Puma concolor (puma): 112862713 Help Entry 112862713         CDS       T08890                                  Symbol MDN1 Name (RefSeq) midasin   KO K14572   midasin Organism pcoo  Puma concolor (puma) Pathway pcoo03008   Ribosome biogenesis in eukaryotes Brite KEGG Orthology (KO) [BR:pcoo00001]  09120 Genetic Information Processing   09122 Translation    03008 Ribosome biogenesis in eukaryotes     112862713 (MDN1)  09180 Brite Hierarchies   09182 Protein families: genetic information processing    03009 Ribosome biogenesis [BR:pcoo03009]     112862713 (MDN1) Ribosome biogenesis [BR:pcoo03009]  Eukaryotic type   Pre-60S particles    Other pre-60S particles     112862713 (MDN1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  AAA_5 AAA_lid_7 AAA_lid_5 AAA_16 AAA AAA_3 AAA_7 AAA_22 TsaE nSTAND3 Sigma54_activ_2 Sigma54_activat AAA_14 AAA_18 ABC_tran MDN1_4th AAA_6 AAA_2 DUF815 Dynein_heavy AAA_25 PduV-EutP ResIII VWA Pus10_N_euk Motif Other DBs NCBI-GeneID:  112862713 NCBI-ProteinID:  XP_025781751 UniProt:  A0A6P6I179 LinkDB All DBs Position Unknown AA seq 5600 aa AA seqDB search MEHLFLEVAAAPLRLLAAKNEKSRSELGRFLAKQVWTPQDRQCILSTLAQLLLDKDCTVL VGRQLRPLLLDLLERNAEAIKAGGQINHDLHERLCVSMSKLICYHPDVLPFALRYFKDTS PVFQRLFLESSDANPVRYGRRRMKLRDLMEAAYKFLQNEQSVFRELWDWSVCVPLLRSHD TLVRWYTANCLALVTCMNEEHKLSFLKKIFNTEELIHFRLRLLEEAQLQDLEKALVLANP EASLWRKEKELQYLQGHLVSADLSAGVTAVCGVVLPGQPPAPGEQASNRSSSREQELAFR SYVLVDSICKNLQTLAMAVASQNAVLLEGPIGCGKTSLVEYLGAMTGRRKPPQLLKVQLG DQTDSKMLLGMYRCTDVPGEFVWQPGTLTQAATKGHWILLEDIDYAPLDVVSVLIPLLEN GELLIPGRGDCLKVAPGFQFFATRRLLSCGGNWYRPLNSHAALLDKYWTKIHMDNMDKKE LNEVLQNIYPSLLAVTDHLLDIYIQITGEKHHSQNDSSVTCEQAPEEVSEARRENKGLSL EGRELSLRDLLNWCNRIVHSFDSLSSSASLNIFQEALDCFTAMLSKHTSKLKMAEVIGSK LNISKKKAEFFCQLYKPEIVINELDVQVGRVRLLRKQSEAVHIQREKFTFAPTRPSSILI EQLAVCVSKGEPVLLVGETGTGKTSTVQYLAHITGHHLRVVNMNQQSDTADLLGGYKPVD HKLIWLPLREAFEELFAQTFSKKQNFTFLGHIQTCYRQKRWHDLLRLMQHVHKSAVNKDG KESETGLLLKEKWEAFGLRLSHAQQQMKMTENALLFAFVEGTLAQAVKKGEWILLDEINL AAPETLECLSGLLEGSSGSLVLLDRGDTEPLVRHPDFRLFACMNPATDVGKRNLPPGIRN RFTELYVEELESKEDLQILIVDYLKGLSVNKITVQGIINLYTALRKDSGTKLVDGTGHRP HYSLRTLCRALRFAASNPCSNIQRSLYEGFCLGFLTQLDRASHPVVQKLICQHLISGSVK SLLKQPIPEPKGGRLIQVEGYWISVGDSEPTIDETYILTSSVKLNLRDIVRVVSAGTYPV LIQGETSVGKTSLIRWLAAATGNHCVRINNHEHTDIQEYIGCYTSDSSGKLVFKEGILID AMRKGYWIILDELNLAPTDVLEALNRLLDDNRELLITETQEVVKAHPRFMLFATQNPPGL YGGRKVLSRAFRNRFVELHFDELPSSELETILHKRCSLPPSYCSKLVKVMLDLQSYRRSS SVFAGKQGFITLRDLFRWAERYRLAEQTEKEYDWLQHLANDGFMLLAGRVRKQEEIDVIQ EVIEKHFKKKLCPQSLFSKENVLKLLSKLSTRVSMLESEFSHIVWTEGMRRLAMLVGRAL EFGEPVLLVGDTGCGKTTVCQMFAGLANQKLYSVNCHLHMETSDFLGGLRPVRQKPKDKE EIDTSRLFEWHDGPLVLAMKEDGFFLLDEISLADDSVLERLNSVLEVEKSLVLAEKGSVE DKDNEVELLTAGKKFRILATMNPGGDFGKKELSPALRNRFTEIWCPQSTGREDLIQIISH NLRPGLSLGKIDHKGADIAEVMLDFIEWLTHQEFGRRCVVSIRDILSWVNFMNTMGEEAA LKRPETISTVTSFVHAACLVYIDGIGSGVTSSGFGTALLARKECLKFLIKKLSKIVRLTE CQKNELKIYDRLKAKEFTGIDNLWGIHPFFIPRGPVLHRNNIADYALSAGTTAMNAQRLL RATKLNKPILLEGSPGVGKTSLVTALAKASGNILVRINLSEQTDITDLFGADLPVEGGKG GEFAWRDGPLLAALKAGHWVVLDELNLASQSVLEGLNACFDHRGEIYVPELGMSFQVQHE KTKIFGCQNPFRQGGGRKGLPRSFLNRFTQVFVDPLTVVDMEFIASTLFPAIDKNIVEKM VAFNNQIDHEVTVEKKWGQKGGPWEFNLRDLFRWCQLMLVDQSPGCYDPGQHVFLVYGER MRTKEDKEKVIAVFKNVFSSNSSPYMGTRLFHITPYDVQLGYSVLSRGSYAPLLSRHPLS LLHQSLQSLESVMKCVQMSWMVILVGPASVGKTSLVQLLAHLTGHTLKIMAMNSAMDTTE LLGGFEQVDLIRPWRQLLEKVEGTVRALLRDSLLISADDAEVVLRAWSHFLLTYKPKCLG DGGKGITMEIVNKLEAVLLLMQRLNNKINSYSKAEFAKLVEEFRNFGAKLLQSTSGRSHG TFEWVDSMLVRALKSGDWLLMDNVNFCNPSVLDRLNALLEPGGVLTISERGMIDGSTPTI TPNPNFRLFLSMDPVHGEISRAMRNRGLEIYISGEGDGNIPDNLDLKVLLHSLGLVGDSV CDTLLALHMEIQSTVVGSPTSSISTLIQTALLIVQCLQRGLSLDTAFSEVCWEAYVRSQH SPANQKLVQALLEKHVFSLQAHETWGNSILAMGLWPDSLPSAIFATEDSHLSRVRSDGQV LVYCLNRMSMKTSSWARIQPLTLPDLEKIMQSSNPESLKFSSIEVATYWIDEPDVLAMAV KLLIERATNQDWVLRVKWLYHLAKNIPQGLESIQIHLEASAASLRNFYSNSLSAGVSNVI KILQPNITDEFVIPLDPRWNIQALDIIRNSMDFDPQTDQPEQLFALLESVANKTIIYLDR EKRIFTEANLVSVGGIKLRNSVLRMSFEFHKDPESYHSLPHEIVVNLAAFFELGDALILL WVQSSQGMVSDVSVMEILDSLRWRDRFWTIADTVKVDASGLALLALHWHWVLKHLVHQIP QLLMNHEDKYYKEVQTVSEHIQNCLGSPTGGFTGVKKLQKFLGRPFPFKNKLVVECFSQL KVLNKALAIREWMPALGESGWWEDVNRLQVVASKWTLKKSLLQAWGLVLRANILEDVNPD ELKDLVNAHCLELKAKGISLGFLEKKHNEASSLFQPDFTSLIQLTRSVQLWPAMEYLALL WQYKVTADFMTQACLRRSSKNQQPQTDKERSPHILFCLKHTPIAPQELQAFWYLLHHQKV STEEIISLWSDLFNSTFMSFWSSTVTTNPEYWLMWSPLPGVQQREMPKSLLDSTLKGPGS LSRAIFSKCCFEVLTSSCRASPWDVSGLPILSSSHVTLGEWVERAQQLRDISLVLWTNMA VPSVAEFRYTDSQLQRLVLCRHLAGLAELLPESQQQEYMQNCEQLLLGDKQTFQHVGQTL GDMAGQEALPKELLCLLLTSLRHLFGEGDGKRDLPEPARRGSLWVSLGLLQIQTWLPQAR FDPAVKREYKLKYAKEELHQLQCEWKTRNLSSQLHTGRDLEDEVILSYCHPHIRLLRQRI DHLENLICSLSKKQAFRPQVPAYESLVQEIHHYVTSIAKAPAVQDLLTRLLQALHMDGPR SAQVAQNLLKEEASWQQSHHQFRKRLAEEYALYPDSVAPLQASILQLQHGMRLVASEVYA SFHGSVVCADRLGALATSLLAFPSVGPTFPTYYAHADALCSVKSEEVLRGLGKLILKRSG GKELEGKGQRPCPTREQLLMNALLYLRSHVLCKGELDHRALQLFRHVCQEIINEWDEQER IAQEKAEQENSLYRYRSRNSRTALSEEEEEEREFRKQFPLHEKDFADILVEPTLEEKKGT SDGQEEGAASDPGLLSQSSMQAVMLIHQQLCLSFARSLWYQQTLPPHETKHYLGLFLSCY QTGASLVTQFYPLMGAELNDQLLGSQLLAFTLSHNTLFGEAASDLIVKPDGPYDFYQHPN VPEARHCQPVLQGFSEAVSQLLQDWPEHPALEQLLVVIDRIRSFPLSSPISKLLNGLEIL LAKAQDWEENASRALSLRKHLDLVSQTIIRWRKLELNCWSMSLDNTMKRHTEKSTKHWFS IYQMLEKHMQEQTEEQEDDKQMTLMLLVSTLQAFIEGSSLGEFHVRLQMLLVFHCHVLLM PQVEGKDSLCSVLWNLYHYYKQFFDRVQAKIVELRSPLEKELKEFVKISKWNDVSFWSIK QSVEKTHRTLFKFMKKFEAILSEPCRSSLVESDKEEQPDFLSQPAATSEASPIQSLNMAL RETLLARPVAAQAVIPEQCQGASFPLEGELLCRLPKLMKRMRKVCLTLMKESHLPYLVEG LDHFTGEVISSVSELQSLKVEPSAEKEKQRSEAKHILLRKQRALADLFQHLAKTGLSYRK GLAWARSKNPQEMLHLHPLDLRSALSVVSSTQADSRLLTEISSSWDGCQKYFFRSLARHA RLSAALAAPAKELGMSNVERCKGFSAHLMKVLIQQRRSLTTLTEQWILLRNLLGCVQEIH GRLTEPLVYPVAFPPQDGVQQWTERLQHLAMQSQILLEQLSLLLQCCPSAGPTPGHSGAQ VQGQPSAPYPEGPELTNGQLSGAIQDLIQSELSCPSPLPRNQLPSGCWMRKQDELWQQST ARLTEMLKTIKTVKADVDKIRQQSCETLFHSWKDFEVCSSGLSCLSQVSVHLQGLESLFI IPRIQVEQTDQQMALVESLDYLRGEINKATDDFTSWKTHLLASGSQSGNQMLDEGFVEDF SEQVETAIRAILCAIQNLAERNSKKTEENTDQSRPQEEDGAAGLEGLQSGHLTKLLEDDL WADVSTLHVQKIISAVSELLERLKSYGEDGTAAKHTFFSQSCCLLVRLVPMLSRYSDLVL FFLTMSLATHRSTAKLLSVLAQVFTELAQEGFCLPKEFMEDSAGEGATEFHDYEGGGIGE GEGMKDVSDQIENEEQAEDTLQKGQEKDKEDPDSKPDIKGEDNAIEMSEDFDGKMHDGEL EKEEDDGKSDSEGGDLDKQMGDLNGEEADKLDERLWGDDDDEEDEEEEDSKTEETGPGMD EEDCGLVAKDDNLDAGKSNRDKNRDKEEKEEAEVADDRQGQDKINEQIDEREYDENEVDP YHGNQEELPEPEALDLPDDLNLDSEDKNGSEDTDQEEGEEDNPLEIKEKPMDTEEAGHEA EEIKEQTEADHSEGQGQPEPEEGPSEDDKGEGEEEMDTGADDQDKDTAEHPEENSDDERQ SLEDKDKEANEESANHDVPVDQGLQPQEEEEEEEEEGSGENSDTEEQVPEATEREEHDSC GQTGVESVQSAQAVELAGAAPEKEQGKEEHGSGAADANQAEGHQSNFIARLASQKQTRKD TQSFKRKPGQADNERSMGDHNERVHKRLRTVDMESHTEQGPAQPHAQVEDADAFEHIKQG SDPYDAQTYDVASKEQQQSAKDSSRGQEEEMEDTFMDTEEEELQAADAEQLKPEEIKSGT TVSPGNDEVDMETHNVRTEEDQDPRTDISYGETEDMKPERSQDSTIHTAHQFLVDTVFQP FLKDVSELRQELERQLETWHPHESGNPEEEKAAVEMWQSYLAVTAPLSQQLCEQLRLILE PTQAAKLKGDYRTGKRLNMRKVIPYIASQFRKDKIWLRRTKPSKRQYQICLAIDDSSSMV DNHTKQLAFESLAVIGNALTLLEVGQIAVCSFGESVKLLHPFHEQFSDSSGSQILRLCKF QQKKTKIAQFLESVASMFAAAQQPSQHASPENAQLLLVVSDGRGLFLEGKDRVLAAVQAA RNANIFVIFVVLDNPSSRDSILDIKVPIFKGPGEMPEIRSYMEEFPFPFYIILRDVNALP ETLSDALRQWFELVAASDHL NT seq 16803 nt NT seq  +upstreamnt  +downstreamnt atggagcaccttttcctagaggtggcggccgcgccgctgcgcttactcgctgccaagaac gagaagagccgcagcgaactgggcaggttcttggccaagcaggtgtggacacctcaagat cgccagtgtatcctgagcaccttagcacaattacttctggataaagactgtactgtgctg gttggtcgccagctgcgccctcttcttttggatttgttggaaaggaatgctgaagccatt aaagccggaggccaaatcaaccacgatctacacgaacggctctgtgtgtcaatgagcaaa ctcatttgttaccatcctgacgtcctcccgtttgccctgaggtatttcaaggacacttct ccagtcttccaaagactcttcctagagagttcagatgctaatccagtccgctatgggcgc aggcggatgaagctccgggacctaatggaagcagcttacaagtttctgcagaatgagcag tctgtgttccgggagctctgggactggagtgtgtgtgtccctctcctcagaagccatgac accttggtccgctggtacacagccaattgtcttgctttggtcacctgtatgaatgaagag cacaagttatcattccttaagaagatttttaatactgaggaactgatccatttcaggtta aggttattagaagaggcccagctgcaggatttggagaaggccttggttttggctaatcca gaagcctccctttggcgtaaggagaaagagctgcagtacttacagggccatcttgtttca gctgatctctctgccggggtgactgctgtctgtggcgtggtgctgcctgggcagccacca gcccctggagagcaggctagtaatagaagttcttctcgtgaacaggagctggcctttagg tcttatgtgctggttgattcaatctgcaaaaatcttcagacgctggctatggcagtggct tctcagaatgctgtgttgttggaaggaccgataggatgtggcaaaacttccttagttgaa tacttaggtgcaatgacgggtagaaggaagccccctcagcttcttaaagtccagcttgga gatcagaccgacagtaagatgctgttgggaatgtatcgctgcacagatgtcccaggagag tttgtgtggcaacctggtaccctgacacaggcagccacaaagggacactggatccttctg gaggatattgactatgcccctttagatgtggtttctgtgctgatccctctcttggagaac ggagagctcttgattcccggccgaggtgactgtctgaaagtggctcctggatttcagttc tttgcaactaggagactcttgagctgtggaggaaattggtatcgacctctaaatagtcat gctgctctgctagacaaatattggaccaaaattcacatggataacatggataagaaagaa ctgaatgaggttcttcagaacatatatcccagcctcttggcagtaactgatcacttgctt gacatttacatccaaattactggagagaaacatcactctcagaatgatagttctgttaca tgtgaacaggcacctgaggaagtttcagaagccagaagagaaaacaaaggactaagcctt gagggaagagagttgtctctaagggatctactgaattggtgtaataggatcgttcatagc tttgacagtctgtcttcatcagcatccttaaatatttttcaagaggctctggactgtttc acagcaatgctttctaagcatacaagcaaactgaaaatggcagaagtcattggaagcaaa ttgaacatttccaagaaaaaggctgaatttttctgtcaactttataaaccggaaattgtg atcaatgagttagatgtgcaagtgggtcgagtgcggcttcttcggaaacaaagtgaggct gtccacatacagagggagaagttcacgtttgctcccacaaggccatcctccattcttatc gaacagcttgcagtgtgtgttagcaaaggggaaccggtattactggtgggagagactggg actggcaaaacctctactgtccagtacttggctcacattacaggccaccatttgagggtt gtcaatatgaatcaacaaagtgacactgcagacttgcttggaggttacaaaccggtggac cataaacttatttggctgcccttacgggaggcatttgaagaactctttgcccagacgttt tccaagaagcaaaactttacattcttaggacacattcagacctgttacaggcagaaacgg tggcatgatctcctcagactaatgcagcatgtacacaagtcggccgtcaacaaggatgga aaagaaagtgaaactgggttactcctaaaagagaaatgggaagcatttggtcttagactc agccatgctcagcaacagatgaaaatgactgaaaatgccctcttgtttgcattcgtagag ggtacactagctcaagccgtaaagaaaggagagtggatcttattggatgagattaatctg gctgctccagaaacattagaatgcctcagtggtttactcgaaggctcctctggctcactg gtgttgctagatcgaggagatacagaaccactggttcgtcatcccgacttccgtttattt gcctgtatgaacccagcaacagatgtgggcaaaaggaatcttccaccaggaataagaaac aggttcacagaactttatgtagaagaattggaaagtaaagaagatttacagattcttatt gtggattatctgaaaggactgagtgtgaataagatcacagtgcaaggaattatcaacttg tacacagctctacggaaggactctgggacaaaattagtggatggaactggccatagacct cactacagccttcggactctttgcagggccctgcgatttgcagcctccaatccgtgtagc aacatccagcgctcactctatgagggcttttgtttgggtttcttaacacagcttgatagg gcatcacatccagtagttcagaagctcatttgtcaacaccttatctctggcagtgtaaaa agtctgctgaagcagcctattccagaaccaaaaggaggtcgtcttatccaagtcgaagga tactggatttcggtgggagacagtgaacctacaatagatgagacctacattcttacgtct tctgttaagctaaacctgagagacatagtccgagtggtttctgcaggaacctatccagtg ttgattcagggagagacatcagttggtaaaacaagcctgatccggtggctggcagcagct actggtaaccattgtgtgcgtattaacaatcacgaacacacagatattcaggagtatatt ggttgttacacatctgactcttcagggaagcttgtgtttaaagaaggtattcttattgat gctatgagaaagggctattggattatcttagatgaattaaatttggcccctaccgatgtg ttagaggcactgaacagattactggatgataaccgtgaattgctcatcacagaaacacaa gaagttgttaaagctcaccctcggttcatgctttttgctacccaaaatcccccaggactt tatggaggcagaaaggtgctttctagagccttcaggaatcggtttgtggagctgcatttt gatgaactgcctagttctgagctggagacaatcttgcataagcgctgcagtttgccaccc tcctattgtagcaagttggttaaagtcatgctggaccttcagtcctatcgcagaagttct tcagtgtttgctggaaaacagggcttcatcacccttcgtgatctgtttcgatgggctgaa agatacagattggctgaacagactgagaaagagtatgactggctacagcatttagccaat gatggatttatgcttctcgcaggccgagtcaggaagcaggaggaaattgatgtgattcaa gaagttattgaaaaacatttcaagaaaaaattgtgtcctcaatcccttttctccaaagaa aatgtcttaaaattactgagtaaattgtccactcgggtatccatgttggaatctgagttc agccacattgtgtggactgagggcatgcggagactggcgatgctggtaggaagggcgctg gaatttggtgaaccagtgctactggttggggacactgggtgtgggaaaactactgtctgt cagatgtttgcaggcttggcaaatcagaaactatactctgttaactgccacttacacatg gagacatcggatttcctgggagggctgcgaccagtgagacagaagccaaaggacaaggaa gaaattgatacatcaagactttttgagtggcatgatggtcctctagttctggccatgaag gaggatggcttttttctcttggatgaaatctcactggctgacgactctgttctggaaaga ctcaatagtgtccttgaagtggaaaagtccttggtattagctgaaaaaggcagtgtagaa gacaaggataatgaggtagagctgttgactgctgggaagaaattccgtatcttagcaacc atgaaccctgggggcgactttggaaaaaaagagttgtctcctgccttaagaaacaggttt acagaaatatggtgcccacaaagcacaggtcgtgaagatttaattcagattatcagccat aaccttcgtccaggattgtctctgggaaaaatagatcataaaggggctgacatagctgag gtgatgctggatttcattgaatggctgacccaccaggaatttggccgaaggtgtgtggtc agtatcagagatatcctgtcctgggttaacttcatgaacacaatgggggaggaagctgct ttgaaacggccagagaccatctccactgtgacatcttttgtccatgctgcatgcctggtg tacatagatggaataggttcaggggtaacttcctcagggtttggtacagctctcttggct cgcaaagaatgtctgaaattcctaatcaagaaactttccaaaatagtgagacttacagag tgtcagaaaaatgaattgaagatttatgacagactcaaggccaaagaatttactggaata gataacctttggggaattcatccattttttataccaaggggacctgtccttcacaggaat aatattgctgactatgcactcagtgcaggcaccactgctatgaatgcccagaggctctta agagctacaaaattgaataaacccattctcctggagggctctcctggtgttggcaagaca agtttggtgacagcattagcaaaggcttcaggcaacatccttgttcgaatcaacttgtca gaacagacggacatcacagacctgtttggagcagatctacctgttgaaggtggcaaggga ggagagtttgcctggcgggatggccctttgctggcggctctgaaggcaggccattgggtt gtgttggatgagctcaacctggcttctcagtctgtattggaaggactcaatgcttgtttt gaccaccgaggagaaatttatgttcctgagttaggaatgagctttcaagtacagcatgaa aagacgaagatttttgggtgtcagaatccctttagacaaggaggtgggaggaagggcttg ccaagatctttccttaacagattcactcaggtctttgtggatccccttacagtagttgac atggaattcattgccagtactctgtttccagccattgacaaaaatattgttgagaagatg gttgctttcaacaaccaaattgatcacgaagtgactgttgaaaagaaatgggggcaaaaa ggaggaccctgggaattcaaccttcgggaccttttccgctggtgtcagttgatgctggtt gaccagtcccctgggtgttatgatcctggtcagcatgtgtttttggtctatggtgaaaga atgagaaccaaggaagacaaggaaaaggtcattgctgtattcaagaatgtgtttagttca aattccagcccatacatgggaaccagactatttcacatcactccctatgatgttcagctg ggctactcagtcctctcccgtggcagttacgctcctctcctgtctcgccatccactgtca ctcctgcaccaatcattacagtctctggagtcagttatgaagtgtgtgcagatgagttgg atggtcatccttgtggggccagcctctgtgggcaagaccagcctggtgcagctcctggca caccttactggtcacacgttaaagatcatggctatgaacagtgcaatggacactacggag cttctaggtggatttgagcaggttgatcttatacggccatggaggcagctgctagaaaag gtggaaggcactgtaagggcacttttaagagacagcctccttatcagtgctgacgacgca gaagtagtgctgcgagcctggagtcatttccttctgacttacaaacccaagtgtcttgga gatggtggtaaaggtatcacgatggagattgtcaacaagctggaagcagtattattgctt atgcagagactcaacaataaaatcaactcctactccaaggcagagtttgccaaacttgtg gaagaattccgaaattttggggcgaagcttctgcagtccaccagtggtcgcagccatggc acatttgaatgggttgacagcatgttggttcgggctctgaagtctggagattggcttttg atggacaatgttaacttctgcaacccatcagtgctggatcgtttgaatgctttgctggaa cctggaggtgttctcactattagtgaaagaggaatgatagatggatccactcccaccata acaccaaatcccaatttcagactttttctctcgatggatcctgttcatggagaaatatcc cgagcgatgaggaatcgtggacttgaaatctacatttcaggagaaggggatgggaacatt ccagataacctggatctgaaagttctcctgcacagccttgggttggtgggggacagtgtg tgtgacaccctcttggctctacacatggagatccagagtactgttgtaggttctccaaca tcatctatttcaactttaattcagacagccttactcattgtgcagtgcctacagcgaggg ctgagtttagacacagccttttctgaagtatgctgggaagcatatgtccgctcccagcat tcaccagcaaaccaaaagcttgtgcaggctttactggagaaacatgttttttctctacaa gcccatgaaacctggggtaactccatccttgccatgggcctgtggccagattctctgccc tcagcaatctttgctacagaagattctcacctctctagagtccgaagtgatggacaagtc ttagtatattgccttaacaggatgagcatgaaaaccagcagctgggccaggattcagcct cttaccttaccagacttggagaaaattatgcagtcctctaaccctgagagcttgaaattc agttcaatcgaagtggctacttactggattgatgaaccagatgttctggccatggctgtt aaattgcttatagaaagagcaaccaatcaagattgggtgctcagagttaaatggctttat catttagccaagaatataccacaggggcttgaatcaatacagattcatttggaagccagt gctgcatcacttaggaatttttactcaaattctctctcagctggggtcagtaatgtcatc aaaatattacaaccaaatataacagatgaatttgtgatccctttggacccccggtggaat atacaggctttggacatcattagaaattcgatggactttgacccacaaaccgatcagcct gagcagctctttgcccttttagagtctgttgcaaacaagacaatcatatatcttgaccgg gaaaaacggatatttactgaagcaaatttggtttctgttggtggcataaagttaagaaat agtgttttgagaatgtcctttgaattccataaagatccagagagctatcacagcctgccc catgaaattgtggtcaatcttgctgctttttttgaacttggtgatgcactaatcctgctc tgggtacagtcctcccaggggatggtgtctgatgtcagtgtcatggagatcttggattcc ctgcggtggcgggaccggttttggaccatagctgacacagtaaaagtggatgcctcaggc ctggccctgcttgcccttcattggcactgggttttaaaacatctggtccatcagatccct caactcctaatgaaccatgaagacaaatactacaaagaggttcagactgtctcagaacat attcagaattgcttggggagcccaactggcggcttcactggtgtaaagaagttgcaaaag ttcctgggacggccatttccttttaagaacaagctggtggtagagtgtttttctcaattg aaagtacttaacaaagcacttgccatcagggagtggatgcctgcccttggggaaagcgga tggtgggaagatgttaatcgtctccaagtggttgcttctaaatggactttaaagaaaagt ctcttgcaggcgtgggggctggtcctcagagctaatattctggaagatgtcaacccagat gagctgaaggatcttgtgaatgctcactgtttagaactaaaagccaaaggaatttcactt ggttttctggagaaaaagcacaatgaagcttcctccctgttccaaccagactttacctcc ttaatccaactcaccaggagtgttcagttgtggcctgcaatggagtacctggctctgctt tggcagtacaaagtgacagctgattttatgacacaagcttgcctaagaaggtccagcaaa aatcagcaaccccagacagataaggagagaagtcctcacatcctgttttgtcttaagcac acaccaattgctccacaagagcttcaagccttttggtacttactgcaccatcagaaggtg tctactgaagaaattatttccttgtggtctgacttatttaattccacatttatgtctttc tggagcagtactgttactacaaatccagagtactggctaatgtggagccctctgcctggt gtacagcagagggagatgcccaagtcccttttggactccacattgaagggccctggcagt ctcagtagagccatcttctccaagtgctgctttgaagtattgaccagcagctgcagagca agtccctgggatgtgagcggcctccccatcctgtcctcctcacacgtcaccctgggagag tgggttgagagagcccagcagctccgggatatcagcttggtgctttggaccaacatggct gtgccttcagtcgcagagttcagatacacagattcccagctccagagacttgtgctgtgc cggcacttggcgggtttggcagagctgctccctgaatcccagcagcaggaatacatgcaa aactgtgagcagctgctgctcggggacaagcagaccttccagcatgtgggccagactctt ggggacatggctgggcaggaggccctgcccaaagagctgctatgcctcttgcttacctcc ctgcgccacttgtttggggaaggggatggtaagcgggacctgcccgagccagcacggcgt gggagcctgtgggtgagccttggcttgctccagattcagacatggcttccgcaggcccgc tttgaccccgcagtgaagagggaatacaagctcaagtacgctaaggaagagttacaccag ctgcagtgtgagtggaagacccgaaacctctcatcccagctacacactggaagagacctg gaagatgaagtcattctcagttactgtcatcctcacatcagattacttcgccaaagaata gatcatctggagaacttaatctgcagcctgtcgaagaagcaggccttcagaccccaggtg cctgcctatgagtcattggtgcaggaaatccaccactatgtcaccagcattgccaaggcc cctgctgttcaggatctgctcacacggctcctgcaggctctccacatggatgggcctcgg tctgcccaggtggcccaaaatcttctgaaggaggaggcttcctggcagcagtcacaccac cagttcaggaagcggttggccgaggagtatgccctctatccagattctgtggccccactg caggcatccatcttgcagttgcagcatggcatgaggctggtggcatctgaggtctacgct tcattccatggcagtgtggtctgtgcagacaggctgggtgccctggccacatccctgttg gcttttccatcggtgggtcccaccttccccacttactatgctcatgcagacgccttatgc tcagtgaagtcagaggaggttcttcgaggccttgggaagttgatcctcaagcgctcagga ggaaaggagctggaaggcaagggccagagaccttgtcctacccgagagcagctgctgatg aatgccctcctttacctgcgttcccatgtgctgtgcaagggagagctggaccatagggcc ctgcagctcttcagacacgtgtgccaggaaattatcaatgagtgggatgaacaggaacgc atagcccaagagaaggctgagcaggaaaacagcttgtacagatacaggagcaggaactcc aggactgccctgagtgaggaggaggaggaagagcgggagttcagaaagcagttcccactg catgaaaaggattttgcagatattttggtagaaccaacactggaagagaagaagggaact tcagatgggcaagaagagggagcagcttcagaccctggcctcctctcccagagctcaatg caggctgtgatgctcattcatcagcagctgtgcctcagctttgctcggtccctctggtac caacagactttgccaccacatgagacaaagcattaccttggcctgtttctatcctgctat caaactggggcatctcttgtgacacagttctaccctctgatgggagctgaactgaatgac caactcctgggcagccaacttttggcctttaccctctcccataacactctctttggtgag gcagcctcagatctgatagtgaagcctgatgggccctatgacttctaccagcaccccaat gtcccagaagcaaggcattgtcaacctgtgcttcagggtttctcagaggctgtcagtcag ctgctgcaggattggccggaacacccagcccttgagcagctgctggttgtaatagacaga attcgtagtttcccactttccagtcctatctcaaagttgctgaatggcttagagatcctt ctagcaaaggcacaggattgggaggagaatgcaagtcgagctctgtctctgcggaaacat ctcgatttagtcagtcagacgatcattcgttggcgtaaactggaactgaactgctggtct atgagtttggataatactatgaagcgccatactgagaaatccaccaagcactggttctcc atctaccagatgcttgagaagcacatgcaggaacaaacagaggagcaggaagatgataag cagatgaccctgatgttgctggtcagcacattacaagcatttatagagggatcctcactg ggagaattccacgtacggcttcagatgttactggttttccattgtcatgtcttgttgatg cctcaagttgaaggaaaggattcactttgcagtgttctgtggaatttgtaccattattac aagcaattctttgaccgggtccaagccaaaattgtggaacttcgttcccccctagaaaaa gaacttaaagaatttgtaaaaatatccaagtggaatgatgtcagcttctggtccattaaa caatctgtggaaaagacacacaggaccctctttaaattcatgaagaaatttgaagccatc ctgagtgaaccctgccggtcatccttggtggagagtgacaaggaggaacagcctgacttt ttgtcacagccagcagccaccagcgaggcatcccccattcagagtctgaacatggcactg agggagaccctgttggcccggccagtagctgcacaggctgtgattccagaacagtgtcag ggtgcttctttccccttggagggagagctgctgtgtcgcttgccaaagctcatgaaacga atgaggaaggtgtgcctgacgctcatgaaggaaagccatctgccttacctagtggagggc cttgatcacttcactggtgaagtgatttcctctgtgagtgagctgcagagcttgaaggtg gagccctctgcagagaaggagaagcagcggtcagaagccaagcatattctcctgcggaag cagcgagctttagcagacctctttcaacaccttgccaaaactggtttgtcatatcgcaaa ggtcttgcctgggcccgttcaaaaaaccctcaagagatgcttcatcttcacccgttagat ctccggagtgcattgtctgtagtcagcagcactcaggctgattctaggctgctgacagaa atctcctcttcatgggatggatgccagaagtacttctttcgctctcttgcacggcacgcc aggcttagtgcagccttagcagctcctgccaaggagttgggcatgagcaacgtcgagcga tgcaaagggttctcggcacatctgatgaaggtgcttatccaacagcggcgctccctgacc acgctgactgagcagtggatcctcctcaggaacctccttggctgtgttcaggagattcat ggcaggctgactgagccgctggtctacccggtggccttcccccctcaggatggtgtgcag cagtggacagaaaggctgcagcatctggccatgcagagccagatcctgcttgagcagctc tccttgctcctccagtgctgccccagtgcagggccaactccaggccacagtggtgcccag gtacagggtcagccttctgccccctacccagaaggaccagagctcaccaacggccagctt tctggagccatacaggacctcatccaatcagaattgagttgcccatccccactacctcga aatcagctgccctctggttgctggatgcggaaacaggacgagctttggcaacagtcaact gcaagattaacagagatgctgaaaaccattaaaacagtgaaagctgatgttgacaaaatc aggcagcagtcttgtgagactctctttcattcttggaaagattttgaagtttgttcttct gggctgagttgcctgtcccaggtgtcagttcatttgcaaggactagagtccttgttcatt attcccaggatacaagttgagcaaacagaccaacaaatggcattagttgagagcctggac tatttaagaggagaaatcaataaagccacagatgactttacttcctggaagacacatcta cttgcttcaggaagccaaagtggaaaccaaatgttagatgaagggtttgtggaagatttt tcagaacaggtggaaactgccatccgggccatcctttgtgccatccagaacttagcagaa agaaacagtaaaaagacagaggagaacactgaccaaagcagaccacaagaagaggatggg gcagcaggcttggagggactgcaatcaggacatctaacaaaactgttagaggatgatttg tgggccgacgtgagcactctgcatgtgcagaaaatcatttctgctgtctctgagctgttg gagaggctgaaatcgtacggtgaagatggcacagcagcaaaacacacgttcttcagccaa tcctgctgcttattggtgcgtctggtgcccatgctctccaggtattcagacctcgtcctc ttcttcctgaccatgtctttggcaactcaccgtagcactgcaaagctgctctctgttctt gcccaggtctttacagagctcgcccaggagggattttgcctgcccaaagaattcatggaa gattcagcaggagagggagcaactgagttccatgactatgagggaggtggaattggggaa ggcgagggcatgaaggatgtgagtgaccagattgaaaatgaagaacaggcagaagataca cttcagaaaggccaagaaaaggataaagaggatcccgactcaaaaccagacattaagggc gaggataatgccattgagatgtcagaagactttgatgggaaaatgcatgatggggaactt gaaaaagaagaggatgatgggaaatcagacagtgagggtggagacctggataaacagatg ggcgatctgaatggtgaggaagctgacaaacttgatgagaggctttggggtgatgacgat gatgaggaagatgaggaagaagaagacagtaaaactgaagaaacaggaccaggaatggat gaggaagattgtggacttgttgccaaagacgacaacttggatgctgggaagtcaaacaga gataaaaaccgagataaggaagaaaaggaagaagcagaagttgctgatgatagacaaggc caagacaaaattaatgaacaaatagatgagagggaatatgatgagaatgaggtggatcct taccatggcaatcaggaagagctgccggaacctgaggccttggaccttccagatgacttg aacctggatagtgaagacaagaatggtagtgaggacacagaccaggaagaaggagaagaa gataatcctttggaaattaaagaaaagccaatggatactgaagaagcaggtcatgaagct gaggaaataaaggaacagaccgaggctgaccacagtgaaggtcagggtcaacctgaacct gaagaaggccccagtgaagatgataagggtgagggagaagaagagatggacacaggagct gatgaccaagataaagacactgctgaacatcctgaagaaaactcagacgatgagcgtcag tctctggaggacaaggacaaggaagccaatgaggaaagtgcaaaccatgacgttcctgtt gaccaaggtctccagccccaggaagaagaagaagaagaagaagaagaagggagcggggag aactctgacacagaggagcaggtgccagaggccacggaaagggaagaacacgattcctgc gggcagaccggggtggagagtgtgcagagtgcacaggctgtggagctggctggggccgcg cccgaaaaggagcagggaaaggaggagcacgggagtggagctgcagatgcaaaccaggca gaaggccaccagtccaacttcattgctcgactggcttcccagaaacagaccaggaaggac acacagagtttcaagaggaaacctggacaggctgacaatgaacgctccatgggtgatcac aatgaacgagtgcataagcggctgaggactgtggatatggagagccacactgagcagggg ccagcccagccccatgcccaggtggaggacgcagatgcatttgagcacattaaacaaggc agtgacccttatgatgcacagacgtatgatgtggccagcaaggagcagcaacagtctgca aaagattccagcaggggtcaggaggaggagatggaggacactttcatggacacagaggag gaagagctccaagcagcagacgcagagcagctgaagccagaggagatcaagtcagggacc acagtgagccccggcaatgatgaggtggacatggagacccacaatgttagaacagaagaa gaccaagatcccaggaccgacatatcctatggggagacagaggatatgaaaccagagaga agccaagattcgaccattcacacagcccatcagttccttgtggacacagttttccagccc tttttaaaagatgtcagtgagctaagacaggagctggagaggcagctggaaacatggcat ccacacgaatctggaaacccagaagaagagaaggctgcagtggagatgtggcagagttac ctggccgtaactgcacctctttcacaacagttgtgtgaacagcttcgtctcatcttagag cctacccaggccgccaagctgaaaggagactatcgaactgggaagcggctgaacatgcgg aaggtcattccatacattgctagtcaatttcggaaagacaagatttggcttcgaaggacc aagcccagtaaacgccagtatcagatttgtttggccattgatgactcttctagcatggta gacaaccataccaaacagctggcatttgaatctttggctgtgattggaaatgctctaacc ctcctggaagtgggtcagattgctgtgtgcagttttggagagtccgtaaagctattacac ccattccacgagcagttcagtgattcctcgggttcccagattctgcggctctgcaaattc cagcaaaagaaaaccaagattgctcagtttctcgagtctgtagccagcatgtttgcagct gctcagcagccctcccagcacgccagtccagaaaacgcacagctcctcctggtggtctct gatggccgcggccttttcctcgagggcaaagacagagtcctggcagcagtccaggctgcc cggaatgctaacatcttcgtcatttttgttgtattggacaatcccagttcacgggattct atcttggacatcaaagtgcccatatttaaaggacctggagagatgcctgaaatccgatcc tacatggaagagttcccgttcccattctacatcatccttcgcgatgtgaacgcgctcccc gagacgctcagtgatgctcttaggcagtggtttgagttggtggcagcctctgaccacctg tag

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