Pteropus alecto (black flying fox): 102898620 Help Entry 102898620         CDS       T02993                                  Symbol JAK3 Name (RefSeq) tyrosine-protein kinase JAK3   KO K11218   Janus kinase 3 [EC:2.7.10.2] Organism pale  Pteropus alecto (black flying fox) Pathway pale04062   Chemokine signaling pathway pale04151   PI3K-Akt signaling pathway pale04217   Necroptosis pale04550   Signaling pathways regulating pluripotency of stem cells pale04630   JAK-STAT signaling pathway pale04658   Th1 and Th2 cell differentiation pale04659   Th17 cell differentiation pale05161   Hepatitis B pale05162   Measles pale05166   Human T-cell leukemia virus 1 infection pale05169   Epstein-Barr virus infection pale05200   Pathways in cancer pale05203   Viral carcinogenesis pale05223   Non-small cell lung cancer pale05340   Primary immunodeficiency Brite KEGG Orthology (KO) [BR:pale00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102898620 (JAK3)    04151 PI3K-Akt signaling pathway     102898620 (JAK3)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102898620 (JAK3)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102898620 (JAK3)  09150 Organismal Systems   09151 Immune system    04658 Th1 and Th2 cell differentiation     102898620 (JAK3)    04659 Th17 cell differentiation     102898620 (JAK3)    04062 Chemokine signaling pathway     102898620 (JAK3)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102898620 (JAK3)    05203 Viral carcinogenesis     102898620 (JAK3)   09162 Cancer: specific types    05223 Non-small cell lung cancer     102898620 (JAK3)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102898620 (JAK3)    05161 Hepatitis B     102898620 (JAK3)    05162 Measles     102898620 (JAK3)    05169 Epstein-Barr virus infection     102898620 (JAK3)   09163 Immune disease    05340 Primary immunodeficiency     102898620 (JAK3)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:pale01001]     102898620 (JAK3) Enzymes [BR:pale01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102898620 (JAK3) Protein kinases [BR:pale01001]  Non-receptor tyrosine kinases   JAK family [OT]    102898620 (JAK3) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 FERM_F1 Jak1_Phl Kdo FERM_C_FAK1 ABC1 Haspin_kinase Motif Other DBs NCBI-GeneID:  102898620 NCBI-ProteinID:  XP_015441664 UniProt:  L5L7Y5 LinkDB All DBs Position Unknown AA seq 1104 aa AA seqDB search MVPPSEETPLISQRSCSLSSSEAGVLHVLLPPRGPGPLQRLSFSFGDHSAEELCVRAAKA SGILPVYHSLFALATEDLSCWFPPSHIFSVEDTGTQVLVYRLRFYFPNWFGLEKCHRFGL RKDLASAILDLPVLEHLFAQHRNDLVSGRFHVGLGLKEQGECLSLAVLDLARMAREQAQR PEELLKTVSYKACLPPGLRNLIQGLSFVTRRRIRRTVRQALCRVAACQADRHSLMAKYIM DLERLDPARAAETFLVGLPGVAGGQDAPGLLHVAGDSGIAWSSGEQEVFQPFCDFPEIVD ISIKQALRVGTAGEHRLVTVTRTDNQILEAEFPGLPAALSFVALVDGYFRLTVDSRHYFC KEVAPPRLLEEVAQQCHGPITLDFAINKLKMGGSLPGSYVLRRSPQDFDSFLLTVCVQTP LGPDYKGCLIRCDPTGAYSLAGLGRPHSSLRELLAACWDGGLHVDGVALNLTFCCTPRPK EKSNLIVVRRGCSPPTSSPVQPHSGCQLSQMTFHKIPADSLEWHENLGHGSFTKIYRGCR HEAMDGEPRKTEVLLKVLDAKHKNCMESFLEAASLMSQVSYQHLVLLHGVCMAGDSIMVQ EFVHLGALDTYLRKCGQLVPASWKLQVIKQLAYALNYLEDKGLPHGNVSARKVLLAREGA EGSPPFIKLSDPGVSPTVLSLEMLTDRIPWVAPECLQEARTLGLEADKWGFGATVWEVFS GVTMPISTLDPAKKLQFYEERQQLPAPKWMELALLIQQCMAYEPGHRPSFRAVIRDLNNL ITSDYELLSDPTPGALAPRDGLWNGAQLYACQDPTIFEERHLKYISQLGKGNFGSVELCR YDPLGDNTGALVAVKQLQHSGPDQQRDFQREIQILKALHSDFIVKYRGVSYGPGRQSLRL VMEYLPSGCLRDFLQRHRARLGAGRLLLYASQICKGMEYLGSCRCVHRDLAARNILVESE THVKIADFGLAKLLPLDKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYEL FTYSDKSCSPSAEFLRMMGCERDIPALCRLLDLLAEGQRLPAPPACPGEVHELMKLCWAP SPQDRPTFSALGPQLDALWSGSQG NT seq 3315 nt NT seq  +upstreamnt  +downstreamnt atggtgcctccgagtgaggagacacccctgatctctcagcgctcttgcagcctctcatct tcagaggctggtgtgctgcatgtgctgctgccacctcggggccctggacccctgcagcgt ctatccttctcctttggggaccactcggctgaagagctgtgtgttcgggctgctaaggcc agtggcatcctgcctgtgtaccactccctctttgctctggccacggaggacctgtcctgc tggttccccccgagccacatcttctccgtggaggacacaggcacccaagtccttgtctac aggctccgcttttacttccccaactggtttgggctagagaagtgtcaccgcttcgggctt cgaaaggacttggctagtgccatccttgacctgccagttctggagcacctcttcgcccag caccgcaatgacctggtgagcggccgcttccacgtgggccttggcctcaaggagcagggc gaatgtctcagcttggcagtgctggacctggccaggatggcccgcgagcaggcccagcgg ccagaggagctgctaaagaccgtcagctacaaggcctgcctgccccctggcctgcgcaac ctgatccagggcctgagcttcgtgactcggaggcgcattcggaggactgtacgccaggcc ctgtgccgcgtggccgcctgccaggctgacaggcactcgctcatggccaagtacatcatg gacttggagcgactggacccggccagggccgctgagaccttcctcgtgggcctccccggg gttgctggtggtcaggatgcaccggggctgctccacgtggctggtgacagcggcatcgcc tggagttcaggagaacaggaggtcttccagcccttttgcgactttccagaaatcgtggac atcagcatcaagcaggctctacgcgttggcacggccggggagcaccgcctggtcactgtc accaggacagacaaccagatcctggaggccgagttccctgggctgcccgccgcgttgtcc tttgtggcgctcgtggatggctacttccggctgactgttgactctcggcactacttctgc aaggaggtagcaccgccgcggttgctggaggaggtggcgcagcagtgccatggccccatc accctggattttgcaatcaacaagctcaagatgggggggtcccttcctggctcctacgtt ctccgccgcagcccccaggatttcgacagcttcctcctcactgtctgtgttcagaccccc ctgggccctgattacaagggctgcctcatccggtgtgaccccacaggagcctactccctg gctggccttggccgaccccacagtagtctgcgagagctcctggcagcctgctgggatggt gggctgcatgtggatggggttgcactgaaccttaccttctgctgcacccctagacccaaa gaaaagtccaacctgattgtggtccggagaggttgcagcccacccacatcatcccccgtg cagccccactcaggatgccagctgagtcagatgacatttcacaagatacctgctgacagc ttggagtggcatgagaacctgggtcatggatccttcacgaagatttacaggggctgtcgc cacgaggccatggatggggagccccggaagacagaggtgctgctcaaggtgttggatgcc aaacacaagaactgcatggagtcattcctggaagcagcaagtttgatgagccaagtatcg taccagcatctcgtgttgcttcatggcgtgtgcatggctggagacagcatcatggtgcag gaatttgtacacctgggagcactggacacgtatctacgcaagtgtgggcagctggtgcca gccagctggaagctgcaggtgatcaaacagctggcctatgccctcaactatctggaggac aaaggccttccccatggcaatgtctcagcccggaaggtgctcctggctcgggaaggggct gaggggagcccgcccttcatcaagctgagtgatcccggtgtcagccccactgtactaagc ctggagatgctcactgacaggatcccctgggtagctcctgagtgtctccaggaggcccgg acacttggcttggaagctgacaagtggggcttcggtgccacagtctgggaggtgttcagt ggtgtcacgatgccaatcagtaccctggatcctgccaagaagctccagttttatgaggaa cggcagcagctgcctgcccccaagtggatggagctggccctgctgatccaacagtgcatg gcctacgagccaggccacaggccctccttccgcgccgtcatccgtgacctgaacaacctt atcacgtcagactatgagctcctctcagaccccacacctggtgccttggcaccccgtgac gggctgtggaatggcgcccagctctatgcctgccaggaccctactatctttgaggagaga cacctgaagtatatctcacagctgggcaagggtaactttggcagcgtggaactatgtcgc tatgacccgctgggagacaacacaggtgccctggtggccgtgaagcagctgcagcacagt gggccagaccagcagagggacttccaacgggagatccagatcctcaaagccctgcacagt gacttcattgtcaagtaccgtggtgtcagctatggcccaggccgtcagagcctgcggcta gtcatggagtacctgcccagtggctgcctgagagatttcctgcagcggcaccgcgcacgc ctcggcgccggccgcctgctcctctatgcttcgcagatctgcaagggcatggagtatctg ggctcctgccgctgcgtgcaccgcgacctggcagcgcgtaacatcctggtggagagcgag acgcacgtcaagatcgccgactttggcctcgccaagctgctgccgctggacaaagactat tacgttgtccgcgagccaggccagagccccattttctggtacgccccggagtccctctca gacaacatcttctcgcgccagtcggacgtctggagcttcggagtcgtcctgtacgagctt ttcacctacagtgacaagagctgcagcccctccgccgagttcctgcggatgatgggttgt gagcgagatatcccggctctttgccgcctcctggacctgctggcagagggccagaggctg ccggcgcctccagcctgccctggagaggttcatgagctcatgaagctgtgctgggctcct agcccgcaagaccggccgaccttcagtgccctcggaccccagctggatgcgctgtggagt ggaagccaggggtag

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