KEGG   ENZYME: 2.1.1.238
Entry
EC 2.1.1.238                Enzyme                                 
Name
mycinamicin VI 2''-O-methyltransferase;
MycE
Class
Transferases;
Transferring one-carbon groups;
Methyltransferases
Sysname
S-adenosyl-L-methionine:mycinamicin VI 2''-O-methyltransferase
Reaction(IUBMB)
S-adenosyl-L-methionine + mycinamicin VI = S-adenosyl-L-homocysteine + mycinamicin III [RN:R09822]
Reaction(KEGG)
R09822
Substrate
S-adenosyl-L-methionine [CPD:C00019];
mycinamicin VI [CPD:C15682]
Product
S-adenosyl-L-homocysteine [CPD:C00021];
mycinamicin III [CPD:C15681]
Comment
The enzyme is involved in the biosynthesis of mycinamicin macrolide antibiotics. Requires Mg2+ for optimal activity.
History
EC 2.1.1.238 created 2011
Pathway
ec00522  Biosynthesis of 12-, 14- and 16-membered macrolides
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K21540  mycinamicin VI 2''-O-methyltransferase
Reference
1  [PMID:19415708]
  Authors
Li S, Anzai Y, Kinoshita K, Kato F, Sherman DH
  Title
Functional analysis of MycE and MycF, two O-methyltransferases involved in the biosynthesis of mycinamicin macrolide antibiotics.
  Journal
Chembiochem 10:1297-301 (2009)
DOI:10.1002/cbic.200900088
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 2.1.1.238
IUBMB Enzyme Nomenclature: 2.1.1.238
ExPASy - ENZYME nomenclature database: 2.1.1.238
BRENDA, the Enzyme Database: 2.1.1.238
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