Panthera tigris altaica (Amur tiger): 102960189 Help Entry 102960189         CDS       T02988                                  Symbol JAK1 Name (RefSeq) Janus kinase 1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg01521   EGFR tyrosine kinase inhibitor resistance ptg04151   PI3K-Akt signaling pathway ptg04217   Necroptosis ptg04380   Osteoclast differentiation ptg04550   Signaling pathways regulating pluripotency of stem cells ptg04620   Toll-like receptor signaling pathway ptg04621   NOD-like receptor signaling pathway ptg04630   JAK-STAT signaling pathway ptg04658   Th1 and Th2 cell differentiation ptg04659   Th17 cell differentiation ptg05140   Leishmaniasis ptg05145   Toxoplasmosis ptg05152   Tuberculosis ptg05160   Hepatitis C ptg05161   Hepatitis B ptg05162   Measles ptg05163   Human cytomegalovirus infection ptg05164   Influenza A ptg05165   Human papillomavirus infection ptg05166   Human T-cell leukemia virus 1 infection ptg05167   Kaposi sarcoma-associated herpesvirus infection ptg05168   Herpes simplex virus 1 infection ptg05169   Epstein-Barr virus infection ptg05171   Coronavirus disease - COVID-19 ptg05200   Pathways in cancer ptg05203   Viral carcinogenesis ptg05212   Pancreatic cancer ptg05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:ptg00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     102960189 (JAK1)    04151 PI3K-Akt signaling pathway     102960189 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     102960189 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     102960189 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     102960189 (JAK1)    04621 NOD-like receptor signaling pathway     102960189 (JAK1)    04658 Th1 and Th2 cell differentiation     102960189 (JAK1)    04659 Th17 cell differentiation     102960189 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     102960189 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102960189 (JAK1)    05203 Viral carcinogenesis     102960189 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     102960189 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     102960189 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102960189 (JAK1)    05161 Hepatitis B     102960189 (JAK1)    05160 Hepatitis C     102960189 (JAK1)    05171 Coronavirus disease - COVID-19     102960189 (JAK1)    05164 Influenza A     102960189 (JAK1)    05162 Measles     102960189 (JAK1)    05168 Herpes simplex virus 1 infection     102960189 (JAK1)    05163 Human cytomegalovirus infection     102960189 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     102960189 (JAK1)    05169 Epstein-Barr virus infection     102960189 (JAK1)    05165 Human papillomavirus infection     102960189 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     102960189 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     102960189 (JAK1)    05140 Leishmaniasis     102960189 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     102960189 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:ptg01001]     102960189 (JAK1) Enzymes [BR:ptg01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      102960189 (JAK1) Protein kinases [BR:ptg01001]  Non-receptor tyrosine kinases   JAK family [OT]    102960189 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  102960189 NCBI-ProteinID:  XP_007089908 LinkDB All DBs Position Un AA seq 1158 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLRLGSGEYTAEEL LXXXXXXQECCISPLCHNLFALYDENTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHG TNDNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKT EQDGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRM RINNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENE MNWFHPDDSGNILYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKWKKLENKHKKDEEKNKI REEWNNFSYFPEITHIVIKECVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADA HHYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTV TCFEKSEVVGSQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMNHLKKQILRTDNISFVL KRCCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIVQGEHLGRGTRTHIYSG TLLDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL LLAREGIDSEFGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA IMRDINKLEEQNPDIVSERKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDS DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPTNRT TFQNLIKGFEALLEALLK NT seq 3477 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagacggaggtgaatctggaggcccccgaaccaggagtggaagtgctcttc tatctgtccgatagggagccgctccggctgggcagcggggagtacacagcagaggagctg cttnnnnnnnnnnnnnnnnnncaggaatgctgtatctctcctctgtgtcacaaccttttt gccctgtatgatgagaacaccaagctttggtacgctccgaatcgcacgatcacagttgac gacaagacatcactccggctccactaccggatgaggttctatttcaccaactggcatggg accaatgataatgagcagtctgtatggcgacattctccgaagaagcagaaaaatggctac gagaaaaaaaaagttccagatgcaacccctctccttgacgccagctccctggagtatctg tttgctcagggacaatatgatttggtcaaatgcctggctcccattcgagaccccaagacc gagcaggatggacacgatattgagaacgagtgtctgggaatggctgtcctggccatctcc cactacgccatgatgaagaagatgcaattgccagaactgcccaaggacatcagctacaag cgatatatcccagaaacattgaataagtccatcaggcagaggaatcttctcaccaggatg cggataaataacgttttcaaggatttcctaaaggaatttaacaacaagaccatctgtgac agcagtgtatctactcatgacctgaaggtgaaatacctggcgaccttggagactttgaca aaacattatggtgctgaaatatttgagacttccatgttactgatttcgtcagaaaatgag atgaattggtttcatccagatgacagtggaaacattctctatgaagtgatggtaactgga aatcttggaatccagtggagacagaaaccaaatgttgttcctgttgaaaaggaaaaaaac aaactgaaatggaaaaagctggaaaataaacacaagaaggatgaggagaaaaacaaaatc cgggaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggag tgtgtggtcagcatcaataagcaggacaataaaaaaatggaactgaagctttcgtcccac gaggaggccttgtcctttgtgtccctggtagacggctacttccggctcacagcggatgcc catcattacctctgcactgatgtggctcccccactgattgtccacaacatacagaatggt tgtcacggtcccatctgcacagaatatgccatcaataaattgcggcaagaaggaagcgag gagggaatgtatgtgctgaggtggagctgtaccgactttgacaatatcctcatgactgtc acctgctttgaaaaatctgaggtggtgggtagccaaaaacagttcaagaactttcagatc gaggtgcagaagggccgttacagcctgcatggctcggaccgcagcttccccagcctgggg gacctcatgaaccacctcaagaaacagatcctgcggacggacaacatcagcttcgtgctg aagcgctgctgccagcccaagccccgagagatctccaatttgctggtggctactaagaaa gcccaggagtggcagcctgtctactctatgagccagctgagttttgaccggatcctcaag aaagatatcgtgcaaggcgagcaccttgggagaggcacgcggacgcacatctactctgga acccttctggattacaaagatgacgaaggaacttccgaagaaaagagaataaaagtgatc ctcaaagtcttagaccccagccacagggacatttctctggccttctttgaggcagccagc atgatgaggcaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgagat gtggaaaatatcatggtggaggagtttgtggagggggggcccctggatctcttcatgcac cggaaaagcgatgtcctcaccacaccgtggaagtttaaagttgccaaacaactggccagt gccttgagttacttggaggataaagacctggtccacggaaatgtgtgcactaaaaacctc ctcttggcccgtgagggcatcgacagcgagttcggcccgttcatcaagctcagtgacccc ggcatccccatcaccgtgctgtccaggcaagagtgcatagaacgaatcccgtggattgct cccgagtgtgttgaagactccaagaacctgagtgtggccgctgacaaatggagctttgga accacactctgggaaatctgctacaatggcgagatccctctgaaagacaagacactgatt gagaaagagcgattctatgaaagccggtgccggccagtgacaccatcttgtaaggagctg gctgacctcatgacccgctgtatgaactatgaccccaaccagagacccttcttccgagcc atcatgagagacatcaataaactggaggagcagaatccagacattgtttcagaacgaaag ccggcaaccgaagtggatcccacacattttgaaaagcggttcttgaagagaatccgtgac ttgggagagggccactttgggaaggttgagctctgcagatacgaccctgagggtgacaat accggggagcaggtggctgtcaaatccctgaagcctgagagtggaggtaaccacatagct gatctgaagaaggaaattgaaatcttaaggaacctctatcatgagaacattgtgaagtac aaaggcatctgtacagaagacggaggaaatggtattaagctcatcatggagtttctacct tcaggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacaacag ttaaaatatgctgttcagatttgtaaggggatggactacttggggtctcggcagtacgtt caccgggacttagcagcaagaaatgtcctcgttgagagtgagcaccaagtgaaaattgga gacttcggtttaaccaaagccattgaaaccgacaaagagtactacacagtcaaggatgat cgggacagccctgtgttttggtatgctccagaatgtttaattcagtgtaaattttatatc gcctctgacgtctggtcgtttggagtgactctgcatgagctgctcacttactgtgactcc gattccagccccatggcattgttcctgaaaatgataggcccaacgcatggccagatgaca gtcacaagacttgtgaacacgttaaaagaaggaaaacgtttgccctgtccacctaactgc ccagatgaggtttatcaactcatgagaaagtgctgggaattccaaccaactaataggaca acttttcagaacctaattaaaggatttgaagcacttttagaagcacttttaaaataa

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