Sarcophilus harrisii (Tasmanian devil): 100918350
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Entry
100918350 CDS
T02286
Symbol
DOT1L
Name
(RefSeq) histone-lysine N-methyltransferase, H3 lysine-79 specific isoform X1
KO
K11427
[histone H3]-lysine79 N-trimethyltransferase [EC:
2.1.1.360
]
Organism
shr
Sarcophilus harrisii (Tasmanian devil)
Pathway
shr00310
Lysine degradation
shr01100
Metabolic pathways
shr05202
Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:
shr00001
]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
100918350 (DOT1L)
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
100918350 (DOT1L)
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins [BR:
shr03036
]
100918350 (DOT1L)
Enzymes [BR:
shr01000
]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.360 [histone H3]-lysine79 N-trimethyltransferase
100918350 (DOT1L)
Chromosome and associated proteins [BR:
shr03036
]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
100918350 (DOT1L)
HMT complexes
Dot1-containing complex
100918350 (DOT1L)
BRITE hierarchy
SSDB
Ortholog
Paralog
Gene cluster
GFIT
Motif
Pfam:
DOT1
Motif
Other DBs
NCBI-GeneID:
100918350
NCBI-ProteinID:
XP_031803965
Ensembl:
ENSSHAG00000010977
LinkDB
All DBs
Position
1:complement(665094024..665209404)
Genome browser
AA seq
1761 aa
AA seq
DB search
MGEKLELRLKSPVGAEPAVYPWPLPVYDKHHDAAHEIIETIRWVCEEIPDLKLAMENYVL
IDYDTKSFESMQRLCDKYNRAIDSIHQLWKGTTQPMKLNTRPSNGLLRHILQQVYNHSVT
DPEKLNNYEPFSPEVYGETSFDLVAQMIDEIKMTEDDLFVDLGSGVGQVVLQVAAATNCK
HHYGVEKADIPAKYAETMDREFRKWMKWYGKKHAEYTLERGDFLSEEWRERIANTSVIFV
NNFAFGPEVDHQLKERFANMKEGGRIVSSKPFAPLNFRINSRNLSDIGTIMRVVELSPLK
GSVSWTGKPVSYYLHTIDRTILENYFSSLKNPKLREEQEAARRRQQRENKSNTTTPTKVQ
ENKGAVALEPRVDSGAEEDKNGTTTLKKPSPSKPRKKKLNKKGRKMAGRKRGRPKKMSAA
NPERKPKKTPTALELLHAQTVSQAAASSPQDAYKSPHSPYYQLPPKVQRHSSNQLLATPT
PPALQKLLESFKVQYLQFLAYMKTPQYKANLQQLVEQEKEKNTQLLGTAQQLFSHCQAQK
EEIKRLFQQKLDELGVKALTYNDLIQAQKEISAHNQQLKEQTKQLESDNSELRNQSLQLL
KARCEELKLDWSTLSLENLLKEKQALKNQISEKQKHCLELQISIVELEKSQRQQELLQLK
SYAPADEALSVHLRSKSSFSRELETDPARFQLELECSKLSLPHINSMSPELSMNGHATTY
EIHSMLSRPSSKQNTPQYLTSHLDQEIVPCTPIHNNRQKADKLSSLSLPDYTRFSPAKLA
LRRHLNQDHVVHGKATTNEIHHRTEHAKENGLTYQSAGLSNGLKLSPQETRPSSPSALQI
AGEKSSDKVLKERAYASNGETITSLPISIPLSTVQPNKLPVSIPLASVVLPSRAEKVRNT
PSPVHQNRESTSATLEKQFGANSHNGMNSAVGNKSLALATSGFSYSGSLAVNGTLSSSPA
HLNHGAEQAALDDSSNSGSLFNSVGSRSSTPQHPSLLMMQSRNSGQNSPAHPLAASPRLN
GASQSMLGILQYSDTTKLFSEGNKGDLPLDSGFSDPESEVKRRILFTISTNTGNLKQSPS
NKHSPLTTSIRPDCGQACVQEGKKRGRRKRSSTGNPSVNSAVSPKRKPLPSVAGLFTQSS
GSPLNINSMVNNINQPLEITAISSPENSLKNSPIPYQDNDQPPVLKKEKPLIQTNGAHYS
PLTSDEEQGSEDEHNSIRIERKIATISLESKSPQKTENGGGLTGRKQTQLTEGINSSKWK
STFSPISDINLTKTSDSPLQAASSLSQNSLFAFRPSSEDTMAIDAKISVHPRKSFPSSLS
GSDGLSPNTNSSNGFSYTGGLSAADMSLHSFHDGASLSHKTTEAAGLSSPLGFQAQRSKD
ASDANPFLNKRQLDGLGSMKGEELPRAGGRSKEVLDMALQLGGPPDKGSLQHIGKAGKGR
DREVEFKNGHNLFISAAAAVPPGGLLNGKGLSSTASVVGHPASSVSAHHPFLNTFTTGSQ
FPLGPMSLQANLSSVAGSSVLQSLFNSMPAAASLVHVSSAATRLTNSHAMGNFSSGVTGG
TVGGVFNHAVPSASSHQFGASFSSSAVCSSTMLSLNPVQAVVTPTSSSFQAPSSSIGTCS
EARAPQHLNQVPVQPALHPPPPAPPPPNVSLPPPPPLLTASNPEPGLLQTLTSIPANKAF
VAPSSAASLQANASLSIKLASLPHKASRPSFTVHHQPLPRLALAQAAPAVPQSDAAGPPA
MWVTLGMQSPYASHLSGVKPR
NT seq
5286 nt
NT seq
+upstream
nt +downstream
nt
atgggtgagaagctggaattgaggctcaagtcgcccgtgggagccgagcccgccgtgtac
ccgtggcccctgccggtctatgacaaacaccatgatgctgctcatgaaatcattgagacc
attagatgggtctgcgaagaaataccagatctcaagcttgccatggaaaattatgtttta
attgactatgataccaaaagctttgaaagcatgcagagactctgtgacaagtacaaccga
gccattgatagcattcatcaactgtggaaaggaacaactcagcccatgaaattgaacact
cggccatccaatgggcttcttcgacatatcttgcagcaagtatataaccactcagtcaca
gatccagagaaactcaacaactatgagcccttttctccagaggtgtatggagaaacttca
ttcgacttagttgcccaaatgattgatgagattaaaatgacagaggatgatttgtttgtt
gatttgggcagtggagtggggcaggtggttttgcaagtggctgcagccacaaattgtaaa
catcactatggtgtggagaaagcagacatcccggcaaaatatgctgagacaatggaccga
gaattcagaaaatggatgaaatggtatgggaagaagcatgcagaatacacactggaaaga
ggtgacttcctttcagaagaatggcgggaaagaattgcaaatacaagtgttatttttgtg
aataattttgcctttggtcctgaggtggatcaccaactgaaggagcgatttgctaacatg
aaagaaggtggcagaattgtgtcctccaaaccttttgcacctctaaattttagaataaac
agtagaaacttgagtgatattggcactataatgagagttgtggaactatcaccactgaaa
gggtcggtttcatggactggcaagccagtttcttactacctgcatactattgatcgaacc
atacttgaaaactatttttctagtctcaaaaatccaaaactcagggaggagcaggaggca
gcccgccgccggcaacaaagagagaacaagagcaacacgacgactcccaccaaggtccaa
gaaaataagggtgctgttgctttggagcctcgagtggattctggtgctgaagaagataaa
aatgggacaactactcttaaaaaaccatctccttccaagcctcgcaaaaagaaattaaac
aaaaaaggaaggaagatggcaggaagaaaacgtggacgtcccaagaaaatgagtgctgca
aaccctgaaaggaaacccaagaagactcccactgcactggagcttctgcatgctcagact
gtgtcccaggcagctgcatcctctcctcaggatgcatacaagtcacctcatagtccatac
tatcaactacctcctaaagtacaacggcattcctccaaccagctattggcaacaccaacc
ccacctgcactccagaagctgttagaatcctttaaggttcagtacttgcagtttctggcc
tatatgaaaaccccacagtacaaagctaacctacagcaattggtggagcaggagaaggaa
aagaacactcaattgttaggtacagcccagcagttgttcagccactgtcaggctcagaaa
gaggagatcaagagactgtttcagcagaaacttgatgagttgggagttaaggctctgacc
tacaatgatctgatacaagctcagaaagagatctctgctcacaaccaacagctaaaagaa
cagacaaagcagctagaaagtgataacagtgaactcaggaatcaaagcttgcagctgctt
aaggctcggtgtgaagagctgaagctggattggtctactctctcactggaaaatttgctg
aaggagaagcaggcactgaagaatcaaatttccgagaagcaaaagcactgtctggagctt
cagatcagcattgtggagcttgagaaaagccaaaggcagcaggaactactgcagctgaaa
tcctacgcgccggcagatgaggccctgtccgtccacctgcgaagtaaaagcagcttcagc
cgtgagctggagactgaccctgccaggttccagctggagctcgagtgctccaagttgtct
ttgccccacatcaatagcatgagccccgaactttctatgaatggccatgcaaccacctat
gagattcatagtatgcttagtcgaccttcttccaaacaaaacactccacagtatctgacc
tcccacctggaccaagaaatagttccttgcacccccattcataacaacagacagaaggca
gacaaattgtcaagcttgtccttgcctgattacaccaggttttcccccgctaagttagcc
ctaaggagacacttgaatcaggatcatgtagtccatggaaaagctacaactaatgaaata
caccacagaactgaacatgcaaaagagaatggcctgacatatcagagtgctggtctgtca
aatggcctaaagctgagccctcaggaaactcggccttcctccccctcggccttacagatt
gcaggagagaagagcagtgacaaggttttaaaagagagagcctatgccagcaatggggaa
acaatcaccagcctacctatcagtattcctctcagtacagtgcagcccaataaacttcct
gtcagtatcccattggccagtgtagtgttgcctagccgtgcggagaaagtgaggaacaca
cctagtccagttcatcagaatcgagagtctacttcagcaacacttgaaaaacagtttggt
gctaattcccataatggtatgaacagtgctgtaggaaacaagtcccttgctttggctacc
tcaggtttttcttatagtggctccttggcagtcaatggcacactttccagtagcccagcc
catcttaaccatggtgctgagcaggcagcccttgatgattcctccaattcagggagcctc
tttaattcagtggggtcccggagttctacgccccagcatccttctttactcatgatgcag
tcccggaactctggccagaactctccagcccatccacttgctgccagcccgcgcctcaat
ggagcttctcaaagcatgttggggattttgcagtactcggatactacaaaattgttctct
gaaggtaacaagggggatcttccactagattcaggtttttcagatcctgaaagtgaagtc
aagagaagaatcctctttacaatctcgaccaatacagggaacctgaagcagtctccttcc
aacaaacacagccctctgaccactagcattcgcccggattgtggacaggcttgtgtgcag
gagggcaagaagaggggcagaaggaagcggtcttccacggggaaccccagtgtgaactca
gcggtatctcccaagcgcaagcccttaccatctgtggcaggcctttttacccaatcttca
ggctcacctctcaacatcaactctatggtcaataacattaatcaacctttagaaataaca
gccatttcctcccctgaaaactccctgaagaactctcctattccttaccaggacaacgac
cagcctcctgtgctgaaaaaggagaagcccttgatccagacgaacggggcacattactcg
cccctgacctcggatgaagagcaaggatctgaagatgagcacaacagtatcaggattgaa
aggaaaatcgcaacaatctctttagagagcaagtctccccagaaaacagaaaatggtggt
ggccttacaggaaggaagcaaacccagctgactgaaggcataaacagtagtaaatggaag
tctaccttttcaccaatatcagacatcaaccttaccaaaacatccgacagccccttacag
gcagcttcgtccctgagccagaattccctgtttgccttccggccgtcctccgaggacacg
atggccattgatgccaagatctctgtgcacccaaggaagagcttccccagttccttgtcg
gggtcggatggtctcagccccaacacaaactcctccaatggattctcctataccgggggc
ctgtctgctgctgacatgagtttacacagctttcacgatggtgcttctctttctcacaaa
accaccgaggcggccggcctaagctcccctctgggttttcaggcacagcggagcaaagat
gcatcagatgccaatccttttctgaacaagaggcagctggacggcctgggcagtatgaag
ggagaagagttgccgagggccggaggcagaagtaaagaggtgcttgacatggccctgcag
ctgggggggccccccgacaaaggctccctgcagcacattggcaaggctggcaaagggcgg
gaccgggaggtggagtttaagaatggccacaacctcttcatttctgctgcggccgccgta
cctccagggggcctcctcaacggcaaagggctgtctagcacggcctctgtggttggtcac
cctgcttcttctgtatcggcgcaccatcccttcctcaacactttcaccactggatcccag
tttcccctgggccccatgtccctgcaggccaacctcagctcggtggcaggctcttcagta
ttgcagtctttatttaattccatgcccgccgctgccagtttggtccacgtgtcatcagcc
gcgaccagattgacaaattctcacgctatgggaaacttctcttctggggttacaggtgga
accgttggaggtgtttttaaccatgcggtgccttctgcctcttctcatcagtttggagcc
agtttcagcagtagtgctgtgtgtagcagcaccatgctaagcttaaacccagtgcaggct
gtggtcacccccacttcctcttccttccaggccccttcctctagcataggaacatgtagc
gaggctagagccccccagcacctgaaccaagtgcctgtgcagcctgccctgcatcctcct
ccccccgctcctcctcctcctaacgtctcattacctcccccccctccattactcactgct
tctaacccggagccggggcttctgcagaccctaacgtccattcctgctaacaaagctttt
gttgccccctcctcagctgcttctctccaggctaacgcttctctgtctatcaagctggcc
tccctcccccacaaagcttcccgcccctccttcacagtccaccatcagcctctgccccgt
ttggccctggcccaggctgcacccgcggtcccgcagtccgacgccgctggcccacccgct
atgtgggttacccttggcatgcagtctccttacgcttcgcacctttctggggttaagccg
cgataa
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