KEGG ENZYME: 1.1.1.404

ENZYME: 1.1.1.404

Entry

EC 1.1.1.404                Enzyme

Name

tetrachlorobenzoquinone reductase;
pcpD (gene name);
TCBQ reductase

Class

Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor

Sysname

2,3,5,6-tetrachlorohydroquinone:NAD+ oxidoreductase

Reaction(IUBMB)

2,3,5,6-tetrachlorohydroquinone + NAD+ = 2,3,5,6-tetrachloro-1,4-benzoquinone + NADH + H+ [RN:R11585]

Reaction(KEGG)

R11585

Substrate

2,3,5,6-tetrachlorohydroquinone [CPD:C03434];
NAD+ [CPD:C00003]

Product

2,3,5,6-tetrachloro-1,4-benzoquinone [CPD:C18933];
NADH [CPD:C00004];
H+ [CPD:C00080]

Comment

Contains FMN. The enzyme, characterized from the bacterium Sphingobium chlorophenolicum, participates in the degradation of pentachlorophenol.

History

EC 1.1.1.404 created 2017

Pathway

ec00361

Chlorocyclohexane and chlorobenzene degradation

ec01100

Metabolic pathways

ec01120

Microbial metabolism in diverse environments

Orthology

K21607

tetrachlorobenzoquinone reductase

Genes

SLIG:

GTU79_01065

PAO:	Pat9b_4735

STEQ:

ICJ04_16820

PRE:	PCA10_15680

PFUW:

KF707C_16670

PAE:

PA3498

PAEV:

N297_3621

PAEI:

N296_3621

PAEC:

M802_3620

PAEO:

M801_3486

PCQ:	PcP3B5_07920(pobB_1)

PFUV:

NLK61_07335

PFC:	PflA506_5354(vanB)

PMUD:

NCTC8068_05358(vanB)

PSV:	PVLB_18300

PALK:

PSAKL28_39360

PSIL:

PMA3_18885

PEZ:	HWQ56_28435

PPII:

QL104_31085

PSAM:

HU731_015665

PSHH:

HU773_000600

PTK:	EXN22_08330

PHYG:

JTY93_27045

PSKP:

KU43P_13840

PSMZ:

V6L79_20675

PSIV:

LZ023_04805

PIM:	OQ460_00435

PBAB:

AAEO81_15985

EMO:	DM558_02380

EAZ:	JHT90_02500 JHT90_04155

ENTO:

MTZ49_08520

HPEG:

EAO82_07115

ACIG:

BS636_11045

APIS:

ACDW34_12290

AAL:	EP13_18330

AAUS:

EP12_19110

ALTO:

AltI4_01270

ALTB:

IUA53_19265

VRS:	V8F66_21060

ADI:

B5T_04413

AXE:

P40_21510

RPI:

Rpic_4500

RPF:	Rpic12D_4632

RPJ:	N234_24525

RMN:	TK49_17075

RIN:	ACS15_4618

RWE:	KOL96_07595

REH:	H16_B0739(h16_B0739)

CNC:	CNE_2c06820(pobB)

CUH:	BJN34_24895

REU:	Reut_B3579 Reut_B4797 Reut_B5777

RME:	Rmet_5549(pobB)

CTI:	RALTA_B0575

CBW:	RR42_m2771 RR42_s1575

CCUP:

BKK81_20595 BKK81_29830

CUP:	BKK80_21285 BKK80_26525

CUU:	BKK79_26500 BKK79_32410

CPAU:

EHF44_27450

COX:	E0W60_08555 E0W60_20470

CCAM:

M5D45_27255

CUK:	KB879_21125

CNAN:

A2G96_23660

CUPP:

CTP10_R39540

BUU:	WS70_13205

BCEN:

DM39_1986

BYI:	BYI23_C004950 BYI23_D008340

BGP:	BGL_2c01180

BPLA:

bpln_1p1360 bpln_2g01180

BURT:

BTHE68_50550 BTHE68_67730

BXE:

Bxe_B2369

BXB:

DR64_4701

BGE:	BC1002_4697

BPY:	Bphyt_4243

BCAI:

K788_00002315

PSPW:

BJG93_04570

PTRO:

G5S35_25095

PACS:

FAZ98_16390

PDIO:

PDMSB3_0712.1(pobB)

PBON:

QS306_14170

PPAI:

E1956_21855 E1956_21970 E1956_36270

PLAD:

PPGU16_52540

PAZZ:

PBP221_37330

PPK:	U875_18000

PPNO:

DA70_10510

PPNM:

LV28_20550

PRB:	X636_16120

PPUL:

RO07_06165

PSPU:

NA29_21435 NA29_22295

PAPI:

SG18_14725

PVE:	UC34_06025

POX:	MB84_08065 MB84_10465

PTX:	ABW99_12525

PFG:	AB870_17050 AB870_18760

PNR:	AT302_01050 AT302_05955

PAND:

DRB87_05410 DRB87_13355

PFIB:

PI93_022220 PI93_023925

PCOM:

NTU39_06945 NTU39_07760

PANN:

PanNE5_03720

PANX:

OYT13_05275

BUO:	BRPE64_DCDS03390

CABK:

NK8_60920

BUE:	BRPE67_CCDS06780 BRPE67_DCDS10270

BAV:

BAV0615

BHZ:	ACR54_03867(pobB)

BBRO:

BAU06_03630

BFZ:	BAU07_13835

BPDZ:

BBN53_03795

BGM:	CAL15_17825

BOJ:	CBF45_01150

BGV:	CAL12_23490

ASW:	CVS48_25005

ACHR:

C2U31_19590

AAEG:

RA224_28125

AFA:	UZ73_13830

ALCN:

MID00_06155

PIG:	EGT29_10560 EGT29_19400 EGT29_23160

KGY:	EHF36_01335

PARK:

LSG25_14010

NARM:

N7E01_05860

RHOB:

HTY51_11695 HTY51_11760

POL:

Bpro_3680

ACIP:

CBP36_17870

ACIN:

CBP34_18210

ACIS:

CBP35_01040

VEI:

Veis_2771

DAC:

Daci_0965

DEL:	DelCs14_5558

DTS:	BI380_19870

DHK:	BO996_04910

DLA:	I6G47_19800 I6G47_32225

VAP:	Vapar_3159

VPE:	Varpa_3582

VPD:	VAPA_1c32460 VAPA_2c09730

VBO:	CKY39_14805

VAM:	C4F17_30660

VAZ:	H7F35_33940

VAV:	IG196_12455

VAE:	RZE79_13030

VAW:	SFB74_19150

CTT:	CtCNB1_4601

CTES:

O987_27295 O987_28190

CODO:

LAD35_19190

CRJ:	QMY55_23530

CENP:

M9799_09940 M9799_18545

CPIS:

HS961_04225

HYR:	BSY239_2702 BSY239_3348

HYB:	Q5W_01280 Q5W_24670

HYN:	F9K07_00825 F9K07_07505 F9K07_11515 F9K07_11635 F9K07_30140 F9K07_30190 F9K07_30240 F9K07_30385 F9K07_30435

HTN:	KI616_03630

HCZ:	G9Q37_00975 G9Q37_13985

HYY:	JNX00_07015 JNX00_19840

HYDA:

ABSY19_17160 ABSY19_17260 ABSY19_21510 ABSY19_24165

DIH:	G7047_06755

DRG:	H9K76_11925

STHM:

IS481_17575

SMIO:

CATMQ487_34520

ATER:

MW290_29035

MMS:

mma_2506

HHT:	F506_19590

HRB:	Hrubri_1309

HEE:	hmeg3_00175

HFR:	G5S34_07830

CARE:

LT85_0544

MVAR:

MasN3_30340

MUM:	FCL38_03880

APET:

ToN1_02080

THK:	CCZ27_15675

MESO:

BSQ44_11255

AAK:	AA2016_5653

AMIS:

Amn_pa01550

AMIO:

N7E70_029725

AOL:

S58_21520

BRK:	CWS35_19805

BEL:	BE61_31180 BE61_64930

BDG:	LPJ38_20665

BSEP:

HAP48_0032610

BQB:	J4P68_0033845

BBRA:

QA636_27060

BGK:	IC762_13675

BPAH:

QA639_17950

BRAA:

NL528_11735

RHOR:

ONR75_23650

RHOL:

RBJ75_26355

RHZ:	RHPLAN_44340

XDI:	EZH22_10380

MTEZ:

HPT29_026805

HMC:	HYPMC_3536(pobB)

DEQ:	XM25_18610

YTI:	FNA67_00260

MEMC:

OGR47_20620

AEX:	Astex_2477

ASTI:

Q1W73_15840

CID:

P73_2874

CON:	TQ29_05730

CBOT:

ATE48_17525

SSAN:

NX02_22630

SBIN:

SBA_ch1_21300

SNAP:

PQ455_00690 PQ455_15845

SNOS:

K8P63_05730

SAAP:

E2E30_04355

SMAZ:

LH19_26280

SCH:	Sphch_3460

SBD:	ATN00_07600

SPHR:

BSY17_2022

SPHT:

K426_02680

SPYG:

YGS_C1P1167

SPAG:

sphantq_03243(pobB)

AAY:	WYH_01862(pobB_1) WYH_03339(pobB_2)

CMAN:

A9D14_14475

AACE:

A0U92_13920

RHDM:

HFP48_25090

RHMM:

ISO16_14740

STRL:

HEP84_46900

SRPZ:

HEP85_06540

» show all

Reference

1 [PMID:19325743]

Authors

Chen L, Yang J

Title

Biochemical characterization of the tetrachlorobenzoquinone reductase involved in the biodegradation of pentachlorophenol.

Journal

Int J Mol Sci 9:198-212 (2008)
DOI:10.3390/ijms9030198

Reference

2 [PMID:23676275]

Authors

Yadid I, Rudolph J, Hlouchova K, Copley SD

Title

Sequestration of a highly reactive intermediate in an evolving pathway for degradation of pentachlorophenol.

Journal

Proc Natl Acad Sci U S A 110:E2182-90 (2013)
DOI:10.1073/pnas.1214052110

Sequence

[sch:Sphch_3460]

Other DBs

ExplorEnz - The Enzyme Database:

1.1.1.404

IUBMB Enzyme Nomenclature:

1.1.1.404

ExPASy - ENZYME nomenclature database:

1.1.1.404

BRENDA, the Enzyme Database:

1.1.1.404

LinkDB

DBGET integrated database retrieval system