KEGG   ORTHOLOGY: K02161
Entry
K02161                      KO                                     
Symbol
BCL2
Name
apoptosis regulator Bcl-2
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map01524  Platinum drug resistance
map04064  NF-kappa B signaling pathway
map04066  HIF-1 signaling pathway
map04071  Sphingolipid signaling pathway
map04115  p53 signaling pathway
map04140  Autophagy - animal
map04141  Protein processing in endoplasmic reticulum
map04151  PI3K-Akt signaling pathway
map04210  Apoptosis
map04215  Apoptosis - multiple species
map04217  Necroptosis
map04261  Adrenergic signaling in cardiomyocytes
map04340  Hedgehog signaling pathway
map04510  Focal adhesion
map04621  NOD-like receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04722  Neurotrophin signaling pathway
map04725  Cholinergic synapse
map04915  Estrogen signaling pathway
map04928  Parathyroid hormone synthesis, secretion and action
map04933  AGE-RAGE signaling pathway in diabetic complications
map05014  Amyotrophic lateral sclerosis
map05022  Pathways of neurodegeneration - multiple diseases
map05131  Shigellosis
map05132  Salmonella infection
map05145  Toxoplasmosis
map05152  Tuberculosis
map05161  Hepatitis B
map05162  Measles
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05206  MicroRNAs in cancer
map05207  Chemical carcinogenesis - receptor activation
map05210  Colorectal cancer
map05215  Prostate cancer
map05222  Small cell lung cancer
map05226  Gastric cancer
map05417  Lipid and atherosclerosis
map05418  Fluid shear stress and atherosclerosis
Disease
H00005  Chronic lymphocytic leukemia
H00013  Small cell lung cancer
H00028  Choriocarcinoma
H00030  Cervical cancer
H00041  Kaposi sarcoma
H00054  Nasopharyngeal cancer
H01613  Follicular lymphoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K02161  BCL2; apoptosis regulator Bcl-2
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04630 JAK-STAT signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04064 NF-kappa B signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04066 HIF-1 signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04071 Sphingolipid signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04151 PI3K-Akt signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K02161  BCL2; apoptosis regulator Bcl-2
  09143 Cell growth and death
   04210 Apoptosis
    K02161  BCL2; apoptosis regulator Bcl-2
   04215 Apoptosis - multiple species
    K02161  BCL2; apoptosis regulator Bcl-2
   04217 Necroptosis
    K02161  BCL2; apoptosis regulator Bcl-2
   04115 p53 signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K02161  BCL2; apoptosis regulator Bcl-2
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
   04928 Parathyroid hormone synthesis, secretion and action
    K02161  BCL2; apoptosis regulator Bcl-2
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K02161  BCL2; apoptosis regulator Bcl-2
  09156 Nervous system
   04725 Cholinergic synapse
    K02161  BCL2; apoptosis regulator Bcl-2
   04722 Neurotrophin signaling pathway
    K02161  BCL2; apoptosis regulator Bcl-2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05206 MicroRNAs in cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05207 Chemical carcinogenesis - receptor activation
    K02161  BCL2; apoptosis regulator Bcl-2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05226 Gastric cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05215 Prostate cancer
    K02161  BCL2; apoptosis regulator Bcl-2
   05222 Small cell lung cancer
    K02161  BCL2; apoptosis regulator Bcl-2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K02161  BCL2; apoptosis regulator Bcl-2
   05161 Hepatitis B
    K02161  BCL2; apoptosis regulator Bcl-2
   05162 Measles
    K02161  BCL2; apoptosis regulator Bcl-2
   05168 Herpes simplex virus 1 infection
    K02161  BCL2; apoptosis regulator Bcl-2
   05169 Epstein-Barr virus infection
    K02161  BCL2; apoptosis regulator Bcl-2
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K02161  BCL2; apoptosis regulator Bcl-2
   05131 Shigellosis
    K02161  BCL2; apoptosis regulator Bcl-2
   05152 Tuberculosis
    K02161  BCL2; apoptosis regulator Bcl-2
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K02161  BCL2; apoptosis regulator Bcl-2
  09164 Neurodegenerative disease
   05014 Amyotrophic lateral sclerosis
    K02161  BCL2; apoptosis regulator Bcl-2
   05022 Pathways of neurodegeneration - multiple diseases
    K02161  BCL2; apoptosis regulator Bcl-2
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K02161  BCL2; apoptosis regulator Bcl-2
   05418 Fluid shear stress and atherosclerosis
    K02161  BCL2; apoptosis regulator Bcl-2
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K02161  BCL2; apoptosis regulator Bcl-2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K02161  BCL2; apoptosis regulator Bcl-2
   01524 Platinum drug resistance
    K02161  BCL2; apoptosis regulator Bcl-2
   01522 Endocrine resistance
    K02161  BCL2; apoptosis regulator Bcl-2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K02161  BCL2; apoptosis regulator Bcl-2
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K02161  BCL2; apoptosis regulator Bcl-2
Genes
HSA: 596(BCL2)
PTR: 738409(BCL2)
PPS: 100992951(BCL2)
GGO: 101136123(BCL2)
PON: 100938429(BCL2)
NLE: 100599011(BCL2)
HMH: 116468493(BCL2)
MCC: 707407(BCL2)
MCF: 102138212(BCL2)
MTHB: 126941201
MNI: 105477002(BCL2)
CSAB: 103244166(BCL2)
CATY: 105590006(BCL2)
PANU: 101026183(BCL2)
TGE: 112611529(BCL2)
MLEU: 105535165(BCL2)
RRO: 104682248(BCL2)
RBB: 108526412(BCL2)
TFN: 117099723(BCL2)
PTEH: 111528437(BCL2)
CANG: 105520028(BCL2)
CJC: 100408947(BCL2)
SBQ: 101051366(BCL2)
CIMI: 108304605(BCL2)
CSYR: 103274703(BCL2)
MMUR: 105876728(BCL2)
LCAT: 123621883(BCL2)
PCOQ: 105811149(BCL2)
OGA: 100955447(BCL2)
MMU: 12043(Bcl2)
MCAL: 110302433(Bcl2)
MPAH: 110321591(Bcl2)
RNO: 24224(Bcl2)
MCOC: 116097315(Bcl2)
ANU: 117716348(Bcl2)
MUN: 110557800(Bcl2)
CGE: 100774873(Bcl2)
MAUA: 101833785(Bcl2)
PROB: 127236284(Bcl2)
PLEU: 114702810(Bcl2)
MORG: 121445969(Bcl2)
MFOT: 126487103
AAMP: 119827718(Bcl2)
NGI: 103740099(Bcl2)
HGL: 101701667(Bcl2)
CPOC: 100733337(Bcl2)
CCAN: 109693757(Bcl2)
DORD: 105987599(Bcl2)
DSP: 122119434(Bcl2)
PLOP: 125363906(Bcl2)
NCAR: 124965545
MMMA: 107139463(Bcl2)
OCU: 103349397
OPI: 101517543(BCL2)
TUP: 102474592(BCL2)
GVR: 103606686(BCL2)
CFA: 403416(BCL2)
CLUD: 112644027(BCL2)
VVP: 112919203(BCL2)
VLG: 121481811(BCL2)
NPO: 129495480 129514527
AML: 100484344(BCL2)
UMR: 103676164(BCL2)
UAH: 113253490(BCL2)
UAR: 123787450(BCL2)
ELK: 111154217
LLV: 125081686
MPUF: 101681308(BCL2)
MNP: 132023669(BCL2)
MLK: 131811845(BCL2)
NVS: 122902835(BCL2)
ORO: 101372267(BCL2)
EJU: 114208840(BCL2)
ZCA: 113912489(BCL2)
MLX: 118004389(BCL2)
NSU: 110577152(BCL2)
LWW: 102744561(BCL2)
FCA: 493934(BCL2)
PYU: 121032687(BCL2)
PCOO: 112868295(BCL2)
PBG: 122470833(BCL2)
PVIV: 125149087(BCL2)
LRUF: 124517105
PTG: 102953487(BCL2)
PPAD: 109275625(BCL2)
PUC: 125914709
AJU: 106985187
HHV: 120245032(BCL2)
BTA: 281020(BCL2)
BOM: 102268592(BCL2)
BIU: 109577782(BCL2)
BBUB: 102402077(BCL2)
BBIS: 104999231(BCL2)
CHX: 100861254(BCL2)
OAS: 101119602(BCL2)
BTAX: 128067358(BCL2)
ODA: 120880862(BCL2)
CCAD: 122425862(BCL2)
MBEZ: 129549902(BCL2)
SSC: 100049703(BCL2)
CFR: 102518434(BCL2)
CBAI: 105073903(BCL2)
CDK: 105088999(BCL2)
VPC: 102538080(BCL2)
BACU: 103015542(BCL2)
BMUS: 118880049(BCL2)
LVE: 103077294(BCL2)
OOR: 101276750(BCL2)
DLE: 111180199(BCL2)
PCAD: 102987942(BCL2)
PSIU: 116738931(BCL2)
NASI: 112406137(BCL2)
ECB: 100050934(BCL2)
EPZ: 103550767(BCL2)
EAI: 106832883(BCL2)
MYB: 102248597(BCL2)
MYD: 102769473(BCL2)
MMYO: 118663765(BCL2)
MLF: 102432611(BCL2)
PKL: 118707440(BCL2)
EFUS: 103303728(BCL2)
MNA: 107545431(BCL2)
DRO: 112322759(BCL2)
SHON: 118979386(BCL2)
AJM: 119057575(BCL2)
PDIC: 114507071(BCL2)
PHAS: 123826047(BCL2)
MMF: 118619009(BCL2)
PPAM: 129078764(BCL2)
HAI: 109390784(BCL2)
RFQ: 117011845(BCL2)
PALE: 102896443(BCL2)
PGIG: 120584396(BCL2)
PVP: 105292717(BCL2)
RAY: 107503915(BCL2)
MJV: 108385222(BCL2)
TOD: 119243742(BCL2)
SARA: 101545820(BCL2)
SETR: 126020600(BCL2)
LAV: 100675268(BCL2)
TMU: 101347007
ETF: 101659722(BCL2)
DNM: 101445333(BCL2)
MDO: 100016570(BCL2)
GAS: 123238254(BCL2)
SHR: 100934666(BCL2)
AFZ: 127543678
PCW: 110214751(BCL2)
OAA: 114807635(BCL2)
GGA: 396282(BCL2)
PCOC: 116226390(BCL2)
MGP: 100545008(BCL2)
CJO: 107309650(BCL2)
TPAI: 128087755(BCL2)
LMUT: 125690650(BCL2)
NMEL: 110395041(BCL2)
APLA: 110352991(BCL2)
ACYG: 106039908(BCL2)
CATA: 118250974(BCL2)
AFUL: 116486210(BCL2)
TGU: 100224888(BCL2)
LSR: 110470703(BCL2)
SCAN: 108964924(BCL2)
PMOA: 120508336(BCL2)
OTC: 121348363(BCL2)
PRUF: 121358052(BCL2)
GFR: 102032008(BCL2)
FAB: 101818228(BCL2)
OMA: 130249137(BCL2)
PHI: 102113262(BCL2)
PMAJ: 107200701(BCL2)
CCAE: 111923860(BCL2)
CCW: 104698161(BCL2)
CBRC: 103618673(BCL2)
ETL: 114065315(BCL2)
ZAB: 102071693(BCL2)
ACHL: 103807855(BCL2)
SVG: 106850823(BCL2)
MMEA: 130577633(BCL2)
HRT: 120757785(BCL2)
FPG: 101921728(BCL2)
FCH: 102056589(BCL2)
CLV: 102092853(BCL2)
NNI: 104021857(BCL2)
ACUN: 113476058(BCL2)
TALA: 116961324(BCL2)
PADL: 103919231(BCL2)
AFOR: 103898839(BCL2)
ACHC: 115353069(BCL2)
HLE: 104843196(BCL2)
AGEN: 126048590
GCL: 127013629
CSTI: 104554883(BCL2)
CMAC: 104485178(BCL2)
MUI: 104537605(BCL2)
BREG: 104634110
FGA: 104074711(BCL2)
LDI: 104348269(BCL2)
MNB: 103782574(BCL2)
NNT: 104401803(BCL2)
SHAB: 115615414(BCL2)
DPUB: 104304231(BCL2)
PGUU: 104471887
ACAR: 104521957(BCL2)
CPEA: 104391630(BCL2)
RTD: 128905627(BCL2)
CUCA: 104066731(BCL2)
TEO: 104384091
BRHI: 104493687(BCL2)
AAM: 106482986(BCL2)
AROW: 112972797(BCL2)
NPD: 112943408(BCL2)
TGT: 104580966(BCL2)
DNE: 112992509(BCL2)
SCAM: 104145935(BCL2)
ASN: 102370035(BCL2)
AMJ: 102564752(BCL2)
CPOO: 109314888(BCL2)
GGN: 109300860(BCL2)
PSS: 102444136(BCL2)
CMY: 102941395(BCL2)
CCAY: 125632069(BCL2)
DCC: 119851560(BCL2)
CPIC: 101937209(BCL2)
TST: 117873081(BCL2)
CABI: 116832013(BCL2)
MRV: 120398465(BCL2)
ACS: 100564886(bcl2)
ASAO: 132774529(BCL2)
PVT: 110075422(BCL2)
SUND: 121929439(BCL2)
PBI: 103059077(BCL2)
PMUR: 107283580(BCL2)
CTIG: 120297252(BCL2)
TSR: 106551867(BCL2)
PGUT: 117674759(BCL2)
APRI: 131194707(BCL2)
PTEX: 113436597(BCL2)
NSS: 113417136(BCL2)
VKO: 123021682(BCL2)
PMUA: 114600980(BCL2)
ZVI: 118090513(BCL2)
HCG: 128323552(BCL2)
GJA: 107108130
STOW: 125439074(BCL2)
EMC: 129333903(BCL2)
XLA: 100271914(bcl2.S) 108719105(bcl2.L)
XTR: 100485267(bcl2)
NPR: 108793666(BCL2)
RTEM: 120940635(BCL2)
BBUF: 121001044(BCL2)
BGAR: 122937918(BCL2)
MUO: 115472967(BCL2)
GSH: 117356048(BCL2)
DRE: 100007048(bcl2b) 570772(bcl2a)
SRX: 107711715 107727540 107729657 107757715
SANH: 107671740 107677290 107697692
SGH: 107558547 107559382 107590259 107593762
CCAR: 109049771 109050096(bcl2)
CAUA: 113038847 113042494 113046085 113066145
CGIB: 127946353 127950859 128013154 128025189
PTET: 122329786(bcl2a) 122360187(bcl2b)
LROH: 127155642(bcl2a) 127182809(bcl2b)
OMC: 131521209(bcl2b) 131533091(bcl2a)
PPRM: 120482147(bcl2b) 120488185(bcl2a)
RKG: 130084029(bcl2a) 130096571(bcl2b)
MAMB: 125251012(bcl2b) 125258583(bcl2a)
CIDE: 127498514 127505882
MASI: 127431947 127434146 127441660 127442656
TROS: 130547262(bcl2a) 130553901(bcl2b)
TDW: 130413545(bcl2a) 130418423(bcl2b)
MANU: 129425599(bcl2a) 129442741(bcl2b)
IPU: 108256596(bcl2a) 108267470(bcl2b)
IFU: 128599461(bcl2a) 128609779(bcl2b)
PHYP: 113540646 113541265
SMEO: 124375481(bcl2a) 124387116(bcl2b)
TFD: 113640103(bcl2b) 113660203(bcl2a)
TVC: 132840495(bcl2a) 132848205(bcl2b)
AMEX: 103039548 103042278
CMAO: 118798671(bcl2a) 118826264(bcl2b)
EEE: 113570065(bcl2) 113573821
CHAR: 105889308(bcl2a) 105891347(bcl2b)
TRU: 101071405(bcl2)
TFS: 130539428(bcl2b)
LCO: 104918293(bcl2) 104939569
NCC: 104957668
TBEN: 117488347(bcl2b)
CGOB: 115021999(bcl2)
PGEO: 117462238(bcl2b)
GACU: 117558349(bcl2b)
EMAC: 134865945(bcl2b)
ELY: 117262998(bcl2b) 117264318
EFO: 125882016 125901887(bcl2b)
PLEP: 121951449(bcl2b)
SLUC: 116046065(bcl2b) 116057842
ECRA: 117953749(bcl2b)
ESP: 116698657
PFLV: 114549636 114565630
GAT: 120815681(bcl2b)
PPUG: 119209072(bcl2b)
AFB: 129117031(bcl2b)
CLUM: 117746625(bcl2b)
PSWI: 130198144(bcl2b)
MSAM: 119897619 119897632 119902077(bcl2b)
SCHU: 122866503 122887137(bcl2b)
CUD: 121519978(bcl2b)
ALAT: 119011053(bcl2b)
MZE: 101466853(bcl2) 101477921
ONL: 100710191(bcl2) 102079353
OAU: 116316987(bcl2b) 116336531
OLA: 101163032(bcl2)
OML: 112147591(bcl2b)
CSAI: 133452737(bcl2b)
XMA: 102223266(bcl2)
XCO: 114146495(bcl2)
XHE: 116721302(bcl2)
PRET: 103479578(bcl2)
PFOR: 103143027(bcl2)
PLAI: 106949142(bcl2)
PMEI: 106919799(bcl2)
GAF: 122841204(bcl2b)
PPRL: 129361940(bcl2b)
CVG: 107080667 107083382
CTUL: 119782733 119795680(bcl2b)
GMU: 124858074 124870196(bcl2b)
NFU: 107383942(bcl2)
KMR: 108229311 108239676(bcl2b)
ALIM: 106534253(bcl2)
NWH: 119415072(bcl2b)
AOCE: 111579931 111588684
MCEP: 125010408(bcl2b)
CSEM: 103396176(bcl2)
POV: 109640281
SSEN: 122765183(bcl2b)
HHIP: 117778459(bcl2b)
HSP: 118117191(bcl2b)
SMAU: 118310900(bcl2b)
LCF: 108883441(bcl2b) 108890128
SDU: 111236887 111239004(bcl2)
SLAL: 111649666 111666676 111670485(bcl2)
XGL: 120789915 120799277(bcl2b)
HCQ: 109521170
SSCV: 125984498
SBIA: 133510584(bcl2b)
PEE: 133411802(bcl2b)
PTAO: 133488470(bcl2b)
BPEC: 110157967(bcl2)
MALB: 109957760
BSPL: 114844269(bcl2b) 114853980
SJO: 128369151(bcl2b) 128382756
SASA: 106569189 106579593 106590353 106599248
STRU: 115150453 115157106 115169669 115195542
OTW: 112226859 112227752 112232698 112260550
OMY: 110489720(bcl2a) 110508652 110530404 110535287
OGO: 123991358 124009817 124039599 124041790
ONE: 115103013 115104895 115114494 115130175
OKI: 109872384 109874825 109899300 109909828
OKE: 118361192 118370586 118394741 118401676
SALP: 111953485 111972792 111979635
SNH: 120019795 120027961 120051010 120055940
CCLU: 121535292 121549890 121569203 121581520
ELS: 105018981 105027305
SFM: 108931633 108937589
PKI: 111845833 111851660
AANG: 118225426 118233789
LOC: 102684940(bcl2)
PSPA: 121313099 121314579
ARUT: 117394930 117399761
PSEX: 120529419(bcl2b)
CMK: 103183201(bcl2a)
RTP: 109930204
CPLA: 122549716
HOC: 132815631
LERI: 129711578(bcl2b)
CIN: 100183575
SKO: 100374347
ZNE: 110829820
DSV: 119442335
RSAN: 119387224 119396280
RMP: 119159576 119174514
CSCU: 111613180 111619779 111623288
PTEP: 107438756
ABRU: 129966040
PMEO: 129597453
PVUL: 126832132
HRJ: 124273145
MYI: 110449714
MMER: 123530735 123566645
RPHI: 132756454
OSN: 115216413 115220385
EPA: 110231689
ATEN: 116289198 116289912 116299929
ADF: 107334727
AMIL: 114959371
PDAM: 113666743 113675715
SPIS: 111341929
DGT: 114531784
XEN: 124439487 124457023
AQU: 100635395
VG: 26836919(vBcl-2)
 » show all
Reference
PMID:3523487
  Authors
Tsujimoto Y, Croce CM
  Title
Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
  Journal
Proc Natl Acad Sci U S A 83:5214-8 (1986)
DOI:10.1073/pnas.83.14.5214
  Sequence
[hsa:596]
Reference
PMID:18570871
  Authors
Wei Y, Pattingre S, Sinha S, Bassik M, Levine B
  Title
JNK1-mediated phosphorylation of Bcl-2 regulates starvation-induced autophagy.
  Journal
Mol Cell 30:678-88 (2008)
DOI:10.1016/j.molcel.2008.06.001
  Sequence
[hsa:596]
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