KEGG ORTHOLOGY: K17451

ORTHOLOGY: K17451

Entry

K17451                      KO

Symbol

EZH1

Name

[histone H3]-lysine27 N-trimethyltransferase EZH1 [EC:2.1.1.356]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map03083

Polycomb repressive complex

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
09120 Genetic Information Processing
  09126 Chromosome
   03083 Polycomb repressive complex
    K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.356  [histone H3]-lysine27 N-trimethyltransferase
     K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
   Polycomb repressive complex (PRC) and associated proteins
    PRC2.1
     K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1
    PRC2.2
     K17451  EZH1; [histone H3]-lysine27 N-trimethyltransferase EZH1

Other DBs

GO:

0046976

Genes

HSA:	2145(EZH1)

PTR:	454697(EZH1)

PPS:	100967877(EZH1)

GGO:	101126515(EZH1)

PON:	100171872(EZH1)

NLE:	100604860(EZH1)

HMH:	116474881(EZH1)

MCC:	711173(EZH1)

MCF:	102130547(EZH1)

MTHB:

126938434

MNI:	105472105(EZH1)

CSAB:

103243395(EZH1)

CATY:

105579681(EZH1)

PANU:

101009052(EZH1)

TGE:	112609092(EZH1)

MLEU:

105552946(EZH1)

RRO:	104680126(EZH1)

RBB:	108526767(EZH1)

TFN:	117066944(EZH1)

PTEH:

111537351(EZH1)

CANG:

105502991(EZH1)

CJC:	100411881(EZH1)

SBQ:	101038203(EZH1)

CIMI:

108289813(EZH1)

CSYR:

103270693(EZH1)

MMUR:

105859397(EZH1)

LCAT:

123620971(EZH1)

PCOQ:

105820263(EZH1)

OGA:	100953538(EZH1)

MMU:	14055(Ezh1)

MCAL:

110304611(Ezh1)

MPAH:

110331872(Ezh1)

RNO:	303547(Ezh1)

MCOC:

116078739(Ezh1)

ANU:	117710591(Ezh1)

MUN:	110550881(Ezh1)

CGE:	100760595(Ezh1)

MAUA:

101829787(Ezh1)

PROB:

127216586(Ezh1)

PLEU:

114682787(Ezh1)

MORG:

121442390(Ezh1)

MFOT:

126510201

AAMP:

119811825(Ezh1)

NGI:	103735912(Ezh1)

HGL:	101723063(Ezh1)

CPOC:

100720693(Ezh1)

CCAN:

109687337(Ezh1)

DORD:

106003218(Ezh1)

DSP:	122103240(Ezh1)

PLOP:

125365186(Ezh1)

NCAR:

124979151

MMMA:

107150556(Ezh1)

OCU:

100351852

OPI:	101532815(EZH1)

TUP:	102485788(EZH1)

GVR:	103589846(EZH1)

CFA:	480516(EZH1)

CLUD:

112655496(EZH1)

VVP:	112910738(EZH1)

VLG:	121473241(EZH1)

NPO:	129508144(EZH1)

AML:	100472619(EZH1)

UMR:	103672584(EZH1)

UAH:	113265406(EZH1)

UAR:	123781811(EZH1)

ELK:

111151338

LLV:

125087359

MPUF:

101683241(EZH1)

MNP:	132004387(EZH1)

MLK:	131816628(EZH1)

NVS:	122906181(EZH1)

ORO:	101379551(EZH1)

EJU:	114201361(EZH1)

ZCA:	113939411(EZH1)

MLX:	118024929(EZH1)

NSU:	110573309(EZH1)

LWW:

102750824

FCA:	101099602(EZH1)

PYU:	121045039(EZH1)

PCOO:

112854058(EZH1)

PBG:	122485620(EZH1)

PVIV:

125158457(EZH1)

LRUF:

124522075

PTG:	102961028(EZH1)

PPAD:

109258535(EZH1)

PUC:

125927686

AJU:

106972615

HHV:	120248460(EZH1)

BTA:	533087(EZH1)

BOM:	102276653(EZH1)

BIU:	109573994(EZH1)

BBUB:

102407322(EZH1)

BBIS:

104990428(EZH1)

CHX:	102189343(EZH1)

OAS:	101104765(EZH1)

BTAX:

128064455(EZH1)

ODA:	120867077(EZH1)

CCAD:

122441439(EZH1)

MBEZ:

129544439(EZH1)

SSC:	100518394(EZH1)

CFR:	102516907(EZH1)

CBAI:

105080100(EZH1)

CDK:	105090473(EZH1)

VPC:	102537185(EZH1)

BACU:

103015379 103020966

BMUS:

118886863(EZH1)

LVE:	103073364(EZH1)

OOR:	101285746(EZH1)

DLE:	111166246(EZH1)

PCAD:

102994197(EZH1)

PSIU:

116745673(EZH1)

NASI:

112398349(EZH1)

ECB:	100052411(EZH1)

EPZ:	103550351(EZH1)

EAI:	106826432(EZH1)

MYB:	102259730(EZH1)

MYD:	102755313(EZH1)

MMYO:

118671482(EZH1)

MLF:	102417096(EZH1)

PKL:	118726309(EZH1)

EFUS:

103293078(EZH1)

MNA:	107528927(EZH1)

DRO:	112298572(EZH1)

SHON:

118978195(EZH1)

AJM:	119051949(EZH1)

PDIC:

114502985(EZH1)

PHAS:

123817024(EZH1)

MMF:	118633783(EZH1)

PPAM:

129086995(EZH1)

HAI:	109395755(EZH1)

RFQ:	117012939(EZH1)

PALE:

102879627(EZH1)

PGIG:

120611077(EZH1)

PVP:	105306277(EZH1)

RAY:	107513838(EZH1)

MJV:	108386069(EZH1)

TOD:	119230360(EZH1)

SARA:

101556796(EZH1)

SETR:

126017177(EZH1)

LAV:	100673691(EZH1)

TMU:

101360468

ETF:	101658357(EZH1)

DNM:	101440065(EZH1)

MDO:	100010738(EZH1)

GAS:	123247838(EZH1)

SHR:	100932535(EZH1)

AFZ:

127560106

PCW:	110198374(EZH1)

OAA:	100082851(EZH1)

GGA:	420023(EZH1)

PCOC:

116233592(EZH1)

MGP:	100547448(EZH1)

CJO:	107325326(EZH1)

TPAI:

128089108(EZH1)

LMUT:

125684708(EZH1)

NMEL:

110388515(EZH1)

APLA:

101791765(EZH1)

ACYG:

106048025(EZH1)

CATA:

118259168(EZH1)

AFUL:

116498539(EZH1)

TGU:	100227472(EZH1)

LSR:	110471820(EZH1)

SCAN:

103821570(EZH1)

PMOA:

120496610(EZH1)

OTC:	121347663(EZH1)

PRUF:

121351146(EZH1)

GFR:	102035477(EZH1)

FAB:	101811414(EZH1)

OMA:	130263963(EZH1)

PHI:	102103576(EZH1)

PMAJ:

107215126(EZH1)

CCAE:

111940096(EZH1)

CCW:	104697765(EZH1)

CBRC:

103621230(EZH1)

ETL:	114063607(EZH1)

ZAB:	102071551(EZH1)

ACHL:

103801322(EZH1)

SVG:	106858696(EZH1)

MMEA:

130581428(EZH1)

HRT:	120763768(EZH1)

FPG:	101915579(EZH1)

FCH:	102052374(EZH1)

CLV:	102097006(EZH1)

EGZ:	104134781(EZH1)

NNI:	104009878(EZH1)

PCRI:

104034436(EZH1)

PLET:

104614357(EZH1)

ACUN:

113489070

TALA:

104365743 122152827

PADL:

103919098(EZH1)

AFOR:

103901881(EZH1)

ACHC:

115344618(EZH1)

HALD:

104322961(EZH1)

HLE:	104842949(EZH1)

AGEN:

126038535

GCL:

127026423

CCRI:

104160341

CSTI:

104557499(EZH1)

CMAC:

104487486(EZH1)

MUI:	104545865(EZH1)

BREG:

104641591

FGA:	104077897(EZH1)

GSTE:

104261338(EZH1)

LDI:	104342534(EZH1)

OHA:	104338691(EZH1)

SHAB:

115617636(EZH1)

DPUB:

104309571(EZH1)

CPEA:

104385652(EZH1)

CVF:	104295343(EZH1)

RTD:	128919318(EZH1)

CUCA:

104054392(EZH1)

TEO:	104375779(EZH1)

AAM:	106491114(EZH1)

AROW:

112968758(EZH1)

NPD:	112951845(EZH1)

TGT:	104578212(EZH1)

DNE:	112995826(EZH1)

SCAM:

104153616(EZH1)

ASN:	102383438(EZH1)

AMJ:	102566481(EZH1)

CPOO:

109320378(EZH1)

GGN:	109289608(EZH1)

PSS:	102463087(EZH1)

CMY:	102934538(EZH1)

CCAY:

125626681(EZH1)

DCC:	119848921(EZH1)

CPIC:

101934118(EZH1)

TST:	117869136(EZH1)

CABI:

116820359(EZH1)

MRV:	120392159(EZH1)

ACS:	100559669(ezh1)

ASAO:

132778389(EZH1)

PVT:	110080273(EZH1)

SUND:

121934119(EZH1)

PBI:	103052924(EZH1)

PMUR:

107302416(EZH1)

CTIG:

120301016(EZH1)

TSR:	106554239(EZH1)

PGUT:

117664836(EZH1)

APRI:

131197311(EZH1)

PTEX:

113447275(EZH1)

NSS:	113420059(EZH1)

VKO:	123031879(EZH1)

PMUA:

114581626(EZH1)

PRAF:

128400001(EZH1)

ZVI:	118094881(EZH1)

HCG:	128330017(EZH1)

GJA:	107123351(EZH1)

EMC:	129338808(EZH1)

XLA:	108701022(ezh1.L) 108702719(ezh1.S)

XTR:	100493532(ezh1)

NPR:	108796324(EZH1)

RTEM:

120918306(EZH1)

BBUF:

121004042(EZH1)

BGAR:

122941062(EZH1)

MUO:	115481816(EZH1)

GSH:	117347407(EZH1)

DRE:	664754(ezh1)

SRX:	107720007 107721487

SANH:

107654511 107688127

SGH:	107590376 107601290

CCAR:

109057529 109102790

CAUA:

113046841 113097179

CGIB:

127951387 127952888

PTET:

122342087(ezh1)

LROH:

127163486(ezh1)

OMC:	131536328(ezh1)

PPRM:

120489865(ezh1)

RKG:	130076064(ezh1)

MAMB:

125271852(ezh1)

CIDE:

127509033

MASI:

127449771 127451124

TROS:

130561746(ezh1)

TDW:	130426412(ezh1)

MANU:

129433583(ezh1) 129433788

IPU:

108279279

IFU:	128603001(ezh1)

PHYP:

113528051(ezh1)

SMEO:

124396605(ezh1)

TFD:	113652122(ezh1)

TVC:	132861544(ezh1)

AMEX:

103044086(ezh1)

CMAO:

118820890(ezh1)

EEE:

113590056

CHAR:

105898624(ezh1)

TRU:	101070195(ezh1)

TFS:	130514975(ezh1)

TNG:	GSTEN00022022G001

LCO:	104923910(ezh1)

NCC:

104944052

TBEN:

117493372(ezh1)

CGOB:

115012089(ezh1)

PGEO:

117451145(ezh1)

GACU:

117548328(ezh1)

EMAC:

134878111(ezh1)

ELY:	117268570(ezh1)

EFO:	125880116(ezh1)

PLEP:

121956843(ezh1)

SLUC:

116059672(ezh1)

ECRA:

117957411(ezh1)

ESP:	116702481(ezh1)

PFLV:

114569339(ezh1)

GAT:	120828335(ezh1)

PPUG:

119220821(ezh1)

AFB:	129097979(ezh1)

CLUM:

117734833(ezh1)

PSWI:

130188705(ezh1)

MSAM:

119892146(ezh1)

SCHU:

122868348(ezh1)

CUD:	121529431(ezh1)

ALAT:

119014259(ezh1)

MZE:	101474304(ezh1)

ONL:	100695015(ezh1)

OAU:	116312482(ezh1)

OLA:	101166385(ezh1)

OML:	112146093(ezh1)

CSAI:

133421960(ezh1)

XMA:	102228014(ezh1)

XCO:	114160264(ezh1)

XHE:	116735642(ezh1)

PRET:

103468644(ezh1) 103469387

PFOR:

103142220

PLAI:

106952635

PMEI:

106917493(ezh1)

GAF:	122821237(ezh1)

PPRL:

129352499(ezh1)

CVG:	107091776(ezh1)

CTUL:

119778867(ezh1)

GMU:	124863422 124864203

NFU:	107378461(ezh1)

KMR:	108243802(ezh1)

ALIM:

106528219(ezh1)

NWH:	119421914(ezh1)

AOCE:

111564547(ezh1)

MCEP:

124998234(ezh1)

CSEM:

103393149(ezh1)

POV:	109634330(ezh1)

SSEN:

122785080(ezh1)

HHIP:

117765699(ezh1)

HSP:	118123196(ezh1)

SMAU:

118288457(ezh1)

LCF:

108900993

SDU:	111217595(ezh1)

SLAL:

111660565(ezh1)

XGL:	120785995(ezh1)

HCQ:

109508596

SSCV:

125983811

SBIA:

133514174(ezh1)

PEE:	133414903(ezh1)

PTAO:

133465488(ezh1)

BPEC:

110166859(ezh1)

MALB:

109964204(ezh1)

BSPL:

114859794(ezh1)

SJO:	128378277(ezh1)

SASA:

106601045 106607313

STRU:

115171134 115198163

OTW:	112226003 112258676(ezh1)

OMY:	110486277 110538212

OGO:	123999293 124015525

ONE:	115104148 115110290

OKI:	109891924 109898438

OKE:	118365283 118370832

SALP:

111980227

SNH:	120034253 120036107

CCLU:

121550571 121569566

ELS:	105013194(ezh1)

SFM:	108928200 108941744

PKI:	111842507 111855907

AANG:

118221790(ezh1)

LOC:	102693111(ezh1)

PSPA:

121301885(ezh1) 121324064

ARUT:

117433259(ezh1) 117434945

PSEX:

120518228(ezh1)

LCM:	102364190(EZH1)

HOC:	132830997(ezh1)

BCOO:

DFR:

CBR:

MCAF:

GSL:	Gasu_06840

» show all

Reference

PMID:19026781

Authors

Margueron R, Li G, Sarma K, Blais A, Zavadil J, Woodcock CL, Dynlacht BD, Reinberg D

Title

Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms.

Journal

Mol Cell 32:503-18 (2008)
DOI:10.1016/j.molcel.2008.11.004

Sequence

[hsa:2145]

LinkDB

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