Lynx rufus (bobcat): 124523268 Help Entry 124523268         CDS       T08475                                  Name (RefSeq) insulin receptor   KO K04527   insulin receptor [EC:2.7.10.1] Organism lruf  Lynx rufus (bobcat) Pathway lruf04010   MAPK signaling pathway lruf04014   Ras signaling pathway lruf04015   Rap1 signaling pathway lruf04022   cGMP-PKG signaling pathway lruf04066   HIF-1 signaling pathway lruf04068   FoxO signaling pathway lruf04072   Phospholipase D signaling pathway lruf04150   mTOR signaling pathway lruf04151   PI3K-Akt signaling pathway lruf04152   AMPK signaling pathway lruf04211   Longevity regulating pathway lruf04213   Longevity regulating pathway - multiple species lruf04520   Adherens junction lruf04910   Insulin signaling pathway lruf04913   Ovarian steroidogenesis lruf04923   Regulation of lipolysis in adipocytes lruf04930   Type II diabetes mellitus lruf04931   Insulin resistance lruf04932   Non-alcoholic fatty liver disease lruf04960   Aldosterone-regulated sodium reabsorption lruf05010   Alzheimer disease lruf05415   Diabetic cardiomyopathy Brite KEGG Orthology (KO) [BR:lruf00001]  09130 Environmental Information Processing   09132 Signal transduction    04010 MAPK signaling pathway     124523268    04014 Ras signaling pathway     124523268    04015 Rap1 signaling pathway     124523268    04066 HIF-1 signaling pathway     124523268    04068 FoxO signaling pathway     124523268    04072 Phospholipase D signaling pathway     124523268    04022 cGMP-PKG signaling pathway     124523268    04151 PI3K-Akt signaling pathway     124523268    04152 AMPK signaling pathway     124523268    04150 mTOR signaling pathway     124523268  09140 Cellular Processes   09144 Cellular community - eukaryotes    04520 Adherens junction     124523268  09150 Organismal Systems   09152 Endocrine system    04910 Insulin signaling pathway     124523268    04923 Regulation of lipolysis in adipocytes     124523268    04913 Ovarian steroidogenesis     124523268   09155 Excretory system    04960 Aldosterone-regulated sodium reabsorption     124523268   09149 Aging    04211 Longevity regulating pathway     124523268    04213 Longevity regulating pathway - multiple species     124523268  09160 Human Diseases   09164 Neurodegenerative disease    05010 Alzheimer disease     124523268   09166 Cardiovascular disease    05415 Diabetic cardiomyopathy     124523268   09167 Endocrine and metabolic disease    04930 Type II diabetes mellitus     124523268    04932 Non-alcoholic fatty liver disease     124523268    04931 Insulin resistance     124523268  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:lruf01001]     124523268   09183 Protein families: signaling and cellular processes    04090 CD molecules [BR:lruf04090]     124523268 Enzymes [BR:lruf01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.1  receptor protein-tyrosine kinase      124523268 Protein kinases [BR:lruf01001]  Receptor tyrosine kinases (RTK)   INSR family [OT]    124523268 CD molecules [BR:lruf04090]  Proteins   124523268 BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Recep_L_domain Pkinase Furin-like Insulin_TMD fn3 Kinase-like B2 DUF4476 Motif Other DBs NCBI-GeneID:  124523268 NCBI-ProteinID:  XP_046951085 LinkDB All DBs Position Unknown AA seq 1369 aa AA seqDB search MGAGAGRGAATAPLLVAVAALLLGAAGHLYPGEVCPGMDIRNNLTRLHELANCSVIEGHL QILLMFKTRPEDFRDLSFPKLVMITDYLLLFRVYGLESLKDLFPNLTVIRGSRLFFNYAL VIFEMVHLKELGLYSLMNITRGSVRIEKNNELCYLATIDWSRILDSVEDNYIVLNKDDNE ECGDICPGTAKGKTNCPATVINGQFVERCWTHGHCQKVCPTICKSHGCTADGLCCHSECL GNCSEPDDPTKCVACRNFYLDGRCVETCPPPYYHFQDWRCVNFSFCRDLHNKCKNSRRQG CHQYVIHNNRCIPECPSGYTMNSSNLMCTPCLGPCPKVCHILEGEKTIDSVTSAQELRGC TVVNGSLIINIRGGNNLAAELEANLGLIEEISGYLKIRRSYALVSLSFFRKLRLIRGETL EIGNYSFYALDNQNLRQLWDWSKHNLTITQGKLFFHYNPKLCLSEIHKMEEVSGTKGRQE RNDIALKTNGDQASCENELLKFSYIRTSYDKILLKWEPYWPPDFRDLLGFMLFYKEAPYQ NVTEFDGQDACGSNSWTVVDIDPPLRSNDPKSQNHPGWLMRGLKPWTQYAIFVKTLVTFS DERRTYGAKSDIIYVQTDATNPSVPLDPISVSNSSSQIILKWKPPSDPNGNITHYLVFWE RQAEDSELYELDYCLKGLKLPSRTWSPPFESEGSQKHNQSEYEESAGECCSCPKTDSQIL KELEESSFRKTFEDYLHNVVFVPRPSRKRRALADAGNVTAAVPTVPGFPNTSSSVPTSPE EHKPFEKVVNKESLVISGLRHFTGYRIELQACNQDAPEERCSVAAYVSARTMPEAKADDI VGPVTHEIFENNVVHLMWQEPKEPNGLIVLYEVSYRRYGDEELHLCVSRRHFALERGCRL RGLPPGNYSVRVRATSLAGNGSWTEATYFYVTDYLDVPSNIAKIIIGPLIFVFLFSVVIG SIYLFLRKRQPDGPLGPLYASSNPEYLSASDVFPCSVYVPDEWEVPREKITLLRELGQGS FGMVYEGNARDIVKGEAETRVAVKTVNESASLRERIEFLNEASVMKGFTCHHVVRLLGVV SKGQPTLVVMELMVHGDLKSYLRSLRPEAENNPGRPPPTLQEMIQMAAEIADGMAYLNAK KFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRWMAPESLKDGVF TTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCPERVTDLMHMCW QFNPKMRPTFLEIVDLLKDDLHPSFPEVSFFHSEENKAPESEELEMEFEDMESVPLDRAS HSQREEAGGRDGVSSLGLKRNYEDHIPYTHMNGGKKNGRILTLPRSNPS NT seq 4110 nt NT seq  +upstreamnt  +downstreamnt atgggcgccggggctgggcggggggcggccaccgcgccgctgctggtggcggtggccgcg ctgctgctgggcgccgcgggccacctgtaccccggagaggtctgccctggcatggatatc cggaacaacctgacgaggctgcacgaactggccaactgctcggtcattgaaggtcatttg cagatactgctcatgttcaaaacgaggcccgaggacttccgagacctcagtttccccaaa ctcgtcatgatcactgattacctgctgctcttccgggtgtacgggctggagagcctgaag gacctcttccccaacctcacggtcatccggggctcgcgcctcttcttcaactacgcgctg gtcatcttcgagatggtgcacctgaaggagcttggcctctacagcttgatgaacattacc cggggctccgtccgcatcgagaagaataatgagctgtgctacctggccaccatcgactgg tcgcgcatcctggattcggtggaggataattacattgtgttgaacaaagacgacaacgag gagtgtggggacatttgtccaggcactgcaaagggcaagaccaactgccctgccactgtc atcaacgggcagtttgtggagcgttgttggacacacggccattgccagaaagtttgtccg accatctgcaagtcgcacggctgcacggccgacggcctctgctgccacagcgagtgtttg ggcaactgctccgagcccgacgaccccaccaagtgcgtggcctgtcgtaacttctacctg gacggcaggtgcgtggagacctgcccgcccccctactaccacttccaagactggcgctgc gtgaacttcagcttctgccgggacctgcacaataaatgcaagaactcccggagacagggt tgccaccagtatgtcattcacaacaacaggtgcatccctgagtgcccctcagggtacacg atgaattccagcaacctcatgtgtactccctgcctgggcccctgtcccaaggtctgccac atcctggaaggcgagaagaccatcgactcggtgacatctgcccaggagctccgaggctgc accgtcgtcaacggaagcctaatcatcaacattcgagggggcaacaacctggcagctgag ctggaggccaacctcggactcattgaagaaatttctgggtatctgaagatccgaagatcc tatgctcttgtgtcactttcctttttccggaagttacggctgattcggggagagaccttg gaaatcgggaactactctttctatgccttggacaaccagaacctgaggcagctatgggac tggagcaaacacaacctcaccatcactcaggggaaactcttcttccactataatcccaaa ctctgcttgtcggaaattcacaagatggaggaggtttcaggaaccaaggggcgccaggag cggaacgacattgccctgaagaccaatggggaccaggcgtcttgtgaaaatgaactactt aaattttcttacattcggacatcttacgacaagatcttgctgaaatgggagccgtactgg ccccctgacttccgagacctcctgggcttcatgctcttctacaaagaggccccttaccag aatgtgaccgagttcgacgggcaggacgcgtgtggctcaaacagctggacggtggtggac attgacccgcctctgaggtccaatgaccccaagtcgcagaaccacccagggtggctgatg cggggtctcaagccctggacccagtatgccatctttgtcaagaccttggtcaccttctct gatgagcgccgcacgtatggggccaagagtgacatcatctatgtccagaccgatgccacc aacccttccgtccccctggatcctatctcggtttcgaattcctcctctcagatcattctg aagtggaagcctccctcggaccccaatggcaacatcacacactacctggtgttctgggag aggcaggcggaggacagcgagctgtatgagttggattattgcctcaaagggttgaagctg ccttcccggacctggtccccgccgttcgagtccgagggctcccagaagcacaatcagagt gaatacgaggagtccgctggcgaatgctgctcgtgtcccaaaaccgactctcagatcctg aaggagctggaggagtcctctttcaggaagacgttcgaggattacctgcacaatgtggtt ttcgtgcccaggccatcgcggaagcgcagggccctcgccgacgctgggaacgtgacggcc gccgtgcccacggtgcctggtttccccaacacttccagcagcgtgcccacgagcccggaa gagcacaagcccttcgagaaggtggtgaacaaagagtcgctggtcatctccggcctgcgt cacttcaccggctaccgcatcgagctgcaggcttgcaaccaagatgcccccgaggagagg tgcagcgtggccgcctacgtcagcgccaggaccatgcccgaagccaaggcagacgacatt gttggccctgtgacccatgaaatctttgagaacaacgtggttcacttgatgtggcaagag cctaaagaacccaatggattgatcgtgctgtatgaagtgagttaccgacggtatggtgat gaggagctgcacctctgtgtctcccgtagacactttgctctggagcggggctgcaggctg cgagggctgccgccggggaattacagtgtgcgagttcgggccacctccctggcgggcaac ggctcctggacagaagccacttatttctatgtgacggactatttagatgtcccatcgaac attgcaaaaattatcatcgggcctctcatctttgtctttctcttcagtgttgtgattgga agtatttatctattcctgagaaagaggcagccggatgggccactggggccgctgtatgct tcttcaaaccctgagtacctcagtgccagtgatgtgtttccctgctctgtgtatgtgccg gacgagtgggaggtgcctcgggagaagatcactctcctgcgcgagctggggcagggctcc ttcggcatggtgtacgagggcaatgccagggacatcgtcaagggcgaggcggagacccgc gtggcggtgaagacggtcaacgagtccgccagtctgcgagagaggatcgagtttctcaac gaggcctcagtcatgaagggcttcacctgtcatcacgtggtccgcctcctgggggtggtg tccaaaggccagccgacgctggtggtgatggagctgatggttcacggagacctgaagagc tacctccgctccctgcggccggaggctgagaataaccctggccgccctccccctactctg caagagatgattcagatggcggcggagatcgccgacgggatggcgtacctgaatgccaag aagtttgtgcaccgggatctcgcagctcgaaattgcatggtggcccacgacttcaccgtc aaaattggagacttcggaatgaccagagacatctatgaaacggattactaccggaaagga ggcaagggtctgctccccgtgcggtggatggcaccggaatccctgaaggacggggtcttc accacttcttctgacatgtggtcctttggtgtggtcctttgggaaatcaccagcttggcg gaacaaccttaccaaggcctgtctaatgaacaggtgttgaaatttgtcatggacggagga tatttggaccaacctgacaactgtccggagagagtcaccgacctgatgcacatgtgctgg cagttcaatcccaagatgcggcccaccttcctggagatcgttgacctgctcaaggacgac ctgcaccccagctttccggaagtttccttcttccacagcgaggagaacaaggcgcctgag agtgaggagttggaaatggagtttgaggacatggagagtgtccccctggatcgggcctca cactcacagagggaagaggccgggggccgggatggagtgtcctcgctgggcctcaagcgg aactacgaggaccacatcccctacacccacatgaacgggggcaagaaaaacggacggatt ctgaccctgccgaggtcgaatccttcctaa

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