Rousettus aegyptiacus (Egyptian rousette): 107497246
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Entry
107497246 CDS
T06036
Symbol
IRS1
Name
(RefSeq) insulin receptor substrate 1
KO
K16172
insulin receptor substrate 1
Organism
ray
Rousettus aegyptiacus (Egyptian rousette)
Pathway
ray04022
cGMP-PKG signaling pathway
ray04068
FoxO signaling pathway
ray04140
Autophagy - animal
ray04150
mTOR signaling pathway
ray04151
PI3K-Akt signaling pathway
ray04152
AMPK signaling pathway
ray04211
Longevity regulating pathway
ray04213
Longevity regulating pathway - multiple species
ray04722
Neurotrophin signaling pathway
ray04910
Insulin signaling pathway
ray04920
Adipocytokine signaling pathway
ray04923
Regulation of lipolysis in adipocytes
ray04930
Type II diabetes mellitus
ray04931
Insulin resistance
ray04932
Non-alcoholic fatty liver disease
ray04935
Growth hormone synthesis, secretion and action
ray04960
Aldosterone-regulated sodium reabsorption
ray05010
Alzheimer disease
ray05206
MicroRNAs in cancer
ray05415
Diabetic cardiomyopathy
Brite
KEGG Orthology (KO) [BR:
ray00001
]
09130 Environmental Information Processing
09132 Signal transduction
04068 FoxO signaling pathway
107497246 (IRS1)
04022 cGMP-PKG signaling pathway
107497246 (IRS1)
04151 PI3K-Akt signaling pathway
107497246 (IRS1)
04152 AMPK signaling pathway
107497246 (IRS1)
04150 mTOR signaling pathway
107497246 (IRS1)
09140 Cellular Processes
09141 Transport and catabolism
04140 Autophagy - animal
107497246 (IRS1)
09150 Organismal Systems
09152 Endocrine system
04910 Insulin signaling pathway
107497246 (IRS1)
04923 Regulation of lipolysis in adipocytes
107497246 (IRS1)
04920 Adipocytokine signaling pathway
107497246 (IRS1)
04935 Growth hormone synthesis, secretion and action
107497246 (IRS1)
09155 Excretory system
04960 Aldosterone-regulated sodium reabsorption
107497246 (IRS1)
09156 Nervous system
04722 Neurotrophin signaling pathway
107497246 (IRS1)
09149 Aging
04211 Longevity regulating pathway
107497246 (IRS1)
04213 Longevity regulating pathway - multiple species
107497246 (IRS1)
09160 Human Diseases
09161 Cancer: overview
05206 MicroRNAs in cancer
107497246 (IRS1)
09164 Neurodegenerative disease
05010 Alzheimer disease
107497246 (IRS1)
09166 Cardiovascular disease
05415 Diabetic cardiomyopathy
107497246 (IRS1)
09167 Endocrine and metabolic disease
04930 Type II diabetes mellitus
107497246 (IRS1)
04932 Non-alcoholic fatty liver disease
107497246 (IRS1)
04931 Insulin resistance
107497246 (IRS1)
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Ortholog
Paralog
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Motif
Pfam:
IRS
PH
PH_11
Motif
Other DBs
NCBI-GeneID:
107497246
NCBI-ProteinID:
XP_015974374
UniProt:
A0A7J8JFV9
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Position
Unknown
AA seq
1237 aa
AA seq
DB search
MASPPETDGFSDVRKVGYLRKPKSMHKRFFVLRAASEAGGPARLEYYENEKKWRHKSSAP
KRSIPLESCFNINKRADSKNKHLVALYTRDEHFAIAADSEAEQDSWYQALLQLHNRAKGH
HDGASALGAGGGGSSCSGSSGLGEAGEDLSYGDGLPGPAFKEVWQVILKPKGLGQTKNLI
GIYRLCLTSKTISFVKLNSEAAAVVLQLMNIRRCGHSENFFFIEVGRSAVTGPGEFWMQV
DDSVVAQNMHETILEAMRAMSDEFRPRSKSQSSSNCSNPITVPLRRHHLNNPPPSQVGLT
RRSRTESITATSPASMVGGKQGSFRVRASSDGEGTMSRPASVDGSPVSPSTNRTHAHRHR
GGSRLHPPLNHSRSIPMPSSRCSPSATSPVSLSSSSTSGHGSTSDCLFPRRSSASVSGSP
SDGGFISSDEYGSSPCDFRSSFRSVTPDSLGHTPPARGEEELSNYICMGGKGASTLTAPN
GHYILPRGGNGHRYIPGAGLGMSPALAGDEAAGAADLDNRFRKRTHSAGTSPTISHQKTP
SQSSVASIEEYTEMMPAYPPGGGSGGRLPGYRHSAFVPTQSYPEEGLEGHPLERRGGHNR
PDTSTHHTDDGYMPMSPGVAPVPSSRKGSGDYMPMSPKSVSAPQQIVNPVRRHPQRVDPN
GYMMMSPSGSCSPDIGGGPSSSAAPSGSSYGKPWTNGVGGHHSHALPHPKLPAESSGSKL
LSCTGDYMNMSPVGDSNTSSPSDCYYGPEDPQHKPVLSYYSLPRSFKHTQRPGELEETAR
HQHLRLSSSSGRLLYAAAAEDSSSSTSSDSLGGGHSGARPEPGLPHHLHHQVLQSHLPRK
VDTAAQTNSRLARPTRLSLGDPKASTLPRAREQQQRPALLHPPEPKSPGEYVNIEFGSDQ
PGYLCGPVAPHSSPSIRCPTQLQPAPKEEETGTEEYMNMDLGPGRRATWQESPGIQPGRV
GPAPPGTASMSRPTRAVPSGRGDYMTVQVGRTRQSYVDTSPVAPVSYAEIRTGIVEEASL
PGAPAAAPSSSSAAPASPTVPQGAGKPEARSSLLGGPQGPGGMSAFTRVNLSPSCNQSAK
VIRADPQVCRRRHSSETFSSTPNATRAGNTVPLGGGAAVGDSGGGSSSSTEDVKRHSSAS
FENVWLRPGELGGVPKEPAQVCGTAGGLENGLNYIDLDLVKDVKQRPQERPPQAQPPAPP
PQHQPMGSSENGSTNRSSEDVSAYASISFQKQPEDLQ
NT seq
3714 nt
NT seq
+upstream
nt +downstream
nt
atggcgagccctccggagaccgacggcttctcggacgtgcgcaaggtgggctacctgcgc
aaacccaagagcatgcacaagcgcttcttcgtgctgcgggcggccagcgaggcggggggc
ccggcgcgcctcgagtactacgagaacgagaagaagtggcggcacaagtcgagcgccccc
aaacgctcgatccccctcgagagctgtttcaacatcaacaagcgggcggactccaagaac
aagcacctggtggccctctacacccgggacgagcactttgccatcgcggcggacagcgag
gctgagcaggacagctggtaccaggccctcctgcagctgcacaaccgtgccaagggccac
cacgacggggcctctgcccttggggcaggaggtggcgggagcagctgcagtggcagctcc
ggccttggcgaggctggggaggacttgagctacggggacgggctcccaggacctgcgttc
aaggaggtctggcaggtgatcctgaaacccaagggcctgggtcagacaaagaacctgatt
ggcatctaccgcctctgcctgaccagcaagaccatcagcttcgtgaagctgaactcagag
gcggcggccgtggtgctgcagctgatgaacatccggcgctgtggccactcagagaacttc
ttcttcatcgaagtgggccgttccgcagtgacaggacccggggagttctggatgcaggtg
gatgactcggtggtggcccagaacatgcacgagacaatcctggaggccatgcgagccatg
agcgatgagttccgccctcgcagcaaaagccagtcctcctccaactgctccaaccccatt
accgtccccctgcgcaggcatcacctcaacaacccgccgcctagccaggtggggctgacc
cgccgctcgcgcaccgagagcatcaccgccacctctcccgccagcatggtgggcgggaag
cagggctccttccgggtccgcgcctccagcgatggcgaaggcaccatgtcccgcccggct
tcggtggacggcagccccgtgagtcccagcaccaaccggacccacgcccaccggcatcgg
ggcggctcccggctgcaccccccgctcaaccacagccgttccatccccatgccttcttct
cgctgctcgccttcggccactagcccggtcagcctgtcgtccagcagcaccagcggccac
ggctccacctccgactgcctcttcccgcggcggtctagtgcttctgtgtcgggttccccc
agcgatggcggattcatctcttcggatgagtacggctccagtccctgcgacttccgaagt
tccttccgcagtgtcaccccggattccctgggccacactccacctgcgcgcggagaggaa
gagctgagcaactacatctgcatgggaggcaagggggcctccactcttaccgcccccaat
ggccactacattttgccgcggggtggcaacggtcaccgctacatcccaggcgccggcttg
ggcatgagccctgccctggctggcgatgaggcagccggtgctgcagatctggacaaccgg
ttccgcaagcggactcactctgctggtacatctcccaccatctcccaccagaagacccca
tcccagtcctccgtggcctccattgaggagtatacagagatgatgcctgcctacccacca
ggaggtggcagtggaggccggctgccggggtaccggcactccgccttcgtgcccacccag
tcctacccggaggagggtctggaagggcacccgttggagcgccgcggaggccacaaccgc
ccagacacctccactcaccacaccgatgatggctacatgccgatgtccccaggagtggcc
ccagtgcccagcagccgaaaaggcagtggggactacatgcccatgagccccaagagtgtg
tctgccccgcagcagatcgtcaaccccgtgagacgccatccccagagagtggatcccaac
ggctacatgatgatgtccccgagtggcagctgctcccctgacattggcggcgggcccagc
agcagcgccgccccttctgggagtagttacgggaagccgtggactaatggggtagggggc
caccactcccacgccctgccgcaccccaaactacccgcggagagcagcgggagcaagctc
ttgtcttgtacaggtgactacatgaacatgtcgccagtgggggactccaataccagcagc
ccctctgactgctactatggccctgaggacccccagcacaagccggttctctcctactac
tcattgccaaggtcctttaagcacacccagcgccccggggagctggaggagacagcccgg
caccagcacctccgactttcctccagctctggtcgccttctctatgctgcagcggccgaa
gactcctcttcctccaccagcagcgacagtctgggcgggggacacagcggggcaaggcct
gagcccggcctcccgcatcatctccaccatcaggtgctgcagtcccatctgcctcgaaag
gtggacacagctgcgcagaccaacagccgcctggctcggcccaccagactgtccctgggg
gaccccaaggccagcaccttacctcgggcccgagagcagcagcagcggccagccctgctg
caccctccggagcccaagagcccaggggaatatgtgaatatagaatttgggagtgatcag
ccaggctacttatgcggccccgtggcaccccacagctcgccttccatcaggtgtccaacc
cagctccagccggctcccaaagaggaagagactggcactgaagagtatatgaacatggac
ctggggccgggccggagggccacctggcaggagagccctgggatccagccaggcagagtg
ggccctgcacctccggggactgccagcatgtccaggccgacccgggcagtgcctagtggc
cggggtgactacatgacggtgcaggtgggtcgtacccggcagagctatgtggacacctct
ccagttgcccctgtcagctacgctgaaattcggacgggcatcgtggaggaggccagcctt
cctggggccccagcggctgctccctcctcatcctcagcagctccggcttcacccactgtg
cctcaaggagcggggaagccggaggctcgctcttccctgctggggggcccgcagggcccc
gggggcatgagcgccttcaccagggtgaaccttagtcccagctgcaaccagagtgccaaa
gtgatccgcgcagacccgcaagtgtgccggcggcggcacagctccgagaccttctcctct
acacctaatgccaccagggcgggcaacacggtgccccttggaggaggggctgcagttggg
gacagcggtggtggcagcagcagcagcactgaggacgtgaaacgccacagctctgcttcc
tttgagaatgtgtggctgaggcccggggagcttgggggagtccccaaggagccggctcag
gtgtgtgggactgcggggggtttggagaatggtctcaactacatagacctggatttggtc
aaggacgtcaaacagcgccctcaggagcgcccccctcaagcgcagcctcccgcacccccg
ccccagcatcagccaatgggcagcagtgagaacggttccaccaaccgctccagcgaggat
gtaagcgcctatgccagcatcagtttccagaagcagccagaggacctccagtag
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