KEGG   ORTHOLOGY: K18276
Entry
K18276                      KO                                     
Symbol
hspB
Name
6-hydroxy-3-succinoylpyridine 3-monooxygenase [EC:1.14.13.163]
Pathway
map00760  Nicotinate and nicotinamide metabolism
map01100  Metabolic pathways
map01120  Microbial metabolism in diverse environments
Module
M00811  Nicotine degradation, pyrrolidine pathway, nicotine => succinate semialdehyde
Reaction
R09472  4-(6-hydroxypyridin-3-yl)-4-oxobutanoate,NADH:oxygen oxidoreductase (3-hydroxylating, succinate semialdehyde releasing)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K18276  hspB; 6-hydroxy-3-succinoylpyridine 3-monooxygenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.163  6-hydroxy-3-succinoylpyridine 3-monooxygenase
     K18276  hspB; 6-hydroxy-3-succinoylpyridine 3-monooxygenase
Other DBs
GO: 0034910
Genes
PPT: PPS_4061
PMON: X969_19895
PMOT: X970_19530
PMED: E3Z27_20725(hspB)
PVK: EPZ47_21865
PSJY: AA098_03885 AA098_21340
MBRG: PVT68_16200
SNAP: PQ455_11180
SLAA: EUU25_06880
ACOB: P0Y56_10165 P0Y56_13060
 » show all
Reference
  Authors
Tang H, Yao Y, Zhang D, Meng X, Wang L, Yu H, Ma L, Xu P
  Title
A novel NADH-dependent and FAD-containing hydroxylase is crucial for nicotine degradation by Pseudomonas putida.
  Journal
J Biol Chem 286:39179-87 (2011)
DOI:10.1074/jbc.M111.283929
  Sequence
[ppt:PPS_4061]
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