Mycobacterium novum: MNVM_13170
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Entry
MNVM_13170 CDS
T06926
Symbol
hemD
Name
(GenBank) bifunctional uroporphyrinogen-III C-methyltransferase/uroporphyrinogen-III synthase
KO
K13542
uroporphyrinogen III methyltransferase / synthase [EC:
2.1.1.107
4.2.1.75
]
Organism
mnm
Mycobacterium novum
Pathway
mnm00860
Porphyrin metabolism
mnm01100
Metabolic pathways
mnm01110
Biosynthesis of secondary metabolites
mnm01120
Microbial metabolism in diverse environments
mnm01240
Biosynthesis of cofactors
Module
mnm_M00846
Siroheme biosynthesis, glutamyl-tRNA => siroheme
mnm_M00926
Heme biosynthesis, bacteria, glutamyl-tRNA => coproporphyrin III => heme
Brite
KEGG Orthology (KO) [BR:
mnm00001
]
09100 Metabolism
09108 Metabolism of cofactors and vitamins
00860 Porphyrin metabolism
MNVM_13170 (hemD)
Enzymes [BR:
mnm01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.107 uroporphyrinogen-III C-methyltransferase
MNVM_13170 (hemD)
4. Lyases
4.2 Carbon-oxygen lyases
4.2.1 Hydro-lyases
4.2.1.75 uroporphyrinogen-III synthase
MNVM_13170 (hemD)
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GFIT
Motif
Pfam:
HEM4
TP_methylase
B12-binding
Motif
Other DBs
NCBI-ProteinID:
BBX12236
UniProt:
A0A7I7JK14
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Position
complement(1423313..1425013)
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AA seq
566 aa
AA seq
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MARQVSVRGQKPKPGRIVFVGSGPGDPGLLTARARTALTNAALVFVDPDVPEAVLGLVGT
DLPPIAGPVPPDPKADKTDTAQEGAADAEDAAATVPGGPDIRPALGEPAEVAKILTAEAR
SGADVVRLVAGDPLSVDSVITEVNAVARTTVQFEIVPGLPATSAVPTYAGLPLGSSHTVA
DVRDPHVDWAALAAAPGPLILQATTSHLPEAARTLIEYGLADATPCVVTTSGTTCAQRSV
EASLSALTDPASLASIDPVILPNGQETAAGPLVVTIGKTVNNRAKLNWWESRALYGWTVL
VPRTKDQAGEMSEKLVGHGASPVEVPTIAVEPPRSPAQMERAVKGLVDGRYQWVVFTSTN
AVRAVWEKFGEFGLDARAFSGVKIACVGEATAERVRAFGISPELVPAGEQSSLGLLDEFP
PYDDVFDPVNRVLLPRADIATETLAEGLRERGWEIEDVTAYRTVRAAPPPATIREMIKTG
GFDAVCFTSSSTVRNLVGIAGKPHARTIVACIGPKTAETAAEFGLRVDVQPETAAVGPLV
DALAEHAARLRAEGALPPPRKKSRRR
NT seq
1701 nt
NT seq
+upstream
nt +downstream
nt
atggctcgccaagtgagcgtgcgagggcagaagcccaagccgggccgcattgtgttcgtc
ggttcgggtccgggtgacccgggcctgctgacggcgcgggcgcggacggcgctgacgaac
gccgcgctggtgttcgtcgaccccgacgtgcccgaggcggtgctggggctggtcggcacg
gacctgcccccgatcgccgggccggtgccgccggaccccaaggcggacaagaccgatacg
gcccaggaaggcgccgccgacgccgaagacgccgccgcgaccgtcccgggcgggcccgac
atccgtcccgcactgggcgaaccggccgaggtggccaagatcctgaccgccgaggcgcgc
tccggcgccgacgtggtgcgtctggtggccggcgacccgctgtccgtcgactccgtcatc
accgaggtcaacgcggtagcccgcaccaccgtgcagttcgagatcgtgccgggactgccc
gccaccagcgcggtgcccacctacgccggcctgccgctcggctcgtcgcacaccgttgcc
gacgtccgcgacccgcacgtcgactgggccgccctggctgcggccccgggcccgctgatc
ctgcaggccaccacctcgcacctgcccgaggcggctcgcacgctgatcgaatacggcctc
gcggacgccaccccgtgcgtggtcaccacctcgggcaccacctgcgcacagcgctcggtg
gaggccagcctcagcgcgctgaccgacccggcgtcgctggccagcatcgacccggtcatc
ctgcccaacggtcaggagaccgccgccggtccattggtggtgaccatcggcaagacggtg
aacaaccgggccaagctgaactggtgggagagccgcgcgctgtacggctggacggtgctg
gtgccgcgcaccaaggatcaggccggcgagatgagcgagaagctggtcgggcacggcgcc
tcgcctgtcgaggtgcccaccatcgccgtggaaccgccgcgcagccccgcccagatggaa
agggccgtcaagggtttggtcgacggccgctaccagtgggtggtgttcacctcgaccaac
gcggtacgtgcggtctgggagaagttcggtgaattcgggctggacgcccgcgcattctcc
ggggtgaagatcgcctgtgtcggcgaagcgaccgccgagcgggtccgggcgttcgggatc
agccccgagctggtgcccgccggggagcagtcctcgctgggcctgctcgacgaattcccg
ccctacgacgacgttttcgatccggtgaaccgggtgctgctgccgcgcgccgacatcgct
accgagacgctggccgaggggctgcgtgagcggggttgggagatcgaggacgtcaccgcc
taccgcacggtgcgggccgccccgccgccggcgaccatccgggagatgatcaagaccggc
ggattcgacgcggtgtgcttcacgtcgagttccacggtgcgcaacctggtcggcatcgcc
ggcaagccgcacgcccgcacgatcgtggcctgcatcggccccaagaccgccgagacggca
gcggaattcgggttgcgggtcgacgtgcagcccgagacggccgcggtcggtccgctggtc
gacgcgctggccgagcacgccgcccggttgcgtgccgagggcgccctgccgccgccgcgc
aagaagagccgccggcgctga
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