Ursus maritimus (polar bear): 103663059 Help Entry 103663059         CDS       T03271                                  Symbol JAK1 Name (RefSeq) tyrosine-protein kinase JAK1   KO K11217   Janus kinase 1 [EC:2.7.10.2] Organism umr  Ursus maritimus (polar bear) Pathway umr01521   EGFR tyrosine kinase inhibitor resistance umr04151   PI3K-Akt signaling pathway umr04217   Necroptosis umr04380   Osteoclast differentiation umr04550   Signaling pathways regulating pluripotency of stem cells umr04620   Toll-like receptor signaling pathway umr04621   NOD-like receptor signaling pathway umr04630   JAK-STAT signaling pathway umr04658   Th1 and Th2 cell differentiation umr04659   Th17 cell differentiation umr05140   Leishmaniasis umr05145   Toxoplasmosis umr05152   Tuberculosis umr05160   Hepatitis C umr05161   Hepatitis B umr05162   Measles umr05163   Human cytomegalovirus infection umr05164   Influenza A umr05165   Human papillomavirus infection umr05166   Human T-cell leukemia virus 1 infection umr05167   Kaposi sarcoma-associated herpesvirus infection umr05168   Herpes simplex virus 1 infection umr05169   Epstein-Barr virus infection umr05171   Coronavirus disease - COVID-19 umr05200   Pathways in cancer umr05203   Viral carcinogenesis umr05212   Pancreatic cancer umr05235   PD-L1 expression and PD-1 checkpoint pathway in cancer Brite KEGG Orthology (KO) [BR:umr00001]  09130 Environmental Information Processing   09132 Signal transduction    04630 JAK-STAT signaling pathway     103663059 (JAK1)    04151 PI3K-Akt signaling pathway     103663059 (JAK1)  09140 Cellular Processes   09143 Cell growth and death    04217 Necroptosis     103663059 (JAK1)   09144 Cellular community - eukaryotes    04550 Signaling pathways regulating pluripotency of stem cells     103663059 (JAK1)  09150 Organismal Systems   09151 Immune system    04620 Toll-like receptor signaling pathway     103663059 (JAK1)    04621 NOD-like receptor signaling pathway     103663059 (JAK1)    04658 Th1 and Th2 cell differentiation     103663059 (JAK1)    04659 Th17 cell differentiation     103663059 (JAK1)   09158 Development and regeneration    04380 Osteoclast differentiation     103663059 (JAK1)  09160 Human Diseases   09161 Cancer: overview    05200 Pathways in cancer     103663059 (JAK1)    05203 Viral carcinogenesis     103663059 (JAK1)    05235 PD-L1 expression and PD-1 checkpoint pathway in cancer     103663059 (JAK1)   09162 Cancer: specific types    05212 Pancreatic cancer     103663059 (JAK1)   09172 Infectious disease: viral    05166 Human T-cell leukemia virus 1 infection     103663059 (JAK1)    05161 Hepatitis B     103663059 (JAK1)    05160 Hepatitis C     103663059 (JAK1)    05171 Coronavirus disease - COVID-19     103663059 (JAK1)    05164 Influenza A     103663059 (JAK1)    05162 Measles     103663059 (JAK1)    05168 Herpes simplex virus 1 infection     103663059 (JAK1)    05163 Human cytomegalovirus infection     103663059 (JAK1)    05167 Kaposi sarcoma-associated herpesvirus infection     103663059 (JAK1)    05169 Epstein-Barr virus infection     103663059 (JAK1)    05165 Human papillomavirus infection     103663059 (JAK1)   09171 Infectious disease: bacterial    05152 Tuberculosis     103663059 (JAK1)   09174 Infectious disease: parasitic    05145 Toxoplasmosis     103663059 (JAK1)    05140 Leishmaniasis     103663059 (JAK1)   09176 Drug resistance: antineoplastic    01521 EGFR tyrosine kinase inhibitor resistance     103663059 (JAK1)  09180 Brite Hierarchies   09181 Protein families: metabolism    01001 Protein kinases [BR:umr01001]     103663059 (JAK1) Enzymes [BR:umr01000]  2. Transferases   2.7  Transferring phosphorus-containing groups    2.7.10  Protein-tyrosine kinases     2.7.10.2  non-specific protein-tyrosine kinase      103663059 (JAK1) Protein kinases [BR:umr01001]  Non-receptor tyrosine kinases   JAK family [OT]    103663059 (JAK1) BRITE hierarchy SSDB OrthologParalogGFIT Motif Pfam:  PK_Tyr_Ser-Thr Pkinase Jak1_Phl FERM_F2 FERM_F1 ABC1 SH2 RIO1 FERM_C_FAK1 Motif Other DBs NCBI-GeneID:  103663059 NCBI-ProteinID:  XP_040483137 UniProt:  A0A384C3J0 LinkDB All DBs Position Unknown AA seq 1153 aa AA seqDB search MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVLFYLSDREPLRLGSGEYTAEEL CIRAAQECCISPLCHNLFALYDENTKLWYAPNRTITVDDKTSLRLHYRMRFYFTNWHGTN DNEQSVWRHSPKKQKNGYEKKKVPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN WFHPNDSGNVLYYEVMVTGNLGIQWRQKPNVVPVEKEKHKLKRKKLENKHKKDEEKNKIR EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT CFEKSEVLGGQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFVLK RCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDIVQGEHLGRGTRTHIYSGT LVDYKDDEGTAEEKRIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRDV ENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNLL LAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFGT TLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRAI MRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDNT GEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLPS GSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGD FGLTKAIETDKEYYTVKDDRDSPVFWYAPECLIQCKFYIASDVWSFGVTLHELLTYCDSD YSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPLHCPDEVYQLMRKCWEFQPSNRTT FQNLIEGFEALLK NT seq 3462 nt NT seq  +upstreamnt  +downstreamnt atgcagtatctaaatataaaagaggactgcaatgccatggctttctgtgctaaaatgagg agctccaagaagaccgaggtgaatctggaggcccccgagccaggggtggaagtgctcttc tatctttcggacagggagcccctccggctgggcagcggggagtacacggcagaggagctc tgcatcagggccgcgcaggaatgttgtatctctcctctgtgtcacaacctctttgctctg tatgatgagaacaccaagctctggtatgccccgaatcgcaccatcactgttgatgacaag acatcgctccggctccactaccggatgagattctatttcaccaactggcatgggaccaat gataatgagcagtctgtatggcgacattctccaaagaagcagaaaaatggctatgagaaa aaaaaagtcccagatgcaacccctctccttgacgccagctctctggagtatctgtttgct cagggacaatatgatttggtcaaatgcctggctcccattcgagaccccaagaccgagcag gatgggcatgatatcgagaatgagtgtctgggaatggcagtcctggccatctcccactac gctatgatgaagaagatgcagttgccagaactgcccaaggacatcagctacaagcgatat attccagaaacattgaataagtccatcagacagaggaaccttctcaccaggatgcggata aataatgttttcaaagatttcttgaaggaatttaacaacaagactatttgtgacagcagt gtatctactcatgacctgaaggtgaaatacctggccaccttggaaactttgacaaaacat tatggcgctgaaatatttgagacttccatgttactgatttcatcagaaaatgagatgaat tggtttcatccaaatgacagtggaaatgttctctactatgaagtgatggtaactggaaat cttggaatccagtggagacagaaaccaaatgttgttcctgttgaaaaggaaaaacacaaa ctgaaacggaaaaagctggaaaataaacacaagaaggatgaggagaaaaacaaaatccgg gaagagtggaacaatttttcttacttccctgaaatcactcacattgtaataaaggagtct gtggtcagcatcaataagcaggacaacaaaaaaatggaactgaagctctcatcccatgaa gaggccttgtcctttgtgtccctggtagacggctacttccggctcacagcagatgcccat cattacctctgcaccgatgtggctcccccgttgatcgtccacaacatacagaatggttgt catggtccaatctgcacagaatatgccatcaataagttgcggcaagaaggaagcgaggag gggatgtatgtgctgaggtggagctgtaccgactttgacaatatcctcatgactgtcacc tgctttgaaaaatctgaggtgctgggtggccagaaacagttcaagaactttcagatcgag gtgcagaaaggccgctacagcctgcacggctcggaccgcagcttccccagcctgggggac ctgatgagccacctcaagaagcagatcctgcgcacggacaacatcagtttcgtgctgaag cgctgctgccagcccaagccccgagagatctccaatctgcttgtggctactaagaaagcc caagagtggcagcctgtctaccccatgagccagctgagttttgaccggatcctcaagaaa gatattgtgcagggcgagcacctcgggagaggcacacggacacacatctactctggtacc ctggtggattacaaggatgacgaaggaactgcggaagaaaagagaataaaagtgatcctc aaagtcttagaccccagccacagggacatttctctggccttctttgaggcagccagcatg atgaggcaggtctcccacaaacacatcgtgtacctctatggcgtctgtgtccgagatgtg gagaatatcatggtggaggagtttgtggagggggggcccctggatctcttcatgcaccgg aaaagtgatgtcctcaccacaccatggaagttcaaagttgccaagcagctggccagtgcc ctgagttacttggaggataaagacctggtccacggaaacgtgtgcacgaaaaatcttctc ctggcccgtgagggcattgacagcgagtgcggcccgttcatcaagctcagtgaccctggc atccccatcactgtgctgtccaggcaagagtgcatagaacgaatcccatggattgctcca gagtgtgttgaagactccaagaacctgagtgtggctgctgacaaatggagctttggaacc acactctgggaaatctgctacaatggcgagatccctctgaaagacaagaccctgattgag aaagagagattctacgaaagccggtgccggccagtgacaccatcttgtaaggagctggct gaccttatgacccgctgcatgaactatgaccccaaccagagacctttcttccgagccatc atgagagacatcaataaactggaagagcagaatccagacattgtttctgaaaaaaagccg gcaaccgaagtggatcccacgcattttgaaaagcggttcttgaagaggatccgtgacttg ggagagggccacttcgggaaggtcgagctctgcaggtatgaccctgagggggacaatact ggggagcaggtggcagtcaaatccctgaagcccgagagtggaggtaaccacatagctgat ctgaagaaggaaattgaaatcctaaggaacctctatcatgagaacattgtgaagtacaaa ggcatctgtaccgaagatggaggaaatggtattaagctcatcatggaatttctgccttca ggaagccttaaggaatatcttccaaagaataagaacaaaattaacctcaaacagcagtta aaatatgccgttcagatttgtaaggggatggactatttgggttctcgtcagtatgttcac cgggacttggcagcaagaaacgtcctcgttgagagtgagcaccaagtgaaaattggagac tttggtttgaccaaagccattgaaactgacaaggagtattacacagtcaaggatgatcgg gacagccctgtgttttggtatgctcccgaatgtttaattcagtgtaaattttatatcgcc tctgacgtctggtcgtttggagtgactctgcacgagctgcttacttactgtgactccgat tacagccccatggcgttgttcctgaaaatgataggcccaactcatggccagatgacagtc acaagacttgtgaatacattaaaagaaggaaaacgtttgccttgtccacttcactgtcca gatgaggtttatcaacttatgagaaaatgctgggaattccaaccatccaatcggacaact tttcagaaccttattgaaggatttgaagcacttttaaaataa

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