Propionibacterium freudenreichii subsp. freudenreichii DSM 20271: RM25_0870
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Entry
RM25_0870 CDS
T03860
Name
(GenBank) D-alanine--D-alanine ligase
KO
K01921
D-alanine-D-alanine ligase [EC:
6.3.2.4
]
Organism
pfre
Propionibacterium freudenreichii subsp. freudenreichii DSM 20271
Pathway
pfre00470
D-Amino acid metabolism
pfre00550
Peptidoglycan biosynthesis
pfre01100
Metabolic pathways
pfre01502
Vancomycin resistance
Brite
KEGG Orthology (KO) [BR:
pfre00001
]
09100 Metabolism
09106 Metabolism of other amino acids
00470 D-Amino acid metabolism
RM25_0870
09107 Glycan biosynthesis and metabolism
00550 Peptidoglycan biosynthesis
RM25_0870
09160 Human Diseases
09175 Drug resistance: antimicrobial
01502 Vancomycin resistance
RM25_0870
09180 Brite Hierarchies
09181 Protein families: metabolism
01011 Peptidoglycan biosynthesis and degradation proteins [BR:
pfre01011
]
RM25_0870
Enzymes [BR:
pfre01000
]
6. Ligases
6.3 Forming carbon-nitrogen bonds
6.3.2 Acid-D-amino-acid ligases (peptide synthases)
6.3.2.4 D-alanine---D-alanine ligase
RM25_0870
Peptidoglycan biosynthesis and degradation proteins [BR:
pfre01011
]
Precursor biosynthesis
Amino acid ligase
RM25_0870
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Gene cluster
GFIT
Motif
Pfam:
Dala_Dala_lig_C
Dala_Dala_lig_N
ATP-grasp
CPSase_L_D2
ATP-grasp_4
Motif
Other DBs
NCBI-ProteinID:
AJQ90592
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All DBs
Position
1004054..1005181
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AA seq
375 aa
AA seq
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MASDTADLINVAVIFGGQSNEHEVSCLTAAGVLGAIDQTRYRVHGIGIDKSGLWHRYSVD
EIRALQIVDGVMPSIGADHPLAELFRDAGGVHLATLDEDRLTAREPIDVAFPLMHGAYAE
DGTVQGKLEMLGLKYVGCGVTSSALGMDKEYTHTVLEAAGVPAAAWVRVGRDEWMRDPDA
IVARIGSQLGYPVFVKPARGGSSVGISRVTGPDSLAAAIDAARLVDPKVLVEQAVVGARE
VECGILGGDGTAPRASHTGEIVMHTEDRFYDYRAKYLPEEQVDLRVPAGLEPQVERRVQE
LALQCFTALDCEGLARVDTFVLPDGQVLINEINTMPGFTKFSMYPNMWRASGIDYPELID
QLIALALSRPATVLR
NT seq
1128 nt
NT seq
+upstream
nt +downstream
nt
atggcctcggatactgcagacctgatcaatgtggccgtcatcttcggcggccagtcgaac
gagcacgaggtgtcgtgcctcacggccgccggcgtcctcggcgccatcgaccagacccgc
taccgggttcacgggatcggcatcgacaagtcaggtctgtggcaccgctactcggtcgac
gagattcgtgccctgcagatcgtcgacggcgtgatgccctcaattggcgcggaccatccg
ctcgcggaactcttccgcgacgccgggggagtccacctggcgaccctggatgaggatcgg
ctcactgcccgcgagcccatcgacgtcgcttttcccctcatgcacggcgcctacgccgag
gacggaaccgtccaggggaagctggaaatgctcggcctgaagtatgtgggctgcggcgtc
accagcagcgccctggggatggacaaggagtacacccacaccgtcctcgaggcggcggga
gtccccgcggctgcctgggtgcgcgtgggacgcgacgaatggatgcgtgatccggatgcc
atcgtggcccggatcggcagccagctcggctatccggtgttcgtcaagcccgcgcgggga
ggatcctcggtgggcatcagccgcgtcaccgggccggactcgctggccgccgccatcgac
gcagcgcgcctggttgatccgaaggtgctcgtggaacaggcagtggtcggtgcccgtgag
gtggagtgcgggatcctcggcggggatggcacggccccccgcgcgtcgcacaccggcgag
atcgtcatgcataccgaggaccgcttctacgactaccgggcgaagtacctgcccgaggaa
caagtcgacctgcgggtgccggccggactcgagccccaggtggaacggcgggtccaggaa
ctggcactgcagtgcttcacggccctggactgcgaggggctggcccgcgtggacaccttc
gtcctgcccgatgggcaggtgctgatcaatgagatcaacaccatgcccggattcaccaag
ttctcgatgtatccgaatatgtggcgggccagcggaatcgactaccccgagctgatcgac
cagctcatcgccctggcgctgtcacgcccggccacggtgctgcgctag
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