Ovis aries (sheep): 101102089 Help Entry 101102089         CDS       T03117                                  Symbol ADCY2 Name (RefSeq) adenylate cyclase type 2   KO K08042   adenylate cyclase 2 [EC:4.6.1.1] Organism oas  Ovis aries (sheep) Pathway oas00230   Purine metabolism oas01100   Metabolic pathways oas01522   Endocrine resistance oas04015   Rap1 signaling pathway oas04020   Calcium signaling pathway oas04022   cGMP-PKG signaling pathway oas04024   cAMP signaling pathway oas04062   Chemokine signaling pathway oas04072   Phospholipase D signaling pathway oas04114   Oocyte meiosis oas04211   Longevity regulating pathway oas04213   Longevity regulating pathway - multiple species oas04261   Adrenergic signaling in cardiomyocytes oas04270   Vascular smooth muscle contraction oas04371   Apelin signaling pathway oas04540   Gap junction oas04611   Platelet activation oas04713   Circadian entrainment oas04714   Thermogenesis oas04723   Retrograde endocannabinoid signaling oas04724   Glutamatergic synapse oas04725   Cholinergic synapse oas04727   GABAergic synapse oas04750   Inflammatory mediator regulation of TRP channels oas04911   Insulin secretion oas04912   GnRH signaling pathway oas04913   Ovarian steroidogenesis oas04914   Progesterone-mediated oocyte maturation oas04915   Estrogen signaling pathway oas04916   Melanogenesis oas04918   Thyroid hormone synthesis oas04921   Oxytocin signaling pathway oas04922   Glucagon signaling pathway oas04923   Regulation of lipolysis in adipocytes oas04925   Aldosterone synthesis and secretion oas04926   Relaxin signaling pathway oas04927   Cortisol synthesis and secretion oas04928   Parathyroid hormone synthesis, secretion and action oas04934   Cushing syndrome oas04935   Growth hormone synthesis, secretion and action oas04970   Salivary secretion oas04971   Gastric acid secretion oas04972   Pancreatic secretion oas04976   Bile secretion oas05032   Morphine addiction oas05163   Human cytomegalovirus infection oas05166   Human T-cell leukemia virus 1 infection oas05200   Pathways in cancer oas05207   Chemical carcinogenesis - receptor activation oas05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:oas00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     101102089 (ADCY2)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     101102089 (ADCY2)    04371 Apelin signaling pathway     101102089 (ADCY2)    04020 Calcium signaling pathway     101102089 (ADCY2)    04072 Phospholipase D signaling pathway     101102089 (ADCY2)    04024 cAMP signaling pathway     101102089 (ADCY2)    04022 cGMP-PKG signaling pathway     101102089 (ADCY2)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     101102089 (ADCY2)   09144 Cellular community - eukaryotes    04540 Gap junction     101102089 (ADCY2)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     101102089 (ADCY2)    04062 Chemokine signaling pathway     101102089 (ADCY2)   09152 Endocrine system    04911 Insulin secretion     101102089 (ADCY2)    04922 Glucagon signaling pathway     101102089 (ADCY2)    04923 Regulation of lipolysis in adipocytes     101102089 (ADCY2)    04912 GnRH signaling pathway     101102089 (ADCY2)    04913 Ovarian steroidogenesis     101102089 (ADCY2)    04915 Estrogen signaling pathway     101102089 (ADCY2)    04914 Progesterone-mediated oocyte maturation     101102089 (ADCY2)    04921 Oxytocin signaling pathway     101102089 (ADCY2)    04926 Relaxin signaling pathway     101102089 (ADCY2)    04935 Growth hormone synthesis, secretion and action     101102089 (ADCY2)    04918 Thyroid hormone synthesis     101102089 (ADCY2)    04928 Parathyroid hormone synthesis, secretion and action     101102089 (ADCY2)    04916 Melanogenesis     101102089 (ADCY2)    04925 Aldosterone synthesis and secretion     101102089 (ADCY2)    04927 Cortisol synthesis and secretion     101102089 (ADCY2)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     101102089 (ADCY2)    04270 Vascular smooth muscle contraction     101102089 (ADCY2)   09154 Digestive system    04970 Salivary secretion     101102089 (ADCY2)    04971 Gastric acid secretion     101102089 (ADCY2)    04972 Pancreatic secretion     101102089 (ADCY2)    04976 Bile secretion     101102089 (ADCY2)   09156 Nervous system    04724 Glutamatergic synapse     101102089 (ADCY2)    04727 GABAergic synapse     101102089 (ADCY2)    04725 Cholinergic synapse     101102089 (ADCY2)    04723 Retrograde endocannabinoid signaling     101102089 (ADCY2)   09157 Sensory system    04750 Inflammatory mediator regulation of TRP channels     101102089 (ADCY2)   09149 Aging    04211 Longevity regulating pathway     101102089 (ADCY2)    04213 Longevity regulating pathway - multiple species     101102089 (ADCY2)   09159 Environmental adaptation    04713 Circadian entrainment     101102089 (ADCY2)    04714 Thermogenesis     101102089 (ADCY2)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     101102089 (ADCY2)    05207 Chemical carcinogenesis - receptor activation     101102089 (ADCY2)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     101102089 (ADCY2)    05163 Human cytomegalovirus infection     101102089 (ADCY2)   09165 Substance dependence    05032 Morphine addiction     101102089 (ADCY2)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     101102089 (ADCY2)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     101102089 (ADCY2)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     101102089 (ADCY2) Enzymes [BR:oas01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      101102089 (ADCY2) BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N HNOBA Motif Other DBs NCBI-GeneID:  101102089 NCBI-ProteinID:  XP_027835974 EnsemblRapid:  ENSOARG00020022595 LinkDB All DBs Position 16:complement(65471619..65927574) Genome browser AA seq 1091 aa AA seqDB search MWQEAMRRRRYLRDRAEAAAGGGDGLQRSRDWLYESYYRMSQQHPLIVFLLLIVMGACLA LLAVFFALRLEVEDHVAFLITVPTALAIFFAIFILVCIESVFKKLLRLFSLVIWICLVAM GYLFMCFGGTVSPWDQVSFFLFIIFVVYTMLPFNMRDAIIASVLTSSSHTIVLSVCLSAT PGAKEHLVWQILANVIIFICGNLAGAYHKHLMELALQQTYQDTCNCIKSRIKLEFEKRQQ ERLLLSLLPAHIAMEMKAEIIQRLQGPKAGQMENTNNFHNLYVKRHTNVSILYADIVGFT RLASDCSPGELVHMLNELFGKFDQIAKENECMRIKILGDCYYCVSGLPISLPNHAKNCVK MGLDMCEAIKKVRDATGVDINMRVGVHSGNVLCGVIGLQKWQYDVWSHDVTLANHMEAGG VPGRVHISSVTLQHLNGAYKVEEGDGDIRDPYLKQHLVKTYFVINPKGERRSPQHLFRPR HTLDGAKMRASVRMTRYLESWGAAKPFAHLHHRDSMTTENGKISTTDVPMGQHNFQNRTL RTKSQKKRFEEELNERMIQAIDGINAQKQWIKSEDIQRISLLFYNKILEKEYRATALPAF KYYVTCACLIFFCIFIVQVLVLPKTSILGISFGAAFLSLAFILFVCFAGQLLQCSKKASA SLLWLLKSSGIIANRPWPRISLTVITTAIILTMAVFNMFFLSDSEETIVPTANASNTSLS GASNQAAILRAQNLFFLPYFIYSCILGLISCSVFLRVNYELKMLIMMVALVGYNTIFLHT HAPLLDDYSQVLFERPGIWKDLKTMGSVSLFIFFITLLVLGRQNEYYCRLDFLWKNKFKK EREEIETMENLNRVLLENVLPAHVAEHFLARSLKNEDLYHQSYDCVCVMFASIPDFKEFY TESDVNKEGLECLRLLNEIIADFDDLLSKPKFSGVEKIKTIGSTYMAATGLSAVPSQEHT QEPERQYMHIGTMVEFAFALVGKLDAINKHSFNDFKLRVGINHGPVIAGVIGAQKPQYDI WGNTVNVASRMDSTGVLDKIQVTEETSIILQTLGYTCTCRGIINVKGKGDLKTYFVNTEM SRSLSQSNLTS NT seq 3276 nt NT seq  +upstreamnt  +downstreamnt atgtggcaggaggcgatgcggcggcgccgctacctgcgggaccgcgccgaggcggcagcg ggcggcggagacgggctgcagcggtcccgggactggctctacgaatcctactaccgcatg agccagcagcacccgctcatcgtcttcctgctgctcatcgtcatgggcgcctgcctcgcc ctgctcgccgtcttcttcgcgctccgcctggaagttgaagaccacgtggcatttttaatc acagttccgacagccctggcgattttctttgcgatcttcatcctggtgtgcatcgagtcg gtgtttaagaagctgctgcgcctcttctctttggtgatatggatctgtctcgtggccatg ggctacttgttcatgtgttttgggggcaccgtctctccctgggaccaggtgtcgttcttc cttttcatcatcttcgtggtgtacaccatgctgcccttcaacatgcgagatgccatcatc gccagcgtcctcacctcctcttctcacaccatcgtgctgagcgtctgcctgtctgcgacc ccgggggccaaggagcacctggtctggcagatcctggccaacgtgatcatcttcatctgc gggaacctggcgggggcgtaccataagcacctcatggagcttgctctgcagcagacgtat caggacacgtgcaactgcatcaagtcccggatcaagctggaatttgaaaaacgtcagcag gagcggctgctgctctccttgctgccggcacacatagccatggagatgaaagcagagatc atccagaggctgcagggccccaaagccggccagatggagaacaccaacaacttccacaac ctctatgtcaagcggcacaccaacgtcagtatcctctatgcagacattgttgggttcacc cgtctggccagtgactgctcccctggagagctcgtccacatgctgaatgaactctttgga aagttcgatcaaattgcaaaggagaatgaatgcatgagaataaaaattttaggagactgc tactactgtgtgtccggactgcctatatctctccctaaccatgccaagaattgtgtgaaa atgggactggatatgtgtgaagccataaagaaagtgagggacgccaccggagtggacatc aacatgcgcgtgggagtgcattctgggaacgtcctgtgcggcgtgatcgggctacagaag tggcagtacgacgtgtggtcacatgacgtcaccctggccaaccacatggaagctggaggg gtccctggacgtgttcacatctcttctgttaccctgcaacacttgaatggagcttacaaa gtggaagaaggcgatggtgacatcagagacccgtatttaaagcaacacttggtgaaaact tactttgtaatcaaccccaagggagagcggcggagccctcaacacctcttcaggccccga cacacccttgatggagcgaagatgagggcttctgtccgcatgacccggtacctggagtcc tggggggcggccaagccctttgcacacctgcatcatagagacagcatgactacggagaac ggcaagatcagcaccacggatgtaccaatgggtcagcataattttcaaaaccgcacctta agaaccaagtcacaaaagaaaagatttgaagaggaattaaatgaaaggatgattcaagca attgatggaatcaatgcacaaaagcaatggatcaagtccgaagacattcagagaatctca ttgcttttctacaataaaatactagaaaaagaataccgagccaccgcactgccggccttc aagtattacgtgacttgcgcttgcctcatcttcttctgcatctttatcgtgcaggttctg gtcttacccaaaacgtccattctcgggatttcctttggagcggcgtttctctcacttgcc tttatccttttcgtctgctttgctggacagcttttgcaatgcagcaagaaagcatctgct tctctcctgtggcttttaaagtcatcgggcatcatcgccaaccggccttggcctcggatc tccctgacggtcatcaccacagccatcatattgaccatggccgtgttcaatatgtttttc ctgagtgactcagaggaaacaattgttccgactgccaacgcgtccaacacgagtctttct ggcgcaagtaaccaggcagcgattctgcgtgcgcaaaatttgtttttcctgccgtacttt atatacagctgcatcctcgggctgatctcctgttccgtcttcctgcgtgtgaattacgag ctgaagatgctgatcatgatggtagccttggtgggctacaacaccatcttcctccacact cacgctcccctcctggacgactacagccaggtcctgttcgagagaccgggcatttggaaa gacctaaagaccatgggctcagtatctctctttatatttttcatcacactgcttgttctg ggcagacagaatgaatattactgtaggttagacttcttatggaagaacaagttcaaaaaa gagcgggaggagatagaaaccatggagaacttgaaccgagtgctgctggagaatgtgctt cctgcgcacgtggctgagcacttcctggcccggagcctgaagaacgaggatctataccac cagtcctatgactgcgtctgcgtcatgtttgcctccattcctgacttcaaagagttctac acggagtccgacgtgaacaaggagggtttggaatgccttcggctcctgaacgaaatcatt gccgactttgatgatctgctatccaagccgaagttcagtggcgttgaaaagatcaagacc atcggcagcacgtacatggcagcgacgggtctgagcgcggtgcccagccaggagcacacc caggagcccgagaggcagtacatgcacattggcaccatggtggagtttgcgtttgccctg gtggggaagctggacgccatcaacaagcactccttcaatgacttcaagttacgagtaggt attaaccatggccctgtcatagccggtgtgattggagctcagaagccgcagtatgacatc tggggcaacaccgtcaatgtggccagcaggatggacagcactggagtcctggacaaaatc caggtgacagaggagacgagcatcatcctacagaccctgggctacacgtgcacgtgtcgg ggaatcatcaacgtgaaaggaaagggagacctgaagacctacttcgtcaacacggagatg tcacggtccctttctcagagcaacctgacctcctga

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