KEGG   ORTHOLOGY: K05427
Entry
K05427                      KO                                     
Symbol
CSF2, GMCSF
Name
granulocyte-macrophage colony-stimulating factor
Pathway
map04060  Cytokine-cytokine receptor interaction
map04630  JAK-STAT signaling pathway
map04640  Hematopoietic cell lineage
map04650  Natural killer cell mediated cytotoxicity
map04657  IL-17 signaling pathway
map04660  T cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04668  TNF signaling pathway
map05131  Shigellosis
map05146  Amoebiasis
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05171  Coronavirus disease - COVID-19
map05202  Transcriptional misregulation in cancer
map05221  Acute myeloid leukemia
map05323  Rheumatoid arthritis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   04668 TNF signaling pathway
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   04650 Natural killer cell mediated cytotoxicity
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   04660 T cell receptor signaling pathway
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   04657 IL-17 signaling pathway
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   04664 Fc epsilon RI signaling pathway
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   05171 Coronavirus disease - COVID-19
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   05167 Kaposi sarcoma-associated herpesvirus infection
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
  09174 Infectious disease: parasitic
   05146 Amoebiasis
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
  09163 Immune disease
   05323 Rheumatoid arthritis
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03019 Messenger RNA biogenesis
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
  09183 Protein families: signaling and cellular processes
   04052 Cytokines and neuropeptides
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
   00536 Glycosaminoglycan binding proteins
    K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
Messenger RNA biogenesis [BR:ko03019]
 Eukaryotic type
  mRNA degradation factors
   3'-5' decay
    Other 3'-5' decay factors
     K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
Cytokines and neuropeptides [BR:ko04052]
 Cytokines
  CSF and other factors
   K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate / Heparin
  Cytokines
   K05427  CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
Genes
HSA: 1437(CSF2)
PTR: 471627(CSF2)
PPS: 100995954(CSF2)
GGO: 101133274(CSF2)
PON: 100447424(CSF2)
NLE: 100593532(CSF2)
HMH: 116470324(CSF2)
MCC: 574371(CSF2)
MCF: 102118747(CSF2)
MTHB: 126956025
MNI: 105467187(CSF2)
CSAB: 103244503(CSF2)
CATY: 105599730(CSF2)
PANU: 100126743(CSF2)
TGE: 112626456(CSF2)
MLEU: 105531357(CSF2)
RRO: 104659848(CSF2)
RBB: 108521977(CSF2)
TFN: 117064605(CSF2)
PTEH: 111527561(CSF2)
CANG: 105518179(CSF2)
CJC: 100410164(CSF2)
SBQ: 101043583(CSF2)
CIMI: 108307021(CSF2)
CSYR: 103270135(CSF2)
MMUR: 105869943(CSF2)
LCAT: 123637744(CSF2)
PCOQ: 105821018(CSF2)
OGA: 100958428(CSF2)
MMU: 12981(Csf2)
MCAL: 110305989(Csf2)
MPAH: 110332438(Csf2)
RNO: 116630(Csf2)
MCOC: 116076945(Csf2)
ANU: 117711918(Csf2)
MUN: 110561713(Csf2)
CGE: 100765221(Csf2)
MAUA: 101841789(Csf2)
PROB: 127219779(Csf2)
PLEU: 114700391(Csf2)
MORG: 121456106(Csf2)
MFOT: 126510957
AAMP: 119813689(Csf2)
NGI: 103747042(Csf2)
HGL: 101724943(Csf2)
CPOC: 100135508(Csf2)
CCAN: 109678566(Csf2)
DORD: 105998946(Csf2)
DSP: 122115489(Csf2)
PLOP: 125342101(Csf2)
NCAR: 124987664
MMMA: 107148177(Csf2)
OCU: 100328720(CSF2)
OPI: 101522477(CSF2)
TUP: 102498758(CSF2)
GVR: 103590058(CSF2)
CFA: 403923(CSF2)
CLUD: 112650098(CSF2)
VVP: 112917041(CSF2)
VLG: 121494340(CSF2)
NPO: 129495169(CSF2)
AML: 100473502 109488324(CSF2)
UMR: 103670505(CSF2)
UAH: 113261702(CSF2)
UAR: 123790540(CSF2)
ELK: 111141239
LLV: 125100468
MPUF: 106004834(CSF2)
MNP: 132027865(CSF2)
MLK: 131832013(CSF2)
NVS: 122901675(CSF2)
ORO: 101365120(CSF2)
EJU: 114209409(CSF2)
ZCA: 113929387(CSF2)
MLX: 118017173(CSF2)
NSU: 110591203(CSF2)
LWW: 102726081(CSF2)
FCA: 101094153(CSF2)
PYU: 121010878(CSF2)
PCOO: 112861409(CSF2)
PBG: 122472728(CSF2)
PVIV: 125164229(CSF2)
LRUF: 124523436
PTG: 102966574(CSF2)
PPAD: 109250814(CSF2)
PUC: 125935135
AJU: 106970701
HHV: 120245487(CSF2)
BTA: 281095(CSF2)
BOM: 102275474(CSF2)
BIU: 109561218(CSF2)
BBUB: 102413568(CSF2)
BBIS: 105005554(CSF2)
CHX: 100861208(CSF2)
OAS: 443400(CSF2)
BTAX: 128051607(CSF2)
ODA: 120864738(CSF2)
CCAD: 122439279(CSF2)
MBEZ: 129558731(CSF2)
SSC: 397208(CSF2)
CFR: 102523249(CSF2)
CBAI: 105082096(CSF2)
CDK: 105090018(CSF2)
VPC: 102543825(CSF2)
BACU: 103005117(CSF2)
BMUS: 118892884(CSF2)
LVE: 103089107(CSF2)
OOR: 101286998(CSF2)
DLE: 111182406(CSF2)
PCAD: 102973226(CSF2)
PSIU: 116751328(CSF2)
NASI: 112397464(CSF2)
ECB: 100033981(CSF2)
EPZ: 103556575(CSF2)
EAI: 106841026(CSF2)
MYB: 102242138(CSF2) 106726621
MYD: 102768422(CSF2)
MMYO: 118658639(CSF2)
MLF: 102428104(CSF2)
PKL: 118711341(CSF2)
EFUS: 103286945(CSF2)
MNA: 107525060(CSF2)
DRO: 112301620(CSF2)
SHON: 118990122(CSF2)
AJM: 119037675(CSF2)
PDIC: 114510130(CSF2)
PHAS: 123811909(CSF2)
MMF: 118615980(CSF2)
PPAM: 129066446(CSF2)
HAI: 109382590(CSF2)
RFQ: 117017067(CSF2)
PALE: 102893042(CSF2)
PGIG: 120616524(CSF2)
PVP: 105293539(CSF2)
RAY: 107497048(CSF2)
MJV: 108392857(CSF2)
TOD: 119242737(CSF2)
SARA: 101537997(CSF2)
LAV: 100675335(CSF2)
TMU: 101357995
DNM: 101424799(CSF2)
MDO: 103094208(CSF2)
PCW: 110211657
GGA: 416325(CSF2)
 » show all
Reference
PMID:3925454
  Authors
Lee F, Yokota T, Otsuka T, Gemmell L, Larson N, Luh J, Arai K, Rennick D
  Title
Isolation of cDNA for a human granulocyte-macrophage colony-stimulating factor by functional expression in mammalian cells.
  Journal
Proc Natl Acad Sci U S A 82:4360-4 (1985)
DOI:10.1073/pnas.82.13.4360
  Sequence
[hsa:1437]
Reference
PMID:3488815
  Authors
Shaw G, Kamen R
  Title
A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation.
  Journal
Cell 46:659-67 (1986)
DOI:10.1016/0092-8674(86)90341-7
Reference
PMID:24244449
  Authors
Fjell CD, Thair S, Hsu JL, Walley KR, Russell JA, Boyd J
  Title
Cytokines and signaling molecules predict clinical outcomes in sepsis.
  Journal
PLoS One 8:e79207 (2013)
DOI:10.1371/journal.pone.0079207
  Sequence
[hsa:1437]
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