KEGG   ENZYME: 1.1.1.427
Entry
EC 1.1.1.427                Enzyme                                 
Name
D-arabinose 1-dehydrogenase (NADP+);
AraDH;
adh-4 (gene name)
Class
Oxidoreductases;
Acting on the CH-OH group of donors;
With NAD+ or NADP+ as acceptor
Sysname
D-arabinose:NADP+ 1-oxidoreductase
Reaction(IUBMB)
D-arabinofuranose + NADP+ = D-arabinono-1,4-lactone + NADPH + H+ [RN:R01575]
Reaction(KEGG)
R01575
Substrate
D-arabinofuranose [CPD:C21067];
NADP+ [CPD:C00006]
Product
D-arabinono-1,4-lactone [CPD:C00652];
NADPH [CPD:C00005];
H+ [CPD:C00080]
Comment
The enzyme from the archaeon Saccharolobus solfataricus is tetrameric and contains zinc. L-fucose also is a substrate. In contrast to EC 1.1.1.116 (D-arabinose 1-dehydrogenase (NAD+)) and EC 1.1.1.117 (D-arabinose 1-dehydrogenase [NAD(P)+]), this enzyme is specific for NADP+.
History
EC 1.1.1.427 created 2022
Pathway
ec00053  Ascorbate and aldarate metabolism
ec01100  Metabolic pathways
Orthology
K19590  D-arabinose 1-dehydrogenase (NADP+)
Genes
SSOSSO1300(adh-4)
SOLSsol_2254
SSOASULA_2287
SSOLSULB_2288
SSOFSULC_2285
SSHIJ5U23_01598
SCASSACC_26710
SISLS215_1090
SIAM1425_0567
SIMM1627_0588
SIDM164_0597
SINYN1551_2256
SIILD85_0601
SIHSiH_0792
SIRSiRe_0562
SICSiL_0583
SULABFU36_12575
SULEGFS03_04535
AMANB6F84_05670
SACDHS1genome_1982
CSTYKN1_28410(adh)
CMACmaq_1175
VDIVdis_1460
 » show all
Reference
1  [PMID:16849334]
  Authors
Brouns SJ, Walther J, Snijders AP, van de Werken HJ, Willemen HL, Worm P, de Vos MG, Andersson A, Lundgren M, Mazon HF, van den Heuvel RH, Nilsson P, Salmon L, de Vos WM, Wright PC, Bernander R, van der Oost J
  Title
Identification of the missing links in prokaryotic pentose oxidation pathways: evidence for enzyme recruitment.
  Journal
J Biol Chem 281:27378-88 (2006)
DOI:10.1074/jbc.M605549200
  Sequence
[sso:SSO1300]
Reference
2  [PMID:17610898]
  Authors
Brouns SJ, Turnbull AP, Willemen HL, Akerboom J, van der Oost J.
  Title
Crystal structure and biochemical properties of the D-arabinose dehydrogenase from Sulfolobus solfataricus.
  Journal
J Mol Biol 371:1249-60 (2007)
DOI:10.1016/j.jmb.2007.05.097
  Sequence
[sso:SSO1300]
Other DBs
ExplorEnz - The Enzyme Database: 1.1.1.427
IUBMB Enzyme Nomenclature: 1.1.1.427
ExPASy - ENZYME nomenclature database: 1.1.1.427
BRENDA, the Enzyme Database: 1.1.1.427
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