Panthera uncia (snow leopard): 125913423 Help Entry 125913423         CDS       T08832                                  Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism puc  Panthera uncia (snow leopard) Pathway puc01521   EGFR tyrosine kinase inhibitor resistance puc04151   PI3K-Akt signaling pathway puc04217   Necroptosis puc04380   Osteoclast differentiation puc04550   Signaling pathways regulating pluripotency of stem cells puc04620   Toll-like receptor signaling pathway puc04621   NOD-like receptor signaling pathway puc04630   JAK-STAT signaling pathway puc04658   Th1 and Th2 cell differentiation puc04659   Th17 cell differentiation puc05140   Leishmaniasis puc05145   Toxoplasmosis puc05152   Tuberculosis puc05160   Hepatitis C puc05161   Hepatitis B puc05162   Measles puc05163   Human cytomegalovirus infection puc05164   Influenza A puc05165   Human papillomavirus infection puc05166   Human T-cell leukemia virus 1 infection puc05167   Kaposi sarcoma-associated herpesvirus infection puc05168   Herpes simplex virus 1 infection puc05169   Epstein-Barr virus infection puc05171   Coronavirus disease - COVID-19 puc05200   Pathways in cancer puc05203   Viral carcinogenesis puc05212   Pancreatic cancer puc05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:puc00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     125913423    04151 PI3K-Akt signaling pathway     125913423  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     125913423   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     125913423  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     125913423    04621 NOD-like receptor signaling pathway     125913423    04658 Th1 and Th2 cell differentiation     125913423    04659 Th17 cell differentiation     125913423   09158 Development and regeneration    04380 Osteoclast differentiation     125913423  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     125913423    05203 Viral carcinogenesis     125913423    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     125913423   09162 Cancer: specific types    05212 Pancreatic cancer     125913423   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     125913423    05161 Hepatitis B     125913423    05160 Hepatitis C     125913423    05171 Coronavirus disease - COVID-19     125913423    05164 Influenza A     125913423    05162 Measles     125913423    05168 Herpes simplex virus 1 infection     125913423    05163 Human cytomegalovirus infection     125913423    05167 Kaposi sarcoma-associated herpesvirus infection     125913423    05169 Epstein-Barr virus infection     125913423    05165 Human papillomavirus infection     125913423   09171 Infectious disease: bacterial    05152 Tuberculosis     125913423   09174 Infectious disease: parasitic    05145 Toxoplasmosis     125913423    05140 Leishmaniasis     125913423   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     125913423  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:puc01001]     125913423 Enzymes [BR:puc01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      125913423 Protein kinases [BR:puc01001]  Non-receptor tyrosine kinases   JAK family [OT]    125913423 BRITE hierarchy SSDB OrthologParalogGene clusterGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase FERM_F2 Jak1_Phl FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  125913423 NCBI-ProteinID:  XP_049474488 LinkDB All DBs Position C1 Genome browser AA seq 1156 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPRVEVLFYLSDREPLRLGSGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHPDDSGNILYEVMVTGNLGIQWRQKPNVVPVEKEKNKLKWKKLENKHKKDEEKNKIRE EWNNFSYFPEITHIVIKECVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAHH YLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVTC FEKSEVVGSQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMNHLKKQILRTDNISFVLKR CCQPKPREISNLLVATKKAQEWQPVYSMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGTL LDYKDDEGTSEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDVE NIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLLL AREGIDSEFGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGTT LWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAIM RDINKLEEQNPDIVSERKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNTG EQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPSG SLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDF GLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSDS SPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPTNRTTF QNLIKGFEALLEALLK NT seq 3471 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagacggaggtgaatctggaggcccccgaaccacgagtggaagtgctcttc tatctgtccgatagggagccgctccggctgggcagcggggagtacacggcagaggagctg tgcatcagggcggcgcaggaatgctgtatctctcctctgtgtcacaacctttttgccctg tatgatgagaacaccaagctttggtacgctccgaatcgcacgatcacagttgacgacaag acatcactccggctccactaccggatgaggttctatttcaccaactggcatgggaccaat gataatgagcagtctgtatggcgacattctccgaagaagcagaaaaatggctacgagaaa aaaaaagttccagatgcaacccctctccttgacgccagctccctggagtatctgtttgct cagggacaatatgatttggtcaaatgcctggctcccattcgagaccccaagaccgagcag gatggacacgatattgagaacgagtgtctgggaatggctgtcctggccatctcccactac gccatgatgaagaagatgcaattgccagaactgcccaaggacatcagctacaagcgatat atcccagaaacattgaataagtccatcaggcagaggaatcttctcaccaggatgcggata aataacgttttcaaggatttcctaaaggaatttaacaacaagaccatctgtgacagcagt gtatctactcatgacctgaaggtgaaatacctggcgaccttggagactttgacaaaacat tatggtgctgaaatatttgagacttccatgttactgatttcgtcagaaaatgagatgaat tggtttcatccagatgacagtggaaacattctctatgaagtgatggtaactggaaatctt ggaatccagtggagacagaaaccaaatgttgttcctgttgaaaaggaaaaaaacaaactg aaatggaaaaagctggaaaataaacacaagaaggatgaggagaaaaacaaaatccgggaa gagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtgtgtg gtcagcatcaataagcaggacaataaaaaaatggaactgaagctttcgtcccacgaggag gccttgtcctttgtgtccctggtagacggctacttccggctcacagcggatgcccatcat tacctctgcactgatgtggctcccccactgattgtccacaacatacagaatggttgtcac ggtcccatctgcacagaatatgccatcaataaattgcggcaagaaggaagcgaggaggga atgtatgtgctgaggtggagctgtactgactttgacaatatcctcatgactgtcacctgc tttgaaaaatctgaggtggtgggtagccaaaaacagttcaagaactttcagatcgaggtg cagaagggccgttacagcctgcatggctcggaccgcagcttccccagcctgggggacctc atgaaccacctcaagaaacagatcctgcggacggacaacatcagcttcgtgctgaagcgc tgctgccagcccaagccccgagagatctccaatttgctggtggctactaagaaagcccag gagtggcagcctgtctactctatgagccagctgagttttgaccggatcctcaagaaagat atcgtgcaaggcgagcaccttgggagaggcacgcggacgcacatctactctggaaccctt ctggattacaaagatgacgaaggaacttccgaagaaaagagaataaaagtgatcctcaaa gtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatgatg aggcaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgagatgtggaa aatatcatggtggaggagtttgtggagggggggcccctggatctcttcatgcaccggaaa agcgatgtcctcaccacaccgtggaagtttaaagttgccaaacaactggccagtgccttg agttacttggaggataaagacctggtccacggaaatgtgtgcactaaaaacctcctcttg gcccgtgagggcatcgacagcgagttcggcccgttcatcaagctcagtgaccccggcatc cccatcaccgtgctgtccaggcaagagtgcatagaacgaatcccgtggattgctcccgag tgtgttgaagactccaagaacctgagtgtggccgctgacaaatggagctttggaaccaca ctctgggaaatctgctacaatggcgagatccctctgaaagacaagacactgattgagaaa gagcgattctatgaaagccggtgccggccagtgacaccatcttgtaaggagctggctgac ctcatgacccgctgtatgaactatgaccccaaccagagacccttcttccgagccatcatg agagacatcaataaactggaggagcagaatccagacattgtttcagaacgaaagccggca accgaagtggatcccacacattttgaaaagcggttcttgaagagaatccgtgacttggga gagggccactttgggaaggttgagctctgcagatacgaccctgagggtgacaataccggg gagcaggtggctgtcaaatccctgaagcctgagagtggaggtaaccacatagctgatctg aagaaggaaattgaaatcttaaggaacctctatcatgagaacattgtgaagtacaaaggc atctgtacagaagacggaggaaatggtattaagctcatcatggagtttctaccttcagga agccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacaacagttaaaa tatgctgttcagatttgtaaggggatggactacttggggtctcggcagtacgttcaccgg gacttagcagcaagaaatgtcctcgttgagagtgagcaccaagtgaaaattggagacttc ggtttaaccaaagccattgaaaccgacaaagagtactacacagtcaaggatgatcgggac agccctgtgttttggtatgctccagaatgtttaattcagtgtaaattttatatcgcctct gacgtctggtcgtttggagtgactctgcatgagctgctcacttactgtgactccgattcc agccccatggcattgttcctgaaaatgataggcccaacgcatggccagatgacagtcaca agacttgtgaacacgttaaaagaaggaaaacgtttgccctgtccacctaactgcccagat gaggtttatcaactcatgagaaagtgctgggaattccaaccaactaataggacaactttt cagaacctaattaaaggatttgaagcacttttagaagcacttttaaaataa

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