KEGG   Phodopus roborovskii (desert hamster): 127236205
Entry
127236205         CDS       T08852                                 
Symbol
Raf1
Name
(RefSeq) RAF proto-oncogene serine/threonine-protein kinase isoform X1
  KO
K04366  RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
Organism
prob  Phodopus roborovskii (desert hamster)
Pathway
prob01521  EGFR tyrosine kinase inhibitor resistance
prob01522  Endocrine resistance
prob04010  MAPK signaling pathway
prob04012  ErbB signaling pathway
prob04014  Ras signaling pathway
prob04015  Rap1 signaling pathway
prob04022  cGMP-PKG signaling pathway
prob04024  cAMP signaling pathway
prob04062  Chemokine signaling pathway
prob04068  FoxO signaling pathway
prob04071  Sphingolipid signaling pathway
prob04072  Phospholipase D signaling pathway
prob04140  Autophagy - animal
prob04150  mTOR signaling pathway
prob04151  PI3K-Akt signaling pathway
prob04210  Apoptosis
prob04218  Cellular senescence
prob04270  Vascular smooth muscle contraction
prob04360  Axon guidance
prob04370  VEGF signaling pathway
prob04371  Apelin signaling pathway
prob04510  Focal adhesion
prob04540  Gap junction
prob04550  Signaling pathways regulating pluripotency of stem cells
prob04613  Neutrophil extracellular trap formation
prob04625  C-type lectin receptor signaling pathway
prob04630  JAK-STAT signaling pathway
prob04650  Natural killer cell mediated cytotoxicity
prob04660  T cell receptor signaling pathway
prob04662  B cell receptor signaling pathway
prob04664  Fc epsilon RI signaling pathway
prob04666  Fc gamma R-mediated phagocytosis
prob04720  Long-term potentiation
prob04722  Neurotrophin signaling pathway
prob04726  Serotonergic synapse
prob04730  Long-term depression
prob04810  Regulation of actin cytoskeleton
prob04910  Insulin signaling pathway
prob04912  GnRH signaling pathway
prob04914  Progesterone-mediated oocyte maturation
prob04915  Estrogen signaling pathway
prob04916  Melanogenesis
prob04917  Prolactin signaling pathway
prob04919  Thyroid hormone signaling pathway
prob04921  Oxytocin signaling pathway
prob04926  Relaxin signaling pathway
prob04928  Parathyroid hormone synthesis, secretion and action
prob04929  GnRH secretion
prob04935  Growth hormone synthesis, secretion and action
prob05010  Alzheimer disease
prob05022  Pathways of neurodegeneration - multiple diseases
prob05034  Alcoholism
prob05132  Salmonella infection
prob05152  Tuberculosis
prob05160  Hepatitis C
prob05161  Hepatitis B
prob05163  Human cytomegalovirus infection
prob05164  Influenza A
prob05165  Human papillomavirus infection
prob05167  Kaposi sarcoma-associated herpesvirus infection
prob05170  Human immunodeficiency virus 1 infection
prob05200  Pathways in cancer
prob05205  Proteoglycans in cancer
prob05206  MicroRNAs in cancer
prob05207  Chemical carcinogenesis - receptor activation
prob05208  Chemical carcinogenesis - reactive oxygen species
prob05210  Colorectal cancer
prob05211  Renal cell carcinoma
prob05212  Pancreatic cancer
prob05213  Endometrial cancer
prob05214  Glioma
prob05215  Prostate cancer
prob05218  Melanoma
prob05219  Bladder cancer
prob05220  Chronic myeloid leukemia
prob05221  Acute myeloid leukemia
prob05223  Non-small cell lung cancer
prob05224  Breast cancer
prob05225  Hepatocellular carcinoma
prob05226  Gastric cancer
prob05230  Central carbon metabolism in cancer
prob05231  Choline metabolism in cancer
prob05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Brite
KEGG Orthology (KO) [BR:prob00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    127236205 (Raf1)
   04012 ErbB signaling pathway
    127236205 (Raf1)
   04014 Ras signaling pathway
    127236205 (Raf1)
   04015 Rap1 signaling pathway
    127236205 (Raf1)
   04370 VEGF signaling pathway
    127236205 (Raf1)
   04371 Apelin signaling pathway
    127236205 (Raf1)
   04630 JAK-STAT signaling pathway
    127236205 (Raf1)
   04068 FoxO signaling pathway
    127236205 (Raf1)
   04072 Phospholipase D signaling pathway
    127236205 (Raf1)
   04071 Sphingolipid signaling pathway
    127236205 (Raf1)
   04024 cAMP signaling pathway
    127236205 (Raf1)
   04022 cGMP-PKG signaling pathway
    127236205 (Raf1)
   04151 PI3K-Akt signaling pathway
    127236205 (Raf1)
   04150 mTOR signaling pathway
    127236205 (Raf1)
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    127236205 (Raf1)
  09143 Cell growth and death
   04210 Apoptosis
    127236205 (Raf1)
   04218 Cellular senescence
    127236205 (Raf1)
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    127236205 (Raf1)
   04540 Gap junction
    127236205 (Raf1)
   04550 Signaling pathways regulating pluripotency of stem cells
    127236205 (Raf1)
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    127236205 (Raf1)
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    127236205 (Raf1)
   04625 C-type lectin receptor signaling pathway
    127236205 (Raf1)
   04650 Natural killer cell mediated cytotoxicity
    127236205 (Raf1)
   04660 T cell receptor signaling pathway
    127236205 (Raf1)
   04662 B cell receptor signaling pathway
    127236205 (Raf1)
   04664 Fc epsilon RI signaling pathway
    127236205 (Raf1)
   04666 Fc gamma R-mediated phagocytosis
    127236205 (Raf1)
   04062 Chemokine signaling pathway
    127236205 (Raf1)
  09152 Endocrine system
   04910 Insulin signaling pathway
    127236205 (Raf1)
   04929 GnRH secretion
    127236205 (Raf1)
   04912 GnRH signaling pathway
    127236205 (Raf1)
   04915 Estrogen signaling pathway
    127236205 (Raf1)
   04914 Progesterone-mediated oocyte maturation
    127236205 (Raf1)
   04917 Prolactin signaling pathway
    127236205 (Raf1)
   04921 Oxytocin signaling pathway
    127236205 (Raf1)
   04926 Relaxin signaling pathway
    127236205 (Raf1)
   04935 Growth hormone synthesis, secretion and action
    127236205 (Raf1)
   04919 Thyroid hormone signaling pathway
    127236205 (Raf1)
   04928 Parathyroid hormone synthesis, secretion and action
    127236205 (Raf1)
   04916 Melanogenesis
    127236205 (Raf1)
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    127236205 (Raf1)
  09156 Nervous system
   04726 Serotonergic synapse
    127236205 (Raf1)
   04720 Long-term potentiation
    127236205 (Raf1)
   04730 Long-term depression
    127236205 (Raf1)
   04722 Neurotrophin signaling pathway
    127236205 (Raf1)
  09158 Development and regeneration
   04360 Axon guidance
    127236205 (Raf1)
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    127236205 (Raf1)
   05206 MicroRNAs in cancer
    127236205 (Raf1)
   05205 Proteoglycans in cancer
    127236205 (Raf1)
   05207 Chemical carcinogenesis - receptor activation
    127236205 (Raf1)
   05208 Chemical carcinogenesis - reactive oxygen species
    127236205 (Raf1)
   05230 Central carbon metabolism in cancer
    127236205 (Raf1)
   05231 Choline metabolism in cancer
    127236205 (Raf1)
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    127236205 (Raf1)
  09162 Cancer: specific types
   05210 Colorectal cancer
    127236205 (Raf1)
   05212 Pancreatic cancer
    127236205 (Raf1)
   05225 Hepatocellular carcinoma
    127236205 (Raf1)
   05226 Gastric cancer
    127236205 (Raf1)
   05214 Glioma
    127236205 (Raf1)
   05221 Acute myeloid leukemia
    127236205 (Raf1)
   05220 Chronic myeloid leukemia
    127236205 (Raf1)
   05218 Melanoma
    127236205 (Raf1)
   05211 Renal cell carcinoma
    127236205 (Raf1)
   05219 Bladder cancer
    127236205 (Raf1)
   05215 Prostate cancer
    127236205 (Raf1)
   05213 Endometrial cancer
    127236205 (Raf1)
   05224 Breast cancer
    127236205 (Raf1)
   05223 Non-small cell lung cancer
    127236205 (Raf1)
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    127236205 (Raf1)
   05161 Hepatitis B
    127236205 (Raf1)
   05160 Hepatitis C
    127236205 (Raf1)
   05164 Influenza A
    127236205 (Raf1)
   05163 Human cytomegalovirus infection
    127236205 (Raf1)
   05167 Kaposi sarcoma-associated herpesvirus infection
    127236205 (Raf1)
   05165 Human papillomavirus infection
    127236205 (Raf1)
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    127236205 (Raf1)
   05152 Tuberculosis
    127236205 (Raf1)
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    127236205 (Raf1)
   05022 Pathways of neurodegeneration - multiple diseases
    127236205 (Raf1)
  09165 Substance dependence
   05034 Alcoholism
    127236205 (Raf1)
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    127236205 (Raf1)
   01522 Endocrine resistance
    127236205 (Raf1)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases [BR:prob01001]
    127236205 (Raf1)
Enzymes [BR:prob01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     127236205 (Raf1)
Protein kinases [BR:prob01001]
 Serine/threonine kinases: TKL group
  RAF family [OT]
   127236205 (Raf1)
Motif
Pfam: Pkinase PK_Tyr_Ser-Thr RBD C1_1 Kinase-like ABC1 zf-RING-like Pkinase_fungal RA C1_2
Other DBs
NCBI-GeneID: 127236205
NCBI-ProteinID: XP_051059691
LinkDB
Position
Unknown
AA seq 668 aa
MEHIQGAWKSISNGFGLKDAVFDGSSCISPTIVQQFGYQRRASDDGKLTDSSKTSNTIRV
FLPNKQRTVVNVRNGMSLHDCLMKALKVRGLQPECCAVFRLLQEHKGKKARLDWNTDAAS
LIGEELQVDFLDHVPLTTHNFARKTFLKLAFCDICQKFLLNGFRCQTCGYKFHEHCSTKV
PTMCVDWSNIRQLLLFPNSTVGDSGVPALPSLTIRRMRESVSRMPASSQHRYSTPHAFTF
NTSSPSSEGSLSQRQRSTSTPNVHMVSTTLPVDSRMIENNSLNASPRACSRRFCLRGRDA
IRSHSESASPSALSSSPNNLSPTGWSQPKTPVPAQRERAPGSGTQEKNKIRPRGQRDSSY
YWEIEASEVMLSTRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQLQAFRNEVAVLRKT
RHVNILLFMGYMTKDNLAIVTQWCEGSSLYKHLHVQETKFQMFQLIDIARQTAQGMDYLH
AKNIIHRDMKSNNIFLHEGLTVKIGDFGLATVKSRWSGSQQVEQPTGSVLWMAPEVIRMQ
DNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVGRGYASPDLSRLYKNCPKA
MKRLVADCVKKVKEERPLFPQILSSIELLQHSLPKINRSASEPSLHRAAHTEDINACTLT
TSPRLPVF
NT seq 2007 nt   +upstreamnt  +downstreamnt
atggagcacatacagggcgcttggaagtcgatcagcaatggttttggactcaaagatgcg
gtgtttgatggctccagctgcatctccccaacaattgttcagcagtttggctatcagcgc
cgggcctcagatgatggcaaactcacggattcttctaagacaagcaacactatccgagtt
ttcttgccaaataagcaaagaacggtggtcaatgtgcggaatggaatgagcttgcacgac
tgccttatgaaagctctcaaggtgagaggtctgcaaccagagtgttgtgcagtgttcaga
cttctccaggagcacaaaggtaagaaagcacgcttagactggaacaccgatgctgcctcc
ctgattggagaagaactgcaagtggattttttggatcacgttccactgacaactcacaac
tttgctcggaaaacgttcctgaagcttgcattctgtgacatctgtcaaaagttcctgcta
aatggatttcggtgtcagacttgtggctacaagtttcacgagcactgtagcaccaaagta
cctactatgtgtgtggactggagtaatatcagacagctcttgctgtttccaaattccact
gttggtgatagtggagtcccagcactaccttctttgacaattcgccggatgcgagagtct
gtttcccggatgcctgctagttcccagcacagatactccacacctcatgccttcactttc
aacacctccagcccttcctctgaaggttccctctcccagaggcagaggtcaacgtccact
cccaatgtccacatggtcagcaccactttgcctgtggacagcaggatgattgagaataac
agcctgaatgcctctcccagggcgtgctccagacggttttgtctgaggggaagagatgca
attcgaagtcacagtgaatcagcctcaccttcagccctgtccagcagccccaacaatctg
agcccaacaggctggtcacagcctaaaacccctgtgccagcacaaagagaacgggcacca
ggatctgggacccaggaaaaaaacaaaattaggcctcgtgggcagagagattcaagctat
tactgggaaatagaagccagtgaggtgatgctgtccactcggattgggtcgggctccttt
ggcactgtgtacaagggcaagtggcatggagatgttgcagtaaagatcctaaaagtggtt
gacccaacaccagagcagcttcaggccttcaggaacgaggtggccgtcttgcgtaaaacc
aggcatgttaatatcctgctgttcatgggatacatgacaaaggacaacctggcgattgtg
acccagtggtgtgaaggcagcagtctctataaacacctacatgtccaggagaccaagttc
caaatgttccagctaattgacattgcccgacagacagctcagggaatggactatttgcat
gcaaagaatatcatccacagagacatgaaatccaacaatatatttctccatgaaggcctc
acagtgaaaattggagattttggtttggcaacagtgaagtcacgctggagtggttctcag
caggttgaacagcccaccggctccgtgctgtggatggccccagaagtaatccgaatgcag
gataacaacccgtttagcttccagtctgatgtctactcctatggcattgtgctgtatgag
ctgatgactggggagcttccctactcgcacatcaacaaccgagatcagatcatcttcatg
gtgggccgtggatatgcttccccagatcttagcaggctctacaagaactgccccaaggca
atgaagagattggtggctgactgtgtgaagaaagtaaaagaagagaggccactgtttccc
cagatcctgtcgtccatcgagctgcttcagcactctctgccgaaaatcaacagaagcgcc
tctgagccctctctacatcgggcggcccacactgaggacatcaacgcttgcacactgacc
acatccccgaggctaccggtcttctag

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