Meleagris gallopavo (turkey): 100008574 Help Entry 100008574         CDS       T01523                                  Symbol RYR1 Name (RefSeq) ryanodine receptor 1 (skeletal)   KO K04961   ryanodine receptor 1 Organism mgp  Meleagris gallopavo (turkey) Pathway mgp04020   Calcium signaling pathway mgp04371   Apelin signaling pathway Brite KEGG Orthology (KO) [BR:mgp00001]  09130 Environmental Information Processing   09132 Signal transduction    04371 Apelin signaling pathway     100008574 (RYR1)    04020 Calcium signaling pathway     100008574 (RYR1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01009 Protein phosphatases and associated proteins [BR:mgp01009]     100008574 (RYR1)   09183 Protein families: signaling and cellular processes    04147 Exosome [BR:mgp04147]     100008574 (RYR1)    04040 Ion channels [BR:mgp04040]     100008574 (RYR1) Protein phosphatases and associated proteins [BR:mgp01009]  Protein serine/threonine phosphatases   Phosphoprotein phosphatases (PPPs)    Protein phosphatase-1     PP1-interacting proteins (PIPs)      100008574 (RYR1) Exosome [BR:mgp04147]  Exosomal proteins   Exosomal proteins of other body fluids (saliva and urine)    100008574 (RYR1) Ion channels [BR:mgp04040]  Voltage-gated cation channels   Ryanodine receptor    100008574 (RYR1) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  RYDR_Jsol RYDR_ITPR RyR RR_TM4-6 SPRY Ins145_P3_rec MIR RIH_assoc Ion_trans EF-hand_7 Motif Other DBs NCBI-GeneID:  100008574 NCBI-ProteinID:  NP_001290128 UniProt:  B4XW97 LinkDB All DBs AA seq 5050 aa AA seqDB search MGDGGEGDVQFLRTDDEVVLQCTTTLLKEQLKLCLAAEGFGNRPCFLEPTSNAQNVPPDL AVCCFVLEQSLSVRALQEMLANCAESGRESSQGGGHRTLLYGHAILLRHSHSGMYLSCLT TSRSVTDKLAFDVGLQKDAAGEACWWTLHPASKQRSEGEKVRVGDDIILVSVSSERYLHL STASGELQADASFMQTLWNMNPICSGAEEGYVTGGHVLRLFHGHMDECLSTSPPEQGDER SSVVSYEGGAVCTHARSLWRLEPLRISWSGSHLRWGQPFRVRHVTSGRYLALSEERGLVV VEAAAAGTRAAAFCFRASKEKLEAGTKRDVEGMGPPEIKYGESLCFVQHAASGLWLTYAA ADTKALRLGLMKRRPILHQEGHMDDALSLSRSQGEESQAARMIYSTAGLYGSFIRSLDAL SSRGRGGGAGNAALPIAAVILSLRDLIAYFRAPHTELQHEQRQNRLRSLRRRQDLFQQEG MISLVLNCIDRLNVYSTAAHFAEFAGEEAAAAWKEIVNLLYELLASLIRGNRTNCALFST NLDWLVSKLDRLEASSGILEVLYCVLIESPEVLNIIQENHIKSIISLLDKHGRNHKVLNV LCSLCVCNAVAVRSNQNLITENLLPRRDLLLQTGPVSYVSSIRPNILLGTHEGSTQYPRW YFEVAVDHVEPFVTAQPTHLRVGWAMAEGYSPYPGGGEGWGAYGAGDDLYSFAFDGLHLW AGGVPRAAPSPQQHILAPGDVVSCCLDLSVPTISSRLNGSPVLGMFEKFNRDALFSPVVS FSAGVRLRFLLGGRHGDFQFLPPPGYSPCAEALLPRERLRLEPIKAYRGDGPPPHCLLGP TKALPHTAFTPCPVDTAQIVLPPHLERIREKLAENIHELWALTRIEQGWTYGPIHDDAEQ LHPCLLDFHSLPEPERNYNLQMSGETLKTLLALGCHVGMADEKAEENLRKIKLPKTYTMR NGYKPAPLDLAHVRLTPAQLTLVDRLAENAHNVWARDRVQQGRTYSIVQDIKNKRNPRLV PYNLLDERTKKTNRDSLCEAVRTLIGYGYNIEPPDQESPAQGTPHGPDKVRIFRAERSYA VRAGKWYFEFEAVTTGEMRVGWARPQIRPDIELGADDLAYVFNGHRAQRWHVGGEAFGRS WQAGDVVGCMIDLNESHISFTLNGETLISDGGSEVAFRDFEVGEGFVPVCSLALDQAGRL NLGQDVSSLRFFTICGLQEGFEPFAINMKRPIALWVSKSLPQFGPIDPEDPQLEVTRTDG TVDAPPCLRLSRRTSGSPPAPPELLFLRLSLPVQFQPHFRCPPGTTPLPQTPPEPPDDEV GPEPMSEFEKLRRSAGVRNAEGGEGGRGGREKPRGGGGPGGAPSPNKEQHRGENEKDGSN EKGKTRRGFLFKARKAAFPPPPALPAVPRLEEDVVPDERDDPDVIMNSTTYYFSVRIFAG QDPSHVWVGRVTPDYHQHDPNFDLTRVRTVTVTMGDDRGNVHDSIRRSSCYMLWAGEFGS ASPQSRSHSDAVIGCLVDVATGLMTFTANGKELNTFFQVEPNTKLFPAVFVLPSSQHVVQ FELGKLKNILPLSAALFSSERCNPEPQCPPRLCIQRLTAVTWSRMAAEELPVSSGRAADG RGWEVRCSEPRLMMALHIPEENRCMDIMELWERQDLLRFHWHTLKLYCAVCALGNTRVAH ALCSHVDPSQLLFAIRSPELPGPLRAGYYDLLLAVHLEQGVRARASMSTEFIVPMDEASK RISLFPAGGGGDVKVPGPPGVGLSACLRPRPHFAEPCFVRPPDGRALLGPSIPLRALGRR AIRMLREAVAGGGPHARDPVGGGVEFQLVPVLKLVSALLAVGALRDPEVRKVLRMIEPRV FGGGEEEEEEEERRRRRKAVEAGEEEEEVDEEEEVDEEEDEEEEEDGPEEGLLQMKLPES VKLQMCNLLQFFCDQELQHRVEAIVAFSERHVERLQRDQRRRYGRLMGAVTMSAAETARR TREFRSPPQEQINMLLQYKGGADEEDCPVPPDIRGELLQFHSDLLAHCGIELQGEEEEEE EDASLRQRLLALVQRVVGRQQKEEEEEEATSPEPPVPRTLQELISHTMVHWAQESFIQSP ELVRSMFSLLHRQYDGLGELVRALPKAYTISAHSVPDTTALLECLGQIRSLLIVQMGPEE ENLMIQSIGNIMNNKVFYQHPNLMRALGMHETVMQVMVSVLGGGETKEIRFPKMVTNCCR FLCYFCRISRQNQRSMFDHLGYLLENSSIGLGMQGSTPLDVAAASVIDNNELALALKEQD LEKVVTYLASCGLQSCPMLLSKGYPDIGWNPCGGERYLDFLRFAVFVNGESVEENANVVV RLLIRRPECFGPALRGEGGSGLLAAIEDAIKISEDPARDGPTVKKERRREIFGAEEPHEE NRVHLGNAIMSFYAASIDLLGRCAPEMHLIQAGKGEALRIRAILRSLVPLDDLVGVISLP LQIPAFGKDGNVVQPRMAASFVPDHKAPMVLFLDRVYGIETQQFLLHVLEVGFLPDMRPA ASLDTAAFSTTKMALALNRYLCVPVLPLITKCAPLFAGTEHRAIMVDSMLHTIYRLSRGR ALTKAQRDAIEECLMALCRYIRPSMLQHLLRRLVFDVPILNEFAKMPLKLLTNHYERCWK YYCLPSGWPNYGVSSEEELHLTRKLFWGIFESLAHKKFDPELYKLAMPCLCAIAGALPPD YVDASYSSKTEKKASVDAEGNFDPKPVETLNVIIPEKLDGFINKYAEFTHEKWAFDKIQN NWTYGETVDEEAKTHPMLRPYKTFSEKDKEIYRWPIKESLKAMLAWEWMVEKAREGDEEK AEKKKTRKISQSAQATYDPSHGYNPQPVDLSGVTLSRELQAMAEQLAENYHNTWGRKKKQ ELEAKGGGSHPLLVPYDTLTAKEKARDREKAQELLKFLQLNGYAVTRGLKDMELDTSSIE KRFAYGFLQQLLRWMDISQEFIAHLEAVVSSGRVEKSPHEQEIKFFAKILLPLINQYFHN HCLYFLSTPAKVLGSGGHASNKEKEMITSLFCKLAALVRHRVTLFGTDAPAVVNCLHILA RSLDARTVMKSGPEIVKAGLRSFFESASEDIEKMVENLKLGKVTQSRTQVKGVAQNINYT TVALLPVLTSLFEHIAQHQFGDDVILDDVQVSCYRILCSIYSLGTTRNPYVERQRPALGE CLARLAAAMPVAFLEPRLNEFNPCSVYSTKSPRERANPHLWGTADPHPIFGTPTPVLGLP SHVEEMCPDIPDLERLMKDIGGLAESGARYTEMPHVIEVTLPMLCNYLPRWWERGPDSSP QGPWATAVTGQHLNALAGKHPAHRGQQPGHRRGVLDETLAVFAQPIVSKAKPELLRTHFI PTMEKLKKRAGKVVSEEEQLRMEAKAEAEDAELLIRDEFSVLCRDLYALYPLLIRYVDNS RAKWLTEPNADAEELFRMVGEVFIYWSKSHNFKREEQNFVVQNEINNMSFLTADSKSKMA KSGDGQGGGSEQERTKKKRRGDRYSIHTSLIVATLKKMLPIGLNMCSPTDQELISLAKSR YALKDTDEEVQECLNNNLHLQGKCENSSAMRWQLALYRAMAGRAEDSDSPEKIVRRVQEV SAVLYHLEQTEHPYKSKKAVWHKLLSKQRRRAVVACFRMTPLYNLPRHRACNMFLEAYKL LWLVTEEHPFEDRMIDDLAKSGEEEEEEEEEKDKKPDPLHQLILHFSRTALTEKSKLEKD HLYMAYAGIMAKSCHIEEGNEEEKEEKKEEEDPEDSFEEKEMEKQKLLYQQSRLHTRGAA EMVLQMISACKGERGEMVSSTLKLGISILNGGNADVQQKMLDYLKEKREIGFFQSVQALM QTCSVLDLNAFERQNKAEGLGMVTEEGTIISRENGEKVMSDDEFTQDLFRLLQLLCEGHN NDFQNYLRTQTGNTTTINIIICTVDYLLRLQESISDFYWYYSGKDVIDEQGKRNFSKAMA VAKQVFNSLTEYIQGPCTGNQQSLAHSRLWDAVVGFLHVFAHMMKKLAQDSSQIGLLKEL LDLQKDMVVMLLSLLEGNVVNGTIARQVVDMPVESSSNVTMILKFFDMFLKLRDIVASDA FRDYVTDPRGLISKKDFQKAMDSQKQYEPSEVQFLLSCSEADENEMIDVEAFVGRSQEPA RDIGFNVAVLLTNLAEHVPHDQRLRTFLEQAASILEYFRPFLGRIEIMGAARRIERLYFE ISAANKAQWEMPQVKESKRQFIFDVVNEGGEAEKMELFVSFCEDTILEMQIASRLSEEEG ARDGGDGDEEEEEETPEGGGSPPPAEPTSAFGEMLGGLRRAVGSPQLWRRRIRKMRKRGA GSCCGTSGRPCGGRWSGGLMGVYGAVRAVGCVLWVVLFGGGLVEGAQKLGLAELLGSMPD PTQDAVGGGEAGGAPSGEGAVGGEEGQEESPPPAERPQSSEEEEEEEGAAVVVAAPPVAF GGRKDGGHYRMAPPDAPGGLGDIGEPPGAEPPTPEGTPILKRKIGEDGKEVVEEPQKEEE EAAAETEKADTENGEKGDGGAEGGPEVETPEKQQKASPPRERKEPPPPEGAFEFWTELEV QRVKFLNYLSRNFYNLRFLALFLAFAINFILLFYKVSERPPGMEEAELEGSGMAAVLDGI GDFGDGGDGDGGDGEEEPSVVYYCLEESTGYMQPALRALAVAHTIVAFLCIIGYNCLKIP LVIFKREKEVARRLEFSGLYITEQPPDDDVKGQWDRLVLNAQSFPSNYWDKFVKRKVLEK YGDIYGRERIAELLGMELSSLEIGARGERKPPPDNSVLTWITFIDIRYQIWKFGVIFTDN SFLYLTWYMGMSLLGHYNNFFFVAHLLDIAMGVKTLRTILSSVTHNGSNLAMTVGLLAVV VYLYTVVAFNFFRKFYNKSEDEDEPDMKCDDMMTCYLFHMYVGVRAGGGIGDEIEDPAGD EYELYRVVFDITFFFFVIVILLAIIQGLIIDAFGELRDQQEQVKEDMETKCFICGIGSDY FDTTPHGFETHTLEEHNLANYMFFLMYLINKDETEHTGQESYVWKMYQERCWDFFPAGDC FRKQYEDQLG NT seq 15153 nt NT seq  +upstreamnt  +downstreamnt atgggtgacggaggagagggcgatgtgcagttcctgaggacggacgatgaggtggtgctg caatgcaccacgacgctgctgaaggagcagctgaagctctgcctggcggccgaaggcttc gggaaccgcccgtgcttcctggagcccacgtccaacgcacagaatgtgccccccgacctg gccgtctgctgcttcgtcttggagcagtcgctgtcagtccgagcgctgcaggagatgttg gccaactgtgcagagagcggcagagagtcgtcgcagggcggggggcatcgcacgctgctc tatggacacgccatcctgctgcggcactcccatagcgggatgtacctgagctgcctgacc acctcccgctccgtcaccgacaaactggccttcgatgtggggctgcagaaggacgcagcg ggggaggcctgttggtggacgctgcacccggcgtcgaagcagcgctcagagggggaaaag gtgcgagtgggggacgacatcatcctggtgagcgtctcctccgagcgctacctgcacctc tcgacggccagcggggagctgcaggcggacgcctccttcatgcagaccctgtggaacatg aaccccatctgctcgggggccgaggaaggttatgtgacggggggccacgtgctgcgtctg ttccacggccacatggatgagtgcctcagcacctccccccccgagcagggggacgagcgc agcagcgtggtgagctacgaggggggggccgtctgcacccacgcacggtcgctgtggagg ttggagccgctgcgcatcagttggagcggcagccacctccgctgggggcagcccttccgg gttcgtcacgtgacgtcgggccgctatttggcgctgagcgaagagcgcggcctcgtggtg gtggaagcggcggcggccgggacccgagcggctgcgttctgcttccgggcctccaaggag aagctggaagcggggacgaagcgcgatgtggaggggatgggacccccggagatcaaatat ggggagtcgctgtgcttcgtgcagcacgcggcctcggggctgtggctcacctacgctgct gctgacaccaaagcgctgcgcctggggctgatgaaacggaggcccatcctgcaccaggag ggccacatggacgacgcgctgtcgctcagccgctcgcagggcgaggagtcgcaggcggcg cggatgatttacagcacggcggggctctacgggagcttcatccggagcctggacgcgctg agctctcgtggccgtggcggcggtgcggggaacgcggctctgcccatcgccgccgtcatc ctcagcctgcgggatctgatcgcttatttccgcgccccgcacaccgagctgcagcacgag cagcgccagaaccgcctgcgctccctgcggcgccgccaggacctcttccagcaggagggg atgatctccctggtgctgaactgcatcgaccggctgaacgtgtacagcacggccgcgcac ttcgccgagttcgccggggaggaggcggcggccgcctggaaggagatcgtcaacctcctc tatgagctgctggcgtcgctgatccgggggaaccgaaccaactgcgccctgttctccacc aacctggactggctggtcagcaaactggaccggctggaggcgtcgtcagggatcctggag gtgctttactgcgtcctgatcgagagccccgaggttctgaacatcatccaggagaaccac atcaagtccatcatctccctgctggacaaacacggccgcaaccataaggtcctgaacgtg ctctgctctctgtgtgtctgcaatgctgtggccgttcgttccaaccaaaatctcatcacc gaaaatctgctcccgcgacgcgacctcctgctgcagaccgggccggtcagctacgtcagc agcatccggcccaacatcctcctggggacccacgagggctccacgcagtacccacgctgg tacttcgaggtggccgtggatcacgtggagcccttcgtgacggcgcagcccacccacctg cgcgtggggtgggcgatggcggagggttacagcccctacccgggggggggagagggctgg ggggcctacggagccggagacgacctttattccttcgcctttgatgggctgcacctctgg gccggcggggttccgcgggccgccccctccccccagcagcacatcctggcccccggggac gtggtgagctgctgcctggacctctctgttcccaccatctcctcccgcctcaacggcagc ccggtgctggggatgttcgagaagttcaatcgcgacgcgctcttctcccccgtcgtcagc ttctccgccggcgtgcggctgcgcttcctgctggggggccgccacggggatttccagttc ctgcccccccccggttactccccctgtgccgaggcgctgctgccccgcgagcggctgcgc ctggaacccatcaaagcttataggggcgacggccccccgccccactgcctgctcggcccc acaaaggcgctgccccacaccgccttcaccccctgccccgtggacaccgcgcagatcgtt ctgcccccccacctggagcgcatccgggagaagctggcggagaacatccatgagctgtgg gcgctgacccgcatcgagcagggatggacctacggccccatccatgacgatgctgagcag ctccatccctgcctgctggatttccacagcctccccgagccggagcgcaactacaacctg cagatgtcgggggagacgctcaagacgctgctggcgctgggctgccacgtggggatggcg gacgagaaggcggaggagaacctgaggaaaatcaaactgcccaaaacgtacacgatgcgc aacggttacaaaccggccccgctggacctggcccacgtgcgcctgacgccggcgcagctg acgctggtggatcggctggcggagaacgcgcacaacgtctgggcgcgggaccgcgtgcag cagggccggacctacagcatcgtgcaggacattaagaacaagcgcaacccccgcctggtg ccctacaacctgctggacgagcgcaccaagaagaccaacagggacagcctgtgcgaggcg gtgcggaccctcatcggctacggctacaacatcgagccccccgaccaggagagccccgct caggggacgccccacggccccgataaggtgcgcatcttccgcgccgagcgcagctacgcc gtgcgggccgggaagtggtacttcgagttcgaggccgtcaccacgggggagatgcgtgta gggtgggcccgaccccaaatccgccccgacatcgagctgggagccgacgacttggcctac gtcttcaacggccatcgggcgcagcgctggcacgttggcggggaggcgtttgggcgcagc tggcaggcgggggacgtggttggctgcatgatcgacctgaacgagagccacatcagcttc acgctcaacggggagacgctcatcagcgacggcggctccgaggtggccttcagggacttc gaagtgggagagggcttcgtcccggtgtgcagtctggccctggaccaggcgggtcgcctc aatctgggtcaggacgtctccagcctccgtttcttcaccatctgcggcctgcaggagggc ttcgagcccttcgccatcaacatgaagcgccccatagcgctgtgggtcagcaaaagcctc ccgcagttcggccccatcgaccccgaggacccgcagctggaggtcacccgcactgacggc accgtggacgcccccccctgcctccgcctctcccgccggacgtcgggttcccccccggct ccccccgagctgcttttccttcgcctcagccttccggttcaattccaaccccacttccgg tgcccccccggaacgacccccctcccccagacccccccggagccccccgacgacgaagtc ggcccggagcccatgtcggaattcgagaagcttcggcgctcggcgggggtccgaaacgcc gaggggggggagggggggcggggagggagagaaaaaccacggggggggggcggcccggga ggagccccctccccaaataaagaacagcaccggggggagaacgagaaggacggcagcaac gagaagggaaaaaccaggagggggtttctgttcaaggccaggaaagccgccttcccgccc ccccccgcgctgccggcggtgccgcgcctggaggaggacgtggtgccggacgagcgggac gaccccgatgtcatcatgaacagcaccacgtactacttctcggtgcggatctttgctggc caggacccctcccacgtctgggtgggcagggtgacccccgattaccaccagcacgacccc aacttcgacctgacgcgcgtccgcaccgtcaccgtcaccatgggggacgacagggggaac gtgcacgacagcatcagacgcagcagctgctacatgctgtgggccggggagttcggctcc gcttccccgcagagccgcagccacagcgacgccgtcatcggctgcctggtggacgtggcc acggggctgatgaccttcaccgccaacggcaaggagctcaacaccttcttccaggtggag cccaacaccaagctgttccccgccgtcttcgtgctgcccagcagtcagcacgtggtgcag ttcgagctggggaagctgaagaacatcctgccgctgtcggccgcgctgttcagcagcgag cgctgcaacccggagccgcagtgcccgccccggctgtgcatccagcgcctgaccgccgtc acctggagccggatggcggccgaggagctgcccgtgagcagcggccgggccgccgacggc cgcggctgggaggtgcgctgttccgaaccgcgcctgatgatggcgctgcacattccggag gagaacagatgcatggacatcatggagctgtgggagcggcaggacctgctccgcttccat tggcacacgctgaagctgtactgcgccgtgtgcgcgctgggcaacacgcgggtggcgcac gcgctgtgcagccacgtggatccgtcgcagctcctcttcgccatccgcagcccggagctg cccggccccctccgcgccggttactacgacctgctgctggccgtgcacctggagcagggc gtccgcgcccgggcctccatgagcaccgagttcatcgtccccatggacgaggcgtccaaa cgcatctccctgttccccgccggcggggggggcgacgtcaaagtgcccggcccccccggc gtcgggctcagcgcctgcctccgcccccggccgcacttcgccgagccgtgcttcgtgcgg ccgcccgacggcagggcgctgctgggtccctctatcccgctgcgggcgctgggcaggagg gccatcaggatgctgagggaggcggtggcggggggggggccgcacgcccgggaccccgtc ggcggcggcgtggagttccagctggtgccggtgttgaagttggtgtcggctctgctggcc gtcggggcgctgcgggacccggaggtgcgcaaggtgctgcggatgatcgaacccagggtg ttcggggggggcgaggaggaggaggaggaggaggagaggaggaggaggaggaaggccgtg gaggccggcgaggaggaggaggaggtggacgaggaggaggaggtagatgaggaggaggac gaggaggaggaggaggacgggccggaggaagggctgctgcagatgaagttgccagagtct gtgaagctgcagatgtgcaacctactgcagttcttctgcgaccaggagctgcagcaccgc gtggaagcgatcgtcgccttctcggagcgccacgtggagcggctgcagcgcgaccagagg cggcgctacgggcggctgatgggggccgtgacgatgagcgcggctgagaccgcgaggaga accagggagttccggtcccccccccaggaacagatcaacatgctgctgcagtacaagggg ggggcggacgaggaggactgccccgtgccccccgacatccgcggggagctgctgcaattc cacagcgacctgctggcgcactgcggcatcgagctgcagggcgaggaggaggaggaggag gaagacgcgtcgctgcggcagcggctgctggccttggtgcaacgcgtggtggggaggcag cagaaggaggaggaggaggaggaggcgacgtccccagagccccccgtgccacgcaccctg caggagctgatctcgcacaccatggttcactgggctcaggaatccttcatccagagcccc gagctggttcgctccatgttcagcctgctgcaccggcagtacgacgggctgggggagctg gtgcgggcgctgcccaaggcttacaccatcagcgcccactcggtgcccgacaccacggcg ctgctcgagtgcctggggcagatccgctcgctgctcatcgtacagatggggcccgaggag gagaacctcatgatacagagcatcgggaacatcatgaacaacaaagtcttctaccagcac cccaacctgatgcgggcgctggggatgcacgagacggtcatgcaggtgatggtgagcgtg ctgggcggcggcgagaccaaggagatccgcttccccaaaatggtcaccaactgctgccgc ttcctctgctacttctgccgcatcagccgccagaaccagcgctccatgttcgaccacctg ggctacctgctggagaacagcagcatcggcctgggcatgcagggctccaccccattggac gtggcggccgcttctgtcatcgacaacaacgagttggcactggcactgaaggagcaggac ctggagaaggtggtgacgtacctggcgagctgcgggctgcagagctgccccatgctgctg tccaagggttaccccgacatcggctggaacccctgcgggggggagcgctacctcgacttc ctgcgcttcgccgtcttcgtcaacggtgagagcgtggaggaaaacgccaacgtggtggtc cggctgctgatccgacgccccgaatgcttcgggccggcgctgcgcggggaggggggcagc gggctgctggccgccatcgaggacgccattaagatcagcgaggatccggcacgggacggc cccaccgtcaagaaggagaggaggagggagatattcggggcagaggagccccacgaggag aaccgcgtccacctgggcaacgccatcatgtccttctacgccgcctcgatcgacctgctg ggccgctgcgcccccgaaatgcacctgatccaagcagggaagggcgaagcgctgcggatc cgcgccatcctgcgctccctggtgccactggatgacctggtgggcgtcatcagcctcccc ctgcagatcccggccttcgggaaagacgggaacgtggtgcagccccgcatggctgccagc tttgtgccggaccacaaggctcccatggtgcttttcctggaccgcgtttacggcatcgag acgcagcagttcctgctccacgtgctggaggtcggcttcctgcccgacatgagaccggcc gcctccctcgacacggcggcgttcagcacgacgaagatggcgctggcgctgaaccgctac ctgtgcgtgccggtgttgccgctcatcaccaaatgcgcgccgctgtttgccggcacggag caccgcgccatcatggtggactccatgctgcacaccatctaccgcctgtcgcgcggccgc gcgctcaccaaggcgcagcgcgacgccatcgaggagtgcctgatggctctgtgccggtac atccggccctccatgctgcagcacctcctgcgccgcctcgtcttcgacgtccccatcctc aacgagttcgccaagatgccgctcaagctgctgaccaaccactacgagcgctgctggaag tattactgcctgcccagcgggtggcccaactacggggtcagctccgaggaggagctgcac ctgacccggaagctcttctggggcatctttgagtccctggctcacaagaagttcgacccc gagctgtacaagctggccatgccgtgcctctgcgccatcgcgggcgccctgccccccgac tacgtggacgccagctactcctccaagaccgagaagaaggcgtcggtggacgccgagggc aacttcgaccccaaacccgtcgagaccctcaacgtcatcatccctgagaagttggacggc ttcatcaacaaatacgccgagttcacccacgagaagtgggcgttcgataagatccagaac aactggacctacggggagacggtggacgaggaggccaagacccaccccatgctgcggccc tacaagaccttctcagagaaggacaaggaaatttaccggtggcccatcaaggagtcgctg aaggcgatgctggcgtgggagtggatggtggaaaaggcgcgggagggcgacgaggagaag gcggagaagaagaaaacgcggaagatctcgcagtcggcgcaggccacctacgaccccagc catggctacaacccgcagcccgtggacctctcgggggtgacgctgtcccgagagctgcag gcgatggcggagcagctggctgagaactaccacaacacgtggggccgcaagaagaagcag gagctggaggccaaaggggggggctcccaccccctgctggtgccctacgacacgctgacg gccaaggagaaggcgcgcgaccgcgagaaggcgcaggagctgctcaagttcctgcagctg aacggctacgccgtcacacgggggctgaaggacatggagttggacacgtcttccatcgag aagcgcttcgcctacggcttcctgcagcagctgctgcggtggatggacatctcccaggag ttcatcgcccacctggaggctgtggtgagcagcggccgcgtggagaagtcgccccacgaa caggagatcaaattctttgccaagatcctgctgcccctcatcaaccagtacttccacaac cactgcctctacttcctctccacccccgccaaagtgctgggcagcggcggccacgcgtcc aacaaggagaaggagatgatcaccagcctgttctgcaagctggccgcgctcgtccgccac cgcgtcactctctttggcaccgacgcgccggccgtggtcaactgcctccacatcctggca cggtcgctggacgccaggacggtgatgaagtccggccccgagatcgtgaaggccgggctg cgctccttcttcgagagcgcctcggaggacatcgagaagatggtggagaacctgaagctg ggcaaggtgacgcagagccgcacgcaggtgaagggggtggcccagaacatcaactacacc acggtggctctgctgcccgtcctcacgtcgctcttcgagcacatcgcccagcaccagttt ggggacgacgtcatcctggacgatgtccaggtctcgtgttaccgcatcctgtgcagcatt tactccttgggcaccaccaggaacccctacgtggaaaggcagcgcccggcgctgggggag tgcctggcccggctggcggccgccatgcctgtggccttcctggagccgcggctcaatgag ttcaacccctgctccgtctacagcaccaagtcgccccgcgagcgtgccaacccccatctt tggggcactgcagacccccaccccatctttgggaccccaacaccagtcctggggctgccg agccacgtggaggagatgtgccccgacatcccggacctggagcgcctgatgaaggacatc ggggggctggcggagtcgggcgctcgctacacggagatgccccacgtcatcgaggtgacg ctgcccatgctgtgcaattatttgccccgctggtgggagcgcgggccggacagcagcccc caggggccgtgggccacggccgtcaccgggcagcacctgaacgccctggctgggaaacat cctgcgcatcgtggtcaacaacctgggcatcgacgaggcgtcctggatgaaacgctggca gtgttcgctcagcccatcgtcagcaaggcgaagccggagctgctgcgcacccacttcatc cccacgatggagaagctgaagaagcgggcagggaaggtggtgtcggaggaggagcagctg cgcatggaggcgaaggcggaggccgaggacgccgagctgctcatccgcgacgagttctcc gtgctctgccgcgacctctacgccctgtaccctctgctcatccgctacgtcgacaacagc cgggccaagtggctgacggagcccaacgcggacgcggaggagctgttccgcatggtggga gaggtcttcatctactggtccaaatcccacaactttaagcgcgaggagcagaactttgtg gtgcagaatgagatcaacaacatgtccttcctgacggccgacagcaagagcaagatggcc aagtccggagacggccagggcggtggctcggagcaggagcgcaccaagaagaagcgccgc ggcgaccgttactccatccacacctccctgatcgtggccaccctgaagaagatgctgccc atcggcctcaacatgtgctcccccaccgaccaggagctcatcagcctggccaagagccgc tacgccctgaaggacacggatgaagaggtgcaggagtgcctgaacaacaacctgcacctg cagggcaagtgtgagaactcgtcggccatgcgctggcagctggctctgtatcgcgccatg gccggcagggctgaggactctgacagcccagagaaaatcgtgagacgagtgcaggaggtg tcagcagtgctgtatcacctggagcagacggagcacccctacaagtccaagaaggcggtg tggcacaaactgctctccaagcagcggcgccgcgccgtggtcgcctgtttccgaatgacg ccgctctacaacctgcccaggcatcgcgcctgcaatatgttcctggaggcctacaagctg ctgtggttggtgacggaggagcatcccttcgaggaccgcatgattgacgacctggcgaaa tcaggggaggaggaggaggaggaggaagaggagaaggacaagaagccagacccgctgcat cagctcatcctgcacttcagccgcacggcgctgaccgagaaaagcaagttggagaaggat cacctgtacatggcgtacgcgggtatcatggccaagagctgtcacattgaagaagggaat gaagaggagaaggaggagaagaaggaggaggaggacccggaggattcgtttgaggagaag gagatggagaagcagaagctgctgtaccagcagtcgcggctgcacacgaggggagcagct gagatggtgctgcagatgatcagcgcctgcaaaggggagcggggggagatggtttcctcc acgctgaagttggggatctccatcctcaacgggggaaacgccgatgtgcagcagaaaatg ttggattacctgaaggagaaacgtgagatcggattcttccaaagcgtccaggcgctgatg cagacctgcagcgtcctggacctgaacgcctttgagcggcagaacaaagcggaggggctg gggatggtgacggaggaggggacgatcatcagccgtgagaacggggagaaggtgatgtcg gatgatgagttcacgcaggatctgttccggctgctgcagctgctgtgcgaggggcacaac aacgacttccagaattacctccgcacgcagacgggcaacaccaccaccatcaacatcatc atctgcaccgtggattacctgctgcgcctgcaggagtccatcagcgatttctattggtat tactcggggaaggacgtcatcgacgagcagggaaagcgcaacttctccaaggccatggct gtggccaagcaggtcttcaacagcctcaccgagtacatccagggtccgtgcacggggaac cagcagagcctggctcacagccgcctgtgggacgccgtggtcggattcctgcacgtcttc gcacacatgatgaagaagttggcacaggactccagccagatcgggctgctgaaggagctg ctggacctgcagaaggacatggtggtgatgctgctgtccctgctggaaggcaatgtggtg aacgggacgatcgcacggcaggtggtggacatgccggtggagtcgtccagcaacgtcacc atgatcctgaagttcttcgatatgttcctgaagctgcgcgacatcgtggcctccgacgcc ttccgcgattacgtgacggacccgcgggggctcatctccaaaaaggacttccagaaggcc atggacagccagaagcagtacgagccgtccgaggtgcagttcctgctctcgtgctcggag gcggacgagaacgagatgatcgacgtggaggcgttcgtcgggcgctcccaggagccggct cgcgacatcggcttcaacgtggcggtgctgctgaccaacctggccgagcacgtcccccac gaccagaggctgcgcacctttttggagcaggccgccagcatcctggagtatttccggccg tttctgggccgcatcgagatcatgggagcggcgcggcgcatcgagcgcctctacttcgag atcagcgcggccaacaaggcgcagtgggagatgccccaggtgaaggagtccaagaggcag ttcatcttcgacgtggtcaacgaggggggggaggcggagaagatggagctcttcgtcagc ttctgcgaggacaccatcctcgagatgcagatcgcgtcgcggctctccgaggaggagggg gcgcgggacgggggggacggggacgaggaggaggaggaggagacccccgaggggggtggg agccccccgcccgcagagccgacctcggccttcggggagatgctgggggggctgcggcgc gcggtggggtccccccagctgtggaggaggaggatcaggaagatgaggaagaggggggca gggagctgctgtgggacttcggggcggccgtgtggagggcggtggtcgggggggctgatg ggggtctacggggcggtgagggcggtgggctgcgtgctgtgggtggtgcttttcgggggg gggttggtggagggggcgcagaaattggggttggcggagctgctgggcagcatgccggac cccacgcaggatgcggtggggggcggagaagccgggggggctccgagcggggagggggct gtagggggcgaggaggggcaggaggagagccccccccccgcagagcggccgcagagcagc gaggaggaggaggaggaggaaggagctgcggtggtggtcgccgcccccccggtggccttc ggggggaggaaggacggggggcactaccgcatggccccccccgatgcacccggaggtctg ggggacatcggggaaccccccggtgccgaaccgcccacccccgaggggaccccgatcctg aagaggaagatcggggaggatggaaaggaggtggtggaggaaccgcagaaggaggaggag gaggcggcggccgaaaccgaaaaggccgatacggagaatggagagaagggcgatgggggc gcagaggggggtccggaggtggagacccccgaaaagcagcagaaggcgtcgcccccccgg gagcgtaaagagccccccccgcccgaaggggccttcgagttctggacggagttggaggtg cagagggtgaagttcctgaactacctctcccgcaacttctacaatctccgcttcctggcg ctcttcctcgccttcgccatcaacttcatcctcctcttctataaggtgtcggagcggccg ccgggaatggaggaggcggagttggaggggtcgggaatggcggcggtgttggacgggatc ggagacttcggggacggcggggacggggacggcggggacggggaggaggagccgagcgtg gtgtattactgcctggaggagagcacgggctacatgcagcccgccctgcgcgccctggcc gtggctcacaccatcgtggcgttcctctgcatcatcggctacaactgcctcaagatcccc ctggtgatctttaagcgggagaaggaggtggcccggcgcctggagttctcagggctgtac atcactgagcagccgccggacgacgacgtgaaggggcagtgggatcgcctggtcctgaat gcgcagtccttccctagcaattactgggacaagttcgtcaagagaaaggtgctggagaaa tatggggacatttatggccgtgagcgcatcgcggagctgctggggatggagctctccagc ctcgaaatcggggcacggggggagaggaaacccccccccgacaactccgtgctcacctgg atcaccttcatcgatatccgctatcagatctggaagtttggggtcatcttcactgataac tcgttcctgtacctgacgtggtatatgggcatgtcccttctgggccactacaacaacttc ttcttcgttgcacacctcctggacatcgccatgggggtgaagacgctgcgcaccatcctg tcctccgtcacccataatggaagcaacctggccatgaccgtggggctgctggctgtcgtc gtgtatctttacaccgtcgtggccttcaacttcttccggaaattctacaataagagtgaa gatgaggatgagcccgacatgaaatgcgacgacatgatgacgtgctacctgttccatatg tacgtgggggtccgcgccggggggggcatcggggatgaaatcgaggacccggctggggat gaatacgagctgtaccgcgtggtcttcgacatcaccttcttcttcttcgtcatcgtcatc ctgctggccatcatccaaggtctgatcatcgacgccttcggggagctgcgggaccagcag gagcaggtgaaggaggacatggagacaaaatgcttcatctgtggcattggcagcgattac tttgacacgacgccccacggcttcgagacccacacgttggaggagcacaatttggcaaat tacatgttcttcctgatgtatctgatcaataaggatgagacggagcacacggggcaggag tcctacgtatggaagatgtaccaggagcgctgctgggatttcttccctgccggtgactgc ttccgcaagcagtacgaggaccagctgggctga

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