KEGG   Mus musculus (mouse): 19225Help
Entry
19225             CDS       T01002                                 

Gene name
Ptgs2, COX2, Cox-2, PES-2, PGHS-2, PHS_II, PHS-2, Pghs2, TIS10, gripghs
Definition
(RefSeq) prostaglandin-endoperoxide synthase 2
  KO
K11987  
prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
Organism
mmu  Mus musculus (mouse)
Pathway
Arachidonic acid metabolism
Metabolic pathways
NF-kappa B signaling pathway
VEGF signaling pathway
IL-17 signaling pathway
TNF signaling pathway
Retrograde endocannabinoid signaling
Serotonergic synapse
Ovarian steroidogenesis
Oxytocin signaling pathway
Regulation of lipolysis in adipocytes
Leishmaniasis
Human papillomavirus infection
Kaposi's sarcoma-associated herpesvirus infection
Pathways in cancer
Chemical carcinogenesis
MicroRNAs in cancer
Small cell lung cancer
Brite
KEGG Orthology (KO) [BR:mmu00001]
 Metabolism
  Lipid metabolism
   00590 Arachidonic acid metabolism
    19225 (Ptgs2)
 Environmental Information Processing
  Signal transduction
   04370 VEGF signaling pathway
    19225 (Ptgs2)
   04064 NF-kappa B signaling pathway
    19225 (Ptgs2)
   04668 TNF signaling pathway
    19225 (Ptgs2)
 Organismal Systems
  Immune system
   04657 IL-17 signaling pathway
    19225 (Ptgs2)
  Endocrine system
   04923 Regulation of lipolysis in adipocyte
    19225 (Ptgs2)
   04913 Ovarian Steroidogenesis
    19225 (Ptgs2)
   04921 Oxytocin signaling pathway
    19225 (Ptgs2)
  Nervous system
   04726 Serotonergic synapse
    19225 (Ptgs2)
   04723 Retrograde endocannabinoid signaling
    19225 (Ptgs2)
 Human Diseases
  Cancers
   05200 Pathways in cancer
    19225 (Ptgs2)
   05206 MicroRNAs in cancer
    19225 (Ptgs2)
   05204 Chemical carcinogenesis
    19225 (Ptgs2)
   05222 Small cell lung cancer
    19225 (Ptgs2)
  Infectious diseases
   05167 Kaposi's sarcoma-associated herpesvirus infection
    19225 (Ptgs2)
   05165 Human papillomavirus infection
    19225 (Ptgs2)
   05140 Leishmaniasis
    19225 (Ptgs2)
Enzymes [BR:mmu01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.99  Miscellaneous
    1.14.99.1  prostaglandin-endoperoxide synthase
     19225 (Ptgs2)
BRITE hierarchy
SSDB OrthologParalogGFIT
Motif Motif
Other DBs
NCBI-GeneID: 
NCBI-ProteinID: 
MGI: 
Ensembl: 
Vega: 
UniProt: 
LinkDB All DBs
Structure
PDB: 

Jmol
Position
1 G1; 1 63.84 cM
AA seq 604 aa AA seqDB search
MLFRAVLLCAALGLSQAANPCCSNPCQNRGECMSTGFDQYKCDCTRTGFYGENCTTPEFL
TRIKLLLKPTPNTVHYILTHFKGVWNIVNNIPFLRSLIMKYVLTSRSYLIDSPPTYNVHY
GYKSWEAFSNLSYYTRALPPVADDCPTPMGVKGNKELPDSKEVLEKVLLRREFIPDPQGS
NMMFAFFAQHFTHQFFKTDHKRGPGFTRGLGHGVDLNHIYGETLDRQHKLRLFKDGKLKY
QVIGGEVYPPTVKDTQVEMIYPPHIPENLQFAVGQEVFGLVPGLMMYATIWLREHNRVCD
ILKQEHPEWGDEQLFQTSRLILIGETIKIVIEDYVQHLSGYHFKLKFDPELLFNQQFQYQ
NRIASEFNTLYHWHPLLPDTFNIEDQEYSFKQFLYNNSILLEHGLTQFVESFTRQIAGRV
AGGRNVPIAVQAVAKASIDQSREMKYQSLNEYRKRFSLKPYTSFEELTGEKEMAAELKAL
YSDIDVMELYPALLVEKPRPDAIFGETMVELGAPFSLKGLMGNPICSPQYWKPSTFGGEV
GFKIINTASIQSLICNNVKGCPFTSFNVQDPQPTKTATINASASHSRLDDINPTVLIKRR
STEL
NT seq 1815 nt NT seq  +upstreamnt  +downstreamnt
atgctcttccgagctgtgctgctctgcgctgccctggggctcagccaggcagcaaatcct
tgctgttccaatccatgtcaaaaccgtggggaatgtatgagcacaggatttgaccagtat
aagtgtgactgtacccggactggattctatggtgaaaactgtactacacctgaatttctg
acaagaatcaaattactgctgaagcccaccccaaacacagtgcactacatcctgacccac
ttcaagggagtctggaacattgtgaacaacatccccttcctgcgaagtttaatcatgaaa
tatgtgctgacatccagatcatatttgattgacagtccacctacttacaatgtgcactat
ggttacaaaagctgggaagccttctccaacctctcctactacaccagggcccttcctccc
gtagcagatgactgcccaactcccatgggtgtgaagggaaataaggagcttcctgattca
aaagaagtgctggaaaaggttcttctacggagagagttcatccctgacccccaaggctca
aatatgatgtttgcattctttgcccagcacttcacccatcagtttttcaagacagatcat
aagcgaggacctgggttcacccgaggactgggccatggagtggacttaaatcacatttat
ggtgaaactctggacagacaacataaactgcgccttttcaaggatggaaaattgaaatat
caggtcattggtggagaggtgtatccccccacagtcaaagacactcaggtagagatgatc
taccctcctcacatccctgagaacctgcagtttgctgtggggcaggaagtctttggtctg
gtgcctggtctgatgatgtatgccaccatctggcttcgggagcacaacagagtgtgcgac
atactcaagcaggagcatcctgagtggggtgatgagcaactattccaaaccagcagactc
atactcataggagagactatcaagatagtgatcgaagactacgtgcaacacctgagcggt
taccacttcaaactcaagtttgacccagagctccttttcaaccagcagttccagtatcag
aaccgcattgcctctgaattcaacacactctatcactggcaccccctgctgcccgacacc
ttcaacattgaagaccaggagtacagcttcaaacagtttctctacaacaactccatcctc
ctggaacatggactcactcagtttgttgagtcattcaccagacagattgctggccgggtt
gctgggggaagaaatgtgccaattgctgtacaagcagtggcaaaggcctccattgaccag
agcagagagatgaaataccagtctctcaatgagtaccgcaaacgcttctccctgaagccg
tacacatcatttgaagaacttacaggagagaaggaaatggctgcagaattgaaagccctc
tacagtgacatcgatgtcatggaactgtaccctgccctgctggtggaaaaacctcgtcca
gatgctatctttggggagaccatggtagagcttggagcaccattctccttgaaaggactt
atgggaaatcccatctgttctcctcaatactggaagccgagcacctttggaggcgaagtg
ggttttaagatcatcaatactgcctcaattcagtctctcatctgcaataatgtgaagggg
tgtcccttcacttctttcaatgtgcaagatccacagcctaccaaaacagccaccatcaat
gcaagtgcctcccactccagactagatgacattaaccctacagtactaatcaaaaggcgt
tcaactgagctgtaa

DBGET integrated database retrieval system