biol Chem 264:20961-7 (1989)
  Sequence
[hsa:1585]
Reference
PMID:12452430
  Authors
Bureik M, Lisurek M, Bernhardt R
  Title
The human steroid hydroxylases CYP1B1 and CYP11B2.
  Journal
Biol Chem 383:1537-51 (2002)
DOI:10.1515/BC.2002.174
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