KEGG ORTHOLOGY: K21160

ORTHOLOGY: K21160

Entry

K21160                      KO

Symbol

sgcE2, ncsE2, kedE2

Name

enediyne biosynthesis protein E2

Pathway

map01059

Biosynthesis of enediyne antibiotics

map01100

Metabolic pathways

map01110

Biosynthesis of secondary metabolites

Module

M00824

9-membered enediyne core biosynthesis, malonyl-CoA => 3-hydroxyhexadeca-4,6,8,10,12,14-hexaenoyl-ACP => 9-membered enediyne core

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09109 Metabolism of terpenoids and polyketides
   01059 Biosynthesis of enediyne antibiotics
    K21160  sgcE2, ncsE2, kedE2; enediyne biosynthesis protein E2
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01008 Polyketide biosynthesis proteins
    K21160  sgcE2, ncsE2, kedE2; enediyne biosynthesis protein E2
Polyketide biosynthesis proteins [BR:ko01008]
Polyketide tailoring proteins
  Others
   K21160  sgcE2, ncsE2, kedE2; enediyne biosynthesis protein E2

Genes

NBR:	O3I_032510

NIE:	KV110_31495

NYA:	LTV02_00400

NGP:	LTT66_22010

NSPU:

IFM12276_12590

SGR:	SGR_605(unbL1)

SGB:

STRM:

SCLF:

SPLU:

STIR:

SGZ:	C0216_12030

SSPO:

DDQ41_31030

SDRZ:

NEH16_31935

SGK:	PET44_34865

SFIY:

F0344_34690

RIA:	C7V51_07085

THAO:

NI17_008360

NEX:	NE857_19680

SRO:

Sros_7003

NGN:	LCN96_24395

AMD:

AMN:

AMM:

AMZ:

AOI:

AJA:	AJAP_30160

AMYB:

BKN51_01505

AAB:	A4R43_37060

AMYY:

AORI:

APRT:

AROO:

SESP:

KPHY:

ACTI:

ACAD:

AHG:	AHOG_16590

ACTA:

C1701_26320

ALO:

CRK57500

ACTU:

Actkin_05267

UME:	RM788_41310

STP:	Strop_2701

SAQ:

Sare_0549

MICH:

FJK98_15630

MTEM:

GCE86_08170

VMA:	VAB18032_18435

MPRN:

Q3V37_18520

ACTN:

L083_3207

AIH:	Aiant_18170

PLAB:

PLAT:

PFLA:

PSUU:

CAI:	Caci_6373 Caci_6382

GML:	ISF26_08940

UAM:	UABAM_05782

AG:	AAM78016(ncsE2) AFV52143(kedE2)

» show all

Reference

PMID:12183628 (sgcE2)

Authors

Liu W, Christenson SD, Standage S, Shen B

Title

Biosynthesis of the enediyne antitumor antibiotic C-1027.

Journal

Science 297:1170-3 (2002)
DOI:10.1126/science.1072110

Sequence

[sgb:WQO_34010]

Reference

PMID:15797213 (ncsE2)

Authors

Liu W, Nonaka K, Nie L, Zhang J, Christenson SD, Bae J, Van Lanen SG, Zazopoulos E, Farnet CM, Yang CF, Shen B

Title

The neocarzinostatin biosynthetic gene cluster from Streptomyces carzinostaticus ATCC 15944 involving two iterative type I polyketide synthases.

Journal

Chem Biol 12:293-302 (2005)
DOI:10.1016/j.chembiol.2004.12.013

Sequence

[ag:AAM78016]

Reference

PMID:23360970 (kedE2)

Authors

Lohman JR, Huang SX, Horsman GP, Dilfer PE, Huang T, Chen Y, Wendt-Pienkowski E, Shen B

Title

Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics.

Journal

Mol Biosyst 9:478-91 (2013)
DOI:10.1039/c3mb25523a

Sequence

[ag:AFV52143]

LinkDB

DBGET integrated database retrieval system