Panthera tigris altaica (Amur tiger): 102965866 Help Entry 102965866         CDS       T02988                                  Symbol ADCY4 Name (RefSeq) adenylate cyclase 4   KO K08044   adenylate cyclase 4 [EC:4.6.1.1] Organism ptg  Panthera tigris altaica (Amur tiger) Pathway ptg00230   Purine metabolism ptg01100   Metabolic pathways ptg01522   Endocrine resistance ptg04015   Rap1 signaling pathway ptg04020   Calcium signaling pathway ptg04022   cGMP-PKG signaling pathway ptg04024   cAMP signaling pathway ptg04062   Chemokine signaling pathway ptg04072   Phospholipase D signaling pathway ptg04114   Oocyte meiosis ptg04211   Longevity regulating pathway ptg04213   Longevity regulating pathway - multiple species ptg04261   Adrenergic signaling in cardiomyocytes ptg04270   Vascular smooth muscle contraction ptg04371   Apelin signaling pathway ptg04540   Gap junction ptg04611   Platelet activation ptg04713   Circadian entrainment ptg04714   Thermogenesis ptg04723   Retrograde endocannabinoid signaling ptg04724   Glutamatergic synapse ptg04725   Cholinergic synapse ptg04727   GABAergic synapse ptg04742   Taste transduction ptg04750   Inflammatory mediator regulation of TRP channels ptg04911   Insulin secretion ptg04912   GnRH signaling pathway ptg04913   Ovarian steroidogenesis ptg04914   Progesterone-mediated oocyte maturation ptg04915   Estrogen signaling pathway ptg04916   Melanogenesis ptg04918   Thyroid hormone synthesis ptg04921   Oxytocin signaling pathway ptg04923   Regulation of lipolysis in adipocytes ptg04925   Aldosterone synthesis and secretion ptg04926   Relaxin signaling pathway ptg04927   Cortisol synthesis and secretion ptg04928   Parathyroid hormone synthesis, secretion and action ptg04934   Cushing syndrome ptg04935   Growth hormone synthesis, secretion and action ptg04970   Salivary secretion ptg04971   Gastric acid secretion ptg04972   Pancreatic secretion ptg04976   Bile secretion ptg05032   Morphine addiction ptg05163   Human cytomegalovirus infection ptg05166   Human T-cell leukemia virus 1 infection ptg05200   Pathways in cancer ptg05207   Chemical carcinogenesis - receptor activation ptg05414   Dilated cardiomyopathy Brite KEGG Orthology (KO) [BR:ptg00001]  09100 Metabolism   09104 Nucleotide metabolism    00230 Purine metabolism     102965866 (ADCY4)  09130 Environmental Information Processing   09132 Signal transduction    04015 Rap1 signaling pathway     102965866 (ADCY4)    04371 Apelin signaling pathway     102965866 (ADCY4)    04020 Calcium signaling pathway     102965866 (ADCY4)    04072 Phospholipase D signaling pathway     102965866 (ADCY4)    04024 cAMP signaling pathway     102965866 (ADCY4)    04022 cGMP-PKG signaling pathway     102965866 (ADCY4)  09140 Cellular Processes   09143 Cell growth and death    04114 Oocyte meiosis     102965866 (ADCY4)   09144 Cellular community - eukaryotes    04540 Gap junction     102965866 (ADCY4)  09150 Organismal Systems   09151 Immune system    04611 Platelet activation     102965866 (ADCY4)    04062 Chemokine signaling pathway     102965866 (ADCY4)   09152 Endocrine system    04911 Insulin secretion     102965866 (ADCY4)    04923 Regulation of lipolysis in adipocytes     102965866 (ADCY4)    04912 GnRH signaling pathway     102965866 (ADCY4)    04913 Ovarian steroidogenesis     102965866 (ADCY4)    04915 Estrogen signaling pathway     102965866 (ADCY4)    04914 Progesterone-mediated oocyte maturation     102965866 (ADCY4)    04921 Oxytocin signaling pathway     102965866 (ADCY4)    04926 Relaxin signaling pathway     102965866 (ADCY4)    04935 Growth hormone synthesis, secretion and action     102965866 (ADCY4)    04918 Thyroid hormone synthesis     102965866 (ADCY4)    04928 Parathyroid hormone synthesis, secretion and action     102965866 (ADCY4)    04916 Melanogenesis     102965866 (ADCY4)    04925 Aldosterone synthesis and secretion     102965866 (ADCY4)    04927 Cortisol synthesis and secretion     102965866 (ADCY4)   09153 Circulatory system    04261 Adrenergic signaling in cardiomyocytes     102965866 (ADCY4)    04270 Vascular smooth muscle contraction     102965866 (ADCY4)   09154 Digestive system    04970 Salivary secretion     102965866 (ADCY4)    04971 Gastric acid secretion     102965866 (ADCY4)    04972 Pancreatic secretion     102965866 (ADCY4)    04976 Bile secretion     102965866 (ADCY4)   09156 Nervous system    04724 Glutamatergic synapse     102965866 (ADCY4)    04727 GABAergic synapse     102965866 (ADCY4)    04725 Cholinergic synapse     102965866 (ADCY4)    04723 Retrograde endocannabinoid signaling     102965866 (ADCY4)   09157 Sensory system    04742 Taste transduction     102965866 (ADCY4)    04750 Inflammatory mediator regulation of TRP channels     102965866 (ADCY4)   09149 Aging    04211 Longevity regulating pathway     102965866 (ADCY4)    04213 Longevity regulating pathway - multiple species     102965866 (ADCY4)   09159 Environmental adaptation    04713 Circadian entrainment     102965866 (ADCY4)    04714 Thermogenesis     102965866 (ADCY4)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     102965866 (ADCY4)    05207 Chemical carcinogenesis - receptor activation     102965866 (ADCY4)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     102965866 (ADCY4)    05163 Human cytomegalovirus infection     102965866 (ADCY4)   09165 Substance dependence    05032 Morphine addiction     102965866 (ADCY4)   09166 Cardiovascular disease    05414 Dilated cardiomyopathy     102965866 (ADCY4)   09167 Endocrine and metabolic disease    04934 Cushing syndrome     102965866 (ADCY4)   09176 Drug resistance: antineoplastic    01522 Endocrine resistance     102965866 (ADCY4) Enzymes [BR:ptg01000]  4. Lyases   4.6  Phosphorus-oxygen lyases    4.6.1  Phosphorus-oxygen lyases (only sub-subclass identified to date)     4.6.1.1  adenylate cyclase      102965866 (ADCY4) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  Guanylate_cyc Adcy_cons_dom AC_N CD52 Motif Other DBs NCBI-GeneID:  102965866 NCBI-ProteinID:  XP_007098120 LinkDB All DBs Position Un AA seq 1081 aa AA seqDB search MVQPDTNGKSRCPVSFCYLSLRHISEVAWGGCLFFFSLEAVPHTPHSSLAASTLSSQELA SDPGFLTTVLCALGGFSLLLGLASREQRLQRWTRPLSGLIWAALLGLGHGFLFTGGLVSA WDQVSFFLFVIFTVYAMLPLGMQDAAAAGLASSLSHLLVLGLYLGPQPDSKPALLPQLAA NAVLFLCGNVAGAYHKALMERALRATFREALSSLHSRRRLDTEKKHQEHLLLSILPAYLA REMKAEIMARLQAGQGSRPESTNNFHSLYVKRHQGVSVLYADIVGFTRLASECSPKELVL MLNELFGKFDQIAKEHECMRIKILGDCYYCVSGLPLSLPDHAINCVRMGLDMCRAIRKLR AATGVDINMRVGVHSGSVLCGVIGLQKWQYDVWSHDVTLANHMEAGGVPGRVHITGATLA LLAGAYAVEDAAMEHRDPYLRELGEPTYLVIDPRAEEEDEKGTAGGLLSSLEGPKMRPSL LMTRYLESWGAAKPFAHLSHLESPVSTSTPLPEKALASFGPQWSLDRSRTPRGLDDDLDT GDAKFFQVIEQLNSQKQWRQSKDFNPLTLYFRKKELEKEYRLSALPAFKYYAACTFLVFL SNFIIQMLVTNRPPALAITYSITFLLFLLLLFVCFSEHLTRCVLKGPKMLHWLPALSGLV ATRPGLRVALGTATILLVFVMAIPSLFFLPAASNCPFGALNVSSMAFNISWELPGSLPLI SVPYSMHCCVLGFLSCSLFLHMSFELKLLLLLLWLGASCSLFLHSHAWLSDCLIARLYPD PSDSRPGVLKEPKLMGAISFFIFFFTLLVLARQNEYYCRLDFLWKKKLRQEQEETETMEN LTRLLLENVLPAHVAPQFIGQNRRNEDLYHQSYECVCVLFASVPDFKEFYSESNINHEGL ECLRLLNEIIADFDELLSKPKFSGVEKIKTIGSTYMAATGLNATSGQDAQQDAERSCSHL GTMVEFAVALGSKLDVINKHSFNNFRLRVGLNHGPVVAGVLGAQKPQYDIWGNTVNVASR MESTGVLGKIQVTEETARVLQSLGYTCYSRGIIKVKGKGQLCTYFLNTDLARTGPPSATL G NT seq 3246 nt NT seq  +upstreamnt  +downstreamnt atggttcaacctgatacgaatggcaagtcgaggtgccctgtctccttttgctacttgagt ttgagacacatttcagaagtggcctgggggggctgcctgttcttcttcagcttggaggcg gtcccccatactccacactccagtcttgctgcaagcaccctctcctcgcaggagctagct tcagacccaggcttcctgaccactgtgctgtgcgcgctgggtggcttctcgctgctcctg ggcctggcttcccgggagcaacgactgcagcgctggacacgtcccctgtcgggcctcata tgggcagcgctactcgggctaggccacggcttcctgttcactgggggcctggtgagcgcc tgggaccaggtgtcctttttcctctttgtcatcttcaccgtgtacgccatgttgcccttg ggcatgcaggatgccgctgctgcgggccttgcctcatcgctctcccacttgctggtcctg gggctgtaccttgggcctcagccggactcaaagcctgcgctgctgccacagctggcagcg aacgcggtgttgttcctgtgcgggaacgtggcgggagcgtatcacaaggcgctgatggag cgcgcgctgcgcgccacattccgcgaggcacttagctccctgcactcgcgccggcggctg gacaccgagaagaagcaccaggaacaccttctcttgtccatccttcctgcctacttggcc cgagagatgaaggcagagatcatggcacgactgcaggctggacaggggtcacggccagaa agcaccaacaacttccacagcctctatgtcaagaggcaccagggagtcagtgtgctgtat gctgacatcgtgggcttcacccggctggccagtgagtgctctcctaaggagttggtgctc atgctcaacgagctctttggcaagttcgaccagatcgccaaggagcatgaatgcatgcgg atcaagatcctgggagactgttactactgtgtctctgggctaccgctctccctgccagac cacgccatcaactgcgtgcgcatggggctggacatgtgccgggccatcaggaagctccgg gcagccactggcgtggacatcaacatgcgtgtgggcgtgcattcgggcagtgtgctctgc ggagtcattgggctgcagaagtggcagtatgatgtctggtcccatgatgtcacactggcc aaccacatggaggcgggtggcgtgccaggacgagtacatattacaggggctaccctggcc ctgctggcaggggcttatgctgtggaggatgcagccatggaacaccgggacccatacctt cgggagctaggggagcctacctacctagtcatcgatccccgggctgaggaagaggatgag aagggcactgcaggagggttgctgtcctctcttgagggccccaagatgcgtccgtcactg ctgatgacccgctacctggagtcctggggcgccgccaagccttttgcccatctgagccac ctagagagccctgtgtccacttctacccctctcccggagaaggccctggcttcctttggc ccccagtggagcctggaccggagccgtaccccccgggggctagatgatgacctggacact ggggacgccaagttcttccaggtcatcgaacagctcaactctcagaaacagtggaggcag tcaaaggacttcaacccactgacactgtacttcagaaagaaggaactggagaaagagtac cgactctctgcactccccgccttcaaatactacgcagcctgcaccttcctggttttcctt tccaatttcatcatccagatgctggtgacaaacaggcccccagctcttgccatcacctat agcatcaccttcctcctcttcctcctcctcctcttcgtctgcttctcagagcacctgacg aggtgtgtcttgaaaggccccaagatgctgcactggctgccggcactgtctggcttggtg gccacacggcccggactgcgagttgcccttggcacagctaccatcctcctggtttttgtg atggccattcccagcctgttcttcttaccagcagcatcaaactgcccttttggggctctc aatgtgtcctccatggctttcaacatctcctgggagctccctgggtccctgcctctcatc agcgtcccctactctatgcactgctgcgtgctggggttcctgtcctgctccctctttttg cacatgagcttcgagctgaagttgctgctgctcctgctatggctgggggcctcctgctcc ctcttcctgcactcccatgcctggctgtccgactgcctcatcgcccgcctctatccggat ccctcggactccaggccaggggtgctgaaggagcccaaactgatgggagctatctccttc ttcatcttcttcttcaccctccttgtcctggctcggcagaatgagtattactgccggctg gacttcctgtggaagaagaagctgcggcaggagcaggaggagacagagaccatggagaac ctgactcggctgctgttggagaatgtgctccctgcacatgtggccccccagttcattggc cagaaccggcgcaacgaggacctctaccaccagtcctatgagtgtgtctgtgtcctgttc gcctcagttccagacttcaaggagttttactctgagtccaacataaaccacgagggtcta gagtgtctgcggctgctcaatgagataattgctgattttgatgagctgctctcaaagccc aagtttagtggggtggagaagatcaaaaccatcggtagcacctacatggcagctacaggc ttaaatgccacctccggacaggacgcacagcaggatgctgagcgcagctgcagccacctt ggcaccatggtggagtttgcggtggctcttggatcaaagctggacgtcatcaataagcac tctttcaacaacttccgcttgcgtgtggggttgaaccacggacctgtagtggctggggtg ctcggggcccagaagccgcagtatgacatctggggcaacacagtgaacgtggccagccgc atggagagtacaggagtcctgggcaagatccaggtgactgaagagacggcccgggtgctg cagtccttaggctacacctgctacagccggggtatcatcaaggtcaaaggcaaagggcaa ctctgcacctactttctgaacacagatttggcacgaactggacctccctcggccacccta ggctga

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