Mycobacterium tuberculosis 7199-99: MT7199_1277
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Entry
MT7199_1277 CDS
T02617
Name
(GenBank) 2-HYDROXY-3-OXOADIPATE (HOA) SYNTHASE
KO
K01616
multifunctional 2-oxoglutarate metabolism enzyme [EC:
2.2.1.5
4.1.1.71
1.2.4.2
2.3.1.61
]
Organism
mtub
Mycobacterium tuberculosis 7199-99
Pathway
mtub00020
Citrate cycle (TCA cycle)
mtub00630
Glyoxylate and dicarboxylate metabolism
mtub00785
Lipoic acid metabolism
mtub01100
Metabolic pathways
mtub01110
Biosynthesis of secondary metabolites
mtub01120
Microbial metabolism in diverse environments
mtub01200
Carbon metabolism
mtub01210
2-Oxocarboxylic acid metabolism
Module
mtub_M00009
Citrate cycle (TCA cycle, Krebs cycle)
mtub_M00011
Citrate cycle, second carbon oxidation, 2-oxoglutarate => oxaloacetate
Brite
KEGG Orthology (KO) [BR:
mtub00001
]
09100 Metabolism
09101 Carbohydrate metabolism
00020 Citrate cycle (TCA cycle)
MT7199_1277
00630 Glyoxylate and dicarboxylate metabolism
MT7199_1277
09108 Metabolism of cofactors and vitamins
00785 Lipoic acid metabolism
MT7199_1277
Enzymes [BR:
mtub01000
]
1. Oxidoreductases
1.2 Acting on the aldehyde or oxo group of donors
1.2.4 With a disulfide as acceptor
1.2.4.2 oxoglutarate dehydrogenase (succinyl-transferring)
MT7199_1277
2. Transferases
2.2 Transferring aldehyde or ketonic groups
2.2.1 Transketolases and transaldolases
2.2.1.5 2-hydroxy-3-oxoadipate synthase
MT7199_1277
2.3 Acyltransferases
2.3.1 Transferring groups other than aminoacyl groups
2.3.1.61 dihydrolipoyllysine-residue succinyltransferase
MT7199_1277
4. Lyases
4.1 Carbon-carbon lyases
4.1.1 Carboxy-lyases
4.1.1.71 2-oxoglutarate decarboxylase
MT7199_1277
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Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
E1_dh
2-oxoacid_dh
Transket_pyr
OxoGdeHyase_C
2-oxogl_dehyd_N
DUF5724
Motif
Other DBs
NCBI-ProteinID:
CCG11126
LinkDB
All DBs
Position
complement(1393897..1397592)
Genome browser
AA seq
1231 aa
AA seq
DB search
MANISSPFGQNEWLVEEMYRKFRDDPSSVDPSWHEFLVDYSPEPTSQPAAEPTRVTSPLV
AERAAAAAPQAPPKPADTAAAGNGVVAALAAKTAVPPPAEGDEVAVLRGAAAAVVKNMSA
SLEVPTATSVRAVPAKLLIDNRIVINNQLKRTRGGKISFTHLLGYALVQAVKKFPNMNRH
YTEVDGKPTAVTPAHTNLGLAIDLQGKDGKRSLVVAGIKRCETMRFAQFVTAYEDIVRRA
RDGKLTTEDFAGVTISLTNPGTIGTVHSVPRLMPGQGAIIGVGAMEYPAEFQGASEERIA
ELGIGKLITLTSTYDHRIIQGAESGDFLRTIHELLLSDGFWDEVFRELSIPYLPVRWSTD
NPDSIVDKNARVMNLIAAYRNRGHLMADTDPLRLDKARFRSHPDLEVLTHGLTLWDLDRV
FKVDGFAGAQYKKLRDVLGLLRDAYCRHIGVEYAHILDPEQKEWLEQRVETKHVKPTVAQ
QKYILSKLNAAEAFETFLQTKYVGQKRFSLEGAESVIPMMDAAIDQCAEHGLDEVVIGMP
HRGRLNVLANIVGKPYSQIFTEFEGNLNPSQAHGSGDVKYHLGATGLYLQMFGDNDIQVS
LTANPSHLEAVDPVLEGLVRAKQDLLDHGSIDSDGQRAFSVVPLMLHGDAAFAGQGVVAE
TLNLANLPGYRVGGTIHIIVNNQIGFTTAPEYSRSSEYCTDVAKMIGAPIFHVNGDDPEA
CVWVARLAVDFRQRFKKDVVIDMLCYRRRGHNEGDDPSMTNPYVYDVVDTKRGARKSYTE
ALIGRGDISMKEAEDALRDYQGQLERVFNEVRELEKHGVQPSESVESDQMIPAGLATAVD
KSLLARIGDAFLALPNGFTAHPRVQPVLEKRREMAYEGKIDWAFGELLALGSLVAEGKLV
RLSGQDSRRGTFSQRHSVLIDRHTGEEFTPLQLLATNSDGSPTGGKFLVYDSPLSEYAAV
GFEYGYTVGNPDAVVLWEAQFGDFVNGAQSIIDEFISSGEAKWGQLSNVVLLLPHGHEGQ
GPDHTSARIERFLQLWAEGSMTIAMPSTPSNYFHLLRRHALDGIQRPLIVFTPKSMLRHK
AAVSEIKDFTEIKFRSVLEEPTYEDGIGDRNKVSRILLTSGKLYYELAARKAKDNRNDLA
IVRLEQLAPLPRRRLRETLDRYENVKEFFWVQEEPANQGAWPRFGLELPELLPDKLAGIK
RISRRAMSAPSSGSSKVHAVEQQEILDEAFG
NT seq
3696 nt
NT seq
+upstream
nt +downstream
nt
gtggccaacataagttcaccattcgggcaaaacgaatggctggtcgaagagatgtaccgc
aagttccgcgacgacccctcctcggtcgatcccagctggcacgagttcctggttgactac
agccccgaacccacctcccaaccagctgccgaaccaacccgggttacctcgccactcgtt
gccgagcgggccgctgcggccgccccgcaggcaccccccaagccggccgacaccgcggcc
gcgggcaacggcgtggtcgccgcactggccgccaaaactgccgttcccccgccagccgaa
ggtgacgaggtagcggtgctgcgcggcgccgccgcggccgtcgtcaagaacatgtccgcg
tcgttggaggtgccgacggcgaccagcgtccgggcggtcccggccaagctactgatcgac
aaccggatcgtcatcaacaaccagttgaagcggacccgcggcggcaagatctcgttcacg
catttgctgggctacgccctggtgcaggcggtgaagaaattcccgaacatgaaccggcac
tacaccgaagtcgacggcaagcccaccgcggtcacgccggcgcacaccaatctcggcctg
gcgatcgacctgcaaggcaaggacgggaagcgttccctggtggtggccggcatcaagcgg
tgcgagaccatgcgattcgcgcagttcgtcacggcctacgaagacatcgtacgccgggcc
cgcgacggcaagctgaccactgaagactttgccggcgtgacgatttcgctgaccaatccc
ggaaccatcggcaccgtgcattcggtgccgcggctgatgcccggccagggcgccatcatc
ggcgtgggcgccatggaataccccgccgagtttcaaggcgccagcgaggaacgcatcgcc
gagctgggcatcggcaaattgatcactttgacctccacctacgaccaccgcatcatccag
ggcgcggaatcgggcgacttcctgcgcaccatccacgagttgctgctctcggatggcttc
tgggacgaggtcttccgcgaactgagcatcccatatctgccggtgcgctggagcaccgac
aaccccgactcgatcgtcgacaagaacgctcgcgtcatgaacttgatcgcggcctaccgc
aaccgcggccatctgatggccgataccgacccgctgcggttggacaaagctcggttccgc
agtcaccccgacctcgaagtgctgacccacggcctgacgctgtgggatctcgatcgggtg
ttcaaggtcgacggctttgccggtgcgcagtacaagaaactgcgcgacgtgctgggcttg
ctgcgcgatgcctactgccgccacatcggcgtggagtacgcccatatcctcgaccccgaa
caaaaggagtggctcgaacaacgggtcgagaccaagcacgtcaaacccactgtggcccaa
cagaaatacatcctcagcaagctcaacgccgccgaggcctttgaaacgttcctacagacc
aagtacgtcggccagaagcggttctcgctggaaggcgccgaaagcgtgatcccgatgatg
gacgcggcgatcgaccagtgcgctgagcacggcctcgacgaggtggtcatcgggatgccg
caccggggccggctcaacgtgctggccaacatcgtcggcaagccgtactcgcagatcttc
accgagttcgagggcaacctgaatccgtcgcaggcgcacggctccggtgacgtcaagtac
cacctgggcgccaccgggctgtacctgcagatgttcggcgacaacgacattcaggtgtcg
ctgaccgccaacccgtcgcatctggaggccgtcgacccggtgctggagggattggtgcgg
gccaagcaggatctgctcgaccacggaagcatcgacagcgacggccaacgggcgttctcg
gtggtgccgctgatgttgcatggcgatgccgcgttcgccggtcagggtgtggtcgccgag
acgctgaacctggcgaatctgccgggctaccgcgtcggcggcaccatccacatcatcgtc
aacaaccagatcggcttcaccaccgcgcccgagtattccaggtccagcgagtactgcacc
gacgtcgcaaagatgatcggggcaccgatctttcacgtcaacggcgacgacccggaggcg
tgtgtctgggtggcgcggttggcggtggacttccgacaacggttcaagaaggacgtcgtc
atcgacatgctgtgctaccgccgccgcgggcacaacgagggtgacgacccgtcgatgacc
aacccctacgtgtacgacgtcgtcgacaccaagcgcggggcccgcaaaagctacaccgaa
gccctgatcggacgtggcgacatctcgatgaaggaggccgaggacgcgctgcgcgactac
cagggccagctggaacgggtgttcaacgaagtgcgcgagctggagaagcacggtgtgcag
ccgagcgagtcggtcgagtccgaccagatgattcccgcggggctggccactgcggtggac
aagtcgctgctggcccggatcggcgatgcgttcctcgccttgccgaacggcttcaccgcg
cacccgcgagtccaaccggtgctggagaagcgccgggagatggcctatgaaggcaagatc
gactgggcctttggcgagctgctggcgctgggctcgctggtggccgaaggcaagctggtg
cgcttgtcggggcaggacagccgccgcggcaccttctcccagcggcattcggttctcatc
gaccgccacactggcgaggagttcacaccactgcagctgctggcgaccaactccgacggc
agcccgaccggcggaaagttcctggtctacgactcgccactgtcggagtacgccgccgtc
ggcttcgagtacggctacactgtgggcaatccggacgccgtggtgctctgggaggcgcag
ttcggcgacttcgtcaacggcgcgcagtcgatcatcgacgagttcatcagctccggtgag
gccaagtggggccaattgtccaacgtcgtgctgctgttaccgcacgggcacgaggggcag
ggacccgaccacacttctgcccggatcgaacgcttcttgcagttgtgggcggaaggttcg
atgaccatcgcgatgccgtcgactccgtcgaactacttccacctgctacgccggcatgcc
ctggacggcatccaacgcccgctgatcgtgttcacgcccaagtcgatgttgcgtcacaag
gccgccgtcagcgaaatcaaggacttcaccgagatcaagttccgctcagtgctggaggaa
cccacctatgaggacggcatcggagaccgcaacaaggtcagccggatcctgctgaccagt
ggcaagctgtattacgagctggccgcccgcaaggccaaggacaaccgcaatgacctcgcg
atcgtgcggcttgaacagctcgccccgctgcccaggcgtcgactgcgtgaaacgctggac
cgctacgagaacgtcaaggagttcttctgggtccaagaggaaccggccaaccagggtgcg
tggccgcgattcgggctcgaactacccgagctgctgcctgacaagttggccgggatcaag
cgaatctcgcgccgggcgatgtcagccccgtcgtcaggctcgtcgaaggtgcacgccgtc
gaacagcaggagatcctcgacgaggcgttcggctga
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